Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.53981522
In addition , CD 28 mediated costimulation may prevent the induction of anergy by facilitating the effective association of TCR zeta and CD 3 epsilon with the critical protein tyrosine kinase lck , and the subsequent recruitment of ZAP 70 . 0.53981522^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Moreover , the differential phosphorylation of CD 3 zeta versus CD 3 eta is not due to a selective association of the known TCR associated protein tyrosine kinase , p59fyn ; p59fyn but not p56lck or p62yes is associated with each of the three TCR isoforms containing CD 3 zeta 2 , or CD 3 eta 2 , or CD 3 zeta eta . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
CD 3 zeta surface expression is required for CD 4 p56lck mediated upregulation of T cell antigen receptor CD 3 signaling in T cells . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In the present report , we demonstrated that modulation of CD 26 from T cell surface induced by antiCD 26 ( 1F7 ) led to enhanced phosphorylation of CD 3 zeta tyrosine residues and increased CD 4 associated p56lck tyrosine kinase activity . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Surface modulation of p 58 molecules and their linkage to CD 3 zeta chain , Fc epsilon RI gamma chain and the p56lck kinase . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Importantly , this CD 2 induced tyrosine phosphorylation of p 63 can also occur in the absence of the CD 3 zeta chain membrane expression , and is also distinct from the protein tyrosine kinases p56lck and p59fyn . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
By detailed analysis of the sites of phosphorylation induced in vitro on CD 3 zeta by p56lck we demonstrate that interpretation of the sites of phosphorylation based on 2D phosphopeptide mapping alone is difficult . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
T cells in tumor bearing mice and cancer patients were recently shown to be devoid of CD 3 zeta chain , a signal transducing invariant chain in T cell receptor ( TCR ) complex , and p56lck tyrosine kinase . ^^^ Almost complete loss of CD 3 zeta and p56lck was observed in the preparation from tumor bearing mice as assessed by immunoblotting analysis using whole cell lysates , whereas the amounts of other TCR chains were relatively unchanged . ^^^ However , these changes were due to the increase of contaminating Mac 1+ cells in the spleen of tumor bearing mice because : 1 ) the removal of Mac 1+ cells led to the restoration of CD 3 zeta and p56lck ; and 2 ) CD 3 zeta was clearly present when the preparation was solubilized with ionic detergent . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Using anti CD 3 epsilon mAb as invariant ligand , signals for beta chain selection of DN cells including proliferation of DP cells do not require a Ca2+ response , are independent of CD 3 zeta , and are only slightly impaired in the absence of p56lck ( lck ) . ^^^ Signals that induce positive selection of DP thymocytes require a partial Ca2+ response and CD 3 zeta but are independent of lck . ^^^ Deletion of DP thymocytes requires a full blown Ca2+ response and both , CD 3 zeta and lck . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Our results suggest that the Lck molecule positively regulates the TCR coupled PTK pathway by phosphorylating tyrosines on the TCR associated CD 3 zeta polypeptides . . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
With the use of different Jurkat cell mutants it was demonstrated that CD 2 mediated activation of EMT required expression of LCK , but not require surface expression of the CD 3 zeta chain . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We examined the effects of gp 120 on TCR CD 3 induced phosphorylation and activation of the src type protein tyrosine kinases ( PTK ) , fyn and lck . gp 120 caused minimal changes in lck phosphorylation or lck enzymatic activity , but preincubation of Jurkat cells with gp 120 for 20 min strongly inhibited TCR CD 3 mediated phosphorylation and activation of lck and fyn , as well as phosphorylation of CD 3 zeta . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
These data indicated that in Jurkat T cells , CD 38 receptor triggering results in Lck regulated activation of both Raf 1 / MAP kinase and CD 3 zeta / ZAP 70 / phospholipase C gamma 1 signaling pathways . . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
It facilitates recruitment of SHP 1 phosphatase to TCR CD 3 complex and affects phosphorylation of Lck and ZAP 70 kinase , but not of CD 3 zeta chain upon TCR triggering . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Signal transduction involves CD 3 zeta phosphorylation by Lck tyrosine kinase and activation of ZAP 70 which regulates signaling pathways through PKC , Ca++ and Ras / Raf kinase cascade . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
