| Interacting proteins: O60500 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O60500 and P06241 |
Pubmed |
SVM Score :0.0 |
| Moreover , the Src family kinase Fyn was consistently found to be coimmunoprecipitated with nephrin . ^^^ |
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| Interacting proteins: O60500 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin . ^^^ Described are biochemical and mouse genetics experiments demonstrating that membrane associated Nephrin is tyrosine phosphorylated by the Src family kinase Fyn . ^^^ Nephrin fractionated in detergent resistant glomerular membrane fractions with Fyn and Yes . ^^^ Fyn directly bound Nephrin via its SH 3 domain , and Fyn directly phosphorylated Nephrin . ^^^ Glomeruli in which Fyn , Yes , or Fyn and Yes were genetically deleted in mice were characterized to explore the relationship between these kinases and Nephrin . ^^^ |
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| Interacting proteins: O60500 and P06241 |
Pubmed |
SVM Score :0.0 |
| SRC family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin . ^^^ When nephrin was co transfected with Src family kinases Fyn or Src in Cos 1 cells , nephrin was strongly tyrosine phosphorylated by Fyn and less so by Src . ^^^ When nephrin and podocin were transfected with Fyn , the interaction between nephrin and podocin was augmented significantly . ^^^ Podocin was not tyrosine phosphorylated by Fyn ; thus , the increased interaction is likely to be secondary to tyrosine phosphorylation of nephrin . ^^^ Fyn also significantly augmented the activation of the AP 1 promoter induced by nephrin and podocin . ^^^ |
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| Interacting proteins: O60500 and P06241 |
Pubmed |
SVM Score :0.0 |
| CD2AP , podocin , Fyn kinase , and phosphoinositide 3 kinase are reported intracellular interacting partners of nephrin , although the biological roles of these interactions are unclarified . ^^^ Fyn phosphorylated nephrin proteins efficiently in vitro . ^^^ |
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| Interacting proteins: O60500 and P06241 |
Pubmed |
SVM Score :0.0 |
| Our data support the model that during podocyte intercellular junction formation , engagement of the nephrin ectodomain induces transient Fyn catalytic activity that results in nephrin phosphorylation on specific nephrin cytoplasmic domain tyrosine residues . ^^^ |
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