| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.73581284 |
| FYN binding protein ( FYB or p120 / 130 ) associates with p 59 ( fyn ) , the TcRzeta / CD3 complex , and becomes tyrosine phosphorylated in response to receptor ligation . 0.73581284^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| Augmented catalytic activity was accompanied by p59fyn ( T ) labelling at the autophosphorylation site Tyr 420 , consistent with stimulated fyn catalytic activity , as well as the phosphorylation of polypeptides at 18 20 ( TcR zeta ) , 31 , 90 and 130 kD . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| TCR mediated activation of the src family kinases , Lck and Fyn , results in tyrosine phosphorylation of the TCR zeta and CD 3 chains . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| Here we show that ligation of T cell receptor ( TCR ) by alloantigen alone , which results in anergy , activates tyrosine phosphorylation of TCR zeta and its association with fyn . ^^^ These data suggest that the induction of anergy is an active signaling process characterized by the association of TCR zeta and fyn . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| In vitro kinase assay suggested that the CD 3 zeta dimer but not the FcR gamma dimer associates with the Fyn kinase . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of gp 120 on TCR CD 3 induced phosphorylation and activation of the src type protein tyrosine kinases ( PTK ) , fyn and lck . gp 120 caused minimal changes in lck phosphorylation or lck enzymatic activity , but preincubation of Jurkat cells with gp 120 for 20 min strongly inhibited TCR CD 3 mediated phosphorylation and activation of lck and fyn , as well as phosphorylation of CD 3 zeta . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| In the membrane fraction , tyrosine phosphorylation of Lck , Fyn , and CD 3 zeta can be induced by PTP inhibitors , but not by anti CD 3 . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : Correlations between the development of immunosuppression and changes in expression of TCR signaling proteins ( CD 3 zeta , p 56 ( lck ) , p 59 ( fyn ) ) , calcium mobilization , and total tyrosine kinase activity following TCR stimulation were examined . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that specific inhibition of Lck expression in Th 2 cells , in the presence of normal levels of functional Fyn PTK , has profound consequences on multiple events following TCR stimulation , including an altered pattern of tyrosine phosphorylated substrates , defective phosphorylation of TCR zeta and ZAP 70 , defective Ca2+ mobilization , and a approximately 90 % reduction in proliferative responses to antigenic and mitogenic stimuli . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| Results demonstrate that in BW 5147 wild type TCR , tail less zeta TCR , CD3epsilon , and TCRzeta transduce signals leading to tyrosine phosphorylation of similar sets of cellular substrates , including the receptor subunits , Fyn , ZAP 70 , and phospholipase Cgamma 1 ( PLCgamma 1 ) . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| Aberrant TCR mediated signaling in CD 45 null thymocytes involves dysfunctional regulation of Lck , Fyn , TCR zeta , and ZAP 70 . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that NOD T cell hyporesponsiveness is associated with the ( a ) enhanced TCR beta associated Fyn kinase activity and the differential activation of the Fyn TCR zeta Cbl pathway , which may account for the impaired recruitment of ZAP 70 to membrane bound TCR zeta ; ( b ) relative inability of the murine son of sevenless ( mSOS ) Ras GDP releasing factor activity to translocate from the cytoplasm to the plasma membrane ; and ( c ) exclusion of mSOS and PLC gamma 1 from the TCR zeta associated Grb2 / pp36 38 / ZAP70 signaling complex . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast , the expression of actin , TCR zeta chain , ZAP 70 , and p 59 ( fyn ) remained similar in controls and infected mice . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| Recently , mutation of glycine 2 , cysteine 3 , and lysines 7 and 9 was shown to block binding of Fyn to TCR zeta chain ITAMs , prompting the designation of these residues as an ITAM recognition motif ( Gauen , L . ^^^ Specifically , coexpression of a K 7 , 9A Fyn mutant with N myristoyltransferase restored myristoylation , membrane binding , and association with the cytoplasmic tail of TCR zeta fused to CD 8 . ^^^ We conclude that the Fyn SH 4 domain provides the signals for fatty acylation and specific plasma membrane localization , stabilizing the interactions between the Fyn SH 2 domain and phosphotyrosines in TCR zeta chain ITAMs . . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| As compared to peripheral blood ( PB ) T lymphocytes , SF T cells from some ( but not all ) of the patients analyzed expressed lower levels of TCRalphabeta , CD3epsilon , TCRzeta , p 56 ( lck ) and LAT , while p 59 ( fyn ) , phospholipase C gamma 1 and ZAP 70 expression was unaltered . ^^^ |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20963 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|