| Interacting proteins: P11836 and P06239 |
Pubmed |
SVM Score :0.0 |
| Association of 75 / 80 kDa phosphoproteins and the tyrosine kinases Lyn , Fyn , and Lck with the B cell molecule CD 20 . ^^^ Here , analysis of CD 20 associated molecules has revealed that CD 20 is associated with the Src family tyrosine kinases p56 / 53lyn , p56lck , and p59fyn and with 75 / 80 kDa proteins phosphorylated in vivo on tyrosine residues . ^^^ Mutants were analyzed in the human T lymphoblastoid cell line Molt 4 , in which ectopically expressed wild type CD 20 associated with p59fyn , p56lck , and 75 / 80 kDa phosphoproteins . ^^^ |
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| Interacting proteins: P11836 and P06239 |
Pubmed |
SVM Score :0.0 |
| CD 20 is tightly associated with the Src family kinases Lyn , Fyn and Lck ; however , the mechanism of interaction remains to be determined . ^^^ Lck , however , was not detected in any of the cell lines in which CD 20 failed to coprecipitate kinase activity . ^^^ To test the possibility that Lck was required for assembly of the CD 20 complex , Lck was transfected into one of the 3 CD20 / kinase association deficient lines , namely T 51 . ^^^ CD 20 did not coprecipitate kinase activity from the transfected T 51 cells , despite their expression of high levels of exogenous Lck , as well as endogenous Lyn and Fyn . ^^^ |
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| Interacting proteins: P11836 and P06239 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that anti CD 20 induced apoptosis can be attenuated by PP 1 , an inhibitor of protein tyrosine kinases Lck and Fyn , chelators of extracellular or intracellular Ca2+ , and inhibitors of caspases , suggesting that anti CD 20 induced apoptosis may involve modulation of these signaling molecules . ^^^ |
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| Interacting proteins: P11836 and P06239 |
Pubmed |
SVM Score :0.0 |
| We assessed the expression and methylation status of CD 19 , CD 20 , CD79B , SYK , PU . 1 , BOB . 1 / OBF . 1 , BCMA , and LCK , all of which are typically down regulated in cHL . ^^^ |
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| Interacting proteins: P11836 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
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