| Src , Lyn and Lck tyrosine kinases phosphorylate DAPP 1 at Tyr ( 139 ) in vitro at similar rates in the presence or absence of PtdIns ( 3 , 4 , 5 ) P ( 3 ) , and overexpression of these kinases in HEK 293 cells induces the phosphorylation of Tyr ( 139 ) . ^^^ |