| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| Similarly , proliferation induced by Thy 1 cross linking was reduced in thymocytes but not in splenic T cells . fyn thymocytes were impaired at a late stage of maturation and showed limited clonal deletion to the Mls 1a self super antigen but not to staphylococcal enterotoxin A . ^^^ |
|
| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| Thus , lck is associated with CD 4 , CD 8 , and Thy 1 , whereas fyn is associated with the T cell antigen receptor and Thy 1 . ^^^ |
|
| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen specific T lymphocyte clones through the TCR or Thy 1 . ^^^ The protein tyrosine kinase Fyn has been shown to be involved in signal transduction through the TCR and the glycosyl phosphatidylinositol linked surface molecule Thy 1 expressed on T cells . ^^^ In this study , we examine the requirement for Fyn expression in signaling through the TCR or Thy 1 using a panel of Ag specific T cell clones derived from fyn / mutant mice . ^^^ Thus , Fyn expression is selectively required for functional activation through Thy 1 in these T cell clones . . ^^^ |
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| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| MBCD released substantial quantities of GPI anchored Thy 1 and glycosphingolipid GM 1 , and also other surface proteins including CD 45 , and intracellular Lck and Fyn kinases . ^^^ |
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| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| Microscopy and coimmunoprecipitation show that reggie 1 and 2 are associated with fyn kinase and with the glycosylphosphatidyl inositol anchored proteins Thy 1 and F 3 that , when activated by antibody cross linking , selectively copatch with reggie . ^^^ Jurkat cells , after cross linking of Thy 1 or GM 1 ( with the use of cholera toxin ) , exhibit substantial colocalization of reggie 1 and 2 with Thy 1 , GM 1 , the T cell receptor complex and fyn . ^^^ This , and the accumulation of reggie proteins in detergent resistant membrane fractions containing F 3 , Thy 1 , and fyn imparts to reggie 1 and 2 properties of raft associated proteins . ^^^ In Jurkat cells , reggie 1 and 2 together with fyn and Thy 1 increase in endolysosomes concurrent with a decrease at the plasma membrane . ^^^ |
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| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| We show here that cross linking of PrPc with specific antibodies leads to 1 ) PrPc capping in Jurkat and human peripheral blood T cells ; 2 ) to cocapping with the intracellular lipid raft proteins reggie 1 and reggie 2 ; 3 ) to signal transduction as seen by MAP kinase phosphorylation and an elevation of the intracellular Ca2+ concentration ; 4 ) to the recruitment of Thy 1 , TCR / CD3 , fyn , lck and LAT into the cap along with local tyrosine phosphorylation and F actin polymerization , and later , internalization of PrPc together with the reggies into limp 2 positive lysosomes . ^^^ |
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| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| Under conditions designed to preserve lipid mediated membrane organization , several proteins were found in the prion protein enriched membrane domains ( i . e . the non receptor tyrosine kinases Lyn and Fyn and the neuronal glycosylphosphatidylinositol anchored protein Thy 1 ) . ^^^ |
|
| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|