| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Nonreceptor PTK encoded by mammalian proto oncogenes ( c src , fyn , c yes , c abl ) and their homologs in Drosophila exhibit patterns of expression and activities that suggest functions in axonal or dendritic outgrowth . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| In contrast , Grb 2 , Crk , Abl , p 85 phosphatidylinositol 3 kinase , and GTPase activating protein SH 2 domains showed lower or no binding to Fyn or Lck SH 3 domains . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Comparison of fyn , src , yes , and abl nonreceptor tyrosine kinase mutant mice shows a specific requirement for Fyn in the induction of long term potentiation at CA 1 synapses in the hippocampus . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| We have determined high resolution crystal structures of the complexes between the SH 3 domains of Abl and Fyn tyrosine kinases , and two ten residue proline rich peptides derived from the SH 3 binding proteins 3BP 1 and 3BP 2 . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| In addition , autophosphorylation of ZAP 70 when bound to zeta or eta resulted in the generation of multiple distinct ZAP 70 phosphorylated tyrosine residues which had the capacity to bind the SH 2 domains of fyn , lck , GAP , and abl . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Eight clones , including bFGFR ( xFGFR 1 ) and potential Trk , Ins R . , Fak , Fyn , and Abl homologs , were used to probe temporal and spatial gene expression in early development . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| The orientation of the bound peptide is opposite to that of proline rich peptides bound to the SH 3 domains of Abl , Fyn and p85 . . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Here we report the synthesis and solution structure of the amino terminal SH 3 domain of GRB 2 and of its more stable Ser 32 mutant . 1H NMR analysis of the complex between the Ser 32 GRB 2 N SH 3 domain and the proline rich peptide VPPPVPPRRR , derived from h Sos , shows that relative to the SH 3 peptide complexes described for PI3K , Fyn and Abl , the proline rich peptide in this complex binds in the opposite orientation . . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Identification of Src , Fyn , Lyn , PI3K and Abl SH 3 domain ligands using phage display libraries . ^^^ We have employed a novel modification of phage display involving biased libraries to identify peptide ligands of the Src , Fyn , Lyn , PI3K and Abl SH 3 domains . ^^^ The Src SH 3 domain prefers the sequence XXXRPLPPLPXP , Fyn prefers XXXRPLPP ( I / L ) PXX , Lyn prefers RXXRPLPPLPXP , PI3K prefers RXXRPLPPLPP while the Abl SH 3 domain selects phage containing the sequence PPPYPPPP ( I / V ) PXX . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Sixteen cDNAs were identical to the known kinase genes ( PKC beta , JAK 1 , JAK 2 , TYK 2 , HCK , FGR , FYN , BLK , c FES , FER , c ABL , c KIT , FLK 1 , FLK 2 , IGF1R , and ECK ) . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Mice with mutations in four nonreceptor tyrosine kinase genes , fyn , src , yes , and abl , were used to study the role of these kinases in long term potentiation ( LTP ) and in the relation of LTP to spatial learning and memory . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Here we show that p 85 , the regulatory subunit of PI 3 kinase , binds directly to the SH 3 domains of Abl , Lck , Fyn , and p 85 itself . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| The importance of an intact Src Homology 2 ( SH 2 ) domain for transformation by members of the tyrosine kinase family , including 5 src , c src , c abl , fps and fyn is well documented . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| RPDE 6 exhibited selectivity in binding to the SH 3 domains of c Abl , Crk , Csk , Lck , Lyn , Fyn and 5 Src , with binding to the SH 3 regions of the Src related tyrosyl kinases Lyn and Fyn being the most effective . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| In addition , the c Abl SH 3 domain binds Grb IR / Grb10 , whereas Fyn , phosphatidylinositol 3 kinase p 85 , and Grb 2 SH3 domains do not . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated mDab 1 associates with the SH 2 domains of Src , Fyn and Abl . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Each of these proteins contains an SH 3 domain , conferring association with focal adhesion kinase ; a domain rich in SH 2 binding sites , phosphorylated by or associating with a number of oncoproteins , including Abl , Crk , Fyn , and others ; and a highly conserved carboxy terminal domain . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Our results reveal that the non receptor tyrosine kinases , Abl , Fyn , Lyn , Btk and Csk , are expressed in all three cell types . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| The stability and folding thermodynamics of two SH 3 domains , belonging to Fyn and Abl proteins , have been studied by scanning calorimetry and urea induced unfolding . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| We found that c Abl kinase activity was increased by 10 to 20 fold in these cells , and that Src and Fyn kinases directly phosphorylated c Abl in vitro . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| We identified 30 tyrosine kinases expressed in these tissues : they include 10 non receptor tyrosine kinases ( yes , fyn , lyn , brk , abl , arg , jak 1 , jak 3 , tyk 2 and itk ) , 17 receptor tyrosine kinases ( erbB 2 , PDGF Ralpha , PDGF Rbeta , kit , c fms , met , ron , FGF R 1 , FGF R 2 , FGF R 3 , FGF R 4 , cek 5 , tie 1 , tkt , axl , sky and Ins R ) , 2 dual kinases ( mek and sek ) and one possible novel kinase . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| A proline rich fragment of the NR2D subunit ( 2D ( 866 1064 ) ) bound to the Abl SH 3 domain but not to the SH 3 domains from Src , Fyn , Grb 2 , GAP , or phospholipase C gamma ( PLCgamma ) . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| The information of CR 50 antigen / Reelin is considered to be transmitted inside the neuroblasts to the `` disabled 1 ' ' , which is an adaptor protein to Src , Fyn , Abl tyrosine kinase . . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Moreover , XR 774 inhibited the activity of the tyrosine kinases , Fyn , Lck , Abl and epidermal growth factor receptor ( EGFR ) with nanomolar activity , whereas micromolar concentrations of XR 774 were ineffective on the serine threonine kinase , PKA . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Src homology 3 domains from several Src family PTKs including Lck , Fyn , Abl , and Src associate with ADAM 15 in vitro . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 is a substrate for nonreceptor tyrosine kinases including Src , Fyn , and Abl . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of SSeCKS was apparent in cells deficient in Src , Fyn , Yes , or Abl tyrosine kinases or in NIH3T3 cells expressing a temperature sensitive 5 Src allele , but not in FAK deficient embryo fibroblasts . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Using inhibitors and cells derived from knockout mice , we verified a requirement for both Abl and Fyn in stress induced caveolin phosphorylation in a single cell type . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| One group of SH 2 domains ( Src , Fyn , Lck , Fgr , Abl , Crk , and Nck ) preferred sequences with the general motif pTyr hydrophilic hydrophilic Ile / Pro while another group ( SH 2 domains of p 85 , phospholipase C gamma , and SHPTP 2 ) selected the general motif pTyr hydrophobic 10 hydrophobic . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Using purified proteins , we studied the ability of Syk , Fyn , and Abl to differentiate between tyrosines in a common PTK substrate , c Cbl . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Cotransfection of tau and kinases showed that Tyr 18 was the major site for Fyn phosphorylation , but Tyr 394 was the main residue for Abl . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Each of these residues is targeted by one or more specific kinases : Y 142 by Fyn , Fer and cMet ; Y 489 by Abl ; and Y 654 by Src and the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Using cell lines deficient in Src , Fyn and Yes , we demonstrate that multiple Src family members can stimulate vaccinia induced actin polymerization and also uncover a role for Abl family kinases . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| Virus induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions . ^^^ |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06241 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|