Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have shown previously that the JAK 2 tyrosine kinase and the Src family p 59 Fyn tyrosine kinase are required for Ang 2 induced STAT 1 tyrosine phosphorylation in VSMCs . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Recent studies have suggested that Src family tyrosine kinases , p 60 Src and p 59 Fyn , are activated during P . aeruginosa invasion . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Nucleotide sequence analysis revealed that this gene , termed slk , encoded a 537 residue protein which was 86 % identical to the chicken proto oncogene product , p60c src , over a stretch of 191 amino acids at its carboxy terminus . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Expression of deregulated Xenopus fyn , a src family member , resulted in a phenotype similar to that seen with deregulated src . ^^^ However , in the fyn injected oocytes , many more proteins were phosphorylated on tyrosine than in the src injected oocytes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Nonreceptor PTK encoded by mammalian proto oncogenes ( c src , fyn , c yes , c abl ) and their homologs in Drosophila exhibit patterns of expression and activities that suggest functions in axonal or dendritic outgrowth . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this study , the focus forming activity of normal c src , fyn , and lck cDNAs were compared in NIH 3T3 cell transfection assays . ^^^ These studies support the previously published concept that overexpression of the normal fyn protein contributes to focus formation in transfected NIH 3T3 cells but suggest that the focus forming activity observed after c src or lck transfections is frequently attributable to mutational events . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
It is clear , however , that c src is the prototype of a family of at least 8 closely related genes encoding protein tyrosine kinases , the other family members being blk , c fgr , fyn , hck , lck , lyn , and c yes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Three members of the Src family of tyrosine kinases [ pp60c src ( Src ) , p59fyn ( Fyn ) and pp62c yes ( Yes ) ] are ubiquitously expressed , and are thus likely to have general roles in growth control . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Ig alpha chain cytoplasmic domain bound to the Src family kinases Lyn and Fyn , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and an unidentified 38 kilodalton phosphoprotein ; the cytoplasmic tail of Ig beta bound PI 3 kinase and unidentified 40 and 42 kilodalton phosphoproteins . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Recent reports from other laboratories have demonstrated that mIg coprecipitates with multiple src family protein tyrosine kinases , including blk , lyn , and fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Based upon its migration in one and two dimensional gel electrophoresis we show , however , that p 56 is distinct from the blk , lyn , or fyn src family kinases that have been shown to be associated with sIgM in mature B cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Peptide mapping demonstrated that the fyn protein was distinct from the closely related c src and c fgr proteins . ^^^ This peptide was specifically precipitated by antibodies directed against a peptide modeled on the closely related carboxy termini of the c src and fyn proteins . ^^^ The protein product of the src related proto oncogene , fyn , was isolated from IM 9 cells with antibodies specific for the amino terminal 22 residues of the fyn protein . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To date the src gene family consists of at least 9 closely related protein tyrosine kinases belonging to the non receptor type of kinases : c src , c yes , c fgr , fyn , lyn , lck , hck , tkl and bkl . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The fyn , fgr , and lyn genes were characteristically expressed concomitantly with phenotypic changes and expressions of nuclear proto oncogenes , whereas src , lck , hck , and yes genes were not . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Of the other three spleen tyrosine protein kinases , TPK 1 shows similar biochemical and immunological features , suggestive of close relatedness with TPK IIA , while TPK IIB and TPK 3 are neither related with the lyn protein nor with the products of three other oncogenes of the src subfamily , namely lck , hck and fyn . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The enzyme reacted quantitatively with a monoclonal antibody to the amino terminal sequence ( Cys 3 to Ser 66 ) specific to the human c yes protein , but not with antibodies to the specific amino terminal sequences of the c src , fyn , and lck proteins . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Transfected NIH / 3T3 cells , each overexpressing a normal or activated version of the fyn , fgr , or src translational product , were examined using antibody to phosphotyrosine as a probe . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Since fyn , one of src oncogene family possessing tyrosine++ kinase function , is co precipitated with TCR CD 3 complex , fyn seems to be involved in early phosphorylation for T cell activation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We examined the expression of four different src family genes ( lck , c src , fyn , and c fgr ) in addition to the expression of IL 2 , c fos , c myc , and actin genes in murine T cells which were activated with PMA plus ionomycin or PMA plus anti CD 3 mAb . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have evidence that the activated protein tyrosine kinase may be fyn , a member of the src family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Our finding of fyn transcripts brings to three the number of protein tyrosine kinases of the src family whose mRNAs are found in 10 . laevis oocytes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The transforming activity of the human fyn protein , p59fyn , which is a kinase of the src family , was investigated by testing the effect of recombinant avian retrovirus ( Fyn virus ) expressing p59fyn on chickens or cultured chicken embryo fibroblast ( CEF ) cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this study , a 10 fold elevated activity of PTK encoded by fyn , another src family gene , was demonstrated in CD 4 CD8 T cells in mutant mice . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have previously reported that carboxyl terminal truncations of the normal human fyn gene , a member of the src subfamily , can transform immortal mouse fibroblasts to full malignancy . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The C SRC , C YES , and FYN genes encode three closely related tyrosine protein kinases that are expressed in human neural tissues . ^^^ The C YES and FYN genes share with C SRC similar exon intron boundaries and a high degree of amino acid sequence homology in the 3 / 4 exon coding region . ^^^ In this study we have compared the expression of C SRC , C YES , and FYN RNAs in human lung , liver , brain , and placenta tissues and prepared cDNA clones spanning exons 3 and 4 for each of these genes from the different tissues . ^^^ Sequence analysis of these cDNA clones revealed that the splicing patterns for the FYN and C YES genes were the same among the various tissues , whereas C SRC cDNAs isolated from brain contained 18 additional bases with the capacity to code for the same six amino acids present in the neural specific forms of avian and murine pp60c src . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Sequence similarity with human c src , c yes , and fyn translational products began at amino acid position 76 of the predicted c fgr protein and extended nearly to its C terminus . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Acquisition of transforming properties by FYN , a normal SRC related human gene . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
By screening both human genomic and cDNA libraries using 5 yes DNA as a probe , we obtained DNA clones of the c yes gene , the pseudogene of c yes , c fgr gene and c src gene and two novel yes related genes , fyn and lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To explore whether other members of the c Src family are activated in these mammary tumors , we measured the in vitro kinase activity of the c Yes and Fyn kinases in protein extracts derived from mammary tumor tissue and morphological normal adjacent tissue . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family kinase Fyn , whose Src homology 2 ( SH 2 ) domain binds to the major FAK autophosphorylation site ( tyrosine 397 ) , was also identified in the two hybrid screen . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We previously showed by M 13 phage display that the Src , Fyn , Lyn , and phosphatidylinositol 3 kinase ( PI3K ) SH 3 domains preferred the same class 1 type core binding sequence , RPLPP psi P . ^^^ These libraries were screened for binding to the Src , Fyn , Lyn , Yes , and PI3K SH 3 domains . ^^^ The amino acids selected in the flanking sequences were similar for Src , Fyn , and Yes SH 3 domains ; however , Lyn and PI3K SH 3 domains showed distinct binding specificities . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The potent transforming activity of PyV middle T antigen can , in part , be attributed to its ability to associate with and to activate a number of c Src family tyrosine kinases ( c Src , c Yes , and Fyn ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Specificity of protein interactions with highly related SRC homology ( SH ) domains of FGR and FYN protein tyrosine kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Among these proteins , we identified Fyn tyrosine kinase , one of the non receptor type tyrosine kinases of the Src family . ^^^ The Fyn large MAG association requires amino terminal domains of Fyn that include SH 2 and SH 3 ( Src homology domains 2 and 3 ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
There was 49 % aa sequence identity with human FYN product and 47 % with human SRC product ; however , several structural differences distinguish this clone from other SRC subfamily members . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Neurite extension on laminin was unaltered in src , fyn , or yes neurons , indicating that pp60c src , p59fyn , or pp62c yes is not likely to participate in integrin dependent axon growth . ^^^ To determine whether these tyrosine kinases were capable of regulating substrate dependent axon growth , cultures of cerebellar neurons from wild type , src , fyn , and yes mice were analyzed for neurite outgrowth on the neural cell adhesion molecule L 1 or the extracellular matrix protein laminin . ^^^ The rate of neurite extension on L 1 was reduced in src , but not in fyn or yes neurons . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Two src family kinases , lck and fyn , participate in the activation of T lymphocytes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Rapid T cell receptor mediated tyrosine phosphorylation of p 120 , an Fyn / Lck Src homology 3 domain binding protein . ^^^ Two Src family protein tyrosine kinases , the TCR associated p59fyn ( Fyn ) and the CD4 / 8 associated p56lck ( Lck ) , have emerged as the likely mediators of early tyrosine phosphorylation in T cells . ^^^ Here , we show direct binding of a 120 kDa TCR induced phosphotyrosyl polypeptide , p 120 , to glutathione S transferase fusion proteins of the Src homology 3 ( SH 3 ) domains of Fyn , Lck , and p60src ( Src ) but not other proteins . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain binding proteins occurs in response to antigen receptor ligation in B cells and constitutively in pre B cells . ^^^ Proteins that bind to the Src homology 2 domains of Blk and Fyn were identified in B cells that had been activated with anti IgM but were not identified in unstimulated B cells . ^^^ A number of Blk and Fyn Src homology 2 domain binding phosphoproteins were also observed in pre B cells that had not been stimulated in vitro . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family kinase , Fyn , regulates the activation of phosphatidylinositol 3 kinase in an interleukin 2 responsive T cell line . ^^^ One IL 2 regulated PTK implicated in this cascade is the Src family kinase , Fyn . ^^^ Additional studies of the Fyn PI 3 kinase interaction demonstrated that the Src homology 3 ( SH 3 ) domain of Fyn constitutes a direct binding site for the p 85 subunit of PI 3 kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Identification of Src , Fyn , and Lyn SH 3 binding proteins : implications for a function of SH 3 domains . ^^^ These three proteins , as well as most of the other Src SH 3 ligands , also bound to the SH 3 domains of the closely related protein tyrosine kinases Fyn and Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Native protein kinase C delta from porcine spleen is phosphorylated in vitro by the tyrosine kinase src and to a much smaller extent by fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Raf 1 interacts with Fyn and Src in a non phosphotyrosine dependent manner . ^^^ In this report , we demonstrate that Raf 1 associated with the SH 2 domain of Fyn ( a member of the Src tyrosine kinase family ) but not with the SH 2 domains of phospholipase C gamma 1 , the p 85 alpha subunit of phosphatidylinositol 3 kinase , and SH 2 containing protein tyrosine phosphatase 2 . ^^^ Finally , using the baculovirus / Sf9 cell system , we show that coexpression of Raf 1 with full length Fyn / Src resulted in the coimmunoprecipitation of Raf 1 with Fyn / Src , the tyrosine phosphorylation of Raf 1 , and the stimulation of Raf 1 kinase activity . ^^^ These results suggest that Raf 1 may form a functional complex with Fyn / Src mediated in part by SH 2 domains and the serine phosphorylation of Raf 1 . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Second , we demonstrate a direct binding between purified SH 2 and SH 3 domains of Fyn and Lck Src family kinases . ^^^ Heterologous binding between SH 2 and SH 3 domains of closely related members of the Src family , namely , Fyn , Lck , and Src , was also observed . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Rapid and efficient purification of Src homology 2 domain containing proteins : Fyn , Csk and phosphatidylinositol 3 kinase p 85 . ^^^ To analyse the regulation of Src family tyrosine kinases in vitro , we have purified Fyn and Csk , a kinase capable of regulating Fyn activity by phosphorylation , from baculovirus infected insect cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Thus , src , fyn and yes are activated upon stimulation by platelet derived growth factor or colony stimulating factor in cells expressing high levels of these receptors . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We report here that thrombin induces a rapid ( < or = 30 s ) and transient increase in the kinase activity of Src and Fyn as determined by autophosphorylation in immune complex kinase assays . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Insertion of the Blk SH 3 domain into Lyn restored kinase activity , while insertion of the Fyn or Src SH 3 into Lyn enhanced the kinase activity 2 3 fold . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Consistent with the decrease in the Csk level , the kinase activity of a member of the Src family , Fyn , was greatly enhanced , but that of Src was not correlated inversely with the level of Csk expression . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Chimeric molecules in which the Src SH 3 domain was replaced with those of spectrin or Lck showed derepressed kinase activity , whereas a chimera containing the Fyn SH 3 domain was fully regulated . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The SH 3 domains of the Src related kinases Fyn , Lyn , and Hck bind to this sequence with the same affinity as that of the Src SH 3 . ^^^ In contrast , a quite different proline rich sequence from the Btk protein kinase binds to the Fyn , Lyn , and Hck SH 3 domains , but not to the Src SH 3 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using the anti Src antibody , which is reactive to Src , Fyn and Yes , we obtained evidence for an association between the Src family tyrosine kinase and the tyrosine phosphorylated Sky receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
VEGF induction by hypoxia in c src ( ) cells is impaired , although there is a compensatory activation of Fyn . ^^^ Hypoxia increases the kinase activity of pp60c src and its phosphorylation on tyrosine 416 but does not activate Fyn or Yes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Interestingly , the regulatory effects of lck on ZAP 70 , syk , and PLC gamma 2 could not be replaced by overexpression of either fyn or src , demonstrating a selective role for lck in effectively coupling Fc gamma R stimulation to critical downstream signaling events . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Furthermore , herbimycin A did not inhibit but rather augmented apoptosis at concentrations which effectively degraded the src related kinases lck and fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Comparison of fyn , src , yes , and abl nonreceptor tyrosine kinase mutant mice shows a specific requirement for Fyn in the induction of long term potentiation at CA 1 synapses in the hippocampus . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn and Yes , the other members of the Src family present in fibroblasts , were also found to be activated at mitosis . ^^^ In cells microinjected with a neutralizing antibody specific for Src , Fyn , and Yes ( anti cst . 1 ) during G 2 , cell division was inhibited by 75 percent . ^^^ Microinjection of the Src homology 2 ( SH 2 ) domain of Fyn was also inhibitory . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The c src gene family has nine known members ( blk , c fgr , fyn , hck , lck , lyn , c src , c yes and yrk ) , each encoding a cytoplasmic protein tyrosine kinase ( PTK ) believed to be involved in signal transduction . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Specific binding of Fyn and phosphatidylinositol 3 kinase to the B cell surface glycoprotein CD 19 through their src homology 2 domains . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Specific and redundant roles of Src and Fyn in organizing the cytoskeleton . ^^^ To determine the role of activated Src family kinases in the csk phenotype , we have introduced mutations in the src and fyn genes into the csk mutant background . ^^^ Genetic analysis reveals that src , but not fyn , is partly epistatic to the csk gene . ^^^ Regulation of cortactin and tensin hyperphosphorylation is Src dependent , whereas focal adhesion kinase and paxillin hyperphosphorylation is partly dependent on both Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Overexpression of c src in 32Dcl3 did not result in IL 3 stimulated activation of c src , indicating specificity for fyn , hck , and lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
ZAP 70 , however , increased phagocytosis when coexpressed with the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Since N myristoylation of Fyn PTK , a member of the Src family , has been shown to be a prerequisite for palmitolylation , a new single plasmid vector that allows overexpression of myristoylated Fyn substrate in Escherichia coli was developed . ^^^ It is likely that palmitoylation of Fyn and other Src family members by PAT regulates PTK localization and signaling functions . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show that CSF 1 stimulation resulted in activation of three Src family kinases , Src , Fyn and Yes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This up regulation is specific for p56lck since expression of other src kinases such as fyn , lyn , or yes was not modified . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Cells derived from these embryos exhibit an order of magnitude increase in activity of Src and the related Fyn kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we report the crystal structure of the SH 3 domain of Fyn ( a Src family tyrosine kinase ) at 1 . 9 A resolution . ^^^ The crystal structures of spectrin and Fyn SH 3 domains as well as the solution structure of the Src SH 3 domain show that these all have the same basic fold . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Two other nonreceptor tyrosine kinases , YES and FYN , were concentrated in the GCPs to a similar degree as that seen for SRC . ^^^ Our results show that FYN , like SRC , reaches a peak of expression early in development , and declines thereafter . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn immunoprecipitates displayed fourfold lower levels of middle T phosphorylation than that detected in the Src and Yes immunoprecipitates . ^^^ In Src negative cells , the level of middle T phosphorylation in Yes and Fyn immunoprecipitates was not significantly different from that detected in the Src positive cells , suggesting that the absence of Src does not lead to a compensating increase in the proportion of middle T associated with these kinases . ^^^ Taken together , these results indicate that Src is not required for middle T induced hemangiomas in mice or for focus induction in immortalized fibroblasts , and that the residual level of Yes , Fyn and phosphatidylinositol kinase activity associated with middle T in Src negative cells may compensate for the absence of Src . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To examine the role of Src related proteins in human colon carcinoma we measured the tyrosine kinase activity of pp60c src ( Src ) , p62c yes ( Yes ) , p56lck ( Lck ) , p59fyn ( Fyn ) , p59hck ( Hck ) , p56lyn ( Lyn ) and p55c fgr ( Fgr ) from colonic cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this report , we have expressed normal and enzymatically activated versions of the fyn , fgr , and src translational products by transfection of appropriate cDNAs into mouse fibroblasts . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show that phospholipase C gamma 1 , Ras GTPase activating protein , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , Vav , Fyn , and Src are components of the Flk2 / Flt3 signal transduction pathway . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Subsequently , K protein was shown to bind sequence specific single and double stranded DNA , stimulate transcription , and bind Src , Fyn , Lyn , and Vav via SH 3 interactions . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To analyze in more detail which amino acids surrounding the phosphorylated tyrosine at position 579 were important for high affinity interaction with Src family kinases , we synthesized a series of phosphopeptides corresponding to this binding site in which single amino acids were individually changed and tested their ability to compete with the PDGF receptor for binding of Fyn . ^^^ The activated colony stimulating factor 1 ( CSF 1 ) receptor , which is known to associate with Src family kinases , has a sequence in its juxtamembrane region similar to that surrounding Tyr 579 of the PDGF receptor , and a phosphopeptide modeled on this sequence competed the association of Fyn with the receptor in vitro . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fetal rat brain ( E 18 ) expresses at least three c src like , membrane associated non receptor tyrosine kinases : c src , fyn , and lyn . c src and fyn are the most abundant and are highly enriched in a subcellular fraction of nerve growth cones ( GCPs ) . ^^^ All three non receptor tyrosine kinases are associated with the cytoskeleton to a significant degree with the relative affinities : fyn > c src > lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Recombinant GST fusion proteins containing the Hck , Src , Fyn , or Lck SH 3 domains associated with full length GAP , delta CAT , and delta SH , all of which share an N terminal proline rich region resembling an SH 3 binding motif ( PPLPPPPPQLP ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src family kinases ( Lyn , Fyn , Lck , and Blk ) and Syk , a tandem SH 2 domain containing tyrosine kinase , have been demonstrated to be associated with the antigen receptor in B cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
