| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.72120658 |
| Recent findings indicate that Ig alpha associates with Src family kinases , including Fyn and Lyn , via an approximately 26 amino acid motif termed ARH 1 . 0.72120658^^^ |
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| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| The Ig alpha chain cytoplasmic domain bound to the Src family kinases Lyn and Fyn , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and an unidentified 38 kilodalton phosphoprotein ; the cytoplasmic tail of Ig beta bound PI 3 kinase and unidentified 40 and 42 kilodalton phosphoproteins . ^^^ |
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| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| Of the tyrosine kinases transfected ( Lyn , Blk , Hck , Syk , Fyn ) , only Blk was able to phosphorylate and subsequently associate with cotransfected Ig alpha and Ig beta chimeras in vivo . ^^^ Sequences within the amino terminal unique domain of Blk are responsible for recognition and subsequent phosphorylation of the Ig alpha chimera since transfer of the unique region of Blk to Fyn results in the chimeric kinase ' s ability to phosphorylate the cytoplasmic domain of Ig alpha . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| Both Ig alpha and Ig beta were able to trigger Fyn , Lck , and ZAP directly without involvement of TCR components . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| Alternatively , Lyn , may be a downstream effector of phosphorylated Ig alpha and Ig beta as suggested by the reported ability of biphosphorylated Ig alpha to activate Fyn PTK in vitro . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| In addition to binding to the phosphorylated cytoplasmic domains of Ig alpha and Ig beta , blk and fyn ( T ) , two members of the src family kinases , have been shown to bind overlapping but distinct sets of phosphoproteins [ Malek & Desiderio ( 1993 ) J . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| B cell antigen receptors ( BCR ) are composed of an antigen binding subunit , the membrane Ig , and Ig alpha / Ig beta heterodimers , that contain a transducing motif named ITAM for `` immuno receptor tyrosine based activation motif . ' ' Ig alpha and Ig beta ITAMs only differ by four amino acids located before the second conserved tyrosine ( DCSM in Ig alpha and QTAT in Ig beta ) , which determine the in vitro association of Ig alpha with the src kinase fyn . ^^^ These data show that alterations that modify the ability of Ig alpha and Ig beta to interact in vitro with the src kinase fyn ( switch between QTAT and DCSM ) also determine signal transduction capabilities of these molecules expressed in B cells . . ^^^ |
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| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , at least 25 % of phosphorylated p40 / 42 co immunoprecipitated with Ig alphabeta , but none precipitated with MHC 2 , CD 40 , Fc ( gamma ) RII , Fyn , HS 1 , or Syk , suggesting that this protein complex specifically associates with the Ig alphabeta heterodimer . p40 / 42 did not react with Abs to Ig alpha , Ig beta , mitogen activated protein kinase , or Lnk . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| Addition of a palmitylation site to Blk abrogates its phosphorylation of the substrate , while mutation of Fyn ' s palmitylation sites results in recognition and phosphorylation of Ig alpha . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , crosslinking of the chimeras resulted in tyrosine phosphorylation of the Ig alpha and Tg beta tails and their association with the tyrosine kinases PTK 72 , p53 / 56 ( lyn ) and p 59 ( fyn ) . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| Among the targets of mIg induced tyrosine phosphorylation are the tyrosine kinases encoded by the lyn , blk , fyn , and syk genes , the mIg associated proteins MB 1 and Ig beta , phospholipase C gamma 1 and gamma 2 , as well as many unidentified proteins . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this study , we confirm previous findings demonstrating that the B cell Ag receptor coprecipitates with the MB 1 / B29 heterodimer as well as the protein tyrosine kinases blk , lyn , and fyn under mild detergent conditions ( 1 % digitonin ) . ^^^ MB 1 and B 29 were however , found to coprecipitate with blk , lyn , and fyn isolated from B cell lysates containing 1 % NP 40 . ^^^ |
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| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| These results suggested that src type tyrosine kinases as Fyn and Lyn are responsible for the phosphorylation of MB 1 and B 29 heterodimer , but anti MB 1 stimulation can induce tyrosine phosphorylation reaction mediated by other kinase molecule ( s ) in the progenitor type cells . . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| The 60 kDa phosphoprotein coprecipitated with MB 1 and the BCR related complex is very similar to the Src type Fyn tyrosine kinase or a Fyn related protein . . ^^^ |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|