| Interacting proteins: O75674 and P06241 |
Pubmed |
SVM Score :0.0 |
| In the brain , srcasm mRNA distribution correlates with that of fyn , with both being highly expressed in the hippocampal and cerebellar Purkinje neurons . ^^^ Fyn can phosphorylate Srcasm , and association of these molecules relies on cooperative binding between the SH 2 and SH 3 domains of Fyn and corresponding canonical binding sites in Srcasm . ^^^ |
|
| Interacting proteins: O75674 and P06241 |
Pubmed |
SVM Score :0.0 |
| Data presented here demonstrate that epidermal growth factor ( EGF ) receptor ligands promote the tyrosine phosphorylation of endogenous and adenovirally transduced Srcasm in keratinocytes , and that increased levels of Srcasm activate endogenous SFKs , with a preference for Fyn and Src . ^^^ |
|
| Interacting proteins: O75674 and P06241 |
Pubmed |
SVM Score :0.0 |
| Moreover , expression of a constitutive active form of Fyn also promoted the recruitment of Tom1L1 to enlarged endosomes . ^^^ |
|
| Interacting proteins: O75674 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we report that Tom1L1 negatively regulates SFK mitogenic signaling induced by platelet derived growth factor ( PDGF ) through modulation of SFK receptor association : ( 1 ) Tom1L1 inhibits DNA synthesis induced by PDGF ; ( 2 ) inhibition is overcome by c myc expression or p 53 inactivation , two regulators of SFK mitogenic function ; ( 3 ) Src or Fyn coexpression overrides Tom1L1 mitogenic activity ; ( 4 ) overexpression of the adaptor reduces Src association with the receptor ; and ( 5 ) protein inactivation potentiates receptor complex formation , allowing increased SFK activation and DNA synthesis . ^^^ |
|