| Interacting proteins: P10586 and P06241 |
Pubmed |
SVM Score :0.0 |
| The CD 45 transmembrane protein tyrosine phosphatase ( PTPase , EC 3 . 1 . 3 . 48 ) plays an essential role in T cell activation by activating the Lck and / or Fyn protein tyrosine kinases . ^^^ |
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| Interacting proteins: P10586 and P06241 |
Pubmed |
SVM Score :0.0 |
| We postulated that LAR regulates Lck and Fyn in the immature thymocytes . ^^^ LAR mutants , with Cys to Ser mutation in the catalytic center of PTPase D 1 , bound to tyrosine phosphorylated Lck and Fyn , and LAR PTPase domain 2 was tyrosine phosphorylated by Fyn tyrosine kinase . ^^^ The phosphorylated LAR was associated with Fyn Src homology 2 domain . ^^^ Moreover , LAR dephosphorylated phosphorylated tyrosine residues in both the COOH terminus and kinase domain of Fyn in vitro . ^^^ Our results indicate that Lck and Fyn would be substrates of LAR in immature thymocytes and that each LAR PTPase domain plays distinct functional roles in phosphorylation and dephosphorylation . . ^^^ |
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| Interacting proteins: P10586 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10586 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|