| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Among the targets of mIg induced tyrosine phosphorylation are the tyrosine kinases encoded by the lyn , blk , fyn , and syk genes , the mIg associated proteins MB 1 and Ig beta , phospholipase C gamma 1 and gamma 2 , as well as many unidentified proteins . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Two of these proteins represented the tyrosine kinase fyn and the mouse homologue of phospholipase C gamma 1 , whereas two genes encoded proteins similar to 5 crk and NCK . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Pervanadate induced activation of the tyrosine kinases lck and fyn ( 4 and 3 fold respectively ) and a dramatic increase in tyrosine phosphorylation of cellular proteins , notably phospholipase C gamma 1 . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that Raf 1 associated with the SH 2 domain of Fyn ( a member of the Src tyrosine kinase family ) but not with the SH 2 domains of phospholipase C gamma 1 , the p 85 alpha subunit of phosphatidylinositol 3 kinase , and SH 2 containing protein tyrosine phosphatase 2 . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| We show that phospholipase C gamma 1 , Ras GTPase activating protein , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , Vav , Fyn , and Src are components of the Flk2 / Flt3 signal transduction pathway . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Platelet activating factor induces the tyrosine phosphorylation and activation of phospholipase C gamma 1 , Fyn and Lyn kinases , and phosphatidylinositol 3 kinase in a human B cell line . ^^^ We have thus demonstrated that the activation of tyrosine kinases is an important proximate step in PAF mediated signal transduction in B cells , leading to tyrosine phosphorylation and activation of PLC gamma 1 , Fyn and Lyn kinases , and PtdIns 3 kinase . . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Nevertheless , IL 4 stimulation could induce activation of FYN but not LYN kinase , suggesting that additional molecule ( s ) might link FYN kinase to PLC gamma 1 . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 1 and Fyn are also found in activated Grap signaling complexes , although these interactions may not be direct . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Results demonstrate that in BW 5147 wild type TCR , tail less zeta TCR , CD3epsilon , and TCRzeta transduce signals leading to tyrosine phosphorylation of similar sets of cellular substrates , including the receptor subunits , Fyn , ZAP 70 , and phospholipase Cgamma 1 ( PLCgamma 1 ) . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that NOD T cell hyporesponsiveness is associated with the ( a ) enhanced TCR beta associated Fyn kinase activity and the differential activation of the Fyn TCR zeta Cbl pathway , which may account for the impaired recruitment of ZAP 70 to membrane bound TCR zeta ; ( b ) relative inability of the murine son of sevenless ( mSOS ) Ras GDP releasing factor activity to translocate from the cytoplasm to the plasma membrane ; and ( c ) exclusion of mSOS and PLC gamma 1 from the TCR zeta associated Grb2 / pp36 38 / ZAP70 signaling complex . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with gp 160 resulted in marked inhibition of tyrosine phosphorylation of p 59 ( fyn ) , PLC gamma 1 , ras activation , and TNF alpha secretion in anti CD 3 mAb activated CD4+ T cells , and a subset of CD4+ cells underwent activation induced cell death . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Proteins that also underwent redistribution in response to the tyrosine phosphatase inhibitor included paxillin , phospholipase C gamma 1 , mitogen activated protein kinase , and the tyrosine kinases Src and Fyn . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Dimethylbenz [ a ] anthracene activates protein tyrosine kinases Fyn and Lck in the HPB ALL human T cell line and increases tyrosine phosphorylation of phospholipase C gamma 1 , formation of inositol 1 , 4 , 5 trisphosphate , and mobilization of intracellular calcium . ^^^ The mechanism of DMBA induced tyrosine phosphorylation of phospholipase C gamma 1 may have been due to an increase in protein tyrosine kinase activity , since it was found that DMBA produced a > 2 fold increase in the activity of the T cell receptor associated Src family kinases Fyn and Lck . ^^^ Thus , it is likely that the Fyn kinase or other protein tyrosine kinases may be responsible for the early tyrosine phosphorylation of phospholipase C gamma 1 , which results in inositol 1 , 4 , 5 trisphosphate release and mobilization of intracellular Ca2+ . . