| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :1.0117841 |
| Fyn has been shown to associate with the TCR CD 3 complex , the protein tyrosine phosphatase CD 45 and several co receptors such as CD 28 which are crucial for initiating T cell activation and proliferation . 1.0117841^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Signaling through ICAM 3 stimulates a number of T cell functions and involves phosphorylation of Fyn , Lck , CD 45 , and other proteins . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Neither blk nor fyn were observed to interact with CD 45 even though they have been implicated in antigen receptor signal transduction . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Significantly , CD 45 did not influence the binding of Fyn , PLC gamma 1 , GAP and Vav to the same phosphopeptide . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Aberrant TCR mediated signaling in CD 45 null thymocytes involves dysfunctional regulation of Lck , Fyn , TCR zeta , and ZAP 70 . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| The CD 45 protein tyrosine phosphatase ( PTPase ) has been shown to regulate the activity of Lck and Fyn protein tyrosine kinases in T cells . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| CD 45 is a leukocyte specific protein tyrosine phosphatase that dephosphorylates the Src family kinases , Lck and Fyn , in T cells . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Here we show that neither Fyn nor CD 45 is affected in these patients . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn co immunoprecipitated with CD 45 from differentiating wild type OPCs in vitro , while CD 45 deficient OPCs failed to differentiate . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| The CD 45 transmembrane protein tyrosine phosphatase ( PTPase , EC 3 . 1 . 3 . 48 ) plays an essential role in T cell activation by activating the Lck and / or Fyn protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Among them , forty six cases were immunostained using antibodies against vimentin , CD 34 , muscle specific actin ( MSA ) , smooth muscle actin ( SMA ) , neuron specific enolase ( NSE ) , S 100 protein , synaptophysin ( SYN ) , cytokeratin ( CK ) , CEA , LCA . ^^^ Immunophenotypically , percentage of positivity for the 10 antibodies was as follows : vimentin , 100 % ( 39 / 39 ) , CD 34 , 64 % ( 23 / 36 ) , MSA , 47 % ( 16 / 34 ) , SMA , 41 % ( 14 / 34 ) , NSE , 61 % ( 17 / 28 ) , S 100 protein , 19 % ( 4 / 21 ) , SYN , 15 % ( 3 / 20 ) , CK , CEA , and LCA were negative . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Immunokinase assays of Lck and Fyn precipitated from untreated or anti CD 45 treated wild type transfectants demonstrated that CD 45 cross linking dephosphorylated Lck and reduced its capacity to phosphorylate enolase . ^^^ In contrast , neither Fyn autophosphorylation nor its activity was affected by CD 45 cross linking . . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Differential effects of expression of the CD 45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck , fyn , and c src tyrosine protein kinases . ^^^ We have studied the phosphorylation of the closely related lck , fyn , and c src tyrosine protein kinases in leukemic murine T cell lines that have lost the expression of CD 45 . ^^^ The expression of CD 45 therefore regulates the phosphorylation and potentially the activity of the lck and fyn tyrosine protein kinases , but the effect on the lck kinase is much greater than on the fyn kinase . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| We determined whether differences in phosphorylation between naive and proliferating T cells were due to altered regulation of p56lck ( Lck ) or p59fyn ( Fyn ) by their positive or negative regulators , CD 45 or p5Ocsk ( Csk ) , respectively . ^^^ Therefore , although the protein expression level of CD 45 was increased in proliferating T cells it only partially compensated for the hyperactivity of Csk resulting in a 2 fold reduction in the specific activity of Lck and Fyn in proliferating T cells . . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the T cell antigen receptor CD 3 complex signaling pathway by the tyrosine phosphatase inhibitor pervanadate is mediated by inhibition of CD 45 : evidence for two interconnected Lck / Fyn or zap 70 dependent signaling pathways . ^^^ CD 45 dependent events such as tyrosine phosphorylation of Shc , activation of nuclear factor kappa B ( NF kappa B ) , activator protein 1 ( AP 1 ) , transcription factors , and stimulation of interleukin 2 ( IL 2 ) promoter and of CD 69 and CD 25 surface expression paralleled activation of the tyrosine kinases lck and fyn . