| Interacting proteins: P28907 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28907 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28907 and P06239 |
Pubmed |
SVM Score :0.0 |
| Further evidence that Erk 2 activation is regulated by CD 38 ligation was obtained indirectly with the observed induction of Raf 1 , Lck , and Sos 1 mobility shifts , processes that are believed to be dependent , at least in part , on MAP kinase activation . ^^^ CD 38 ligation in a Jurkat Lck deficient mutant , JCam 1 , failed to induce substrate tyrosine phosphorylation and activation of Erk 2 . ^^^ These data indicated that in Jurkat T cells , CD 38 receptor triggering results in Lck regulated activation of both Raf 1 / MAP kinase and CD 3 zeta / ZAP 70 / phospholipase C gamma 1 signaling pathways . . ^^^ |
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| Interacting proteins: P28907 and P06239 |
Pubmed |
SVM Score :0.0 |
| Direct interaction of the CD 38 cytoplasmic tail and the Lck SH 2 domain . ^^^ Cd 38 transduces T cell activation signals through associated Lck . ^^^ CD 38 ligation has been shown to induce activation of intracellular signaling cascade in T lymphocytes through a Lck dependent pathway . ^^^ However , it is not clear how Lck initiates the CD 38 mediated signaling process . ^^^ In the present study , we showed that CD 38 and Lck were physically associated through the cytoplasmic tail and the Src homology 2 domain , respectively . ^^^ |
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| Interacting proteins: P28907 and P06239 |
Pubmed |
SVM Score :0.0 |
| CD 38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD 3 zeta subunit of the T cell antigen receptor . ^^^ In this study we present data supporting that most CD 38 is pre assembled in a subset of Brij 98 resistant raft vesicles , which were stable at 37 degrees C , and have relatively high levels of Lck and the CD 3 zeta subunit of T cell antigen receptor CD 3 complex in contrast with a Brij 98 soluble pool , where CD 38 is associated with CD 3 zeta , and Lck is not detected . ^^^ Our data further indicate that following CD 38 engagement , LAT and Lck are tyrosine phosphorylated exclusively in Brij 98 resistant rafts , and some key signaling components translocate into rafts ( i . e . ^^^ Taken together , these results suggest that , unlike the non raft pool , CD 38 in rafts is able to initiate and propagate several activating signaling pathways , possibly by facilitating critical associations within other raft subsets , for example , LAT rafts via its capacity to interact with Lck and CD 3 zeta . ^^^ |
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