| Interacting proteins: P16410 and P06241 |
Pubmed |
SVM Score :0.67445322 |
| In this report , we show that CTLA 4 can associate with the Src kinases Fyn and Lck and that transfection of Fyn or Lck , but not the unrelated kinase ZAP 70 , can induce tyrosine phosphorylation of CTLA 4 on residues Y 201 and Y 218 . 0.67445322^^^ |
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| Interacting proteins: P16410 and P06241 |
Pubmed |
SVM Score :0.0 |
| The T cell receptor specific kinases FYN , LCK , and ZAP 70 as well as the RAS pathway were found to be activated in T cells of Ctla 4 / mutant mice . ^^^ |
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| Interacting proteins: P16410 and P06241 |
Pubmed |
SVM Score :0.0 |
| Src family tyrosine kinases Fyn , Lyn , and Lck associate with CTLA 4 and phosphorylate both Y 165 and Y 182 that are mainly responsible for interaction with Fyn through its SH 2 domain . ^^^ SHP 2 associates with CTLA 4 , in a Fyn dependent manner . ^^^ |
|
| Interacting proteins: P16410 and P06241 |
Pubmed |
SVM Score :0.0 |
| Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA 4 and its association with PI 3 kinase in intracellular compartments of T cells . ^^^ Transfection of Lck or Fyn resulted in increased phosphorylation of intracellular CTLA 4 and recruitment of PI 3 kinase . ^^^ |
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| Interacting proteins: P16410 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16410 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|