| Interacting proteins: Q13444 and P06239 |
Pubmed |
SVM Score :0.0 |
| Src homology 3 domains from several Src family PTKs including Lck , Fyn , Abl , and Src associate with ADAM 15 in vitro . ^^^ This was confirmed in vitro for Hck , Lck , and Grb 2 , which showed enhanced association with tyrosine phosphorylated glutathione S transferase ADAM 15 cytoplasmic domain compared with unphosphorylated protein . ^^^ Immunoprecipitation of ADAM 15 from Jurkat cells confirmed the association with Lck in vivo , and upon PMA stimulation , the phosphorylation level of ADAM 15 was increased . ^^^ Hck , and to a lesser extent Lck , phosphorylated the ADAM 15 cytoplasmic domain in vitro in immune complex kinase assays . ^^^ Binding of ADAM 15 cytoplasmic domain to Hck and Lck was also shown by Far Western analysis . ^^^ |
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| Interacting proteins: Q13444 and P06239 |
Pubmed |
SVM Score :0.0 |
| ADAM15v2 protein interacted more strongly with the Src family proteins Lck and Src than ADAM 15 protein , when examined by pull down and immunoprecipitation followed by immunoblot analysis using a T lymphocyte line . ^^^ |
|
| Interacting proteins: Q13444 and P06239 |
Pubmed |
SVM Score :0.0 |
| On the other hand , we confirmed previously mapped Lck SH 3 binding sites in ADAM 15 , HS 1 , SLP 76 , and NS5A , and identified putative Lck SH 3 binding sites of Sam 68 , FasL , c Cbl , and Cbl b . ^^^ |
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