An antibody specific for the carboxy terminus of Src , Fyn , and Yes ( anti cst . 1 ) inhibited Src kinase activity in vitro and caused morphological reversion of Src transformed cells in vivo . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We demonstrate here that LFA 1 is physically associated in the YT human NK like cell line cells with a PTK ( s ) that is distinct from Src family PTKs such as Lck , Fyn , or Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Recently , the cDNA sequence of a novel Src and Fyn binding protein called AFAP 110 , for Actin Filament Associated Protein 110 kDa , was reported . ^^^ This protein was distinctive in that it is both an SH 2 and SH 3 binding partner for the non receptor tyrosine kinases Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The effect of GM CSF and M CSF on the activation of fyn kinase , a 59 kDa src family related protein tyrosine kinase ( PTK ) , was studied . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Several tyrosine kinases have been shown to be associated with the BCR , including the src family members Lyn , Fyn , Blk , and Lck and the non src kinase Syk . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have examined interactions between FGF receptor 1 ( FGFR 1 ) and Src , Fyn and Yes . ^^^ In contrast , in porcine aortic endothelial cells ( FGFR 1 / PAE ) and lung fibroblasts from chinese hamster ( CCL 39 ) , activation of FGFR caused reduced autophosphorylation of Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In vitro , c Cbl bound to the Src homology 3 domains of Src , Fyn , and Lyn in both unstimulated and Fc gamma R stimulated macrophages . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This distribution pattern is similar to that of the Src family kinases including Yes , Src , Fyn and Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Both the src family tyrosine protein kinases Lck , Fyn , Lyn and Blk and the syk family tyrosine protein kinases Syk and ZAP 70 play a role in lymphocyte activation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Peptides based upon the 7 amino acid SH 3 binding domain core motif displayed strong binding to both the Src and to the Fyn SH 3 domains , but failed to bind to the SH 3 domain of p 21 Ras GTPase activating protein ( Ras GAP ) and other proteins . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Members of the Src family such as Fyn and Yes showed an increased level of phosphorylation upon VEGF stimulation of cells expressing Flt 1 but not in cells expressing KDR . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In B cells , two classes of protein tyrosine kinases ( PTKs ) , the Src family of PTKs ( Lyn , Fyn , Lck , and Blk ) and non Src family of PTKs ( Syk ) , are known to be involved in signal transduction induced by the stimulation of the B cell antigen receptor ( BCR ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This type of analysis has only recently become possible , with the generation of ' gene knock out ' mice lacking each of the kinase genes src , fyn and yes . ^^^ RESULTS : Hemangiomas develop efficiently in newborn mice lacking either src , fyn or yes after inoculation with a PymT transducing retrovirus . ^^^ In src and fyn deficient mice , the kinetics of induction and the histological properties of the tumors were indistinguishable from those in wild type mice . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Mutations in the c src and fyn genes were shown previously to lead to restricted nonoverlapping phenotypes only in a subset of cells in which these kinases are expressed . ^^^ Combined deficiencies of Src , Fyn , and Yes tyrosine kinases in mutant mice . ^^^ Three members of the Src family of tyrosine kinases , src , fyn , and yes , are broadly expressed throughout mouse development . ^^^ Whereas most of the src / fyn or src / yes double mutants die perinatally , a substantial proportion of fyn / yes double mutants are viable but undergo degenerative renal changes leading to diffuse segmental glomerulosclerosis . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To determine whether src related tyrosine kinases mediate NCAM dependent neurite outgrowth , cultures of cerebellar and sensory neurons from fyn , src , and yes minus mice were analyzed for neurite outgrowth on monolayers of NCAM 140 transfected L fibroblasts . ^^^ NCAM dependent neurite outgrowth was selectively inhibited in cultures of cerebellar and dorsal root ganglion neurons from fyn , but not src or yes mice . ^^^ Neurite outgrowth by fyn , src , or yes neurons on untransfected fibroblast monolayers was unaffected , indicating that these kinases do not contribute significantly to axon growth on at least some integrins or other adhesive substrates present on fibroblasts . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have investigated whether the Src , Fyn , Yes and Lck gene products are palmitoylated . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Identification of Src , Fyn , Lyn , PI3K and Abl SH 3 domain ligands using phage display libraries . ^^^ We have employed a novel modification of phage display involving biased libraries to identify peptide ligands of the Src , Fyn , Lyn , PI3K and Abl SH 3 domains . ^^^ The Src SH 3 domain prefers the sequence XXXRPLPPLPXP , Fyn prefers XXXRPLPP ( I / L ) PXX , Lyn prefers RXXRPLPPLPXP , PI3K prefers RXXRPLPPLPP while the Abl SH 3 domain selects phage containing the sequence PPPYPPPP ( I / V ) PXX . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Several members of the Src family , including Blk , Lyn , Fyn ( T ) , and Lck , are expressed in B cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Mice with mutations in four nonreceptor tyrosine kinase genes , fyn , src , yes , and abl , were used to study the role of these kinases in long term potentiation ( LTP ) and in the relation of LTP to spatial learning and memory . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SRC family members including lck , lyn and fyn have been demonstrated to associate with IL 2R beta through binding of the kinase domain to the acidic domain of IL 2R beta . ^^^ The cascade includes SRC family kinase members such as lck , fyn , and lyn , activation of Raf 1 and PI 3K , and ras , and increased expression of the fos , fra 1 , and jun protooncogenes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Most of the nine members of the Src family of tyrosine kinases are restricted in their expression , often to cells of the haematopoietic lineage , while some , particularly Src , Fyn and Yes , are more ubiquitously expressed . ^^^ We have been studying the functions of Src , Fyn and Yes in fibroblasts . ^^^ We have shown that stimulation of quiescent fibroblasts with platelet derived growth factor ( PDGF ) causes Src , Fyn and Yes to become activated , and to associate transiently with the PDGF receptor . ^^^ To address the role of Src , Fyn and Yes in the response to PDGF , we have used a dominant negative approach , in which cells were engineered to express catalytically inactive forms of Src kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn is a member of the Src family of tyrosine kinases which are thought to play important roles in cell to cell interactions during morphogenesis . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Binding of Bruton ' s tyrosine kinase to Fyn , Lyn , or Hck through a Src homology 3 domain mediated interaction . ^^^ Here , we show that Btk interacts with Src homology 3 domains of Fyn , Lyn , and Hck , protein tyrosine kinases that get activated upon stimulation of B and T cell receptors . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Analysis of signal transduction events shows that pervanadate induces the activity of the src family of tyrosine kinases lck and fyn and the tyrosine phosphorylation of a major IL 2 responsive protein of 97 kDa . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here it was found that the Src homology 3 ( SH 3 ) domain of Lyn and Fyn bound to a proline rich region ( residues 84 to 99 ) within the 85 kilodalton subunit ( p 85 ) of PI 3 kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Several genes of the src family encode protein tyrosine kinases that associate with the B cell antigen receptor complex and are activated upon receptor cross linking , including blk , lyn , and fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this report , we identify cysteine residues within the N terminal region of the Src family member Fyn which serve as sites for palmitylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have deleted the SH 2 and SH 3 domains from Fyn and Fgr and have generated two point mutations in residues completely conserved in all members of the Src family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src like protein tyrosine kinase Fyn is associated with T cell antigen receptor . ^^^ Csk , which phosphorylates tyrosine residues in the negative regulatory sites of Src family kinases , down regulated Fyn and Lck mediated stimulation of the serum response element and Fyn mediated enhancement of IL 2 promoter activity . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Non receptor type tyrosine kinases of the Src family , such as Src , Yes and Fyn , are strongly expressed in the brain and have been suggested to have an important function in the central nervous system . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In T cells , the src family kinases , lck and fyn , are candidates for this regulated kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Expression of various oncogenes ( ras , myc , erbB 2 , src , fyn , yes and sis ) in a high metastatic clone ( MH 02 ) derived from a murine methylcholanthrene induced fibrosarcoma A ( Meth A ) was compared with those of its parent clone ( ML 01 ) by Northern blot analysis . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The src family of non receptor protein tyrosine kinases ( PTKs ) , including the blk , fyn , lyn and lck kinases , is expressed in B lineage cells , may associate with the immunoglobulin receptor complex and , therefore , play a role in signal transduction via membrane IgM . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Three members of the Src family of protein tyrosine kinases Src , Fyn , and Yes associate with the activated platelet derived growth factor ( PDGF ) receptor in vivo . ^^^ We microinjected cells with DNA encoding catalytically inactive forms of the Src and Fyn proteins and examined their effects on PDGF mediated signaling in vivo . ^^^ Kinase inactive Src and Fyn inhibited PDGF stimulated entry of cells into S phase , whereas kinase active forms of the proteins had no inhibitory effects . ^^^ Injection of an antibody specific for Src , Fyn , and Yes also reduced signal transduction through the PDGF receptor but only when injected within 8 hr of PDGF stimulation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Moreover , myristylated peptides corresponding to the NH 2 termini of src , yes , lyn , and fyn inhibit membrane association of pp60c src , p62c yes , and p59fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Differential effects of expression of the CD 45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck , fyn , and c src tyrosine protein kinases . ^^^ We have studied the phosphorylation of the closely related lck , fyn , and c src tyrosine protein kinases in leukemic murine T cell lines that have lost the expression of CD 45 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The importance of an intact Src Homology 2 ( SH 2 ) domain for transformation by members of the tyrosine kinase family , including 5 src , c src , c abl , fps and fyn is well documented . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Thus CD 28 signaling can activate src family kinases lck and fyn , as well as the Tec family kinase emt / itk . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
These nonlymphoid cells endogenously expressed the Src family kinase Fyn but not Syk . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Furthermore , co expression of Byp and the Src family kinase Fyn increased the level of tyrosine phosphorylation of Byp , suggesting that Byp was tyrosine phosphorylated by Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the present study , we demonstrated that binding to this receptor by mab 5C6 produced increased levels of expression of cytoplasmic src family proto oncogene kinases lck , fyn and src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
One of the src family kinases , p59fyn ( Fyn ) , plays an important role in the TCR mediated signaling . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Molecular cloning of a cDNA encoding a phosphoprotein , Efs , which contains a Src homology 3 domain and associates with Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Overexpression of Fyn mutants with an activated kinase mutation and with a Src homology 2 deletion mutation resulted in a stimulation and suppression of the mSOS activity , respectively . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In addition , we have found that some of these phosphorylation sites are involved in mediating the interaction of Raf 1 with potential activators ( Fyn and Src ) and with other cellular proteins ( 14 3 3 ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The sequential phosphorylation of p50 / HS1 as well as its specific blockage by the HS 1 phosphopeptide is also observable if c Fgr is replaced by two other Src related kinases , namely , Lyn and Fyn , as secondary phosphorylating agents . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Csk may be involved in the down regulation of T cell receptor ( TCR ) signaling by C terminal tyrosine phosphorylation of Lck and Fyn ; however , it is not known how Csk activity is regulated or how it targets these Src family members . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Cbl was associated in vivo with Fyn and , to a lesser extent , other Src family kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Middle T antigen of mouse polyomavirus , an oncogenic DNA virus , associates with and activates the cellular tyrosine kinases c Src , c Yes , and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The tyrosine kinases c Fgr , Fyn , C terminal Src kinase and p72syk , as well as the Ser / Thr specific cAMP dependent protein kinase and protein kinases CK 1 and CK 2 do not phosphorylate p 57 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In addition to binding to the phosphorylated cytoplasmic domains of Ig alpha and Ig beta , blk and fyn ( T ) , two members of the src family kinases , have been shown to bind overlapping but distinct sets of phosphoproteins [ Malek & Desiderio ( 1993 ) J . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Specific antibodies against c Src , Fyn , c Yes , c Fgr , Lck , Lyn , Hck , and Blk proteins did not recognize the p 57 Xenopus tyrosine kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Chimeric molecules in which the Src SH 3 domain was replaced with that of spectrin or Lck also blocked PDGF induced DNA synthesis , whereas a chimera containing the Fyn SH 3 domain did not . ^^^ These data suggest that the Src or Fyn SH 3 domain is required either for correct substrate selection or to recruit other proteins to the PDGF receptor . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In NIH3T3 fibroblasts , c Src , Fyn , and c Yes associate with the activated PDGF receptor , are substrates for receptor phosphorylation , and are themselves activated . ^^^ Src family catalytic function is required for RPTK mitogenic signaling as evidenced by the SH 2 dependent dominant negative phenotype exhibited by kinase inactive Src and Fyn mutants ( Twamley Stein , G . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Analysis of tyrosine phosphorylated RAFTK from adherent transfected COS cells showed that the Src homology 2 ( SH 2 ) domains of the Src and Fyn protein kinases as well as the Grb 2 adaptor protein were able to specifically associate with RAFTK . ^^^ These data suggest that RAFTK is a novel member of the FAK family , that it localizes to focal adhesion like structures in CMK megakaryocytic cells , that it participates in integrinmediated signaling pathways in megakaryocytes , and that it is able to associate with the tyrosine kinases Src and Fyn as well as the adaptor protein Grb 2 via SH 2 phosphotyrosine interactions . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The CD 45 tyrosine phosphatase has been reported to activate the src family tyrosine kinases Lck and Fyn by dephosphorylating regulatory COOH terminal tyrosine residues 505 and 528 , respectively . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Ligand induced clustering of the Fc mu R also induced activity of src family kinases , Lck , Fyn , Lyn , and Src , as well as their physical interaction with the receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
RPDE 6 exhibited selectivity in binding to the SH 3 domains of c Abl , Crk , Csk , Lck , Lyn , Fyn and 5 Src , with binding to the SH 3 regions of the Src related tyrosyl kinases Lyn and Fyn being the most effective . ^^^ We suggest that the PDE4A splice variant RPDE 6 has a propensity for interaction with selective SH 3 domains , in particular those from Src and the Src related tyrosyl kinases Lyn and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This Ca ( 2+ ) activated tyrosine kinase activity could not be accounted for entirely by c Src or Fyn ( two nonreceptor tyrosine kinases that are expressed abundantly in chromaffin cells ) , because their in vitro kinase activities were not inhibited by tyrphostin 23 and only partially inhibited by genistein . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We adopt the SH 2 domain from a member of the Src family , Fyn ( whose predominant physiological role is in initiation of signals from the T cell receptor complex ) , to explore the differences in structural , thermodynamic , and kinetic determinants of regulatory and specific interactions using tyrosyl phosphopeptides based on the C terminus and on a putative physiological interacting species from the hamster middle sized tumor antigen . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
B cell antigen receptors ( BCR ) are composed of an antigen binding subunit , the membrane Ig , and Ig alpha / Ig beta heterodimers , that contain a transducing motif named ITAM for `` immuno receptor tyrosine based activation motif . ' ' Ig alpha and Ig beta ITAMs only differ by four amino acids located before the second conserved tyrosine ( DCSM in Ig alpha and QTAT in Ig beta ) , which determine the in vitro association of Ig alpha with the src kinase fyn . ^^^ These data show that alterations that modify the ability of Ig alpha and Ig beta to interact in vitro with the src kinase fyn ( switch between QTAT and DCSM ) also determine signal transduction capabilities of these molecules expressed in B cells . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
WASp bound preferentially in vitro to SH 3 domains from c Src family kinases , and analysis of proteins expressed in insect cells using a baculovirus vector demonstrated a specific interaction between WASp and the Fyn protein tyrosine kinase . ^^^ Members of the c Src family of protein tyrosine kinases , including Fyn , are involved in a range of signalling pathways such as those regulating cytoskeletal structure in both haematopoietic and non haematopoietic cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
RESULTS : We have determined the solution structure of the SH 3 domain from the Src family tyrosine kinase Fyn in two forms : unbound and complexed with a peptide corresponding to a putative ligand sequence from phosphatidylinositol 3 ' kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
