| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.95814354 |
| In vivo association between Lck and LckBP 1 was confirmed by immunoprecipitation of lysates from a pre T cell line and adult thymocytes using antibodies specific for Lck and LckBP 1 . 0.95814354^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.74125743 |
| Using unstimulated T lymphocytes , we further demonstrated that Lck binds to HS 1 in vivo and that HS 1 is tyrosine phosphorylated upon TCR stimulation . 0.74125743^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.65298935 |
| Because HS 1 associates with the p 56 ( lck ) and p 59 ( lyn ) tyrosine kinases in vitro and in vivo , and becomes tyrosine phosphorylated upon various receptor stimulations , our present data suggest that HS 1 mediates linkage between Lck or Lyn and Grb 2 in lymphoid lineage cells . . 0.65298935^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| With this method , we previously isolated an Lck tyrosine kinase associated protein , LckBP 1 , which is identical to HS 1 ( Kitamura et al . , 1989 , 1995 ; Takemoto et al . , 1995 ) . ^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| In vivo studies indicated that CD 3 induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD 45 , did not require MEK 1 kinase activity , and was regulated by protein kinase C activation . ^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| These analyses identified several cellular proteins inside HIV 1 : elongation factor 1alpha , glyceraldehyde 3 phosphate dehydrogenase , HS 1 , phosphatidylethanolamine binding protein , Pin 1 , Lck , Nm 23 H1 , and the C terminal tail of CD 43 . ^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domains of ZAP 70 , SHP 1 and PLC gamma 1 and the SH 3 domains of lck , vav and HS 1 did not bind to pp 85 90 . ^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results suggest that rosmarinic acid has the potential to specifically inhibit Lck SH 2 domain binding to its cognate ligand , including ZAP 70 , Cbl , HS 1 , and PLCgamma 1 , and Lck dependent Ca 2+ signaling pathway of its downstream effector and finally to modulate IL 2 gene expression after T cell activation . . ^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| On the other hand , we confirmed previously mapped Lck SH 3 binding sites in ADAM 15 , HS 1 , SLP 76 , and NS5A , and identified putative Lck SH 3 binding sites of Sam 68 , FasL , c Cbl , and Cbl b . ^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation also links HS 1 to multiple signaling proteins , including Lck , PLCgamma 1 , and Vav 1 , and is essential for the stable recruitment of Vav 1 to the IS . ^^^ |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14317 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|