| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| T cell activation stimulates p 56 ( lck ) , p 59 ( fyn ) , ZAP 70 , Vav SLP 76 binding , and IL 2 transcription . ^^^ Therefore , while p 56 ( lck ) regulates proximal events , ZAP 70 acts downstream on targets such as SLP 76 . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| T cell receptor zeta ( TcRzeta ) / CD3 ligation initiates a signaling cascade that involves src kinases p 56 ( lck ) and zeta associated protein 70 , leading to the phosphorylation of substrates such as TcRzeta , Vav , SH 2 domain containing leukocyte protein 76 ( SLP 76 ) , cbl , and p120 / 130 . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| The KS chimera and downstream ZAP 70 or Syk substrates , such as SLP 76 , were still phosphorylated when expressed in Lck deficient JCaM1 . 6 T cells . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| TcRzeta / CD3 ligation initiates a signaling cascade involving CD4 / CD8 p 56 ( lck ) , p 59 ( fyn ) , and ZAP 70 , as well as lymphoid downstream proteins VAV , SLP 76 , and FYB / SLAP . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine kinases p 56 ( Lck ) , SYK , and ZAP 70 and downstream adaptors LAT and SLP 76 have been implicated as essential components in T cell activation . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| SLP 76 binding to p56lck : a role for SLP 76 in CD 4 induced desensitization of the TCR / CD3 signaling complex . ^^^ We provide evidence for a SLP 76 interaction with Src homology 3 domains of p56lck and identify amino acids 185 194 of SLP 76 as relevant docking site . ^^^ In view of the multiple functions of p56lck and SLP 76 / Vav in the initiation of TCR / CD3 / CD4 signaling , we propose a model for the CD 4 dependent inhibition of TCR signaling and AICD of preactivated T cells . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| T cell activation involves the participation of protein tyrosine kinases p 56 ( lck ) and ZAP 70 / SYK as well as lymphoid proteins such as SLP 76 and FYB / SLAP . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| Optimal activation of NF kappaB following bpV treatment necessitated downstream effectors of p 56 ( lck ) such as the syk family protein tyrosine kinase ZAP 70 and the molecular adaptor SLP 76 . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| Upon CD 3 CD4 ligation , TCR zeta phosphorylation , ZAP 70 recruitment to the p21 / p23 TCR zeta phosphoisomers , ZAP 70 phosphorylation , as well as p 56 ( lck ) , c Cbl and Slp 76 phosphorylation , were all markedly increased in CD45R0 ( + ) compared with CD45RBC ( + ) cells . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| These signaling pathways , which utilize p 56 ( lck ) and SLP 76 , may be distinct from those used to promote other processes initiated by pre TCR expression . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| A number of signal transducers known to be involved in the TCR / CD3 dependent signal transduction pathway , including p 56 ( lck ) , p 36 ( lat ) , and SLP 76 , as well as capacitative entry of calcium , are crucial for the noticed CD 43 co stimulatory effect . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| CD 45 has also been shown to regulate CXCR 4 mediated activation and phosphorylation of T cell receptor downstream effectors Lck , ZAP 70 , and SLP 76 . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| We have already determined that p 56 ( lck ) , ZAP 70 , SLP 76 , capacitative entry of calcium , and calcium regulated effectors are important in bpV induced NF kappaB activation . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| Cross linking of 4 1BB , a member of the TNFR family , increased tyrosine phosphorylation of TCR signaling molecules such as CD3epsilon , CD3zeta , Lck , the linker for activation of T cells , and SH 2 domain containing leukocyte phosphoprotein of 76 kDa ( SLP 76 ) . ^^^ In addition , incubation of activated CD8+ T cells with p 815 cells expressing 4 1BBL led to redistribution of the lipid raft domains and Lck , protein kinase C theta ; , SLP 76 , and phospholipase C gamma 1 ( PLC gamma 1 ) on the T cell membranes to the areas of contact with the p 815 cells and recruitment of 4 1BB , TNFR associated factor 2 , and phospho tyrosine proteins to the raft domains . 4 1BB ligation also caused translocation of TNFR associated factor 2 , protein kinase C theta ; , PLC gamma 1 , and SLP 76 to detergent insoluble compartments in the CD8+ T cells , and cross linking of 4 1BB increased intracellular Ca2+ levels apparently by activating PLC gamma 1 . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| Importantly , the membrane translocation of Vav 3 was abrogated in Lck , ZAP 70 , LAT , and SLP 76 deficient T cells , where Vav 3 binding to SLP 76 was disrupted . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate the capacity of the Src family kinase Lck and the SLP 76 family adaptor protein Clnk ( cytokine dependent hematopoietic cell linker ) to induce HPK 1 tyrosine phosphorylation and relocation to the plasma membrane , which in lymphocytes results in recruitment of HPK 1 to the contact site of antigen presenting cell ( APC ) T cell conjugates . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| On the other hand , we confirmed previously mapped Lck SH 3 binding sites in ADAM 15 , HS 1 , SLP 76 , and NS5A , and identified putative Lck SH 3 binding sites of Sam 68 , FasL , c Cbl , and Cbl b . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| SLP 76 binds to the src homology 3 domain of Lck in vitro . ^^^ To examine the role of the Lck binding region of SLP 76 in T cell development and function , SLP 76 ( / ) mice were reconstituted with an SLP 76 mutant that lacks amino acids 185 194 . ^^^ These results indicate that the Lck binding region of SLP 76 is essential for T cell antigen receptor signaling and normal T cell development and function . . ^^^ |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|