| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| In fact , at least four protein tyrosine kinases ( PTKs ) are physically associated with IL 2R : p56lck ( and its members ) , Syk PTK , and the Janus kinases , Jak 1 and Jak 3 . cDNA expression studies revealed that the activation of these PTKs is critical for IL 2 induced proliferative signal transmission . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| We have identified IL 7 induced activation of three cyoplasmic tyrosine kinases in T cells , Jak 1 , Jak 3 , and the src like kinase p56lck . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| These signalling pathways , except that for bcl 2 pathway , appear to be mediated by multiple PTKs : p56lck is critical for the induction of the c fos / c jun genes , the activation of Syk PTKs results in the induction of the c myc gene and Jak 3 PTK is required for the induction of both c fos and c myc genes . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| Characterization of the signaling pathways utilized by betagamma interleukin 2 receptors in resting T cells , indicated that pp 56 ( lck ) , but not Jak 1 or Jak 3 , is activated upon receptor triggering . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| Several tyrosine kinases such as Jak 1 , Jak 3 , Lck and Syk are known to participate in IL 2 mediated intracellular signal transduction . ^^^ Jak 1 , Lck and Syk are associated with the cytoplasmic domain of the beta chain , whereas Jak 3 is associated with the cytoplasmic domain of the gamma chain , which is shared among receptors for IL 2 , IL 4 , IL 7 and IL 15 . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| Jak 3 was most sensitive to suppression by RCC S ; however , reduction in expression of p 56 ( lck ) , p 59 ( fyn ) , and ZAP 70 was observed in some experiments . ^^^ To determine whether RCC S suppressed IL 2 dependent signaling , primed T cells were employed since RCC S had no effect on IL 2R expression but did down regulate Jak 3 expression and , to a lesser degree , p 56 ( lck ) and p 59 ( fyn ) . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| To examine the mechanisms whereby Jak 3 influences T cell function , we have reconstituted thymic development in Jak 3 / animals by introducing a Jak 3 transgene in which expression was driven by the lck proximal promoter . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| Reduction in JAK 3 was selective because expression of other tyrosine kinases ( JAK 1 , p 56 ( lck ) , and p 59 ( fyn ) ) and signal transducer and activator of transcription ( STAT ) 5 , which are linked to IL 2 receptor ( IL 2R ) signaling pathway , were not affected . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| This interaction requires the A region of IL 2Rbeta ( residues 313 382 ) , which also mediates the association of IL 2Rbeta with Lck and Jak 3 . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| In agreement with its binding to IL 2Rbeta , p 1 30 activates Shc and p 56 ( lck ) but unlike IL 2 , fails to activate Janus kinase ( Jak ) 1 , Jak 3 , and signal transducer and activator of transcription 5 ( STAT 5 ) . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| Hierarchy of protein tyrosine kinases in interleukin 2 ( IL 2 ) signaling : activation of syk depends on Jak 3 ; however , neither Syk nor Lck is required for IL 2 mediated STAT activation . ^^^ We therefore investigated the functional relationships among Jak 3 , Lck , and Syk in IL 2 signaling . ^^^ We first observed that in the absence of Jak 3 , both Lck and Syk had the capacity to phosphorylate Stat 3 and Stat5a . ^^^ Moreover , pharmacological abrogation of Lck activity did not inhibit IL 2 mediated phosphorylation of Jak 3 and Stat5a . ^^^ Importantly , ligand dependent Syk activation was dependent on the presence of catalytically active Jak 3 , whereas Lck activation was not . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| Gab 2 can be a substrate of all the three major classes of non receptor tyrosine kinases associated with the IL 2R , but in terms of IL 2 signaling , JAK 3 but not Lck or Syk is essential for Gab 2 phosphorylation . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| ITIMs with the restricted consensus sequence occur on IL 4Ralpha , IL 3Rbeta type 2 , gp 130 cytokineR , OB R ( leptinR ) , LIF Rbeta TNF RI , G CSF R , PDGF R , Blk , Ctk / Ntk , Lsk , Zap 70 , PKB / RACalpha , PKC alpha , PKC beta , PKC gamma , PKC delta , PKC zeta , PKC epsilon , PKC eta , PKC phi , PKC mu , calmodulin dependent kinase IIdelta , SLP 76 associated protein , FYN binding protein , Shc binding protein , RasGRF 2 , CDC 25 homologue , Jak 2 , Jak 3 , PLCbeta 1 , and PLCbeta 3 . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| A Jak 3 independent signalling pathway involving p 56 ( lck ) , generating anti apoptotic signals , can be observed and requires the PROX domain of gamma ( c ) . p 56 ( lck ) can be activated by dephosphorylation of an inhibitory carboxyl terminal phosphorylated tyrosine residue ( Y 505 ) . ^^^ Activation of p 56 ( lck ) alone is insufficient for transduction of proliferative signals and thus works in concert with Jak 3 mediated receptor activation . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| In addition to Jaks , several other proteins are rapidly phosphorylated on tyrosine residues in a RANTES dependent manner , including the Src kinase p 56 ( lck ) , which associates with Jak 3 . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| Analysis of in vitro kinase reactions with a panel of recombinant glutathione S transferase ( GST ) fusion tyrosine kinases ( Itk , Lck , ZAP 70 and Jak 3 ) revealed that only GST Itk efficiently phosphorylated a recombinant GST Rch1alpha fusion . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| All these features of lck SSI 1 transgenic mice strikingly resemble the phenotype of mice lacking common gamma chain or Janus kinase 3 , suggesting that transgene derived SSI 1 inhibits the functions of common gamma chain using cytokines . ^^^ |
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| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52333 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
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