| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.55791876 |
| Interaction of the IL 2 receptor with the src family kinase p56lck : identification of novel intermolecular association . 0.55791876^^^ |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Phenotypic changes induced by interleukin 2 ( IL 2 ) and IL 3 in an immature T lymphocytic leukemia are associated with regulated expression of IL 2 receptor beta chain and of protein tyrosine kinases LCK and LYN . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| A nonreceptor type tyrosine kinase , Lck , is associated with IL 2 receptor beta subunit , and the binding of IL 2 to its receptor induces the activation of Lck . ^^^ In this paper , we describe that both of the two regions in IL 2 receptor beta subunit , the indispensable region for the induction of cell growth ( serine rich region ) and the binding region of Lck protein ( acidic region ) , are required for the activation of Ras . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Recently , interleukin 2 ( IL 2 ) has been shown to induce increased activity of the p56lck protein tyrosine kinase ( PTK ) in T cell and natural killer cell lines , and evidence for a direct interaction between the p 75 subunit of the IL 2 receptor ( IL 2R ) and this src family kinase has been reported . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Interleukin ( IL ) 2 and IL 3 induce distinct but overlapping responses in murine IL 3 dependent 32D cells transduced with human IL 2 receptor beta chain : involvement of tyrosine kinase ( s ) other than p56lck . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| In vitro phosphorylation after p56lck immunoprecipitation indicated that p56lck is associated in vivo with the beta chain of the IL 2 receptor and p 42 MAP kinase as well as a number of other proteins . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| When G 0 T cells were activated by phorbol dibutyrate in the absence of IL 2 , the high affinity IL 2 receptor ( IL 2R ) expressed failed to induce a proliferative signal , and neither the tyrosine phosphorylation of the 97 kDa protein nor the transient increase in p56lck kinase activity was detected . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| These changes were also inhibited by treatment of PBMC with Nef , suggesting that Nef interferes with activation of p56lck and as a consequence of signalling via the IL 2 receptor . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| The interaction of the IL 2 receptor with an intracellular tyrosine kinase , lck , has been mapped to the acidic rich region of the beta chain . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Taken together , our results suggest a cross talk between CD 4 and IL 2 receptor mediated signaling via p56lck . . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| In addition , we describe our investigations of Lck and Lyn , two closely related protein tyrosine kinases of the src gene family that physically associate with the IL 2 receptor complex and whose activities are regulated by IL 2 in at least some T cells and B cells , respectively . . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Following T cell activation or signaling through the IL 2 receptor , Ca ( 2+ ) mediated phosphorylation of p56lck occurs on serine / threonine residues . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Association of p56lck with IL 2 receptor beta chain is critical for the IL 2 induced activation of p56lck . ^^^ Previous studies demonstrate that p56lck , a member of the src family of protein tyrosine kinases ( PTKs ) , can physically associate with the interleukin 2 ( IL 2 ) receptor beta chain ( IL 2R beta ) and that IL 2 receptor engagement stimulates p56lck activity . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| In order to understand the mode of PI 3 kinase activation by the IL 2 receptor , we examined the association of PI 3 kinase to SH 2 and SH 3 domains of lck and fyn in IL 2 dependent kit 225 cells . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| The protein tyrosine kinase p 56 ( lck ) is critical for the generation of signals emanating from the T cell antigen receptor ( TCR ) and has also been demonstrated to play a role in IL 2 receptor signaling . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Attenuation of IL 2 receptor signaling by CD 4 ligation requires polymerized cytoskeletal actin but not P56LCK . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Reduction in JAK 3 was selective because expression of other tyrosine kinases ( JAK 1 , p 56 ( lck ) , and p 59 ( fyn ) ) and signal transducer and activator of transcription ( STAT ) 5 , which are linked to IL 2 receptor ( IL 2R ) signaling pathway , were not affected . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| In this study , we have used subdomains of the IL 2 receptor beta chain ( IL 2Rbeta ) expressed in Escherichia coli as GST fusion proteins to identify the tyrosine residues that could be phosphorylated by p 56 ( lck ) , one of the critical tyrosine kinases activated by IL 2 . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Human lymphocyte specific kinase ( Lck ) is a 56 kDa protein involved in T cell and IL 2 receptor signaling . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| To investigate in vivo regulatory mechanisms that control the population of type 2 T cells and disease susceptibility , we have created lines of transgenic mice in which expression of a chimeric cytokine receptor ( the mouse interleukin 2 receptor beta chain [ IL 2Rbeta ] extracellular domain fused to the cytoplasmic tail of IL 4Ralpha ) is targeted to the T lymphoid lineage using the proximal lck promoter . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| This interaction requires the A region of IL 2Rbeta ( residues 313 382 ) , which also mediates the association of IL 2Rbeta with Lck and Jak 3 . ^^^ Correspondingly , CIS inhibits functions associated with both of these kinases : Lck mediated phosphorylation of IL 2Rbeta and IL 2 mediated activation of Stat 5 . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| In agreement with its binding to IL 2Rbeta , p 1 30 activates Shc and p 56 ( lck ) but unlike IL 2 , fails to activate Janus kinase ( Jak ) 1 , Jak 3 , and signal transducer and activator of transcription 5 ( STAT 5 ) . ^^^ |
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| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| Implantation sites from three strains of immunodeficient mice [ tgepsilon 26 , IL 2Rbeta nullxp 56 ( lck ) null and IL 2Rgamma null , now known as common cytokine chain gamma ( gamma ( c ) ) null ] , which lack uterine natural killer ( uNK ) cells , are histologically abnormal . ^^^ |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|