CD 3 zeta ) , receptors on NK cells and their associated protein tyrosine kinases ( PTKs ; p56lck , p59fyn and ZAP 70 ) . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In the membrane fraction , tyrosine phosphorylation of Lck , Fyn , and CD 3 zeta can be induced by PTP inhibitors , but not by anti CD 3 . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Expression of several signal transduction molecules , including the CD 3 epsilon , CD 3 zeta , and FcepsilonRI gamma chains , p 56 ( lck ) protein tyrosine kinase , and phospholipase C gamma 1 , was studied in these cells using Western blotting . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In 50 % of the patients , reduced expression of CD 3 zeta and p 56 ( lck ) was observed in T lymphocytes obtained both from tumor involved LNs and from peripheral blood . ^^^ Cells cultured in the presence of IL 2 demonstrated increased expression of CD 3 zeta and p 56 ( lck ) , which approached the levels detected in normal T cells . ^^^ Decreased expression of CD 3 zeta or p 56 ( lck ) observed in the patients ' T cells was not reversed by immunotherapy with IL 2 at low or high dose in those patients with metastatic melanoma who failed to respond to therapy . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Signal transduction studies performed on FcgammaRIIc 1 expressing Jurkat cells indicated that this molecule is functional , 1 . e . capable of Ca2+ mobilization and activation of Lck , Zap 70 and Syk protein tyrosine kinases , although the CD 3 zeta chain was not found to functionally associate with FcgammaRIIc 1 . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Similar to transmembrane PTP , CD 45 , the membrane associated populations of SHP 1 and SHP 2 are essentially excluded from lipid rafts , where other signaling molecules such as Lck , linker for activation of T cells , and CD 3 zeta are enriched . ^^^ The results indicate that the expression of Lck / SHP 1 chimera inside lipid rafts profoundly inhibits CD 3 induced tyrosine phosphorylation of CD 3 zeta / epsilon , IL 2 generation , and nuclear mobilization of NF AT . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
To dissect the early signalling events leading to TNF alpha gene expression , we established that CD 45 crosslinking resulted in tyrosine phosphorylation of p56lck , ZAP 70 , CD 3 zeta , LAT and Vav . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In this study , we reveal that in Brij 96 based cell lysates , anti CD 5 antibodies coprecipitated TCR zeta chain ( TCR zeta ) / CD3 subunits as well as the protein tyrosine kinases p56lck and p59fyn . ^^^ Anti CD 4 coprecipitated p56lck , p 32 , and CD3 / TCR zeta subunits but precipitated less CD 5 , suggesting the existence of CD 4 TCR zeta / CD3 complexes distinct from the CD 5 TCR zeta / CD3 complexes . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
The T cell specific protein tyrosine kinase ( PTK ) , p56lck , has been implicated in the tyrosine phosphorylation of TCR zeta . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Despite evidence that activation of this enzyme results in TCR zeta chain phosphorylation , it has not been shown that the TCR activates lck . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In mature T cells , CD 4 and CD 8 molecules are each associated with the src like protein tyrosine kinase p 56 lck and signals transduced by TCR and CD 4 activate tyrosine kinases that phosphorylate TCR zeta chains and other intracellular substrates . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
TCR mediated activation of the src family kinases , Lck and Fyn , results in tyrosine phosphorylation of the TCR zeta and CD 3 chains . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
T TIL expressed normal levels of CD 3 epsilon , TCR zeta chain , and the three tyrosine kinases , p56lck ( Lck ) , p59fyn , and ZAP 70 . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Anti TCR / CD3 stimulation of the TCR / CD3+ J 32 3 . 2 cells resulted in a weak stimulation of both the phosphatidyl inositol and tyrosine kinase signal transduction pathways , as measured by changes in the level of free intracellular calcium , tyrosine phosphorylation of TCR zeta , CD 3 epsilon and ZAP 70 , p56lck , or p59fyn tyrosine kinase activity and IL 2 gene activation . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Correlations between the development of immunosuppression and changes in expression of TCR signaling proteins ( CD 3 zeta , p 56 ( lck ) , p 59 ( fyn ) ) , calcium mobilization , and total tyrosine kinase activity following TCR stimulation were examined . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