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| The CD 45 tyrosine phosphatase has been reported to activate the src family tyrosine kinases Lck and Fyn by dephosphorylating regulatory COOH terminal tyrosine residues 505 and 528 , respectively . ^^^ However , recent studies with CD 45 T cell lines have found that despite the fact that Lck and Fyn were constitutively hyperphosphorylated , the tyrosine kinase activity of both enzymes was actually increased . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| The common leukocyte antigen CD 45 plays a central role in T cell activation in coupling the T cell receptor ( TCR ) to the phosphatidylinositol pathway via interactions with TCR associated protein tyrosine kinases lck and fyn . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Optimal signal transduction through the T cell receptor ( TCR ) / CD3 complex requires the coordinated activities of protein tyrosine kinases ( PTKs ) Fyn and Lck in addition to protein tyrosine phosphatases ( PTPases ) such as CD 45 . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| No p 59 ( fyn ) dephosphorylation was observed with an enzymatically inactive mutant form of PTPalpha or with another receptor like PTP , CD 45 . ^^^ No association between CD 45 and p 59 ( fyn ) was detected in similar experiments . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| RPTPalpha did not significantly alter the phosphorylation state or kinase activity of two CD 45 substrates , p 56 ( lck ) or p 59 ( fyn ) , suggesting that RPTPalpha does not have the same specificity or function as CD 45 in T cells . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , in contrast to ligand mediated TCR sorting , recycling of the TCR was independent of the tyrosine phosphatase CD 45 and the Src tyrosine kinases p 56 ( Lck ) and p 59 ( Fyn ) . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| MBCD released substantial quantities of GPI anchored Thy 1 and glycosphingolipid GM 1 , and also other surface proteins including CD 45 , and intracellular Lck and Fyn kinases . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Recombinant CD 45 AP exhibited specific binding to Lck and ZAP 70 protein tyrosine kinases , but not to Fyn or Csk , in lysates of both CD 45 positive and negative T cells . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this report we demonstrate that , in addition to the downregulation of TCR , CD 45 , and Lck ( which are key components of T cell activation ) , HTLV 1 infected cell lines demonstrate a large increase of FynB , a Fyn isoform usually poorly expressed in T cells . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| The inhibitory mechanism acting on Lck and Fyn kinases in these membranes was independent of the protein tyrosine phosphatase CD 45 and was characterized as a mixed , noncompetitive one . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| We propose a model to explain the activating effects of Campath 1H in which CD 52 mAb cross linking causes the trapping of TCR polypeptides within molecular complexes at the cell surface , thereby inducing signals via the TCR by a process which depends on the CD 45 mediated regulation of the p 56 ( lck ) and p 59 ( fyn ) tyrosine kinases . . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Two mucin type glycoproteins , MUC 1 and P selectin glycoprotein ligand 1 ( PSGL 1 ) , and glycosphingolipids ( GSLs ) , expressed in human T cell line HUT 78 , were highly enriched in low density buoyant fraction ( termed `` GEM ' ' ) , together with CD 45 , Yes , Fyn , and lck ( 56 ) . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Substrates of CD 45 include the protein tyrosine kinases p 56 ( lck ) and p 59 ( fyn ) , both of which have been shown to be enriched in detergent insoluble microdomains . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| In both CD 45 and CD45+ U 266 cells , STAT 3 and MAPK ( ERK1 / 2 ) can be activated in response to IL 6 equally between them , but src family kinases such as Lyn , Fyn can be activated only in CD45+ U 266 cells . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| Microglial activation might involve beta amyloid binding and activation of cell surface immune and adhesion molecules such as CD 45 , CD 40 , CD 36 and integrins , with the subsequent recruitment of Src family tyrosine kinases such as Fyn , Lyn and Syk kinases . ^^^ |
|
| Interacting proteins: P08575 and P06241 |
Pubmed |
SVM Score :0.0 |
| However , purified gp 180 alone is unable to induce T cell proliferation and does not activate p 59 ( fyn ) . ^^^ Interestingly , the activation of p 59 ( fyn ) in IEC T cell co cultures was blocked by the anti CD1d mAb D 5 but not by the anti gp 180 mAb B 9 . ^^^ |
|