During the early stage of neurogenesis , FAK is phosphorylated , shows multiple isoforms , and interacts with the proto oncogenes , src , fyn , and lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn . ^^^ We also find that the wild type and the kinase defective FAK were associated with Src and Fyn in CHO cells whereas the F 397 mutant was not . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In contrast , Shc , phosphatidylinositol 3 kinase ( Pl3K ) , Grb 2 , and Ras GTPase activating protein ( GAP ) bound with different affinities to the bis or monophosphorylated peptides , while the Src family protein tyrosine kinase ( PTK ) Fyn did not bind specifically to any of the tested peptides . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn is a Src family protein tyrosine kinase functionally associated with the T cell antigen receptor ( TcR ) / CD3 receptor complex . ^^^ We also demonstrate that Fyn is the Src family kinase that preferentially interacts with c Cbl in T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
An association between active Cdc 2 and the Src related kinases Lyn and Fyn was also demonstrated , although Cdc 2 was not found associated with the tyrosine kinases , Csk and Syk . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This association is mediated by the Src homology 3 ( SH 3 ) domain of Fyn , since a glutathione S transferase Fyn SH 3 fusion protein was able to precipitate CD 43 from lysates of CD 43 activated T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A caveolin peptide derived from this region ( residues 82 101 ) functionally suppressed the auto activation of purified recombinant c Src tyrosine kinase and Fyn , a related Src family tyrosine kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
These findings reveal the potential for redundant functions mediated by Src family PTKs while emphasizing crucial roles for Lck and Fyn in T cell development . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The major autophosphorylation site is tyrosine 397 , which interacts with the Src homology 2 ( SH 2 ) domain of Src family kinases including Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Furthermore , AChRs affinity isolated from C 2 myotubes using alpha bungarotoxin Sepharose were specifically associated with Src and Fyn and had tyrosine phosphorylated beta subunits . ^^^ We suggest that AChRs are initially phosphorylated by Src and subsequently bind Fyn in a phosphotyrosine dependent manner . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
One of the earliest steps in the activation pathway is thought to involve the Src family PTKs , p 56 ( lck ) ( Lck ) and p 59 ( fyn ) ( Fyn ) ; however , the precise contribution of each PTK in TCR mediated signaling remains incompletely understood . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Ligation of the CD 2 cell surface glycoprotein expressed on T lymphocytes and NK cells induces protein tyrosine phosphorylation and activation of the Src kinases , LCK and FYN . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Middle T antigen of mouse polyomavirus ( MomT ) associates with the cellular tyrosine kinases c Src , c Yes , and Fyn , while middle T antigen of hamster polyomavirus ( HamT ) exclusively binds Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylated mDab 1 associates with the SH 2 domains of Src , Fyn and Abl . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Among the protein tyrosine kinases examined , the Src family kinases Fyn and Blk were inducibly tyrosine phosphorylated and activated by receptor ligation only in CD45+ cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Glutamate activated currents ( evoked every 20 s for up to 20 min ) were increased by src and fyn kinases without affecting the desensitization and deactivation kinetics in NR 1 NR2A but the kinases had no effects in NR 1 NR2B , NR 1 NR2C and NR 1 NR2D receptor channels , suggesting that a phosphorylation site in NR2A is targeted . 4 . ^^^ In a mutant channel consisting of NR 1 and a C terminal deletion mutant of NR2A ( NR2A delta C ) , src and fyn kinases lost their potentiating effects indicating that the phosphorylation of tyrosine ( s ) in the C terminal domain of NR2A affects the current flux through native NMDA receptor channels . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Analysis revealed cytoskeletal association of c Src , FAK , and beta 3 integrin , but no Fyn , in the pressure overloaded right ventricle . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src family tyrosine kinases Blk , Fyn , Lck , and Lyn as well as spleen kinase , Syk , are activated to transmit the signal further . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
One candidate is Fyn , a Src kinase coexpressed with Lck in immature and mature T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Presence of some protein tyrosine kinases , such as src and fyn , was also shown . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
These data suggest that Sam 68 participates in the signal transduction pathway downstream of TCR coupled Src family kinases Fyn and Lck in lymphocytes , that is not only in the mitotic pathway downstream of c Src in fibroblasts . . ^^^ Interaction between Sam 68 and Src family tyrosine kinases , Fyn and Lck , in T cell receptor signaling . ^^^ The Src family protein tyrosine kinase , Fyn , is associated with the T cell receptor ( TCR ) and plays an important role in TCR mediated signaling . ^^^ Sam 68 was associated with the Src homology 2 and 3 domains of Fyn and also those of another Src family kinase , Lck . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Use of chimeric Fyn and Src constructs showed that rapid membrane targeting was mediated by the myristoylated NH 2 terminal sequence of Fyn and that a cysteine at position 3 , but not 6 , was essential . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NCAM 140 interacts with the focal adhesion kinase p 125 ( fak ) and the SRC related tyrosine kinase p 59 ( fyn ) . ^^^ Neurite outgrowth mediated by the neural cell adhesion molecule ( NCAM ) requires the src family tyrosine kinase p 59 ( fyn ) in nerve growth cones , but the molecular basis for this interaction has not been defined . ^^^ The NCAM 140 isoform , which is found in migrating growth cones , selectively co immunoprecipitated with p 59 ( fyn ) from nonionic detergent ( Brij 96 ) extracts of early postnatal mouse cerebellum and transfected rat B 35 neuroblastoma and COS 7 cells . p 59 ( fyn ) did not associate significantly with the NCAM 180 isoform , which is found at sites of stable neural cell contacts , or with the glycophosphatidylinositol linked NCAM 120 isoform . pp 60 ( c ) src , a tyrosine kinase that promotes neurite growth on the neuronal cell adhesion molecule L 1 , did not interact with any NCAM isoform . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
After its stimulation , there was an increase in the association of the src cytoplasmic tyrosine kinase Fyn and the adapter protein Grb 2 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Also , tyrosine phosphorylation of STP A 11 by src led to subsequent binding to lck and fyn in vitro . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family protein tyrosine kinases ( PTKs ) , Lck and Fyn , are coexpressed in T cells and perform crucial functions involved in the initiation of T cell antigen receptor ( TCR ) signal transduction . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Expression of Src / Csk , but not DK Src / Csk , caused reduction of the specific activities of Src and Fyn in the differentiated P 19 cells . ^^^ In normally differentiated P 19 cells , cross linking of a cell adhesion molecule , L 1 , induced a short term activation of Src and Fyn . ^^^ In the Src / Csk transfectant , L 1 stimulation induced delayed activation of Src and Fyn peaking at much lower levels than in the control cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In human T lymphocytes the Src family protein tyrosine kinase p 59 ( fyn ) associates with three phosphoproteins of 43 , 55 , and 85 kDa ( pp 43 , pp 55 , and pp 85 ) . ^^^ Employing a GST Fyn Src homology 2 ( SH 2 ) domain fusion protein pp 55 was purified from lysates of Jurkat T cells . ^^^ Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Herein we show that the N terminal SH 4 region of the Src family member p59fyn ( Fyn ) is both necessary and sufficient for targeting of Fyn and heterologous proteins to the plasma membrane and detergent insoluble subdomains . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In addition to binding the src kinase p 59 ( fyn ) , FYB binds specifically to the hematopoietic signaling protein SLP 76 , an interaction mediated by the SLP 76 SH 2 domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
After insulin dependent tyrosine phosphorylation , c Cbl specifically associates with fusion proteins containing the Src homology 2 ( SH 2 ) domains of Crk and the Fyn tyrosine kinase , but not with fusion proteins containing the SH 2 domains of either the p 85 subunit of phosphatidylinositol 3 ' kinase or the tyrosine phosphatase SHPTP2 / Syp . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family kinases , Fgr , Fyn , Lck , and Lyn , colocalize with coated membranes in platelets . ^^^ Src and Src family members are reported to be membrane associated , but detergent extraction studies have demonstrated a major difference in the solubility of Src compared with other members of the Src family ( Fgr , Fyn , Lck , Lyn , and Yes ) , suggesting that their subcellular distributions may be different . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The role of Lck appears to be replaced by another Src family protein tyrosine kinase , Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Csk is probably involved in the downregulation of TCR signaling by C terminal tyrosine phosphorylation of Lck and Fyn , but the mechanism whereby Csk targets these Src family members is not known . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Interestingly , neither Syk and C terminal Src kinase nor three other members of the Src family ( Lyn , Lck , and Fyn ) are susceptible to stimulation by phosphopeptide , as observed with c Fgr . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src kinases Fyn and Lck coprecipitating with activated TCR complexes are significantly less kinase active in the GPI processing mutants than in wild type cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The mammalian members include Sam 68 , which is a target of Src , Fyn , and Grb 2 , and the newly cloned mouse quaking proteins ( qkI ) necessary in early embryogenesis and myelination . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Its association with Fyn , a member of the Src family of tyrosine kinases , has been observed in cell lines . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we show that while only Src and Yes were expressed and activated by EGF , microinjected kinase inactive mutants of Src ( SrcK ) and Fyn ( FynK ) were able to exert a dominant negative effect on the scattering response . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Gp 60 activation also phosphorylated the Src family tyrosine kinases pp 60 ( c Src ) and Fyn . ^^^ The activated pp 60 ( c Src ) and Fyn co immunoprecipitated with caveolin 1 in BPMVEC membrane . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using affinity precipitation , WASP was found to bind to Src SH 3 containing proteins Fyn , Lck , PLC gamma , and Grb 2 , and mutated WASP , if expressed , was able to bind to Fyn glutathione S transferase ( GST ) fusion protein . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Sodium dodecyl sulfate polyacrylamide gel electrophoresis , autoradiography , and phospho amino acid analysis revealed the presence of in vitro tyrosine phosphorylated proteins that were subsequently identified by re precipitation ( and / or by western blotting ) as the respective C type lectin molecules and Src family kinases Lck , Lyn , and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Therefore , the role of Src kinase family members ( c Src and Fyn ) in activation of the BMK 1 by H2O2 in mouse fibroblasts was studied . ^^^ Third , BMK 1 activation in the response to H2O2 was completely inhibited in cells derived from mice deficient in c Src , but not Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Accumulating evidence indicates that this kinase is the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
HBx protein stimulated c Src and Fyn kinases for a prolonged time . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Furthermore , the CRP response is abolished by the Src family kinase inhibitor PP 1 and inhibited in Fyn deficient mice . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn is a member of the Src family of tyrosine kinases that are involved in signal transduction by association with a number of membrane receptors . ^^^ The molecular basis of the signalling roles observed for different Src family members is still not well understood ; although structures have been determined for the SH 2 domains of other Src family molecules , this is the first structure of the Fyn SH 2 domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The presence of the various exons did not alter the interaction of FAK with c Src , n Src , or Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Signal transduction mediated by the B cell Ag receptor involves the activation of multiple protein tyrosine kinases that are members of the Src family ( i . e . , Fyn , Lyn , Blk , Lck ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family protein tyrosine kinase Fyn ( p59fyn ) plays an important role in thymocyte development and T cell receptor ( TCR ) signal transduction . ^^^ Our results revealed that co localization of Fyn with the TCR CD 3 complex requires the unique N terminus whereas co localization with CD 45 depends on the unique N terminus , the Src homology ( SH ) 3 and a functional SH 2 domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Other cytoplasmic tyrosine kinases , Syk , Fyn , and c Src , showed no or only weak ability to activate Stat proteins . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Signal transduction of interleukin 6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src family kinases Fyn , Hck , and Lyn in multiple myeloma cell lines . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
By using co immunoprecipitation techniques and in vitro kinase assays , the uPAR associated proteins were identified as Janus ( Jak ) and Src non receptor protein tyrosine kinases ( PTK ) Jak 1 , Tyk 2 , and p 59 ( fyn ) , p53 / 56 ( lyn ) , p53 / 59 ( hck ) , and p 55 ( fgr ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show here that Fyn , a member of the Src family , is phosphorylated on Tyr 28 in the unique N terminal part of the molecule after interaction with the intracellular domain of the PDGF beta receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have now examined the involvement of the src tyrosine kinase , fyn , in PRL induced the activation of PI 3 kinase in the rat lymphoma cell line , Nb 2 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A direct interaction between Sam 68 and the two src kinases involved in T cell activation , p 59 ( fyn ) and p 56 ( lck ) , as well as a partnership of Sam 68 with various key downstream signaling molecules , like phospholipase Cgamma 1 and Grb 2 , has been shown . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
CD 2 has a relatively long cytoplasmic tail which associates with the src family tyrosine kinases , p 56 ( lck ) and p 59 ( fyn ) , and could potentially signal directly . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Our engineering strategy is generally applicable to the Src family kinases : mutation of the corresponding residue ( Thr 339 to glycine ) in the Fyn kinase confers specificity for N 6 ( benzyl ) ATP on Fyn . ^^^ As the identical mutation in the Src family kinase Fyn confers on Fyn the ability to recognize the same unnatural ATP analog , our strategy is likely to be generally applicable to other protein kinases and may help to identify the direct targets of specific kinases . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The generality of the method was tested by engineering another tyrosine kinase , Fyn , to contain the corresponding active site mutation to the one in 5 Src . ^^^ The same compound that inhibited mutant 5 Src could also potently inhibit the engineered Fyn kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Moreover , two Src family kinases ( Fyn and Yes ) were activated by angiotensin 2 in a time and concentration dependent manner . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Coexpression experiments in COS cells demonstrate that among T cell expressed Src and Syk related protein tyrosine kinases , Fyn , Yes , and Syk appear to play a major role in phosphorylation of c Cbl , whereas Lck and Zap phosphorylate c Cbl ineffectively . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have examined the in vivo activity of receptor like protein tyrosine phosphatase alpha ( PTPalpha ) toward p 59 ( fyn ) , a widely expressed Src family kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Cross linking of the T cell antigen receptor ( TCR ) CD 3 complex induces rapid tyrosine phosphorylation and activation of Src ( Lck and Fyn ) and Syk ( Syk and Zap 70 ) family protein tyrosine kinases ( PTKs ) which , in turn , phosphorylate multiple intracellular substrates . ^^^ These findings implicate Fyn as an adaptor protein that facilitates the interaction between Syk and Cbl , and suggest that Src and Syk family PTKs coordinately regulate the tyrosine phosphorylation of Cbl . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using the substrate region of p 130 ( cas ) as the substrate , we found that Fyn and Src were activated on stimulation with KCl . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Proteins that also underwent redistribution in response to the tyrosine phosphatase inhibitor included paxillin , phospholipase C gamma 1 , mitogen activated protein kinase , and the tyrosine kinases Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Western blotting reveals both c Src and Fyn in the active fractions . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
PKC depletion did not alter Ang 2 dependent tyrosine phosphorylation or activity of p 125 ( FAK ) , CADTK , Fyn or Src , but PKC depletion or incubation with GF109203X resulted in Ang 2 dependent EGF receptor tyrosine phosphorylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
T cell antigen receptor ( TCR ) engagement results in sequential activation of the Src protein tyrosine kinases ( PTKs ) Lck and Fyn and the Syk PTKs , ZAP 70 and Syk . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
CD 44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid rich plasma membrane domains of human peripheral blood lymphocytes . ^^^ In human peripheral blood T lymphocytes , 20 % to 30 % of the Src family protein tyrosine kinases , Lck and Fyn , are recovered from these fractions . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
These responses were markedly reduced in cells overexpressing the Csk kinase or in cells that lack focal adhesion kinase or the Src family kinases Src or Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Whereas skin of fyn / mice appears normal , skin of mice with a disruption in both the fyn and src genes shows intrinsically reduced tyrosine phosphorylation of beta catenin , strongly decreased p 120 Cas levels , and important structural changes consistent with impaired keratinocyte cell adhesion . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Association of the Src family tyrosine kinase Fyn with TrkB . ^^^ Fyn tyrosine kinase , a member of the Src family , was recently reported to be present in neurons and glia cells . ^^^ The Fyn Src homology domain 2 ( SH 2 ) was observed to associate in vitro with the intracellular domain of TrkB ( ICD TrkB ) . ^^^ The Src SH 2 domains showed substantially lower affinity with pICD TrkB , suggesting that the association between Fyn SH 2 and pICD TrkB is not due to nonspecific interactions of SH 2 domains with phosphorylated tyrosine residues . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To study the role of these kinases , we analyzed the trajectory of the olfactory nerve in E11 . 5 homozygous null mutant mice lacking single src or fyn gens and double mutants lacking both genes . ^^^ The fyn minus olfactory nerve had significantly more fascicles than than src minus nerve . ^^^ Most strikingly , the primary olfactory nerve of src / fyn double mutants showed the greatest degree of defasciculation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein 6 Fc receptor gamma chain complex on human platelets . ^^^ Using coprecipitation methods with convulxin coupled beads and antibodies against FcRgamma and the Src family , we showed that Fyn and Lyn , but not Yes , Src , Fgr , Hck , and Lck , were physically associated with the GPVI FcRgamma complex irrespective of stimulation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Binding of the Fyn Src homology ( SH ) 3 domain is regulated by the Fyn SH 2 domain . ^^^ CD 2 has been shown previously to associate physically with the Src family protein tyrosine kinases p 56 ( lck ) and p 59 ( fyn ) . ^^^ Using glutathione S transferase ( GST ) fusion proteins , we found that CD 2 bound to the Src homology ( SH ) 3 domain of Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