CD 38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD 3 zeta subunit of the T cell antigen receptor . ^^^ In this study we present data supporting that most CD 38 is pre assembled in a subset of Brij 98 resistant raft vesicles , which were stable at 37 degrees C , and have relatively high levels of Lck and the CD 3 zeta subunit of T cell antigen receptor CD 3 complex in contrast with a Brij 98 soluble pool , where CD 38 is associated with CD 3 zeta , and Lck is not detected . ^^^ Taken together , these results suggest that , unlike the non raft pool , CD 38 in rafts is able to initiate and propagate several activating signaling pathways , possibly by facilitating critical associations within other raft subsets , for example , LAT rafts via its capacity to interact with Lck and CD 3 zeta . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Thus , we suggest that during TcR signaling , Lck interacts with numerous molecules , including MAPK and TcR zeta , via its SH 2 , 3 domain . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Ligation of the T cell receptor complex and CD 4 leads to activation of the protein tyrosine kinases p56lck and p59fyn resulting in phosphorylation of TcR zeta chain and the recruitment of ZAP 70 . ^^^ In this study , we have reconstituted p56lck phosphorylation of TcR zeta and ZAP 70 recruitment in heterologous cells and examined the role of the tyrosine phosphatase HCP in regulating the process . ^^^ Both p56lck and p59fyn induce significant phosphorylation of TcR zeta . ^^^ However , under conditions of comparable p56lck and p59fyn expression , p56lck was found to induce three to four fold greater in vivo phosphorylation of TcR zeta . ^^^ HCP dephosphorylated p56lck , ZAP 70 and the TcR zeta chain . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We provide evidence that the Src family PTK Lck is responsible for regulating the constitutive tyrosine phosphorylation of the TCR zeta subunit in murine thymocytes . ^^^ Moreover , ligation of the TCR expressed on thymocytes from Lck deficient mice largely failed to induce the phosphorylation of TCR zeta , CD 3 epsilon , or ZAP 70 . ^^^ In contrast , we find that the TCR zeta subunit is weakly constitutively tyrosine phosphorylated in peripheral T cells isolated from Lck null mice . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In contrast to the T cell protein tyrosine kinase , Lck , ZAP 70 did not phosphorylate the cytoplasmic portion of the TCRzeta chain or short peptides corresponding to the CD3epsilon or the TCRzeta immunoreceptor tyrosine based activation motifs . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Chemically synthesized cytoplasmic domains of the TCR zeta chain were fully phosphorylated in vitro with p56lck and used to precipitate TCR zeta binding proteins in naive and proliferating cells . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We have reported that tumor associated T or natural killer ( NK ) lymphocytes purified from ascites of women with ovarian carcinoma show defective expression and function of signaling proteins , including reduced expression of TcR zeta chains and p 56 ( lck ) . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In this report , we demonstrate that specific inhibition of Lck expression in Th 2 cells , in the presence of normal levels of functional Fyn PTK , has profound consequences on multiple events following TCR stimulation , including an altered pattern of tyrosine phosphorylated substrates , defective phosphorylation of TCR zeta and ZAP 70 , defective Ca2+ mobilization , and a approximately 90 % reduction in proliferative responses to antigenic and mitogenic stimuli . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
The ZAP 70 mutant studied here could be phosphorylated on tyrosine when associated to the TCR zeta chain and was able to bind p 56 ( lck ) . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Several Fc gamma RIIIA associated proteins are identified in immune complex kinase assays including the TCR zeta subunit , a p 70 90 zeta associated protein ( ZAP ) , p50a ( acidic ) and p50b ( basic ) , and p56lck . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Aberrant TCR mediated signaling in CD 45 null thymocytes involves dysfunctional regulation of Lck , Fyn , TCR zeta , and ZAP 70 . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
T cell receptor zeta ( TcRzeta ) / CD3 ligation initiates a signaling cascade that involves src kinases p 56 ( lck ) and zeta associated protein 70 , leading to the phosphorylation of substrates such as TcRzeta , Vav , SH 2 domain containing leukocyte protein 76 ( SLP 76 ) , cbl , and p120 / 130 . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In a subset of patients , tumor infiltrating lymphocyte proliferative responses and levels of peripheral blood T cell signal transduction molecules ( TCR zeta , p56lck , p59fyn ) were investigated . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
By contrast , it is sufficient to induce the phosphorylation of tyrosine residues on p56lck , the TCR zeta chain as well as ZAP 70 . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
