| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| We show here that SAP mutants found in XLP patients are defective in binding its physiological ligands signaling lymphocyte activating molecule ( SLAM ) , a co receptor in T cell activation , and Fyn , a Src family protein tyrosine kinase . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| XLP is caused by mutations affecting SAP , an adaptor that recruits Fyn to SLAM family receptors . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| Lyp is expressed in lymphocytes , where it physically associates through its proline rich motif ( called P 1 ) with the SH 3 domain of the protein tyrosine kinase Csk , an important suppressor of the Src family of kinases Lck and Fyn , which mediate TCR signaling . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP couples Fyn to SLAM immune receptors . ^^^ The crystal structure of a ternary SLAM SAP Fyn SH 3 complex reveals that SAP binds the FynT SH 3 domain through a surface surface interaction that does not involve canonical SH 3 or SH 2 binding interactions . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP also binds to the Src family tyrosine kinase Fyn and recruits it to SLAM , which leads to the generation of downstream phosphotyrosine signals . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| Recently , another function for SAP was proposed : SAP can recruit the kinase Fyn to the SLAM ( CD 150 ) immune receptor . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| Regulation of natural cytotoxicity by the adaptor SAP and the Src related kinase Fyn . ^^^ By interacting with SLAM family receptors , SAP enables tyrosine phosphorylation signaling of these receptors by its ability to recruit the Src related kinase , Fyn . ^^^ By analyzing mice lacking Fyn , we showed that similarly to SAP , Fyn was strictly required for 2B4 function . ^^^ Taken together , these results provide evidence that the 2B4 SAP Fyn cascade defines a potent activating pathway of natural cytotoxicity . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP is known to be a downstream molecule of SLAM family receptors and to mediate the activation signal for tyrosine kinase Fyn . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP regulates T cell mediated help for humoral immunity by a mechanism distinct from cytokine regulation . 10 linked lymphoproliferative disease is caused by mutations affecting SH2D1A / SAP , an adaptor that recruits Fyn to signal lymphocyte activation molecule ( SLAM ) related receptors . ^^^ Notably , in contrast to Th 2 cytokine defects , humoral responses , ICOS expression , and CD40L down regulation were rescued by retroviral reconstitution with SAP R78A , a SAP mutant that impairs Fyn binding . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| Taken together , our data strongly suggest that , in addition to the known SAP interacting kinase Fyn , PIX may be another key player in SAP mediated T cell activation . . ^^^ |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|