However , most of the data accumulated so far refer to heterologous expression , and native K+ channel substrates of Src or Fyn in neurons and glia remain to be elucidated . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We utilized yeast two hybrid cloning to identify the product of the tctex 1 gene as a protein that specifically interacts with Fyn , but not with other Src family kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src family tyrosine kinases Fyn , Lyn , and Lck associate with CTLA 4 and phosphorylate both Y 165 and Y 182 that are mainly responsible for interaction with Fyn through its SH 2 domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In contrast to Lyn and Fyn kinases , pp60c src appears to be complexed with alpha IIb beta 3 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using microinjection to introduce catalytically inactive dominant negative form of cSrc , as well as an antibody that neutralizes cSrc , Fyn and cYes , we have shown that Src kinases are required for DNA synthesis induced by most growth factors ( PDGF , EGF , CSF 1 , insulin , IGF 1 ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we report that a proline rich sequence in the amino terminus of tau interacts with the SH 3 domains of fyn and src non receptor tyrosine kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Thermodynamic data , derived from isothermal titration calorimetry , for the binding of Hck SH 3 to HIV 1 Nef show that the binding of Hck ( KD = 1 . 5 microM ) is approximately an order of magnitude tighter than those of other Src family kinases that were investigated ( Fyn , Lck , and Src ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins , including Vav , Cbl , p 85 phosphoinositide 3 kinase , and the Src family kinases Lck and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The unchecked activity of the TCR / CD3 associated src kinase p 59 ( fyn ) may alter the balance needed for regulated T cell responses in SLE patients . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Analysis of DRMs revealed a marked displacement of Src family kinases ( Lck , Fyn ) from DRMs derived from PUFA enriched T cells compared with controls , and the presence of Lck in DRMs strictly correlated with calcium signaling . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Immunoprecipitation assays showed that phosphorylated Vav associated with Fyn after CD 28 triggering and that this interaction , likely to involve binding of Fyn Src homology 2 domain to Vav , was more strongly detectable after concomitant CD 28 and TCR stimulation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Interaction between RA 70 and src family kinases , Fyn , Hck and Lyn , was detected during monocytes / macrophage differentiation of U 937 cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn , a Src family tyrosine kinase . ^^^ Fyn is a 59 kDa member of the Src family of tyrosine kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Furthermore , in contrast to ligand mediated TCR sorting , recycling of the TCR was independent of the tyrosine phosphatase CD 45 and the Src tyrosine kinases p 56 ( Lck ) and p 59 ( Fyn ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The engagement of these receptors leads to the activation of Lck and Fyn , which are protein tyrosine kinases ( PTKs ) of the Src family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Consistent with these data , CD 146 associates with p 59 ( fyn ) , a Src family kinase known to phosphorylate p 125 ( FAK ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Western blot analysis with specific antibodies against Src family members showed expression of Src , Fyn , and Lyn , lower levels of Yes and Hck , and the absence of Lck tyrosine kinase . ^^^ During a 3 day treatment with phorbol 12 myristate , 13 acetate ( PMA ) , which induces differentiation of FLG 29 . 1 cells toward an osteoclast like phenotype , the levels of Src and Fyn increased and the levels of Lyn decreased . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In addition , the proline rich domain of Sos also bound to the SH 3 domains of other src type tyrosine kinases , src and fyn , but not to that of PLC gamma . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Endothelin ( ET ) , a well known hypertrophic agonist , increased activity of c Src , c Yes , and Fyn within minutes and promoted a selective redistribution of each of these kinases within the cell . ^^^ Overexpression of c Src effected a significant increase in activity of a cotransfected human ANP promoter driven chloramphenicol acetyl transferase reporter , while expression of either c Yes or Fyn was considerably less effective in this regard . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Biochemical analyses indicated that FAK mutant DeltaC 14 was mislocalized and functioned as a dominant negative mutant by competing with endogenous FAK in focal contacts for binding signaling molecules such as Src and Fyn , resulting in a decreases of Erk activation in cell adhesion . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have investigated the interaction between Cbl and the Src related tyrosine kinase Fyn . ^^^ Binding studies indicated that Cbl could bind to glutathione S transferase ( GST ) fusion proteins encoding the unique , Src homology domain 3 ( SH 3 ) , and SH 2 domains of Fyn , Hck , or Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn , a member of the Src family protein tyrosine kinase ( PTK ) , is implicated in learning and memory that involves N methyl D aspartate ( NMDA ) receptor function . ^^^ These results suggest that PSD 95 is critical for regulation of NMDA receptor activity by Fyn and other Src family PTKs , serving as a molecular scaffold for anchoring these PTKs to NR2A . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
By screening a phage expression library using the monoclonal antibody ( mAb ) B 16 5 which recognizes Src homology 3 ( SH 3 ) domains of phospholipase C gamma and Nck , we have cloned a cDNA encoding the larger species of fyn mRNA . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this report , we show that CTLA 4 can associate with the Src kinases Fyn and Lck and that transfection of Fyn or Lck , but not the unrelated kinase ZAP 70 , can induce tyrosine phosphorylation of CTLA 4 on residues Y 201 and Y 218 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We showed the following : 1 ) that both Xp 95 isolated from Xenopus oocytes and a synthetic peptide containing the Src phosphorylation consensus sequence of Xp 95 were phosphorylated in vitro by Src kinase and to a lesser extent by Fyn kinase ; 2 ) Xp 95 from Xenopus oocytes or eggs was recognized by an anti phosphotyrosine antibody , and the relative abundance of tyrosine phosphorylated Xp 95 increased during oocyte maturation ; and 3 ) microinjection of deregulated Src mRNA into Xenopus oocytes increased the abundance of tyrosine phosphorylated Xp 95 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of all of these proteins in the in vitro kinase assay was abrogated by the Src family kinase inhibitor PP 1 , suggesting that it is mediated by either Fyn or Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Hyperosmolarity stimulated Fyn and inhibited Src . ^^^ Hyperosmotic cortactin phosphorylation was reduced in Fyn deficient fibroblasts but remained intact in Src deficient fibroblasts . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SLM 1 bound the SH 2 and SH 3 domains of p 59 ( fyn ) , Grb 2 , phospholipase Cgamma 1 ( PLCgamma 1 ) , and / or p 120 ( rasGAP ) , suggesting it may function as a multifunctional adapter protein for Src during mitosis . ^^^ SLM 2 is an RNA binding protein that is not tyrosine phosphorylated by Src or p 59 ( fyn ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Several studies have reported the lack of the Src like protein tyrosine kinase Lck and overexpression of Lyn and Fyn in these cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Dual fatty acylation of p 59 ( Fyn ) is required for association with the T cell receptor zeta chain through phosphotyrosine Src homology domain 2 interactions . ^^^ The first 10 residues within the Src homology domain ( SH ) 4 domain of the Src family kinase Fyn are required for binding to the immune receptor tyrosine based activation motif ( ITAM ) of T cell receptor ( TCR ) subunits . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Among the Src family members ( Src , Fyn , Lck , Yes , and Lyn ) present in MDCK cells , Fyn was the only one specifically associated with SHP 2 , and the physical interaction between them , which requires the Src family kinase activity , was increased in response to the agonists . ^^^ Pertussis toxin , PP 1 ( a selective Src family kinase inhibitor ) , or overexpression of a catalytically inactive mutant of Fyn blocked the UK 14304 or LPA stimulated activity of SHP 2 , SHP 2 tyrosine phosphorylation , and SHP 2 association with Grb 2 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In contrast , another Src family PTK , Fyn , was not affected by A6H ligation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have generated mouse embryos harboring functional null mutations of the ubiquitously expressed SFKs Src , Yes and Fyn . ^^^ To elucidate the molecular mechanisms underlying this phenotype , SYF cells ( deficient for Src , Yes and Fyn ) were derived and tested for their ability to respond to growth factors or plating on extracellular matrix . ^^^ Our studies reveal that while Src , Yes and Fyn are largely dispensable for platelet derived growth factor ( PDGF ) induced signaling , they are absolutely required to mediate specific functions regulated by extracellular matrix proteins . ^^^ Fibronectin induced tyrosine phosphorylation of focal adhesion proteins , including the focal adhesion kinase FAK , was nearly eliminated in the absence of Src , Yes and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Among the individual members of the Fyn complex pp 85 , SKAP 55 and pp 43 are constitutively phosphorylated on tyrosine residue ( s ) in vivo and likely interact with Fyn via its src homology 2 ( SH 2 ) domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
After cotransfection , Tio was phosphorylated in vivo by the protein tyrosine kinases Lck and Src and less efficiently by Fyn . ^^^ Binding analyses indicated a direct interaction of Tio with the SH 3 domains of Lyn , Hck , Lck , Src , Fyn , and Yes . ^^^ In addition , tyrosine phosphorylated Tio bound to the SH 2 domains of Lck , Src , or Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In hematopoietic cells , these low density Triton insoluble ( LDTI ) microdomains ( also called caveolae related domains ) are dramatically enriched in signaling molecules , such as cell surface receptors ( CD 4 and CD 55 ) , Src family tyrosine kinases ( Lyn , Lck , Hck , and Fyn ) , heterotrimeric G proteins , and gangliosides ( GM 1 and GM 3 ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
BACKGROUND : Fyn and c Src are two of the most widely expressed Src family kinases . ^^^ Whereas the identity of such inhibitory Tyr 527 kinases has been well established , no corresponding phosphatases have been identified that , under physiological conditions , function as positive regulators of c Src and Fyn in fibroblasts . ^^^ Fibroblasts derived from these RPTPalpha / mice had impaired tyrosine kinase activity of both c Src and Fyn , and this was accompanied by a concomitant increase in c Src Tyr 527 phosphorylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn . ^^^ A role for the receptor like protein tyrosine phosphatase alpha ( PTPalpha ) in regulating the kinase activity of Src family members has been proposed because ectopic expression of PTPalpha enhances the dephosphorylation and activation of Src and Fyn [ 1 ] [ 2 ] [ 3 ] . ^^^ We have generated mice lacking catalytically active PTPalpha to address the question of whether PTPalpha is a physiological activator of Src and Fyn , and to investigate its other potential functions in the context of the whole animal . ^^^ The kinase activities of Src and Fyn were significantly reduced in PTPalpha / mouse brain and primary embryonic fibroblasts , and this correlated with enhanced phosphorylation of the carboxy terminal regulatory Tyr 527 of Src in PTPalpha / mice . ^^^ Thus , PTPalpha is a physiological positive regulator of the tyrosine kinases Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here , we report that urokinase treated differentiating U 937 monocyte like cells exhibit a rapid and transient inhibition of p56 / 59 ( hck ) and p 55 ( fgr ) whereas no changes in the activity of other Src family kinases , such as p53 / 56 ( lyn ) and p 59 ( fyn ) were observed . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using the hybridoma T cell line , T8 . 1 , or Jurkat T cells , we investigated the respective contribution of the two Src kinases Fyn and Lck , expressed in T cells , in this phenomenon . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The increased tyrosine kinase activity is specific to Fyn , as other Src family members are not active in oligodendrocytes . ^^^ To investigate the function of Fyn activation on differentiation , we used Src family tyrosine kinase inhibitors , PP 1 and PP 2 , in cultures of differentiating oligodendrocyte progenitors . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Three Src class kinases , Fyn , Fyk , and Src , each formed a complex with the endplate specific cytoskeletal protein rapsyn . ^^^ Most importantly , rapsyn regulation of Fyn , Fyk , and Src resulted in phosphorylation of the nicotinic acetylcholine receptor beta and delta subunits and anchoring of the receptor to the cytoskeleton . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Selective association of the tyrosine kinases Src , Fyn , and Lyn with integrin rich actin cytoskeletons of activated , nonaggregated platelets . ^^^ Western immunoblot analysis revealed that the tyrosine kinases Src , Fyn , and Lyn are specifically associated with actin cytoskeletons of activated , nonaggregated platelets . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To determine the specific role of Src and Fyn as mediators of JAK 2 activation and its downstream events , we used fibroblasts derived from transgenic mice deficient in Src ( Src / ) or Fyn ( Fyn / ) . ^^^ Shc tyrosine phosphorylation and Ras activation by H ( 2 ) O ( 2 ) were also significantly reduced in Fyn / cells , but not altered in Src / cells . ^^^ Activation of JAK 2 was restored when Fyn / cells were transfected with B Fyn but not with Src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family tyrosine kinases Lck and Fyn are critical for signaling via the T cell receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show here that an association between CasL and two types of Src family PTKs , Fyn and Lck , is induced by anti CD 3 cross linking of human H 9 T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this study , we demonstrate that the phosphorylation activity of five tyrosine kinases of the src family from both human erythrocytes ( lyn , hck and c fgr ) and bovine synaptosomes ( lyn and fyn ) was stimulated by treatment with 30 250 microM peroxynitrite . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The effect of transient global ischemia on the interaction of Src and Fyn with the N methyl D aspartate receptor and postsynaptic densities : possible involvement of Src homology 2 domains . ^^^ The authors investigated the effects of this increase on the ability of the receptor subunits to bind to the Src homology 2 ( SH 2 ) domains of Src and Fyn expressed as glutathione S transferase SH 2 fusion proteins . ^^^ The level of Src and Fyn in PSDs , but not in other subcellular fractions , was increased after ischemia . ^^^ The ischemia induced increase in the interaction of NR2A and NR2B with the SH 2 domains of Src and Fyn suggests a possible mechanism for the recruitment of signaling proteins to the PSD and may contribute to altered signal transduction in the postischemic hippocampus . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyr 397 is an autophosphorylation site that promotes interaction with c Src or Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Ectopic expression of Fyn , another Src family member , in DT40 / Lyn ( ) cells restores largely the susceptibility of the cells against Topo 2 inhibitor induced apoptosis . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src family kinases Fyn and Lyn associate with the B cell antigen receptor ( BCR ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
GP Ib physically associates with the gamma chain in GST Syk SH 2 precipitates from platelets stimulated through GP Ib , and 2 Src family kinases , Lyn and Fyn , also associate with this signaling complex . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The activity of the other 5 members of the Src tyrosine kinases expressed in the rabbit heart ( Fyn , Fgr , Yes , Lyn , and Blk ) was not affected by ischemic PC . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
T cell receptor ( TCR ) engagement results in the activation of Src family ( Lck and Fyn ) and ZAP 70 protein tyrosine kinases , leading to tyrosine phosphorylation of multiple cellular substrates including the complex adapter protein c Cbl . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In vitro binding experiments revealed that phosphorylation at Tyr 615 in EphA 8 mediates the preferential binding to Fyn SH 2 domain rather than Src and Ras GTPase activating protein ( Ras GAP ) SH 2 domains . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We found that c Abl kinase activity was increased by 10 to 20 fold in these cells , and that Src and Fyn kinases directly phosphorylated c Abl in vitro . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To inhibit the function of kinases in this family , we injected starfish eggs with the SH 2 domains of Src and Fyn kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Signaling by members of the Src family of protein tyrosine kinases , such as Src and Fyn , is important in many biological responses , including gene transcription , cell cycle progression , and cell adhesion and spreading [ 1 ] [ 2 ] . ^^^ Here , we report that loss of csk resulted in a reduction in the abundance of the Src and Fyn proteins , which could be restored by reintroducing catalytically active Csk . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here , we show that the Src protein tyrosine kinase Fyn is required for development of CD1d dependent NKT cells but not for the development of conventional T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show that simultaneous overexpression of FAK and pp 60 ( c src ) or p 59 ( fyn ) results in the enhancement of the tyrosine phosphorylation of a limited number of cellular substrates , including paxillin . ^^^ FAK mutants defective for Src binding or focal adhesion targeting fail to cooperate with pp 60 ( c src ) or p 59 ( fyn ) to induce paxillin phosphorylation , whereas catalytically defective FAK mutants can direct paxillin phosphorylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family tyrosine kinase Fyn regulates natural killer T cell development . ^^^ T lymphocytes express two Src tyrosine kinases , Lck and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have adopted nanoflow electrospray ionization mass spectrometry ( ESI MS ) and isothermal titration calorimetry ( ITC ) to probe the mechanism of peptide recognition by the SH 2 domain from the Src family tyrosine kinase protein , Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Non receptor type tyrosine kinase Fyn in the Src family has been suggested to promote kindling development via tyrosine phosphorylation of the NMDA receptor subunit , NR2B . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The interaction and colocalization of Sam 68 with the splicing associated factor YT 521 B in nuclear dots is regulated by the Src family kinase p 59 ( fyn ) . ^^^ The Src family kinase p 59 ( fyn ) mediated tyrosine phosphorylation of Sam 68 negatively regulates its association with YT 521 B , and overexpression of p 59 ( fyn ) dissolves nuclear dots containing YT 521 B . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Only PDE4D4 and PDE4A5 , but not any other PDE4A , B , C and D isoforms expressed in rat brain , bound to src , lyn and fyn kinase SH 3 domains . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The proline , glutamic acid , serine and threonine enriched protein tyrosine phosphatase PEP , which is expressed primarily in hematopoietic cells , was recently discovered to be physically associated with the 50 kDa cytosolic protein tyrosine kinase ( PTK ) Csk , an important suppressor of Src family PTK , including Lck and Fyn in T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This leads us to hypothesize that CNRs bound to Fyn of the Src family are receptors for Reelin . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The ability of the Src family kinases Fyn and Lck to participate in signaling through the T cell receptor is critically dependent on their dual fatty acylation with myristate and palmitate . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Like E and P cadherin , Ca ( 2+ ) treatment of normal and tumor derived human keratinocytes resulted in c Yes ( and c Src and Fyn ) , as well as their putative substrate p 120 ( CTN ) , being recruited to cell cell contacts . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
