| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| CD 44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid rich plasma membrane domains of human peripheral blood lymphocytes . ^^^ Reprecipitation of the in vitro phosphorylated proteins showed that CD 44 associates not only with Lck but also with Fyn kinase in these membrane domains . ^^^ |
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| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| The Src family non receptor PTKs such as Lck , Fyn , Lyn and Hck were shown to be coupled to CD 44 via sphingolipid rich microdomains ( lipid rafts ) of the plasma membrane . ^^^ |
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| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| Here we provide evidence that CD 44 , which is constitutively associated with Ick and fyn , supports proliferation as well as apoptosis mainly , if not exclusively , by enhancing signal transduction via the TCR / CD3 complex . ^^^ |
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| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| The CD 44 initiated reorganization of the cytoskeleton was associated with the recruitment of CD 44 and the associated tyrosine phosphokinases p 56 ( lck ) and p 59 ( fyn ) into glycolipid enriched membrane microdomains ( GEM ) . ^^^ Due to the association of CD 44 with lck and fyn this colocalization with the TCR allows an abundant provision of these kinases , which are essential to initiate the TCR signaling cascade . . ^^^ |
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| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| Naive CD 44 ( low ) CD 62 ligand ( high ) T cells were substantially reduced in Fyn / mice , presumably due to the inhibition of Cbp phosphorylation . ^^^ |
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| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| Moreover , activation of the LHR in MA 10 cells results in the stimulation of the activity of Fyn and Yes , and overexpression of either of these two tyrosine kinases enhances the LHR mediated phosphorylation of FAK Tyr 576 . ^^^ |
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| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| The LHR mediated phosphorylation of the EGFR and Shc , the activation of Ras , and the phosphorylation of ERK1 / 2 are inhibited by expression of a dominant negative mutant of Fyn , a member of the Src family kinases ( SFKs ) expressed in MA 10 cells and by PP 2 , a pharmacological inhibitor of the SFKs . ^^^ |
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| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|