| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Intracellular acidification observed upon CD 95 triggering is abolished by inhibition of either ORCC or p56lck . ^^^ |
|
| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Furthermore , osmotic cell shrinkage blunted the CD 95 induced activation of the Src like kinase p56lck . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| In this report , Fas cDNA driven by murine lck distal promoter was used to establish transgenic MRL lpr mouse lines . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| We have compared two mutant Jurkat cells , one largely deficient in expression of CD 45 ( J45 . 01 ) and a second one deficient in expression of p56lck ( JCaM1 . 6 ) with wild type Jurkat cells for their ability to undergo APO 1 induced apoptosis . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Experiments using p56lck deficient or p56lck reconstituted Jurkat clones and the tyrosine kinase inhibitor herbimycin A revealed that tyrosine phosphorylation and activation of PI 3 K by CD 95 depends on expression of Src like tyrosine kinases , in particular p56lck . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase lck is required for CD 95 independent caspase 8 activation and apoptosis in response to ionizing radiation . ^^^ We conclude that radiation activates caspase 8 via an Lck controlled pathway independently of CD 95 ligand expression . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Apoptosis induction in response to ionizing radiation , CD 95 or TRAIL receptor stimulation was determined in Jurkat T cells , the Lck deficient Jurkat clone JCaM1 . 6 and Lck retransfected JCaM1 . 6 / Lck . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| We report here that , contrary to wild type Jurkat , the lck deficient mutant JCaM is resistant to anti CD 3 induced apoptosis and fails to express Fas L mRNA upon anti CD 3 treatment . ^^^ Requirement of p56lck in T cell receptor / CD3 mediated apoptosis and Fas ligand induction in Jurkat cells . ^^^ These findings indicate that p56lck is required for TCR / CD3 mediated Fas L induction but not for the transduction of Fas receptor mediated death signal . . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Fas ligation induces apoptosis and Jun kinase activation independently of CD 45 and Lck in human T cells . ^^^ Although prior studies suggest a role for protein tyrosine kinases and phosphatases in Fas signaling , we report here that Fas ligation induces apoptosis in T cells deficient in either CD 45 or Lck . ^^^ Further , in normal and CD 45 or Lck deficient cell lines , Fas stimulation results in activation of Jun kinase ( JNK ) , a proposed mediator of stress activation pathways . ^^^ Our data suggest that although CD 45 and Lck are not required for Fas signaling , JNK activation may play an important role transducing distal signals that lead to apoptosis after Fas ligation . . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| We show , that the Src like protein tyrosine kinase inhibitor herbimycin A and the deficiency of the p 56 ( lck ) tyrosine kinase in mutant Jurkat cells abolished the channel inhibition and phosphorylation by anti Fas antibody , while reconstitution of the p 56 ( lck ) kinase partly restored these effects of Fas receptor triggering . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation studies of anti Fas stimulated human Jurkat and murine 2B4 . 11 T cells revealed activation of the Src family tyrosine kinases Lck and Fyn . ^^^ Pharmacological experiments demonstrated that pretreatment of Jurkat cells with tyrphostins inhibited Fas induced apoptosis ; likewise , Lck activity was inhibited by tyrphostins in a dose dependent fashion . ^^^ Finally , Lck derived from unstimulated Jurkat T cells formed stable complexes with the intracellular domain of the Fas receptor . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| TCR induced Fas ligand ( FasL ) expression is demonstrated to be dependent on Lck SH 2 and kinase activities , although FasL expression can not be correlated with apoptosis . ^^^ Together , these data indicate that TCR induced apoptosis in BI 141 is regulated through a mechanism ( s ) distinct from the Lck induced expression of Fas , FasL , or IL 2 production . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| In this report , we describe the establishment of a line of Fas transgenic MRL lpr mice in which mouse Fas cDNA was expressed using the T cell specific murine lck promoter . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , we observed that depletion of the protein tyrosine kinase p 56 ( lck ) by preincubation of S 15 CTL with herbimycin A severely impaired perforin but not Fas dependent cytotoxicity . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Studies on three different Jurkat cell mutants deficient for src p 56 ( lck ) , ZAP 70 kinase , or TCR / CD3 gamma chain showed that the cells undergo apoptosis after Fas ligation . ^^^ Simultaneous cross linking of MHC 1 and Fas ligation inhibited apoptosis in the ZAP 70 kinase and the TCR / CD3 gamma chain mutants , but did not protect the src p 56 ( lck ) deficient cells . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Before IL 2 culture , TIL showed undetectable or very low levels of T cell receptor ( TCR ) epsilon chain , p 56 ( lck ) , Fas ligand ( FasL ) and Bax expression , while Bcl 2 values were elevated . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| The effects of tumor immunosuppression in lymphocytes inside the tumor ( TCR z and e chains , p56lck , FAS and FAS ligand ) confirmed that the potential function of TIL , immunodepressed at the time of metastasectomy , was significantly restored after in vitro , culture with IL 2 . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| While crosslinking of Fas affected the association of p59fyn and p56lck tyrosine kinases with the TCR zeta chain to a limited degree , it dramatically inhibited the association of the protein tyrosine kinase ZAP 70 with the zeta chain . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Tip , an Lck interacting protein of Herpesvirus saimiri , causes Fas and Lck dependent apoptosis of T lymphocytes . ^^^ Finally , the apoptotic effect of Tip in T cells is mediated by Fas and requires the presence of active Lck in the cell . . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| We investigated pre and post IL 2 stimulation expression of T cell receptor ( TCR ) zeta and epsilon chains , p 56 ( lck ) , Fas , and Fas L by TIL immunostaining . ^^^ Fas L expression was correlated with the TCR epsilon chain and p 56 ( lck ) levels ( P = 0 . 05 ) . ^^^ |
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| Interacting proteins: P25445 and P06239 |
Pubmed |
SVM Score :0.0 |
| Apoptosis of antigen specific T lymphocytes upon the engagement of CD 8 by soluble HLA class 1 molecules is Fas ligand / Fas mediated : evidence for the involvement of p56lck , calcium calmodulin kinase 2 , and Calcium independent protein kinase C signaling pathways and for NF kappaB and NF AT nuclear translocation . ^^^ |
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