VEGF stimulation specifically activated c Src kinase activity but not that of other related Src kinases such as Lyn , Fyn , or Hck in KS cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this study , we investigated whether interaction with Nef induces activation of other Src family kinases ( Lyn , Fyn , Src , and Lck ) following coexpression with Nef in Rat 2 fibroblasts . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Platelet derived growth factor ( PDGF ) induced activation of signal transducer and activator of transcription ( Stat ) 5 is mediated by PDGF beta receptor and is not dependent on c src , fyn , jak 1 or jak 2 kinases . ^^^ Taken together , these results indicate that Stat 5 is a direct substrate for PDGF beta R and that the activation does not require Jak 1 , Jak 2 , c Src or Fyn tyrosine kinases . . ^^^ Finally , fibroblasts derived from Src ( / ) and Fyn ( / ) mice showed normal pattern of PDGF induced tyrosine phosphorylation of Stat 5 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The signaling event originating in the caveolae like domains in response to FGF 2 appeared to require the activation of at least Fyn and Lyn , two members of the Src family of tyrosine kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Differential T cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn . ^^^ Molecular and genetic evidence indicates that both the Fyn and Lck members of the Src family can participate in TCR signal transduction ; however , it is unclear to what extent they utilize the same signal transduction pathways and activate the same downstream events . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using the yeast two hybrid system and immunoblotting we show that , in contrast to HIV 1 Nef , SIV and HIV 2 Nef poorly interact with Hck SH 3 but bind to Src and Fyn SH 3 domains . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Those constructs derived from Lyn and Fyn , which are associated with detergent resistant membranes ( DRMs ) , physically interacted with resting FcepsilonRI and reconstructed clustering induced signaling that leads to calcium mobilization and ERK 1 and 2 activation . c Src derived construct , which was excluded from DRMs , failed to interact with FcepsilonRI and to restore the signaling , whereas creation of palmitoylatable Cys 3 enabled it to interact with DRMs and with FcepsilonRI and to restore the signaling . ^^^ These findings suggest that Lyn and Fyn could , but c Src could not , drive FcepsilonRI signaling and that N terminal palmitoylation and SH 2 domain are required in sequence for the initial interaction with FcepsilonRI and for the signal progression to the molecular assembly . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Moreover , by using the specific platelet derived growth factor receptor ( PDGFR ) inhibitor AG 1296 or by overexpressing a kinase mutant PDGFR , we show that PDGFR kinase activity is essential for 5 HT2B triggered MAPK / cyclin D 1 , but not cyclin E , signaling pathways . 5 HT2B receptor activation also increases activity of the Src family kinase , c Src , Fyn , and c Yes . ^^^ Strikingly , c Src , but not Fyn or c Yes , is the crucial molecule between the G ( q ) protein coupled 5 HT2B receptor and the cell cycle regulators . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we provide evidence that p 55 is the Src family kinase Fyn and p 120 is the focal adhesion kinase family member Pyk 2 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Whereas PSD associated proline rich tyrosine kinase 2 ( PYK 2 ) and gp145TrkB were elevated immediately after the ischemic event , increases in Src and Fyn were not apparent until 6 hours of reperfusion . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we demonstrate that the proposed adapter protein for Src kinases , Sam 68 , is a ligand whose proline rich motifs interact with the SH 3 domains of p 59 ( fyn ) and phospholipase Cgamma 1 as well as with the WW domains of FBP 30 and FBP 21 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In contrast to native low density lipoprotein ( LDL ) , mildly oxidized LDL ( mox LDL ) induced platelet shape change and stimulated during shape change the tyrosine phosphorylation of specific proteins including Syk ; the translocation of Src , Fyn , and Syk to the cytoskeleton ; and the increase of cytosolic Ca ( 2+ ) due to mainly Ca ( 2+ ) entry . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Second , JNK activation in response to H ( 2 ) O ( 2 ) was completely inhibited in cells derived from transgenic mice deficient in Src but not Fyn . ^^^ Crk complex formation in Src / but not Fyn / cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
FIP 200 also inhibited the kinase activity of the Pyk 2 isolated from SYF cells ( deficient in Src , Yes , and Fyn expression ) and the Pyk 2 mutant lacking binding site for Src , suggesting that it regulated Pyk 2 kinase directly rather than affecting the associated Src family kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A proline rich fragment of the NR2D subunit ( 2D ( 866 1064 ) ) bound to the Abl SH 3 domain but not to the SH 3 domains from Src , Fyn , Grb 2 , GAP , or phospholipase C gamma ( PLCgamma ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn ( or Src ) overexpression overrides the G ( 1 ) / S block induced by both SrcK and a Slap mutant with a deletion of its C terminus ( SlapDeltaC ) , but not the block induced by Slap or SlapDeltaSH 3 , implying that the C terminus is a noncompetitive inhibitor of Src mitogenic function . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
High frequency synaptic stimulation induces association of fyn and c src to distinct phosphorylated components . ^^^ HFS enhanced association of the src family kinases fyn and c src with an approximately 120 kDa tyrosine phosphorylated component containing the focal adhesion kinase ( FAK ) and its homologue PYK 2 . ^^^ Association of fyn with FAK and of c src with PYK 2 was increased following the HFS . ^^^ These results suggest that fyn and c src are involved in distinct signaling pathways and provide evidence for activation of FAK and PYK 2 following synaptic stimulation inducing LTP in vitro . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyr phosphorylation of the L 1 cytoplasmic tail and the Src kinase Fyn was observed following pervanadate treatment . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The information of CR 50 antigen / Reelin is considered to be transmitted inside the neuroblasts to the `` disabled 1 ' ' , which is an adaptor protein to Src , Fyn , Abl tyrosine kinase . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Western blot analysis identified the src like protein tyrosine kinases p 53 ( lyn ) , p 56 ( lyn ) , p56 / 59 ( hck ) , p 55 ( fgr ) , and p 56 ( lck ) whereas p 60 ( src ) , p 62 ( yes ) , p 55 ( blk ) , and p 59 ( fyn ) were not detected . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Differential activation and redistribution of c Src and Fyn in platelets , assessed by MoAb specific for C terminal tyrosine dephosphorylated c Src and Fyn . ^^^ Tyrosine kinases , c Src and Fyn , in their active form , have their C terminal tyrosine residue dephosphorylated . ^^^ In this study , we used clone 28 , a monoclonal antibody ( MoAb ) that recognizes dephosphorylated C terminal tyrosine of c Src and Fyn , to investigate the mode of activation and mobilization of these kinases . ^^^ Independently of integrin alphaIIbbeta 3 signaling , the Fyn activity increased by 8 . 3 fold 5 s after stimulation with 20 microM TRAP ( thrombin receptor agonist peptide ) , while that of c Src increased only by 2 . 9 fold 15 s after stimulation . ^^^ Both c Src and Fyn translocated to the Triton insoluble cytoskeletal fraction in an aggregation dependent manner . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A growing body of literature suggests that the ubiquitously expressed Src family kinases ( Src , Fyn and Yes ) are required for agents such as platelet derived growth factor ( PDGF ) to stimulate DNA synthesis . ^^^ Yet Klinghoffer and colleagues recently presented evidence that fibroblasts derived from mice null for Src , Fyn and Yes responded normally to PDGF ( Klinghoffer et al . , 1999 , EMBO J . , 18 : 2459 2471 ) . ^^^ Furthermore , injection of SrcK or the cst . 1 antibody ( which inhibits Src , Fyn and Yes ) failed to inhibit PDGF stimulated DNA synthesis in NIH3T3 cells expressing dominant negative p 53 , and fibroblasts derived from p 53 null embryos . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In accordance with this , each of the Src family members expressed in platelets , namely Fyn , Lyn , Src , Yes , and Hck , was shown to co immunoprecipitate with CD 31 . ^^^ The involvement of Src family kinases in this process was confirmed through the study of mouse platelets deficient in Fyn . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To understand the role of Fyn , a non receptor type tyrosine kinase of Src family kinases , in the mechanism of circadian rhythms , we analyzed the circadian locomotor behavior and morphology of the hypothalamic suprachiasmatic nucleus ( SCN ) , a master circadian oscillator in Fyn mutant mice , because Fyn like immunoreactive substance was observed in the SCN . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Consistent with this finding , Grb 10 tyrosine phosphorylation in cells was inhibited by herbimycin A , a relatively specific inhibitor for members of the Src tyrosine kinase family , and by the expression of dominant negative Src or Fyn . ^^^ In addition , Grb 10 tyrosine phosphorylation was stimulated by expression of constitutively active Src or Fyn in cells and by incubation with purified Src or Fyn in vitro . ^^^ The insulin stimulated or Src / Fyn mediated tyrosine phosphorylation in vivo was significantly reduced when Grb 10 tyrosine 67 was changed to glycine . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Eggs of the ascidian Ciona intestinalis were injected with the Src homology 2 domains of phospholipase C gamma or of the Src family kinase Fyn ( which act as specific dominant negative inhibitors of the activation of these enzymes ) , and the effects on Ca ( 2+ ) release at fertilization or in response to injection of a sperm extract were compared . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
These effects were abolished by the Src family inhibitor PP 2 and strongly mitigated in Fyn deficient but not in Src deficient cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Mechanisms by which the p 64 channel could be regulated are largely unknown . p 59 ( fyn ) is a non receptor tyrosine kinase of the Src family that has been implicated in a variety of intracellular signaling events . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Interestingly , both Pyk 2 and FPhy 2 ( to a greater extent ) were tyrosine phosphorylated and associated with Src and Fyn . ^^^ This suggested that they may inhibit Erk activation in an analogous manner as the mislocalized FAK mutant ( & Dgr ; ) C 14 described previously by competing with endogenous FAK for binding signaling molecules such as Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Finally , we demonstrate that alpha Syn can be phosphorylated directly both in cotransfection experiments using c Src and Fyn expression vectors and in in vitro kinase assays with purified kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The agonist induced tyrosine phosphorylation of ACK 1 was blocked by inhibitors of Src family kinases , and ACK 1 was coprecipitated with Fyn ( but not Src ) in an agonist dependent manner . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Activation of Fyn , a Src kinase family member , is required for normal keratinocyte differentiation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the current study , the role of 2 Src family kinases , Fyn and Lyn , in GPVI signaling has been examined using murine platelets deficient in one or both kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Likewise , inhibition of P . aeruginosa binding to CFTR , which has been shown to block P . aeruginosa internalization , prevents Src and Fyn activation , supporting a pivotal role of Src like tyrosine kinases for invasion by P . aeruginosa . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The purified antibodies are used to analyze the regulation of Src and Fyn activity in a mouse muscle cell line . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have addressed questions regarding the importance of the Src kinase p 59 ( fyn ) ( Fyn ) in this process by using Fyn null mice . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Lupus like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn . ^^^ During the course of investigating the functional interaction of Src family kinases , we generated a mouse strain deficient in both Lyn and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To determine if Src family kinases ( SFKs ) are involved , we demonstrated that CSF 1 activated Fyn and Lyn in cells expressing wild type ( WT ) or DeltaKI receptors . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Constitutive activation of the src kinases Lck and Fyn was demonstrated in a bovine LGL line infected with OvHV 2 and in two rabbit LGL lines infected with AlHV 1 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The non receptor protein tyrosine kinase Fyn , which is a member of the Src family of kinases , has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Functional studies demonstrated that CR 2 activation induced , within a brief span of 2 min , tyrosine phosphorylation of nucleolin and its interaction with Src homology 2 domains of the p 85 subunit of PI 3 kinase and of 3BP2 and Grb 2 , but not with Src homology 2 domains of Fyn and Gap . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The CNRs are originally isolated through the interaction of their intracellular domain with Fyn , a member of the Src kinase family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show that whereas no autoantibodies were found against cSrc or its relative Fyn , up to 20 % of patients with carcinoma had high affinity autoantibodies against Csk . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We found that oligodendrocytes express Src , but there was no significant reduction of myelin content in null mutants lacking the Fyn related kinases Src , Yes , or Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The amino acid sequence of the SH 3 domain has the highest homology with those of Fyn , Yes , and c Src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This surprising result implies that the mechanism of repression of Src family members may vary , explaining functional distinctions between Fyn and Lck . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Furthermore , fibronectin mediated FAK phosphorylation at Tyr 397 was dramatically reduced in SYF cells ( deficient in Src , Yes , and Fyn expression ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using antiphosphotyrosine antibody PY 20 , we find that on expression in HEK cells , 5 Src and Fyn cause detectable tyrosine phosphorylation only of NR2A . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src , Fyn , and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin induced clusters of acetylcholine receptors . ^^^ Mice deficient in src and fyn or src and yes move and breathe poorly and die perinatally , consistent with defects in neuromuscular function . ^^^ Src and Fyn are associated with acetylcholine receptors ( AChRs ) in muscle cells , and Src and Yes can act downstream of ErbB 2 , suggesting roles for Src family kinases in signaling pathways regulating neuromuscular synapse formation . ^^^ We studied neuromuscular synapses in src ( / ) ; fyn ( / ) and src ( / ) ; yes ( / ) mutant mice and found that muscle development , motor axon pathfinding , clustering of postsynaptic proteins , and synapse specific transcription are normal in these double mutants , showing that these pairs of kinases are not required for early steps in synapse formation . ^^^ We generated muscle cell lines lacking src and fyn and found that neural agrin and laminin 1 induced normal clustering of AChRs and that agrin induced normal tyrosine phosphorylation of the AChR beta subunit in the absence of Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src family kinase expression was measured in 52 human mammary tumor ( T ) specimens compared with non tumor ( NT ) tissue from the same patient by enzymatic assays employing a Src kinase family specific peptide substrate and by immunoblotting with an antibody recognizing the Src family kinases Src , Fyn , and Yes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
MuSK was complexed with both Src and Fyn in the C 2 mouse muscle cell line . ^^^ Coupling between MuSK and the Src class kinases in vivo appeared to be caused by a phosphotyrosine SH 2 domain interaction because binding of MuSK to the SH 2 domains of Fyn and Src in vitro was specific , enhanced by phosphorylation , and dependent on MuSK autophosphorylation . ^^^ In addition , Src and Fyn phosphorylated MuSK . ^^^ These data support the conclusion that Fyn and Src act downstream of MuSK to regulate the stable localization of AChRs at the neuromuscular endplate during agrin induced synaptogenesis . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
By using matrix assisted laser desorption / ionization time of flight mass spectrometry , we show that in addition to 14 : 0 ( myristate ) , 14 : 1 and 14 : 2 fatty acids can be attached to the N terminal glycine of the Src family kinase Fyn when the growth media are supplemented with these dietary fatty acids . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Akt activity induced by growth factors is significantly reduced in SYF cells lacking Src , Yes , and Fyn , which can be restored by introducing c Src , but not the kinase inactive Src , back to these cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Similar association of lck ( 56 ) , Yes , Fyn , and cSrc together with MUC 1 was also found in GEM fraction of mouse T cell lymphoma EL 4 cells expressing MUC 1 through transfection of its gene . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
IGF 1 activation of SFK members c Src and Fyn occurred within 1 min of treatment , and activity was back to baseline by 10 min . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Three different membrane targeting motifs from K Ras , Fyn , and Src proteins were fused to the N or C terminus of Raf 1 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Endocannabinoids increased the association of Fyn , but not Src , with FAK+6 , 7 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This is associated with enhanced phosphorylation of STAT 1 , STAT 3 , and Fyn , a Src homology tyrosine kinase , which interacts with both TCR and IFN alpha signal components . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
These SH 3 ligands appeared to be functional as they facilitated interaction with the adaptor protein , Grb 2 , and the Src family tyrosine kinase , Fyn . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
CD 45 is a leukocyte specific protein tyrosine phosphatase that dephosphorylates the Src family kinases , Lck and Fyn , in T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The expression and function of the Src family protein tyrosine kinase Fyn in Xenopus laevis embryos have been examined . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have investigated the tyrosine phosphorylation of NMDA receptor subunits NR2A and NR2B by exogenous Src and Fyn and compared this to phosphorylation by tyrosine kinases associated with the postsynaptic density ( PSD ) . ^^^ Phosphorylation of the receptor by exogenous Src and Fyn was dependent upon initial binding of the kinases to PSDs via their SH 2 domains . ^^^ Src and Fyn phosphorylated similar sites in NR2A and NR2B , tryptic peptide mapping identifying seven and five major tyrosine phosphorylated peptides derived from NR2A and NR2B , respectively . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SynGAP bound to the SH 2 domains of Src and Fyn in a tyrosine phosphorylation dependent fashion , and this interaction increased after ischemia . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Both null cells for pp 60 ( c src ) and triple knockout cells for pp 60 ( c src ) , pp 59 ( fyn ) , and pp 62 ( c yes ) exhibited decreased phosphotyrosine levels in focal contacts when compared with wild type cells . pp 60 ( c src ) null cells also exhibited faster assembly of cell matrix adhesions and a more exuberant recruitment of FAK to these sites . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This includes the protein tyrosine kinases Src , Hck , and Fyn , the p85alpha regulatory subunit of phosphatidylinositol 3 kinase , phospholipase Cgamma , and the adaptor protein Grb 2 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn is a Src family tyrosine kinase expressed abundantly in neurons and believed to have specific functions in the brain . ^^^ To understand the function of Fyn tyrosine kinase , we attempted to identify Fyn Src homology 2 ( SH 2 ) domain binding proteins from a Nonidet P 40 insoluble fraction of the mouse brain . beta Adducin , an actin filament associated cytoskeletal protein , was isolated by two dimensional gel electrophoresis and identified by tandem mass spectrometry . beta Adducin was tyrosine phosphorylated by coexpression with wild type but not with a kinase negative form of Fyn in COS 7 cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Cleavage of Fyn and Lyn in their N terminal unique regions during induction of apoptosis : a new mechanism for Src kinase regulation . ^^^ Fyn and Lyn but not Lck , Src and Hck were processed in vitro by human recombinant caspase 3 and by cellular extracts prepared from Fas stimulated cells . ^^^ Thus , cleavage of Fyn and Lyn during induction of apoptosis represents a new mechanism for the regulation of Src kinases that may have important functional and physiological consequences . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src kinases , Src , Yes and Fyn , enhance the efficiency of GAS uptake but are not absolutely required for GAS entry . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
One molecule that has been implicated in oligodendrocyte differentiation is the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
