| Interacting proteins: P15311 and P06239 |
Pubmed |
SVM Score :0.0 |
| Using the cell line HUT 78 T transfected with either normal human CD 4 or mutated CD 4 molecules unable to associate with p56lck tyrosine kinase , we showed that this kinase plays a major role in the tyrosine phosphorylation of ezrin . ^^^ |
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| Interacting proteins: P15311 and P06239 |
Pubmed |
SVM Score :0.0 |
| Ezrin is a substrate for Lck in T cells . ^^^ We evaluated the role of Lck tyrosine kinase , an early effector of T cell activation , in regulation of the membrane cytoskeleton linker protein ezrin . ^^^ Ezrin was constitutively tyrosine phosphorylated in wild type and CD 45 deficient Jurkat T cells , but not in Lck deficient cells . ^^^ Lck phosphorylated ezrin in vitro , and the major phosphotyrosine was identified as Y 145 . ^^^ These results identify ezrin as the first cytoskeletal substrate for Lck . . ^^^ |
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