| Interacting proteins: Q9NP31 and P06239 |
Pubmed |
SVM Score :0.65674452 |
| Here , we show that human TSAd interacts with Lck through the Lck SH 2 and SH 3 domains and is a substrate for Lck . 0.65674452^^^ The TSAd C terminus , including the proline rich region and five tyrosines , is both necessary and sufficient for TSAd interaction with and phosphorylation by Lck . 0.57567624^^^ |
|
| Interacting proteins: Q9NP31 and P06239 |
Pubmed |
SVM Score :0.58548634 |
| TSAd regulates LCK activity directly through physical interaction with LCK SH 3 and SH 2 domains . 0.58548634^^^ |
|
| Interacting proteins: Q9NP31 and P06239 |
Pubmed |
SVM Score :1.0120052 |
| RESULTS : TSAd was found to interact with Lck in human CD4+ T cells ex vivo . 1.0120052^^^ The SH2D2A exon 7 encoding TSAd aa 239 334 was found to harbour information essential not only for TSAd interaction with Lck , but also for TSAd modulation of Lck activity and translocation of TSAd to the nucleus . 0.80823061^^^ |
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| Interacting proteins: Q9NP31 and P06239 |
Pubmed |
SVM Score :0.0 |
| T cell specific adapter protein inhibits T cell activation by modulating Lck activity . ^^^ Consistent with this , Lck kinase activity was reduced 3 to 4 fold in COS 7 cells transfected with both TSAd and Lck , indicating a regulatory effect of TSAd on Lck . ^^^ |
|
| Interacting proteins: Q9NP31 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NP31 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|