| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| The T cell receptor specific kinases FYN , LCK , and ZAP 70 as well as the RAS pathway were found to be activated in T cells of Ctla 4 / mutant mice . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| In co transfection experiments , both tyrosine residues in the cytoplasmic tail of CTLA 4 ( 165Y and 182Y ) were phosphorylated by the T lymphocyte associated tyrosine kinase , p56lck . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| Src family tyrosine kinases Fyn , Lyn , and Lck associate with CTLA 4 and phosphorylate both Y 165 and Y 182 that are mainly responsible for interaction with Fyn through its SH 2 domain . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| The association of TCRzeta with CTLA 4 , reconstituted in 293 transfectants , was enhanced by p 56 ( lck ) induced tyrosine phosphorylation . ^^^ Coexpression of the CTLA 4 associated tyrosine phosphatase , SHP 2 , resulted in dephosphorylation of TCRzeta bound to CTLA 4 and abolished the p 56 ( lck ) inducible TCRzeta CTLA 4 interaction . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| In this report , we show that CTLA 4 can associate with the Src kinases Fyn and Lck and that transfection of Fyn or Lck , but not the unrelated kinase ZAP 70 , can induce tyrosine phosphorylation of CTLA 4 on residues Y 201 and Y 218 . ^^^ These findings suggest that phosphorylation of CD 28 and CTLA 4 by Lck activates distinct intracellular signaling pathways . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA 4 and its association with PI 3 kinase in intracellular compartments of T cells . ^^^ Transfection of Lck or Fyn resulted in increased phosphorylation of intracellular CTLA 4 and recruitment of PI 3 kinase . ^^^ In this study , we show that tyrosine kinases p56lck and p59fyn phosphorylate the cytoplasmic domain of CTLA 4 in T cells . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| However , the association of p 56 ( lck ) with ZAP 70 was inhibited following CTLA 4 ligation , correlating with reduced actions of p 56 ( lck ) in the ZAP 70 immunocomplex . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| To determine the importance of NF kappaB inhibition upon CTLA 4 engagement in vivo , CTLA 4 ( / ) mice were interbred with mice expressing a transdominant IkappaBalpha mutant under the control of the Lck promoter . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| In this study , four colour flow cytometry was applied to study the surface bound molecules TCRalphabeta , CD 28 , CD 152 and CD 154 involved in T cell signalling and the signal transduction molecules CD3zeta , p56lck , p59fyn , ZAP 70 and phosphatidyl inositol 3 kinase ( PI 3 k ) as well as the intracellular cytokines interferon gamma ( IFN gamma ) , interleukin ( IL ) 4 and IL 2 as a functional read out of non stimulated and superantigen ( staphylococcus enterotoxin B ) stimulated blood T cells of multiple myeloma ( MM ) patients at different stages of the disease . ^^^ There was a marked reduction , particular in advanced stage MM , in the proportion of CD 4 and CD 8 cells expressing CD 28 , CD 152 , CD3zeta , p56lck , ZAP 70 and PI 3 k . ^^^ |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16410 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|