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Significantly , CD 45 did not influence the binding of Fyn , PLC gamma 1 , GAP and Vav to the same phosphopeptide . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| These interactions were specific as molecules known to be tyrosine phosphorylated following TcR cross linking , phospholipase C gamma 1 and Fyn , were not bound . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| We analyzed jacalin induced intracellular signaling events in CD 4 ( + ) T cells and have shown that cell activation resulted in tyrosine phosphorylation of intracellular substrates p 56 ( lck ) , p 59 ( fyn ) , ZAP 70 , p 95 ( vav ) , phospholipase C gamma 1 , and ras activation , as assessed by conversion of ras guanosine 5 ' diphosphate to ras guanosine 5 ' triphosphate . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Tr kit promotes the formation of a multimolecular complex composed by Fyn , PLCgamma 1 and Sam 68 . ^^^ Upon microinjection , tr kit triggers metaphase to anaphase transition in mouse eggs by the sequential activation of Fyn and PLCgamma 1 . ^^^ Western blot analysis indicates that one of these proteins is Sam 68 , an RNA binding protein that is known to interact with and be phosphorylated by Src like kinases in mitosis . tr kit promotes the association of Sam 68 with PLCgamma 1 and Fyn in a multimolecular complex , as demonstrated by co immunoprecipitation of the phosphorylated forms of these proteins using antibodies directed to anyone of the partners of the complex . ^^^ Thus , our data suggest that tr kit promotes the formation of a multimolecular complex composed of Fyn , PLCgamma 1 and Sam 68 , which allows phosphorylation of PLCgamma 1 by Fyn , and may modulate RNA metabolism . . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| SLM 1 bound the SH 2 and SH 3 domains of p 59 ( fyn ) , Grb 2 , phospholipase Cgamma 1 ( PLCgamma 1 ) , and / or p 120 ( rasGAP ) , suggesting it may function as a multifunctional adapter protein for Src during mitosis . ^^^ Moreover , SLM 2 did not associate with the SH 3 domains of p 59 ( fyn ) , Grb 2 , PLCgamma 1 , or p 120 ( rasGAP ) , suggesting that SLM 2 may not function as an adapter protein for these proteins . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Other downstream effectors of the TCR / CD3 transduction machinery , such as phosphatidylinositol 3 kinase p85alpha , p 59 ( fyn ) , linker for activation of T cells ( LAT ) , and phospholipase C gamma 1 , are not affected . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Several CD 2 pathway components regulated by p 59 ( fyn ) have been identified including phospholipase C gamma 1 ( PLC gamma 1 ) , Vav , protein kinase C theta isoform ( PKC theta ) , docking protein ( Dok ) , focal adhesion kinase ( FAK ) and Pyk 2 . ^^^ Moreover , deficiency in fyn dependent PLC gamma 1 catalytic activity may contribute to reduced PKC alpha dependent ERK activation . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| In addition , the reconstituted WASP interacted in vitro with proteins containing SH 3 domain such as Grb 2 , PLC gamma 1 , and Fyn , each of which are connected to signaling pathways linked to the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| The interaction between tr kit and Fyn triggers activation of the kinase as monitored by both autophosphorylation and phosphorylation of PLCgamma 1 . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| Calcium induced human keratinocyte differentiation requires src and fyn mediated phosphatidylinositol 3 kinase dependent activation of phospholipase C gamma 1 . ^^^ In the present study , we investigated whether the activation of PLC gamma 1 by nonreceptor kinases such as src and fyn plays a role in mediating this process . ^^^ Our results showed that the combination of dominant negative src and fyn blocked calcium stimulated PLC gamma 1 activity and human keratinocyte differentiation , whereas each separately has little effect . ^^^ These data indicate that calcium activates PLC gamma 1 via increased PIP 3 formation mediated by c src and fyn activated PI3K . ^^^ |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|