| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| Here we report that Fyn tyrosine kinase is activated during the initial stages of myelination and that it is associated with the large myelin associated glycoprotein ( MAG ) , an adhesion molecule that has been implicated in myelinogenesis . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| Initial events of myelination requiring cell surface interactions may involve signaling via Fyn kinase which functionally associates with myelin associated glycoprotein , an adhesion molecule implicated in myelinogenesis . . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn is present in myelin forming cells and is activated through stimulation of cell surface receptors such as large myelin associated glycoprotein ( L MAG ) . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| Severe hypomyelination of the murine CNS in the absence of myelin associated glycoprotein and fyn tyrosine kinase . ^^^ The analysis of mice deficient in the myelin associated glycoprotein ( MAG ) or Fyn , a nonreceptor type tyrosine kinase proposed to act as a signaling molecule downstream of MAG , has revealed that both molecules are involved in the initiation of myelination . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| Transplantation of neural precursor cells into the dysmyelinated CNS of mutant mice deficient in the myelin associated glycoprotein and Fyn tyrosine kinase . ^^^ Cells were expanded in vitro in the presence of mitogens for up to 14 weeks , and injected into the lateral ventricle of young postnatal mouse mutants deficient in the myelin associated glycoprotein ( MAG ) and the nonreceptor type tyrosine kinase Fyn . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| Mutant mice deficient in the myelin associated glycoprotein ( MAG ) and the nonreceptor type tyrosine kinase Fyn are characterized by a severely hypomyelinated central nervous system ( CNS ) and morphologically abnormal myelin sheaths . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| MAG also specifically bound the Fyn tyrosine kinase , suggesting that MAG serves as a docking protein that allows the interaction between different signaling molecules . . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic domain of L MAG contains a unique phosphorylation site and has been shown to associate with the fyn tyrosine kinase . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| The present study suggests that MBP is required for the regulation of MAG expression in oligodendroglia , involving Fyn therein . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| Animals doubly deficient in MAG and the neural cell adhesion molecule ( NCAM ) show defects similar to those present in MAG single mutants while mice deficient in MAG and the nonreceptor type tyrosine kinase Fyn are severely hypomyelinated , in addition to the MAG specific myelin abnormalities . ^^^ |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20916 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|