| Interacting proteins: Q9Y2R2 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y2R2 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y2R2 and P06239 |
Pubmed |
SVM Score :1.2641927 |
| In vitro experiments with purified recombinant proteins demonstrated that PTPN 22 D195A / C227S interacted directly with activated Lck , Zap 70 , and TCRzeta , confirming the initial substrate trap results . 1.2641927^^^ |
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| Interacting proteins: Q9Y2R2 and P06239 |
Pubmed |
SVM Score :0.0 |
| The CD 45 transmembrane protein tyrosine phosphatase ( PTPase , EC 3 . 1 . 3 . 48 ) plays an essential role in T cell activation by activating the Lck and / or Fyn protein tyrosine kinases . ^^^ |
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| Interacting proteins: Q9Y2R2 and P06239 |
Pubmed |
SVM Score :0.0 |
| Lyp is expressed in lymphocytes , where it physically associates through its proline rich motif ( called P 1 ) with the SH 3 domain of the protein tyrosine kinase Csk , an important suppressor of the Src family of kinases Lck and Fyn , which mediate TCR signaling . ^^^ |
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| Interacting proteins: Q9Y2R2 and P06239 |
Pubmed |
SVM Score :0.0 |
| The proline , glutamic acid , serine and threonine enriched protein tyrosine phosphatase PEP , which is expressed primarily in hematopoietic cells , was recently discovered to be physically associated with the 50 kDa cytosolic protein tyrosine kinase ( PTK ) Csk , an important suppressor of Src family PTK , including Lck and Fyn in T cells . ^^^ In agreement with a more receptor proximal site of action , we found that PEP reduced the TCR induced increase in tyrosine phosphorylation of an Lck mutant , Lck Y505F , which is only phosphorylated on tyrosine 394 , the positive regulatory site . ^^^ |
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| Interacting proteins: Q9Y2R2 and P06239 |
Pubmed |
SVM Score :0.0 |
| Although normal nave T cell functions were retained in pep deficient mice , effector / memory T cells demonstrated enhanced activation of Lck . ^^^ |
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