This CD 4 mediated sequestration of Lck from the TCR correlates with the increased binding of CD 4 associated Lck through its Src homology 2 domain to free TCRzeta and CD3gamma epsilon chains on the plasma membrane . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Diminished expression of TCRzeta and p 56 ( lck ) that are associated with the TCR and reduced nuclear localization of RelA containing nuclear factor kappaB ( NFkappaB ) complexes have been noted . ^^^ To further characterize altered expression of TCRzeta , p 56 ( lck ) , and impaired activation of NFkappaB , T lymphocytes were obtained from 65 patients with RCC , the majority of whom were receiving combination cytokine therapy [ interleukin ( IL ) 2 , IFN alpha containing regimens ] and 37 control individuals . ^^^ In 29 of these patients , levels of TCRzeta and p 56 ( lck ) were determined by Western blots of T cell lysates and semiquantitated using densitometry . ^^^ TCRzeta and p 56 ( lck ) were detected in the peripheral blood T cells in 27 of 29 patients , and overall , reduced levels were noted visually in 12 of 29 ( 41 % ) and 13 of 29 ( 45 % ) individuals , respectively . ^^^ When levels were semiquantitated using densitometry , significant decreases of TCRzeta ( P = 0 . 029 ) and p 56 ( lck ) ( P = 0 . 029 ) but not CD3epsilon ( P = 0 . 131 ) , compared with control levels , were found . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
The presence of the TCRzeta chain is critical for the redistribution , which is enhanced when an active form of the protein tyrosine kinase Lck is coexpressed . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We have previously shown that Lck plays a major role in the tyrosine phosphorylation of the TCR zeta chain and the ZAP 70 PTK . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
The aim of this study was to explore the kinetics of the development of alterations in signal transduction molecules ( TCR zeta chain , NF kappaB family proteins , and tyrosine kinase p 56 ( lck ) ) in mice bearing MC 38 colon adenocarcinoma . ^^^ These initial changes are followed by the eventual loss of TCR zeta chain and p 56 ( lck ) and a marked decrease in cytotoxic function . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
The cytoskeleton associated TCR zeta chain is constitutively phosphorylated in the absence of an active p 56 ( lck ) form . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
As compared to peripheral blood ( PB ) T lymphocytes , SF T cells from some ( but not all ) of the patients analyzed expressed lower levels of TCRalphabeta , CD3epsilon , TCRzeta , p 56 ( lck ) and LAT , while p 59 ( fyn ) , phospholipase C gamma 1 and ZAP 70 expression was unaltered . ^^^ Semi quantitative analysis of T cells from several patients revealed that the degree of TCRzeta chain and p 56 ( lck ) modulation correlated statistically significantly with the level of SF T cell hyporesponsiveness . ^^^ Our results indicate that multiple signaling molecules can be modulated in RA SF T cells and show for the first time a direct quantitative correlation between T cell hyporesponsiveness and modulation of TCRzeta and of p 56 ( lck ) , a critical protein tyrosine kinase required for T cell activation . . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Whereas the inducible tyrosine phosphorylation of TCR zeta and ZAP 70 and the kinase activity of Lck were intact , phosphorylated LAT was rapidly dephosphorylated by raft targeting of activated SHP 1 , leading to defects in LAT activation and subsequent downstream signaling events . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Signal transduction regions studied include the TCR zeta chain , the CD 4 coreceptor , the lck protein tyrosine kinase , and the CD 28 costimulatory receptor . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Our results therefore indicate a mechanism whereby CD 26 engagement promotes aggregation of lipid rafts and facilitates colocalization of CD 45 to T cell receptor signaling molecules p 56 ( Lck ) , ZAP 70 , and TCRzeta , thereby enhancing protein tyrosine phosphorylation of various signaling molecules and subsequent interleukin 2 production . . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
The association of TCRzeta with CTLA 4 , reconstituted in 293 transfectants , was enhanced by p 56 ( lck ) induced tyrosine phosphorylation . ^^^ Coexpression of the CTLA 4 associated tyrosine phosphatase , SHP 2 , resulted in dephosphorylation of TCRzeta bound to CTLA 4 and abolished the p 56 ( lck ) inducible TCRzeta CTLA 4 interaction . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In conclusion , we now demonstrate , for the first time , that A6H ligation triggers Lck phosphorylation , and that cross talk between A6H and the TCR CD 3 complex involves Lck , ZAP 70 and the slow migrating isoform of TCR zeta . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