While CD 2 induced p 62 ( dok ) tyrosine phosphorylation was independent of both the p36 / 38 membrane adapter protein linker of activated T cells ( LAT ) and the ZAP70 / Syk family of kinases , it was dependent upon the Src family of kinases including Lck and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This fraction was enriched in the Src family protein tyrosine kinases c Src , Lyn and Fyn and in the GPI anchored neuronal adhesion molecule TAG 1 . ^^^ Moreover , cholesterol and phosphatidylcholine were detected in the immunoprecipitates by qualitative TLC analysis followed by colourimetric visualization . c Src , Lyn , Fyn and TAG 1 were associated with the anti GD 3 antibody immunoprecipitate . ^^^ These data suggest that a membrane domain containing cholesterol , phosphatidylcholine , sphingolipids and proteins can be separated from the total cell membranes by anti GD 3 antibody immunoprecipitation , and that the association of c Src , Fyn , Lyn , and TAG 1 with the sphingolipid enriched domain is mediated by the interaction with a complex lipid environment , rather than by specific interactions with a single sphingolipid species . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The cadherin related neuronal receptor ( CNR ) family has been identified as a receptor family that cooperates with Fyn , a member of the Src family of tyrosine kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA 4 and its association with PI 3 kinase in intracellular compartments of T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD 95 . ^^^ To test whether and how tyrosine phosphorylation of glutamate ionotropic receptor subunits modulates calpain susceptibility , synaptic membranes were phosphorylated by Fyn or Src , two members of the Src family tyrosine kinases . ^^^ Similar results were observed with NR2A and NR2B C terminal domain fusion proteins phosphorylated by Fyn or Src before incubation with calpain and calcium . ^^^ In addition , phosphorylation of NR2A and NR2B C terminal fusion proteins by Fyn or Src enhanced their binding to spectrin and PSD 95 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A dominant negative form of Fyn , but not Src , prevents tyrosine phosphorylation of beta 4 and disassembly of hemidesmosomes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
HIV SUgp 120 ( HIV surface glycoprotein ) , T cell receptor ( TCR ) CD4+ and co receptors promote aggregation of these lipid `` rafts ' ' which concentrate the Src family tyrosine kinases SFKs ( PTK , Lyn , Fyn , Lck ) , GPI ( glycosyl phosphatidylinositol ) anchored proteins , and phosphatidylinositol kinases PI ( 3 ) K and PI ( 4 ) K , inducing cell signalling . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Mutations in the Lck kinase , Src homology 2 or 3 domains , or the myristoylation site all inhibit conjugation to background levels , and adhesion can not be restored by the expression of Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this report we show that both wild type and hck ( / ) fgr ( / ) macrophages expressed Fyn , Src , and Yes and that these kinases were activated on ingestion of immunoglobulin G ( IgG ) coated particles and redistributed , together with Syk , to actin rich phagocytic cups and the phagosomal membrane . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family tyrosine kinase , Fyn , can facilitate regulation of cell proliferation and differentiation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using a GST fusion protein carrying the cytoplasmic tail of beta dystroglycan , we identified five SH 2 domain containing proteins that interact with beta dystroglycan in a phosphorylation dependent manner , including c Src , Fyn , Csk , NCK , and SHC . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src kinase p 59 ( Fyn ) was thereby identified as being crucial for the receptor mediated suppression of differentiation by down regulating MKP 1 expression . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
MSU crystals induced phosphorylation of p70s6k and the Src kinases c Src , Lyn , Hck , and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src homology 3 domains from several Src family PTKs including Lck , Fyn , Abl , and Src associate with ADAM 15 in vitro . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
RT PCR studies demonstrate expression of multiple Src tyrosine kinases , including Src , Fyn , and Yes , in CSMC . ^^^ Muscarinic stimulation of CSMC with 10 microM ACh results in a twofold increase in Src activity within 10 min but does not increase the activity of Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn is a member of the Src family of non receptor type tyrosine kinases and plays an important role in signal transductions regulating cell proliferation and differentiation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Immunoprecipitation of Fyn , a member of the Src family , from Abeta ( 25 35 ) treated neurons showed an increased association of Fyn with FAK . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Loss of function microinjection studies indicate that the ubiquitous Src , Fyn , and Yes tyrosine kinases are specifically implicated in Xenopus gastrulation movements . ^^^ Injection of mRNAs coding for dominant negative forms of the ubiquitous members of the Src family , namely Fyn , Src , and Yes , perturbs gastrulation movements , resulting in the inability to close the blastopore . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Caveolin 1 is a substrate for nonreceptor tyrosine kinases including Src , Fyn , and Abl . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
PD 173958 decreased autophosphorylation of Src , Fyn , and Lyn kinases and prevented tyrosine phosphorylation of the Src kinase substrate p 120 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Several src family kinases ( Fyn , Hck , Src ) are activated , as is the focal adhesion kinase p 125 FAK and , eventually , members of the p44 / p42 mitogen activated protein kinase ( MAPK ) family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly 49 receptors . ^^^ We show here that the src family kinase Fyn is required for efficient , NK cell mediated lysis of target cells , which lack both self MHC class 1 molecules and ligands for NKG2D , an activating NK cell receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The ubiquitous Src family protein tyrosine kinase ( PTK ) Fyn is not activated by these E 5 constructs , nor are focal adhesion kinase and endogenous receptor PTKs for insulin , epidermal growth factor , basic fibroblast growth factor and insulin like growth factor . ^^^ L26A E 5 does not transform SYF cells that are deficient for Src , Fyn and Yes , unless Src expression is reconstituted , and does not transform NIH3T3 cells in which Src PTK activity is maintained at a basal level by means of kinase defective K295R Src overexpression . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
At least four members of this gene family , Src , Fyn , Yes , and Laloo , are expressed during early embryonic development . ^^^ Ectopic expression of Laloo and Fyn , but not Src , induce mesoderm in ectodermal explants , indicating that these factors are non redundant during early vertebrate development . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The glycoprotein 6 ( GPVI ) Fc receptor ( FcR ) gamma chain complex , a key activatory receptor for collagen on platelet surface membranes , is constitutively associated with the Src family kinases Fyn and Lyn . ^^^ Molecular cloning of GPVI has revealed the presence of a proline rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 ( SH 3 ) domains of Fyn and Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The molecular adaptor adhesion and degranulation promoting adaptor protein ( ADAP ) , also known as Fyn binding protein ( FYB ) or Slp 76 associated protein of 130 kilodaltons ( SLAP 130 ) , interacts with a number of signaling intermediates including Slp 76 , the Src family tyrosine kinase Fyn , vasodilator stimulated phosphoprotein ( VASP ) , and the actin nucleating protein WASP . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fluorescence spectroscopy shows that Tip binds to the SH 3 domains of several Src kinases ( Lck , Hck , Lyn , Src , Fyn , Yes ) , exhibiting the highest affinities for Lyn , Hck , and Lck . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family kinase Fyn mediates signals induced by TCR antagonists . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This study demonstrates that STEP ( 61 ) associates with Fyn , a member of the Src family kinases that is also enriched in PSDs . ^^^ By using human embryonic kidney 293 cells for co transfection , we determined that a substrate trapping variant ( STEP ( 61 ) CS ) binds to Fyn but not to other members of the Src family present in PSDs . ^^^ STEP ( 61 ) binds to Fyn through one of its proline rich domains and the kinase interacting motif domain , whereas Fyn binds to STEP ( 61 ) through its Src homology 2 domain and the unique N terminal domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src is associated with c Cbl , and we have previously demonstrated that the Src like kinase Fyn can phosphorylate c Cbl at a preferred binding site for the p 85 subunit of phosphatidylinositol 3 ' kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Laminin 1 redistributes postsynaptic proteins and requires rapsyn , tyrosine phosphorylation , and Src and Fyn to stably cluster acetylcholine receptors . ^^^ Finally , laminin 1 caused normal aggregation of AChRs and phosphotyrosine in myotubes lacking both Src and Fyn kinases , but these clusters dispersed rapidly after laminin withdrawal . ^^^ Thus , laminin 1 redistributes postsynaptic proteins and , like agrin , requires tyrosine kinases for AChR phosphorylation and clustering , and rapsyn for AChR cluster formation , whereas cluster stabilization depends on Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Although previous studies demonstrated that the Src family kinase Fyn was highly enriched in caveolae , an inhibitor of this kinase had no effect on insulin stimulated caveolin phosphorylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Both mPDK 1 alpha and mPDK 1 beta are autophosphorylated at both serine and threonine residues in vitro and showed similar levels of tyrosine phosphorylation when co expressed with either constitutively active Src or Fyn tyrosine kinases in cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Studies with pharmacologic inhibitors and knockout mice showed that the TCR derived signaling that drives PKC theta ; membrane translocation requires the Src family kinase , Lck , but not Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the corresponding murine fibroblast cell line SYF , which lacks the ubiquitously expressed SRC family kinases SRC , YES , and FYN , forskolin barely stimulated MAP kinase ; this reduction was reversed in cells in which c SRC had been reintroduced . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we show that in cortical neurons , brief selective activation of group 1 mGluRs with ( S ) 3 , 5 dihydroxy phenylglycine ( DHPG ) induced a Ca ( 2+ ) calmodulin dependent activation of Pyk2 / CAKbeta and the Src family kinases Src and Fyn that was independent of protein kinase C ( PKC ) . ^^^ Activation of Pyk 2 and Src / Fyn kinases led to increased tyrosine phosphorylation of NMDA receptor subunits 2A and B ( NR2A / B ) and was blocked by a selective mGluR 1 antagonist , 7 ( hydroxyamino ) cyclopropa [ b ] chromen 1a carboxylate ethyl ester , but not an mGluR 5 antagonist , 2 methyl 6 ( phenylethynyl ) pyridine . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SH 3 SH 2 domain orientation in Src kinases : NMR studies of Fyn . ^^^ Here , the isolated SH 3 SH2 fragment from the Src family member Fyn ( FynSH 32 ) is studied by NMR . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we examine the role of the Src family kinases , p 56 ( lck ) ( Lck ) and p 59 ( fyn ) ( Fyn ) , in the survival of naive T cells . ^^^ The disappearance of T cells in the absence of Fyn and Lck was associated with a complete loss of TCRzeta chain phosphorylation and down regulation of CD 5 , both of which are also MHC contact dependent , indicating that the Src family kinases are critical for transducing a TCR MHC survival signal . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this study , we demonstrate that in microglia and other tissue macrophages , beta amyloid initiates a CD 36 dependent signaling cascade involving the Src kinase family members , Lyn and Fyn , and the mitogen activated protein kinase , p44 / 42 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Activation of PAR 1 leads to an increase in Src , Fyn , and epidermal growth factor receptor ( EGFR ) phosphorylation , with EGFR receptor transactivation by Src family kinases the major mechanism for PAR 1 dependent activation of extracellular signal regulated kinase , p 38 mitogen activated protein kinase , and protein kinase B . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using Sf 9 insect cells , we demonstrate direct STAT 3 tyrosine phosphorylation and stimulation of DNA binding activity by five members of the Src kinase family ( Src , Hck , Lyn , Fyn , and Fgr ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this study , we demonstrate that HGF induces strong tyrosine phosphorylation of the proto oncogene product c Cbl in B cells and increases Cbl association with the Src family tyrosine kinases Fyn and Lyn , as well as with phosphatidylinositol 3 kinase and CrkL . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In T cells , Fyn appears to be the active Src kinase in rafts , but Sam 68 is not expressed in rafts , and its distinct phosphorylation by Fyn and Lck is not affected by raft dispersion . ^^^ The Fyn / Lck specificity does not reflect a higher kinase activity of Fyn in general , as both Fyn and Lck are similarly recognized by an anti active Src antibody . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of SSeCKS was apparent in cells deficient in Src , Fyn , Yes , or Abl tyrosine kinases or in NIH3T3 cells expressing a temperature sensitive 5 Src allele , but not in FAK deficient embryo fibroblasts . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Estrogen stimulation of murine embryonic fibroblasts with homozygous deletions of the c src , fyn , and yes genes failed to induce Akt phosphorylation , whereas cells maintaining c Src expression demonstrated estrogen induced Akt activation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A digitized immunocytochemical analysis in VSMCs revealed that SPC induced translocation of Fyn , but not of c Src , from the cytosol to the cell membrane , an event abolished by EPA . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The activity of these compounds [ named CT SKI ( Celltech Src kinase inhibitors ) ] was investigated by assessing their potential to modulate T cell receptor activation , an event thought to involve the Src kinases Lck and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have shown that an Src family kinase Fyn phosphorylates NR2A and NR2B subunits of the NMDA receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We found that in transgenic thymocytes , SinDeltaC was constitutively phosphorylated by the Src kinase Fyn , but not by the related kinase Lck . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The phosphorylated LAR was associated with Fyn Src homology 2 domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The NY 1 G 1 ITAM was shown to coprecipitate a complex of phosphoproteins from cells , and the G 1 ITAM is a substrate for the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
However , Fyn and Yes , unlike Src , were found to associate preferentially with Flt 1 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Among these LAT , SLP 76 and Gab 2 are critically important as adapters that facilitate events initiated by IgE receptor dependent activation of Src family protein tyrosine kinases , Lyn and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We investigated the mechanism of the enhancement of metastatic potential induced by transfection of the fyn gene , a member of the src family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Recent studies have indicated that tyrosine phosphorylation of NMDA receptor subunit 2A ( NR2A ) by Src family kinases ( Src , Fyn , etc . ) up regulates NMDA receptors activity and postsynaptic density protein 95 kDa ( PSD 95 ) may mediate the regulation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In both CD 45 and CD45+ U 266 cells , STAT 3 and MAPK ( ERK1 / 2 ) can be activated in response to IL 6 equally between them , but src family kinases such as Lyn , Fyn can be activated only in CD45+ U 266 cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
When fyn copy number is reduced , src , but not yes , becomes important , reflecting a partial redundancy between fyn and src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
As the expression pattern of AFAP overlaps with the reported expression patterns of cSrc and Fyn , we hypothesize that AFAP is positioned to modulate signal transduction cascades that direct activation of these nonreceptor tyrosine kinases and concomitant cellular changes that occur in actin filaments during brain development . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Endogenous FAK+ bound specifically to the SH 3 domains of c Src ( but not n Src ) , Fyn , Yes , phosphtidylinositol 3 kinase , amphiphysin 2 , amphiphysin 1 , phospholipase Cgamma and NH 2 terminal Grb 2 . ^^^ The inclusion of boxes 6 , 7 was associated with a significant decrease in the binding of FAK+ to the c Src and Fyn SH 3 domains , and a significant increase in the binding to the Src SH 2 domain , as a consequence of the higher phosphorylation of Tyr 397 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have previously shown that dephosphorylation of Kv2 . 1 by the nonreceptor type tyrosine phosphatase PTPepsilon ( cyt PTPepsilon ) down regulates channel activity and counters its phosphorylation and up regulation by Src or Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD 95 after transient brain ischemia . ^^^ In this study , we investigated the effects of protein tyrosine kinase ( PTK ) and protein tyrosine phosphatase ( PTP ) on the tyrosine phosphorylation of N methyl D aspartate receptor subunit 2A ( NR2A ) and the interactions among NR2A , postsynaptic density protein 95 ( PSD 95 ) , Fyn / Src after brain ischemia / reperfusion ( I / R ) . ^^^ The following results were observed : ( 1 ) the increase in tyrosine phosphorylation of NR2A induced by I / R was suppressed by genistein , an inhibitor of PTK , but was further enhanced by sodium orthovanadate , an inhibitor of PTP , which were administered to the SD rats 20 min before ischemia . ( 2 ) Importantly , genistein and sodium orthovanadate increased and decreased the interactions involving NR2A , PSD 95 , Fyn and Src , respectively . ^^^ These results demonstrated that PTK and PTP were involved in regulating tyrosine phosphorylation of NR2A through changing the interaction among NR2A , PSD 95 , Fyn / Src . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
To address the role of c Src in FGFR 1 signaling , we compared proliferative responses of murine embryonic fibroblasts ( MEF ) deficient in c Src , Yes , and Fyn to MEF expressing either endogenous levels or overexpressing c Src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Protein levels of Src family kinases such as Src , Fyn , and Yes were unchanged by lithium treatment . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Forced localization of CRKL to FAs ( FA CRKL ) by itself was sufficient to induce activation of Rac 1 and Cdc 42 and rescued haptotaxis defects of mouse embryonic fibroblasts ( MEFs ) lacking Src , Yes , and Fyn , three broadly expressed Src family members required for integrin induced migration . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Described are biochemical and mouse genetics experiments demonstrating that membrane associated Nephrin is tyrosine phosphorylated by the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Besides coupling with heterotrimeric G proteins to activate phospholipase C beta ( PLC beta ) , AT1R also activates receptor tyrosine kinases ( PDGF R , EGF R and IGF R ) and non receptor tyrosine kinases ( Src , Fyn , Yes , proline rich tyrosine kinase 2 ( Pyk 2 ) , focal adhesion kinase ( FAK ) and JAK 2 ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
H Ras bound to Src but not Fyn both in vitro and in brain via the Src kinase domain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here , we show evidence for physical and functional interaction between PKCdelta and the Src family kinase Fyn in human platelets activated by alboaggregin A , a snake venom capable of activating both GPIb 5 9 and GPVI adhesion receptors . ^^^ Translocation of Fyn and PKCdelta are blocked by PP 1 and bisindolylmaleimide 1 , showing a dependence upon Src and PKC kinase activities . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show here that the exon structure of these kinases , which we will call the Brk family , is highly conserved and distinct from each of the major families of intracellular kinases containing SH 3 , SH 2 , and tyrosine kinase domains , including c Src and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Insulin receptor phosphorylated IRS5 / DOK4 associates with RasGAP , Crk , Src , and Fyn , but not phosphatidylinositol 3 kinase p 85 , Grb 2 , SHP 2 , Nck , or phospholipase Cgamma Src homology 2 domains , and activates MAPK in cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N methyl D aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus . ^^^ The effects of suppression of postsynaptic density protein 95 ( PSD 95 ) expression on the increased tyrosine phosphorylation of N methyl D aspartate receptor subunit NR2A and interactions of Src and Fyn with NR2A after brain ischemia were investigated by immunoprecipitation and immunoblotting . ^^^ Intracerebroventricular infusion of PSD 95 antisense oligonucleotides ( every 24 h for 3 days before ischemia ) , but not missense oligonucleotides or vehicle , not only markedly decreased the protein level of PSD 95 but also attenuated the elevated tyrosine phosphorylation of NR2A and interactions of Src and Fyn with NR2A induced by 6 h of reperfusion following ischemia in the hippocampus . ^^^ The protein levels of NR2A , Src and Fyn had no differences under the above conditions . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SYF cells , which lack expression of SFKs Src , Yes , and Fyn , were used to determine the role of SFKs in IL 6 family cytokine signaling and gene induction . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family kinases c Src , c Yes , Fyn , and Lyn were expressed and activated by transforming growth factor alpha stimulation in all four SCCHN cell lines examined but not in corresponding normal epithelial cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
