| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| Impaired plasma membrane targeting of Grb 2 murine son of sevenless ( mSOS ) complex and differential activation of the Fyn T cell receptor ( TCR ) zeta Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice . ^^^ We demonstrate that NOD T cell hyporesponsiveness is associated with the ( a ) enhanced TCR beta associated Fyn kinase activity and the differential activation of the Fyn TCR zeta Cbl pathway , which may account for the impaired recruitment of ZAP 70 to membrane bound TCR zeta ; ( b ) relative inability of the murine son of sevenless ( mSOS ) Ras GDP releasing factor activity to translocate from the cytoplasm to the plasma membrane ; and ( c ) exclusion of mSOS and PLC gamma 1 from the TCR zeta associated Grb2 / pp36 38 / ZAP70 signaling complex . ^^^ |
|
| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18583 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|