| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp / PAG phosphorylation in thymocyte lipid rafts . ^^^ |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| Brain and embryo derived fibroblast src and fyn activity is reduced to < 50 % in PTPalpha ( / ) mice . ^^^ |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| The CD 45 transmembrane protein tyrosine phosphatase ( PTPase , EC 3 . 1 . 3 . 48 ) plays an essential role in T cell activation by activating the Lck and / or Fyn protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| We have examined the in vivo activity of receptor like protein tyrosine phosphatase alpha ( PTPalpha ) toward p 59 ( fyn ) , a widely expressed Src family kinase . ^^^ |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| A role for the receptor like protein tyrosine phosphatase alpha ( PTPalpha ) in regulating the kinase activity of Src family members has been proposed because ectopic expression of PTPalpha enhances the dephosphorylation and activation of Src and Fyn [ 1 ] [ 2 ] [ 3 ] . ^^^ |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase alpha ( PTPalpha ) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn . ^^^ |
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| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| Notably , alpha 4 stimulated cell motility was inhibited by catalytically inactive receptor protein tyrosine phosphatase alpha overexpression and blocked by the p50Csk phosphorylation of c Src at Tyr 529 . alpha4beta1 stimulated cell motility of triple null Src ( / ) , c Yes ( / ) , and Fyn ( / ) fibroblasts was dependent on c Src reexpression that resulted in p130Cas tyrosine phosphorylation and Rac GTPase loading . ^^^ |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| METHODS : NSCLC samples from 113 untreated patients were analyzed immunohistochemically with antibodies to glutathion s transferase pi ( GST pi ) , multidrug resistance associated protein ( MRP ) , lung resistance associated protein ( LRP ) , neuro specific enolase ( NSE ) , synaptophysin ( SYN ) and chromogranin ( CgA ) . ^^^ The expression of GST pi was significantly related with MRP , MRP and LRP ( P < 0 . 05 ) . ( 2 ) The positive rates of the NE markers were : NSE , 53 . 1 % ; SYN , 26 . 6 % ; CgA , 6 . 2 % ; and 21 . 2 % for at least two markers . ^^^ |
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| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| Thus , these two amino acids are critical for interaction with phosphotyrosine but not sufficient to supply PTPalpha D 2 with a D 1 like substrate specificity for elements of the phosphotyrosine microenvironment present in RR src and p 59 ( fyn ) . ^^^ |
|
| Interacting proteins: P18433 and P06241 |
Pubmed |
SVM Score :0.0 |
| The NMDAR is a substrate of src family tyrosine kinases , and reduced activity of src , fyn , yes and lck , but not lyn , was apparent in the absence of PTPalpha . ^^^ In a human embryonic kidney ( HEK ) 293 cell expression system , PTPalpha enhanced fyn mediated NR2A and NR2B tyrosine phosphorylation by several fold . ^^^ Together , these findings provide evidence that aberrant NMDAR associated functions in PTPalpha null mice are due to impaired NMDAR tyrosine phosphorylation resulting from the reduced activity of probably more than one of the src family kinases src , fyn , yes and lck . ^^^ |
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