RPTPalpha dependent activation of Src family kinases , in particular activation of Fyn , is required for the force dependent formation of focal complexes and strengthening of alphav / beta3 integrin cytoskeleton connections during the initial phase of ECM contact . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This adhesion induces recruitment and activation of the focal adhesion kinase Pyk 2 , the cytoskeleton linker paxillin , and the Src kinases Lck and Fyn in the contact site . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Increased levels of unphosphorylated N WASP also decreased the activities of Src family kinases in cells but not in experiments in vitro with pure N WASP and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family kinase Syk , the B cell adaptor protein BLNK , and phospholipase C ( PLC ) gamma 2 were consistently absent from Reed Sternberg cells , whereas 2 other Src kinases ( Lyn and Fyn ) were heterogeneously expressed in a proportion of cases ( 12 % and 42 % , respectively ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
PRAP was found to function as a substrate for Src family kinases , such as c Src or Fyn , but not for Pyk2 / RAFTK . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Instead , Fyn and Lck were activated in A 549 cells , indicating activation of specific Src family kinases in response to Cr ( 6 ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Evidence of partial genetic redundancy between Src and Fyn for brain specific targets suggests that these two kinases may occupy overlapping subcellular locations . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This motif was phosphorylated by the tyrosine kinases Src , Lck , Yes , Hck , and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using fibroblasts deficient in Src , Yes and Fyn , we were able to show that there are multiple kinases present in the cell that can phosphorylate LRP 1 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The introduction of this `` methionine clamp ' ' resulted in Src and Fyn kinase alleles that have markedly improved specificity for unnatural N ( 6 ) substituted ATP analogues over the natural substrate , ATP . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Moreover , the Src family kinase Fyn was consistently found to be coimmunoprecipitated with nephrin . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Increased tyrosine phosphorylation of alpha ( 1C ) subunits of L type voltage gated calcium channels and interactions among Src / Fyn , PSD 95 and alpha ( 1C ) in rat hippocampus after transient brain ischemia . ^^^ In this study , we evaluated the alterations in the tyrosine phosphorylation level of alpha ( 1C ) and in the interactions involving Src / Fyn , alpha ( 1C ) and PSD 95 in the hippocampus after transient ( 15 min ) brain ischemia followed by various times of reperfusion using immunoprecipitation and immunoblotting . ^^^ Transient brain ischemia and reperfusion also caused rapid and sustained increases in the interactions of Src and Fyn with alpha ( 1C ) subunits . ^^^ The protein levels of alpha ( 1C ) , Src , Fyn and PSD 95 showed no differences at all time points . ^^^ These results suggest a novel mechanism involving the ischemia / reperfusion induced recruitment of L VGCCs , Src and Fyn to the PSD 95 signaling complex that facilitates the tyrosine phosphorylation of alpha ( 1C ) subunits by Src family kinases and may contribute to the up regulation of L VGCCs activity in postischemic hippocampus . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Inhibition of Src kinase activity by 4 anilino 5 , 10 dihydro pyrimido [ 4 , 5 b ] quinolines . 4 ( 2 , 4 Dichloro 5 methoxy ) anilino 5 , 10 dihydropyrimido [ 4 , 5 b ] quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have found that in a cell line called SYF , which lacks the three ubiquitous Src like kinases ( Src , Yes , and Fyn ) , the organization of the Golgi apparatus is perturbed . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Corresponding to elevated cell motility and spreading ability , Fyn was selectively activated among Src family kinases , and the cell motility was blocked by an inhibitor of Src family kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Identification of PSD 93 as a substrate for the Src family tyrosine kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the present paper , we show that this phosphorylation requires activation of the Src family kinase Fyn . ^^^ Stress induced caveolin phosphorylation was abolished by three Src kinase inhibitors , SU 6656 , PP 2 and PD 180970 , and was not observed in fibroblasts derived from a Src , Yes and Fyn triple knockout mouse ( SYF / ) . ^^^ Using cell lines derived from single kinase knockout mice ( Src / , Yes / and Fyn / ) , we show that expression of Fyn , but not Src or Yes , is required for stress induced caveolin phosphorylation . ^^^ Interestingly , there was a concomitant increase in the phosphorylation of Fyn on its Csk ( C terminal Src kinase ) site , indicating feedback inhibition . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Lithium reduced N methyl D aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD 95 in rat hippocampus following cerebral ischemia . ^^^ Since brain ischemia results in NMDA receptor over excitation and Src family protein tyrosine kinase mediated tyrosine phosphorylation of NMDA receptor subunit 2A ( NR2A ) enhances NMDA receptor activity , we examined the effects of lithium on tyrosine phosphorylation of NR2A and its interactions with Src and Fyn ( two members of the Src family of protein tyrosine kinases ) mediated by PSD 95 ( postsynaptic density protein 95 kDa ) after 6 h of reperfusion following 15 min of ischemia ( I / R ) , which was induced by occlusion of the four vessels in Sprague Dawley rats . ^^^ After abdominal injection of LiCl ( 2 mg / kg ) for 7 days , the data showed that together with the significant decrease in I / R induced tyrosine phosphorylation of NR2A , the interactions of NR2A with Src and Fyn mediated by PSD 95 were also decreased significantly . ^^^ However , lithium pretreatment did not alter the total protein levels of NR2A , Src , Fyn and PSD 95 . ^^^ These results suggest that the inhibition of NR2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD 95 may contribute to the lithium induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Brain and embryo derived fibroblast src and fyn activity is reduced to < 50 % in PTPalpha ( / ) mice . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The N terminal SH 4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation : role in membrane targeting , cell adhesion , and spreading . ^^^ Here we use matrix assisted laser desorption / ionization time of flight ( MALDI TOF ) mass spectrometry to identify fatty acylated species of the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
RESULTS : Array profiles demonstrate that Fyn , Lyn , Fgr , Hck , Src , and Yes are all expressed in cultured human MKs ( Fyn , Lyn > Src , Yes , Fgr , Hck ) . ^^^ Similarly , Western blots of murine MKs identified the same six SFKs ( Fyn , Fgr , Hck , Lyn , Src , and Yes ) . ^^^ CONCLUSION : These results provide the first direct evidence that two Src kinases are activated in primary MKs , Fyn and Lyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show here that SAP mutants found in XLP patients are defective in binding its physiological ligands signaling lymphocyte activating molecule ( SLAM ) , a co receptor in T cell activation , and Fyn , a Src family protein tyrosine kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn is a Src kinase known to have an essential role in mast cell degranulation induced following aggregation of the high affinity IgE receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Five members of the Src family of non receptor protein tyrosine kinases Lck , Lyn , Fyn , Src , and Yes are known to be expressed in the central nervous system . ^^^ Src and Fyn have been shown to play important roles in synaptic transmission and plasticity at excitatory synapses . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of the NMDA receptor subunit NR2A by Src or Fyn has been implicated in the up regulation of NMDA receptor activity . ^^^ In order to investigate the possible mechanism of the neuroprotective action of SY 21 , we examined the effects of SY 21 on the ischemia / reperfusion induced increases in tyrosine phosphorylation of the NMDA receptor subunit 2A ( NR2A ) and on the interactions involving NR2A , PSD 95 and Src / Fyn . ^^^ Also , SY 21 attenuated the increased interactions involving NR2A , PSD 95 , Fyn and Src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The role of Src family protein tyrosine kinases ( SFKs ) in egg activation has been established , in large part , by the observation that GST fusion proteins encoding the SH 2 domain of Src or Fyn suppress the sperm induced calcium transient and cause polyspermy in marine invertebrate eggs . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
RESULTS : Phosphorylation of c Cbl through GpVI is reduced in murine platelets deficient in the Src family kinases Fyn and Lyn , demonstrating that they lie upstream of c Cbl phosphorylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we show that the Src family kinases Yes and Lyn , but not Src and Fyn , are expressed in isolated pancreatic acini of Wistar rats . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
CNR / Pcdhalpha family proteins have been first identified as a receptor family that corporate with Fyn , a family of the Src family of tyrosine kinase , and known as synaptic cadherins . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The first step in T cell receptor for antigen ( TCR ) signaling is the activation of the receptor bound Src kinases , Lck and Fyn . ^^^ Here , we report that the novel Src homology ( SH ) 3 / SH2 ligand Uncoordinated 119 ( Unc 119 ) associates with CD 3 and CD 4 , and activates Lck and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Engagement of the T cell or B cell receptor by antigen initiates a signal transduction cascade that leads to tyrosine phosphorylation of IP3R by Src family nonreceptor protein tyrosine kinases , including Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We found that TRPC 6 is tyrosine phosphorylated in COS 7 cells when coexpressed with Fyn , a member of the Src family PTKs . ^^^ This epidermal growth factor induced tyrosine phosphorylation of TRPC 6 was significantly blocked by PP 2 , a specific inhibitor of Src family PTKs , and by a dominant negative form of Fyn , suggesting that the direct phosphorylation of TRPC 6 by Src family PTKs could be caused by physiological stimulation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
By differential detergent extraction and isopycnic sucrose density gradients , we show that rat 8 protein is associated to lipid membrane domains together with Lyn and Fyn , members of the Src tyrosine kinase family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In transfected COS cells , Dok 4 was a substrate for the cytosolic tyrosine kinases Src and Fyn as well as for Jak 2 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show here that RPTP is a physiological activator of two additional Src family kinases , Yes and Fyn . ^^^ Surprisingly , expression of Yes or of Fyn does not rescue the morphological phenotype of RPTP deficient tumor cells in contrast with the strong ability of Src to do so . ^^^ We conclude that RPTP activates Src , Yes , and Fyn , but that these related kinases play distinct roles in Neu induced mammary tumor cells . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We obtained selective labelling of white cells for eight such molecules ( the ' linker ' molecules SLP 76 and BLNK , the Src family kinases Lyn , Fyn , Syk and Hck , and the phospholipases PLC gamma 1 and PLC gamma 2 ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show here that NS5A interacts with the SH 3 domains of members of the Src family of tyrosine kinases : a combination of in vitro binding assays and co immunoprecipitation experiments revealed an interaction between NS5A and Hck , Lck , Lyn and Fyn , but interestingly not Src itself . ^^^ Using transient transfections and Huh 7 cells harbouring a persistently replicating subgenomic HCV replicon we demonstrate that NS5A bound to native Src family kinases in vivo and differentially modulated kinase activity , inhibiting Hck , Lck and Lyn but activating Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this study we determined that human tau tyr 18 was phosphorylated by the src family tyrosine kinase fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Hyperosmotic exposure ( 405 mosm ) resulted in a rapid activation of the Src kinase family members Yes , Fyn , and Lck . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
All three kinases examined : Fyn , c Src and c Yes are distributed throughout the egg cytoplasm . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
One group of SH 2 domains ( Src , Fyn , Lck , Fgr , Abl , Crk , and Nck ) preferred sequences with the general motif pTyr hydrophilic hydrophilic Ile / Pro while another group ( SH 2 domains of p 85 , phospholipase C gamma , and SHPTP 2 ) selected the general motif pTyr hydrophobic 10 hydrophobic . ^^^ Individual members of these groups selected unique sequences , except the Src subfamily ( Src , Fyn , Lck , and Fgr ) , which all selected the sequence pTyr Glu Glu Ile . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In contrast to other adapters that become phosphorylated upon TCR stimulation , Sin was constitutively phosphorylated in resting cells by the Src kinase Fyn and bound to signaling intermediates , including PLC gamma . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Mouse embryo fibroblasts ( MEFs ) deficient for src , yes and fyn , and those lacking all p38MAPK isoforms displayed normal Aplidin sensitivity ( IC50=12 nM ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Importantly , T cell receptor mediated activation of the Src kinases Lck and ZAP 70 but not Fyn and the phosphorylation of Akt are impaired by the HCV core , suggesting that it inhibits the very early events of T cell activation . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Coimmunoprecipitation analysis of rat brain membrane fractions showed that tamalin is present in a multimolecular protein assembly comprising not only mGluR 1 but also c Src , Fyn , and a protein phosphatase , SHP 2 . ^^^ Mutation analysis of tyrosine with phenylalanine in COS 7 cells revealed that paired tyrosines at the ITAM sequence of tamalin are phosphorylated preferentially by c Src and Fyn , and this phosphorylation can recruit Syk kinase and enables it to be phosphorylated by the Src family kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This became apparent from the hyperresponsive degranulation of lyn / bone marrow derived mast cells , which is driven by hyperactivation of Fyn kinase that occurs , in part , through the loss of negative regulation by COOH terminal Src kinase ( Csk ) and the adaptor , Csk binding protein . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here , we identified a role for the Src family members Lyn and Fyn in osteoblast differentiation promoted by constitutive activation of FGF receptor 2 ( FGFR 2 ) . ^^^ We show that the overactive FGFR 2 S252W mutation induced decreased Src family kinase tyrosine phosphorylation and activity associated with decreased Lyn and Fyn protein expression in human osteoblasts . ^^^ Pharmacological stimulation of Src family kinases or transfection with Lyn or Fyn vectors repressed alkaline phosphatase ( ALP ) up regulation induced by overactive FGFR 2 . ^^^ Transfection with c Cbl in which the RING finger was disrupted or with c Cbl with a point mutation that abolishes the binding ability of the Cbl phosphotyrosine binding domain restored Src kinase activity and Lyn , Fyn , and FGFR 2 levels and reduced ALP up regulation in mutant osteoblasts . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
As reported here , PLD 2 but not PLD 1 is phosphorylated through the Src kinases , Fyn and Fgr , and this phosphorylation appears to regulate PLD 2 activation and degranulation . ^^^ This phosphorylation was blocked by a Src kinase inhibitor or by small interfering RNAs directed against Fyn and Fgr and was enhanced by overexpression of Fyn and Fgr but not by other Src kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Differentiation of oligodendrocyte progenitor cells requires activation of the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In addition , we found this phosphorylation to be independent of the Src family kinases Src , Fyn and Yes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This interaction requires the phosphorylation of caveolin 1 on tyrosine 14 by members of the Src family of protein kinases , such as Src and Fyn , because it is completely abolished by expression of a catalytically inactive Src mutant or by site directed mutagenesis of tyrosine 14 of caveolin 1 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this synopsis , we review the current knowledge on the role of the Src PTKs , Fyn and Lyn , in mast cell activation and discuss the implications of our findings on allergic disease . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we show that netrin 1 induces tyrosine phosphorylation of proteins including focal adhesion kinase ( FAK ) and the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here , we report that the Src family kinases ( SFKs ) Fyn and Lyn regulate each of these distinct integrin driven behaviors . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Immunoprecipitation of the alpha2beta1 integrin in unstimulated SMCs followed by immunoblotting for the PDGFRbeta as well as Src family members , pp 60 ( src ) , Fyn , Lyn , and Yes demonstrated coassociation of alpha2beta1 and the PDGFRbeta as well as pp 60 ( src ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src homology 3 ( SH 3 ) domain of Fyn binds to a conserved PXXP motif on microtubule associated protein 2 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we provide evidence that Fyn kinase , a member of the Src kinase family , is involved in the UVB induced phosphorylation of histone H 3 at serine 10 . ^^^ Fyn kinase inhibitors 4 amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazol ( 3 , 4 d ) pyramide and leflunomide , an Src kinase inhibitor , suppressed both UVB induced phosphorylation of histone H 3 at serine 10 and Fyn kinase activity and phosphorylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Mechanistic studies revealed increased basal as well as stimulated phosphorylation of the Src kinase , Fyn , in Lyn ( / ) BMMCs . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A unique and complete dependency for development on Fyn , a Src family kinase member , also distinguishes the NKT cell and conventional T cell populations . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn , but not Src , is able to phosphorylate the intracellular domain of DCC in vitro , and we demonstrate that Y 1418 is crucial for DCC axon outgrowth function . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The physiological correlation between casein kinase 2 ( CK 2 ) and two Src family tyrosine kinases ( Src TKs , Fyn and Src ) was mainly investigated in vitro . ^^^ These results suggest that CK 2 may be a protein kinase responsible for the suppression of at least three Src TKs ( Fyn , Src and Yes ) through the specific phosphorylation of their Thr residues at the cellular level . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