The proximal signaling events associated with A6H ligation include protein tyrosine kinase phosphorylation and association of p 56 Lck , ZAP 70 and the TCR zeta chain . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Binding of ZAP 70 to the phosphorylated immunoreceptor tyrosine based activation motifs ( ITAMs ) of the TCR zeta chain through its two src homology 2 ( SH 2 ) domains results in its activation coupled to phosphorylation on multiple tyrosine residues , mediated by Src kinases including Lck as well as by autophosphorylation . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We also showed that CD 26 cross linking induced less phosphorylation of T cell receptor signaling molecules , lymphoid T cell protein tyrosine kinase ( Lck ) , zeta associated protein 70 ( ZAP 70 ) , T cell receptor zeta ( TCRzeta ) , and linker for activator of T cells ( LAT ) in CBTCs than in PBTCs . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
While crosslinking of Fas affected the association of p59fyn and p56lck tyrosine kinases with the TCR zeta chain to a limited degree , it dramatically inhibited the association of the protein tyrosine kinase ZAP 70 with the zeta chain . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We have previously demonstrated that anti TCRCbeta responsiveness in this system correlates with the presence of kinase active , membrane associated lck and preformed hypophosphorylated TCRzeta : zeta associated protein of 70 kDa complexes , a phenotype recapitulated in primary resting CD 4 ( + ) T cells . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Induction of Nef ( wt ) , but not Nef ( G ) 2 ( A ) , coincided with an increased association of the src family tyrosine kinase , Lck , and TCRzeta with rafts , but not with nonrafts . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Upon CD 3 CD4 ligation , TCR zeta phosphorylation , ZAP 70 recruitment to the p21 / p23 TCR zeta phosphoisomers , ZAP 70 phosphorylation , as well as p 56 ( lck ) , c Cbl and Slp 76 phosphorylation , were all markedly increased in CD45R0 ( + ) compared with CD45RBC ( + ) cells . ^^^ Upon CD 3 CD4 co ligation , the active p 56 ( lck ) increases the intensity of T cell antigen receptor signal transduction coupling by promoting TCR zeta chain phosphorylation and ZAP 70 recruitment . . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Examination of the earliest initiation events of TCR signal transduction showed that YHB . 46 inhibited TCR zeta chain phosphorylation together with recruitment and tyrosine phosphorylation of the zeta associated protein of 70 kDa tyrosine kinase , particularly at Tyr ( 319 ) , as well as reduced recruitment of p 56 ( lck ) to the TCR zeta and zeta associated protein of 70 kDa complex . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We synthesized chimeric receptors consisting of the extracellular and transmembrane domains of the class 1 MHC H 2K ( b ) molecule linked to the signaling domains of either TCR zeta , CD 28 and zeta , or CD 28 , zeta , and lck . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
SLAT reduced the association of ZAP 70 with TCR zeta and interfered with ZAP 70 but not Lck signaling . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
TCR zeta , p 56 ( lck ) and LAT ) but not all ( e . g . ^^^ We have identified the C terminal part of TCR zeta and the membrane proximal domain of p 56 ( lck ) as potential targets for modifications induced by reactive oxygen species . ^^^ Oxidative stress exposed proteins were differentially susceptible to proteasomal degradation : whereas modified TCR zeta was relatively resistant , reactive oxygen species ( ROS ) altered LAT and p 56 ( lck ) were much more susceptible . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Phenotype analysis and immunohistochemical staining of the TCR zeta and epsilon chains and p56lck were performed with standard techniques on TIL , NTTL , and PBL , and values were compared for each patient . ^^^ Low expression of the TCR zeta chain and an almost complete absence of TCR epsilon chain and p56lck expression was observed in TIL ( median values : 10 % for zeta chain and 0 % for epsilon and p56lck ) . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
We also provide evidence that SLAP functions in a pathway that requires the phosphorylated TCRzeta chain and the Src family kinase Lck , but not ZAP 70 ( zeta associated protein of 70 kD ) . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
Mutant T cell lines contained a more active pool of p56lck tyrosine kinase and responded with increased phosphorylation of Zap 70 and TCR zeta and an enhanced Ca2+ flux to TCR / CD3 stimulation . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
In vitro experiments with purified recombinant proteins demonstrated that PTPN 22 D195A / C227S interacted directly with activated Lck , Zap 70 , and TCRzeta , confirming the initial substrate trap results . ^^^
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
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Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20963 and P06239	Pubmed	SVM Score :0.0
NA