| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.7455395 |
| Furthermore , immunoprecipitations show that CD 44 is physically associated with p56lck . 0.7455395^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :1.0531176 |
| CD 44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid rich plasma membrane domains of human peripheral blood lymphocytes . 1.0531176^^^ The mechanism of signal transduction via CD 44 remains undefined , although CD 44 was shown to physically associate with intracellular protein tyrosine kinase Lck in T lymphocytes . 1.0136911^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.52449561 |
| Due to the association of CD 44 with lck and fyn this colocalization with the TCR allows an abundant provision of these kinases , which are essential to initiate the TCR signaling cascade . . 0.52449561^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.77995884 |
| Furthermore , 2 fold more Lck associated with CD 44 in the low density sucrose fraction from CD 45 ( ) T cells compared with CD 45 ( + ) T cells , suggesting that CD 45 may regulate the association of Lck with CD 44 in this fraction . 0.77995884^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| CD 44 mediated signaling involves activation of p 56 ( lck ) and leads to ZAP 70 phosphorylation . ^^^ The aim of the present study was to identify the signaling pathways that follow CD 44 triggered ZAP 70 phosphorylation and the molecular mechanisms underlying the CD 44 interaction with p 56 ( lck ) . ^^^ CD 44 signaling through p56lck involves lateral association with CD 4 in human CD4+ T cells . ^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| The complex formation of murine CD 44 with the src like protein tyrosine kinases , lck and lyn , was investigated . ^^^ In accordance with previous observations , stable CD 44 lck and CD 44 lyn complexes were detected in nonstimulated lymphoid T and B cells , respectively . ^^^ In addition , a direct modulation of lck and lyn by CD 44 was observed as revealed by the CD 44 dependent translocation of these enzymes to the Triton 10 100 resistant cell fraction . ^^^ Interestingly , the synthetic peptide pCD 44 ( ILAVCIAVNSRRR ) , which corresponds to the plasma membrane cytoplasmic interface region of murine CD 44 , exhibited a high capacity to bind lck and lyn . ^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| We show that p 56 ( lck ) transcripts are detectable in each CD 4 ( ) CD 8 ( ) double negative ( DN ) thymocyte subset defined by CD 25 and CD 44 . ^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| The Src family non receptor PTKs such as Lck , Fyn , Lyn and Hck were shown to be coupled to CD 44 via sphingolipid rich microdomains ( lipid rafts ) of the plasma membrane . ^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the progenitors expressing lck proximal promoter activity in the CD 44 ( + ) CD 25 ( ) DN thymocyte subset have lost most of the progenitor potential for the B and dendritic cell lineage . ^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| In vivo expression of the M 2 ion channel , as a transgene under control of the T cell specific p 56 ( Lck ) proximal promoter , resulted in total ablation of T cell development with the accumulation of three distinct populations of early progenitor cells ( CD 44 ( + ) CD 25 ( ) ; CD 44 ( + ) CD 25 ( + ) ; CD 44 ( + ) CD 25 ( hi ) ) in the thymic rudiment . ^^^ |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|