After consideration of the tertiary structure of the pY+3 binding pocket in SH 2 domains , isoleucine of Ac pYEEIE was replaced with various unnatural aliphatic amino acids and the binding affinities for Lck , Src , and Fyn SH 2 domains were measured . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Data presented here demonstrate that epidermal growth factor ( EGF ) receptor ligands promote the tyrosine phosphorylation of endogenous and adenovirally transduced Srcasm in keratinocytes , and that increased levels of Srcasm activate endogenous SFKs , with a preference for Fyn and Src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SRC family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin . ^^^ When nephrin was co transfected with Src family kinases Fyn or Src in Cos 1 cells , nephrin was strongly tyrosine phosphorylated by Fyn and less so by Src . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Induction of SM22alpha by TGF beta 1 was markedly attenuated in SYF cells ( c Src ( ) , Yes ( ) , and Fyn ( ) ) compared with Src ( ++ ) cells ( c Src ( ++ ) , Yes ( ) , and Fyn ( ) ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Mediated by the proline rich region of tau and the SH 3 domain of fyn or src , this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Studying normal human keratinocytes ( NHKs ) , here we demonstrate strong expression of the Src family kinases Src , Yes , and Fyn ; Src family kinase dependent stimulation of Tyr 845 by EGF ; and potent inhibition of NHK proliferation and migration by two Src family kinase inhibitors PP 1 and PD 173952 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In SYF cells lacking Src , Yes , and Fyn , ezrin was not tyrosine phosphorylated but reintroduction of wild type Src followed by Src activation or introduction of active Src restored phosphorylation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Interestingly , PP 2 , a specific Src like kinase inhibitor , blocked the tyrosine phosphorylation of Src , Fyn , and Lyn and IGF 1 stimulated Akt activation , yet had no significant effects on caspase 3 activation or progenitor survival . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SAP also binds to the Src family tyrosine kinase Fyn and recruits it to SLAM , which leads to the generation of downstream phosphotyrosine signals . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Investigation of the signal transduction events involved in this process revealed a role for Lck and Fyn kinases , since the Src kinase inhibitor PP 1 inhibited the up regulated expression of Gal 1 following T cell activation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the present study , experiments were conducted to compare the ability of other Src family kinases ( Fyn , Src , and Lck ) and Fes , a non Src family tyrosine kinase , to alter Na , K ATPase activity . ^^^ As judged by immunoprecipitation , Src , Fyn , Lyn , and Lck elicited tyrosine phosphorylation of the Na , K ATPase alpha 1 protein . ^^^ Src , Fyn , Lyn , Lck , and Fes were each detectable in the epithelium by Western blot . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Src family kinases Lck and Fyn play an important role in T cell development and function . ^^^ We have synthesized a novel small molecule , A 420983 , which inhibits Lck and Fyn , as well as other Src family kinases , but has selectivity with respect to non Src family kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Flotillin 1 specifically interacts with the adaptor protein CAP , the Src family kinase Fyn , and cortical F actin in lipid raft microdomains in adipocytes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The Csk tyrosine kinase negatively regulates the Src family kinases Lck and Fyn in T cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this work , we examine the possible functional interactions between Vif , APOBEC3G , and two Src family tyrosine kinases , Fyn and Hck , present in T lymphocytes and in monocyte macrophages , respectively . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Greater than 85 90 % of Src and Fyn were present in lipid rafts , whereas Pyk 2 was mainly associated with PSDs . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Modulation of the cardiac sodium channel NaV1 . 5 by Fyn , a Src family tyrosine kinase . ^^^ This study addresses the effects of the Src family tyrosine kinase Fyn on Na ( 5 ) 1 . 5 cardiac sodium channels . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Microglial activation might involve beta amyloid binding and activation of cell surface immune and adhesion molecules such as CD 45 , CD 40 , CD 36 and integrins , with the subsequent recruitment of Src family tyrosine kinases such as Fyn , Lyn and Syk kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
FYN and YES proteins were found in mouse eggs , but other SFKs were not detected ; based on this , we injected mouse eggs with a mixture of FYN and YES Src homology 2 ( SH 2 ) domains . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
These data indicate that calcium activates PLC gamma 1 via increased PIP 3 formation mediated by c src and fyn activated PI3K . ^^^ Calcium induced human keratinocyte differentiation requires src and fyn mediated phosphatidylinositol 3 kinase dependent activation of phospholipase C gamma 1 . ^^^ In the present study , we investigated whether the activation of PLC gamma 1 by nonreceptor kinases such as src and fyn plays a role in mediating this process . ^^^ Our results showed that the combination of dominant negative src and fyn blocked calcium stimulated PLC gamma 1 activity and human keratinocyte differentiation , whereas each separately has little effect . ^^^ The combination of dominant negative src and fyn blocked calcium induced tyrosine phosphorylation of the regulatory subunit of PI3K , p85alpha , and the activity of the catalytic subunit of PI3K . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we report the presence in human sperm of alpha 7 , alpha 9 , alpha 3 , alpha 5 , and beta 4 nicotinic acetylcholine receptor subunits and the following proteins known to be associated with the receptor in the somatic cell : rapsyn and the tyrosine kinases c SRC and FYN . ^^^ We detected the FYN and c SRC tyrosine kinases in the flagellar mid piece region . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Immunoprecipitation and in vitro kinase assays reveal rapid GC induced down modulation of Lck and Fyn kinases using SAM 68 ( Src [ pp60c src ] associated in mitosis 68 kDa ) as a substrate . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
CD95L also induced rapid activation of the Src family kinase Yes , being followed by activation of c Src , Fyn , and c Jun N terminal kinases ( JNK ) . ^^^ Only Yes and JNK activation were sensitive to N acetylcysteine , inhibitors of NADPH oxidase , PKCzeta , or sphingomyelinase , indicating that the CD95L induced ROS response is upstream of Yes and JNK but not of Fyn and c Src activation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We now report that the Src family member Fyn interacts with the intracellular domain of RPTPbeta / zeta in a yeast two hybrid system . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
EphB 6 is constitutively associated with the Src family kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show , upon fMLP stimulation , a rapid and transient association of the Src tyrosine kinase Fyn with LFA 1 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Other SFKs , such as Fyn and Src , remain present and active as ES cells differentiate . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
There was no significant difference in the normalized levels of c Src and Fyn protein and message in the glioblastoma and nonneoplastic brain . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A 770041 is a 147 nM inhibitor of Lck ( 1 mM ATP ) and is 300 fold selective against Fyn , the other Src family kinase involved in T cell signaling . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Lyp is expressed in lymphocytes , where it physically associates through its proline rich motif ( called P 1 ) with the SH 3 domain of the protein tyrosine kinase Csk , an important suppressor of the Src family of kinases Lck and Fyn , which mediate TCR signaling . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the phosphorylated state Tyr ( P ) 192 exposes a docking site for SH 2 domains and efficiently recruits Src and Fyn to sGCbeta 1 , thereby promoting multiple phosphorylation of the enzyme . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show that LMP2A is tyrosine phosphorylated in Jurkat TAg T cells , which requires expression of the Src family tyrosine kinases , Lck and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Each of these residues is targeted by one or more specific kinases : Y 142 by Fyn , Fer and cMet ; Y 489 by Abl ; and Y 654 by Src and the epidermal growth factor receptor . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this article , we show that murine ES cells express seven SFKs , three of which ( Hck , Src , and Fyn ) exhibit constitutive activity in self renewing ES cells . ^^^ Like ES cells , embryoid bodies maintained constitutive Src and Fyn kinase activity . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We have recently shown that tau interacts with the SH 3 domain of Fyn , an Src family non receptor tyrosine kinase , and is tyrosine phosphorylated by Fyn on Tyr 18 . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
A stepwise library based strategy has been employed to acquire a potent ligand for the SH 3 domain of Fyn , a Src kinase family member that plays a key role in T cell activation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In this issue of Chemistry and Biology , Li and Lawrence report an iterative synthesis / selection process to identify chemically modified peptide ligands possessing high affinity and selectivity for the SH 3 domain of Fyn , a member of the Src kinase family . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
SKAP HOM is a cytosolic adaptor protein representing a specific substrate for the Src family protein tyrosine kinase Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This phosphorylation was mediated by Src family tyrosine kinases ( STKs ) , with Fyn appearing to be the dominant kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Compound 17c was found to be highly selective for Src kinase when tested against a panel of other kinases , with modest selectivity versus the Src family kinases Lyn and Fyn . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Absence of Fyn and Src causes a reeler like phenotype . ^^^ Biochemical and in vitro experiments implicate Src and Fyn in the Reelin dependent tyrosine phosphorylation of Dab 1 , which controls the positioning of radially migrating neurons in many brain regions . ^^^ However , genetic evidence that either Src or Fyn mediates Reelin dependent migrations in vivo has been lacking . ^^^ Here , we report that , although Src is dispensable and although the absence of Fyn causes an intermediate phenotype , the combined absence of Src and Fyn almost abolishes tyrosine phosphorylation of Dab 1 and causes defects in the fetal cortex and cerebellum very similar to those of dab 1 mutants of the same age . ^^^ This implies that Src and Fyn are needed for Reelin dependent events during brain development . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
RT PCR revealed mRNA transcripts for FYN , c SRC , YES , FRK , and LYN . ^^^ Fyn , c Src , Yes , and Lyn were identified in cultured airway smooth muscle cells by immunoblot analysis . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Notably , alpha 4 stimulated cell motility was inhibited by catalytically inactive receptor protein tyrosine phosphatase alpha overexpression and blocked by the p50Csk phosphorylation of c Src at Tyr 529 . alpha4beta1 stimulated cell motility of triple null Src ( / ) , c Yes ( / ) , and Fyn ( / ) fibroblasts was dependent on c Src reexpression that resulted in p130Cas tyrosine phosphorylation and Rac GTPase loading . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We studied the mechanism of SFK action using cultured src ( / ) ; fyn ( / ) myotubes , focusing on clustering of postsynaptic proteins , their interaction with AChRs , and AChR phosphorylation . ^^^ Rapsyn and the utrophin glycoprotein complex were recruited normally into AChR containing clusters by agrin in src ( / ) ; fyn ( / ) myotubes . ^^^ Unexpectedly , levels of rapsyn protein were increased in src ( / ) ; fyn ( / ) myotubes , whereas rapsyn cytoskeleton interactions were unaffected . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Src is not detectable in MA 10 cells , but two other prominent members of this family ( Fyn and Yes ) are present . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Using dominant negative mutants of c Src and Fyn and Src deficient SYF cells as well as by co immunoprecipitation studies , we can demonstrate that the M2R mediated transactivation of EGFR specifically involves Fyn but not c Src or Yes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Peptides that mimic the binding sites for either Fyn or Src on receptor for activated C kinase 1 ( RACK 1 ) also enhanced NMDAR in CA 1 neurons , but their effects were blocked by Src ( 40 58 ) , implying that Src is the ultimate regulator of NMDARs . ^^^ RACK 1 serves as a hub for PKC , Fyn , and Src and facilitates the regulation of basal NMDAR activity in CA 1 hippocampal neurons . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
PTPalpha null thymocytes develop normally , but unstimulated PTPalpha / cells exhibit increased tyrosine phosphorylation of specific proteins , increased Fyn activity , and hyperphosphorylation of Cbp / PAG that promotes its association with C terminal Src kinase . ^^^ In the absence of PTPalpha this population of Fyn is activated and phosphorylates Cbp / PAG to enhance association with C terminal Src kinase . ^^^ These findings indicate that PTPalpha is a component of the complex Src family tyrosine kinase regulatory network in thymocytes and is required to suppress Fyn activity in unstimulated cells in a manner that is not compensated for by the major T cell PTP and SFK regulator , CD45 . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we show that Itch is also modulated by an Src kinase Fyn via tyrosine phosphorylation at the Tyr 371 residue . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We show that fibroblast cells deficient of three ubiquitously expressed Src family members ( Src , Yes , and Fyn ) , SYF cells , are refractory to hormonally induced fat accumulation . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The stimulation of neurite outgrowth and polarity formation induced by cholesterol depletion was accompanied by an enhanced localization of Fyn , a Src kinase , in the lipid rafts of hippocampal neurons . ^^^ A concomitant treatment with beta cyclodextrin and a Src family kinase inhibitor , PP 2 , specifically blocked axon outgrowth but not dendrite outgrowth ( both of which were enhanced by beta cyclodextrin ) in hippocampal neurons , suggesting that axon outgrowth modulated by cholesterol is induced in a Fyn dependent manner . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
MIT inhibited Src family kinases ( SFKs ) in cell free assays and led to the physical dissociation of FAK from the signaling complexes that it normally forms with c Src and Fyn in developing neurons . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This requirement is unique for TRPC 3 because ( 1 ) mutation of the cognate tyrosines of the closely related TRPC 6 and TRPC 7 had no effect ; ( 2 ) TRPC 6 and TRPC 7 were activated in src , yes , and fyn deficient cells ; and ( 3 ) src , but not yes or fyn , rescued TRPC 3 activation in src , yes , and fyn deficient cells . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Both EAT 2A and EAT 2B bind to the Src like kinases Fyn , Hck , Lyn , Lck , and Fgr , as determined by a yeast two hybrid assay . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the first presentation , Dorit Ron presented data showing how activation of Fyn or Src tyrosine kinases differentially regulated the cell surface expression and activity of NR2A and NR2B containing NMDA receptors . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We further show that Src , Fyn and Yes have unique specificities towards these tyrosine residues . ^^^ Using cell lines deficient in Src , Fyn and Yes , we demonstrate that multiple Src family members can stimulate vaccinia induced actin polymerization and also uncover a role for Abl family kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Furthermore , we report that Tom1L1 negatively regulates SFK mitogenic signaling induced by platelet derived growth factor ( PDGF ) through modulation of SFK receptor association : ( 1 ) Tom1L1 inhibits DNA synthesis induced by PDGF ; ( 2 ) inhibition is overcome by c myc expression or p 53 inactivation , two regulators of SFK mitogenic function ; ( 3 ) Src or Fyn coexpression overrides Tom1L1 mitogenic activity ; ( 4 ) overexpression of the adaptor reduces Src association with the receptor ; and ( 5 ) protein inactivation potentiates receptor complex formation , allowing increased SFK activation and DNA synthesis . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In the present study , we have taken advantage of a phosphospecific antibody against Tyr 789 phosphorylated RPTPalpha and characterized the phosphorylation of RPTPalpha Tyr 789 in various cultured cells , including SYF cells lacking all three ubiquitously expressed members ( Src , Yes , and Fyn ) of Src family kinases . ^^^ We have obtained substantial evidence indicating that the phosphorylation of RPTPalpha Tyr 789 is regulated predominantly by an Src kinase inhibitor , protein phosphatase 1 ( PP 1 ) sensitive but Src / Yes / Fyn independent tyrosine kinase , in cells . ^^^ We further reported a novel finding that , besides the inhibition of RPTPalpha ' s activity , H ( 2 ) O ( 2 ) at low to moderate concentrations ( 50 250 microM ) markedly suppressed the phosphorylation of RPTPalpha Tyr 789 and the association of RPTPalpha with Grb 2 in cultured cells , which may result from inhibition of such a PP 1 sensitive but Src / Yes / Fyn independent tyrosine kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Our findings show that in our system , Xmrk is sufficient for the induction of pigment cell motility and underlines a role of the src family protein tyrosine kinase fyn in melanoma development and progression . . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Here we show that the rigidity response through increased spreading and growth correlates with leading edge recruitment of Fyn , but not endogenous c Src . ^^^ Recruitment of Fyn requires the palmitoylation site near the N terminus and addition of that site to c Src enables it to support a rigidity response . ^^^ The stretch activated substrate of Fyn and c Src , p130Cas , is also required for a rigidity response and it is phosphorylated at the leading edge in a Fyn dependent process . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
PrP ( C ) associates in rafts with a variety of signalling molecules , including caveolin 1 and Fyn and Src tyrosine kinases . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The LHR mediated phosphorylation of the EGFR and Shc , the activation of Ras , and the phosphorylation of ERK1 / 2 are inhibited by expression of a dominant negative mutant of Fyn , a member of the Src family kinases ( SFKs ) expressed in MA 10 cells and by PP 2 , a pharmacological inhibitor of the SFKs . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The results demonstrate that Fyn , and possibly other Src family members are activated by dephosphorylation of the C terminal tyrosine at fertilization . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Specifically , we demonstrate the following : 1 ) inhibition of Src family kinases suppresses DAP 12 phosphorylation and downstream DAP 12 signals ; 2 ) both Fyn and Lck are capable of phosphorylating DAP 12 ; and 3 ) both kinases coimmunoprecipitate with the Ly 49D / DAP12 complex in NK cells . ^^^ Although we detect enhanced phosphorylation of Fyn upon Ly 49D cross linking in NK cells , Ly 49D mediated events in both Fyn / and Fyn / Lck / mice appear normal , reinforcing the theme of redundancy in the ability of Src family kinases to initiate activation events . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
This notion was corroborated by pull down experiments in which gamma tubulin complex bounds to the recombinant Src homology 2 and Src homology 3 domains of Fyn kinase . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn , a member of the Src family of tyrosine kinases , is implicated in both brain development and adult brain function . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The tyrosine kinase Fyn is a member of the Src kinase family . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
We expressed Fgr , Fyn , Hck , Lck , Lyn , and Yes as well as c Src in yeast and found that each kinase was active and induced growth suppression . ^^^ Nef strongly activated Hck , Lyn , and c Src but did not detectably affect Fgr , Fyn , Lck , or Yes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
After RA induction , neurons derived from ES cells showed significant neurite growth , increased expression of Src , Fyn and Lck and an extension of Src kinase expression from cell body to neurite processes . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
In addition to Fyn , Src and Lck also interact with magicin . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Fyn is a 59 kDa member of the Src family of tyrosine kinases synthesized on cytosolic polysomes and then targeted to the plasma membrane where it clusters in caveolae like membrane microdomains . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Cholesterol treatment also rescued a specific defect in AChR cluster stability in cultured src ( / ) ; fyn ( / ) myotubes . ^^^ Amounts of microdomains and enrichment of postsynaptic proteins into microdomains were decreased in src ( / ) ; fyn ( / ) myotubes but rescued by cholesterol treatment . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Various Ca2+ regulated enzymes found in spines have been implicated in epileptogenesis ; these include the nonreceptor protein tyrosine kinases Src and Fyn and a serine threonine kinase [ Ca2+ calmodulin dependent protein kinase 2 ( CaMKII ) ] and phosphatase ( calcineurin ) . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The authors ' search of amino acid sequences of 38 transforming proteins identified possible finger loop domains in the myc , fms , fps , raf 1 , rfp , src , syn , yes , erbA , int 1 , and TGF alpha gene products . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
Nucleotide sequence analysis of cDNA clones showed that the c syn gene could encode a protein tyrosine kinase that is very similar in primary structure to the 5 yes and human c src proteins . ^^^ A 2 . 8 kilobase transcript of the c syn gene , which differs in size from those of the c yes , c src , and c fgr genes , was observed in various cell types . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
The NMDAR is a substrate of src family tyrosine kinases , and reduced activity of src , fyn , yes and lck , but not lyn , was apparent in the absence of PTPalpha . ^^^ Together , these findings provide evidence that aberrant NMDAR associated functions in PTPalpha null mice are due to impaired NMDAR tyrosine phosphorylation resulting from the reduced activity of probably more than one of the src family kinases src , fyn , yes and lck . ^^^
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06241 and P12931	Pubmed	SVM Score :0.0
NA