| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of in vitro transcribed and translated Stat 5 with the Jak 2 tyrosine kinase , but not with fyn , lyn or lck , confers DNA binding activity . ^^^ |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| We report here that both DNA binding activities and tyrosine phosphorylation of STAT 3 and STAT 5 , but not STAT 1 , are constitutively enhanced in the mouse T cell lymphoma LSTRA , which is a well characterized cell line that overexpresses Lck protein and exhibits high levels of Lck kinase activity . ^^^ |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| The role of Lck in STAT 5 activation was confirmed in a Lck deficient T cell line in which the activation of STAT 5 by TCR stimulation was abolished . ^^^ Expression of Lck induced specific interaction of STAT 5 with the subunits of the TCR , indicating that STAT 5 may be directly involved in TCR signaling . ^^^ |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| Correspondingly , CIS inhibits functions associated with both of these kinases : Lck mediated phosphorylation of IL 2Rbeta and IL 2 mediated activation of Stat 5 . ^^^ |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| In agreement with its binding to IL 2Rbeta , p 1 30 activates Shc and p 56 ( lck ) but unlike IL 2 , fails to activate Janus kinase ( Jak ) 1 , Jak 3 , and signal transducer and activator of transcription 5 ( STAT 5 ) . ^^^ |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| We report here the absence of CIS expression in T lymphoma LSTRA that overexpresses the Lck protein tyrosine kinase and exhibits elevated STAT 5 activity . ^^^ |
|
| Interacting proteins: P42229 and P06239 |
Pubmed |
SVM Score :0.0 |
| We first observed that in the absence of Jak 3 , both Lck and Syk had the capacity to phosphorylate Stat 3 and Stat5a . ^^^ Moreover , pharmacological abrogation of Lck activity did not inhibit IL 2 mediated phosphorylation of Jak 3 and Stat5a . ^^^ |
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