| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.7496204 |
| Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA / CD16 complex in human natural killer cells . 0.7496204^^^ |
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| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.59470114 |
| We show that Fc gamma RIII crosslinking results in activation of the src related kinase p56lck in NK cells and demonstrate a physical association of p56lck with Fc gamma RIIIA in immunoprecipitates from NK cells obtained using anti Fc gamma RIII antibodies or immune complexes . 0.59470114^^^ Our findings demonstrate both functional and physical association of p56lck with Fc gamma RIIIA , through direct interaction of the kinase with the zeta and / or the gamma signal transducer subunits of the receptor . 0.58536416^^^ |
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| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| Abnormalities in signaling via the T cell receptor ( TcR ) in T cells and Fc gamma RIII in NK cells obtained from cancer patients include significantly decreased expression of the receptor associated zeta chains , decreased Ca++ flux as well as impaired kinase activity following triggering with anti CD 3 or anti CD 16 antibodies , respectively , and altered expression of downstream protein tyrosine kinase p56lck . ^^^ |
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| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| Stimulation of Fc gamma RIIIA results in phospholipase C gamma 1 tyrosine phosphorylation and p56lck activation . ^^^ Occupancy of Fc gamma RIIIA by ligand results in phospholipase C ( PLC ) gamma 1 tyrosine phosphorylation in NK cells and in Fc gamma RIIIA transfected CD 3 / CD2 T cells , and induces functional activation of p56lck in Fc gamma RIIIA alpha / zeta 2 transfected T cells , suggesting the possibility that the receptor induced PLC gamma 1 activation occurs upon phosphorylation of its tyrosine residues mediated by this kinase and is , at least in part , responsible for the signal transduction mediated via CD 16 upon ligand binding . . ^^^ |
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| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| Fc gamma RIIIA mediated signaling involves src family lck in human natural killer cells . ^^^ |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| Three protein tyrosine kinases , i . e . , LCK , LYN , and SYK , were activated by occupancy of the Fc gamma RIIIA , and only LCK activity showed a divergence in effects induced by the various ligands , with strong autophosphorylation induced by mIgG upon cross linking . ^^^ |
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| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the transmembrane form of CD 16 transfected in a CD 3 Jurkat cell line associates with p56lck and ZAP 70 PTKs . ^^^ |
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| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| Fusion of non S acylated LCK to a transmembrane protein , CD 16 : 7 , allowed its plasma membrane targeting and also phosphorylation of CD 8 zeta when expressed in COS 18 cells . ^^^ |
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| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| Overexpression of wild type active lck , but not a kinase deficient mutant , enhanced both ligand induced tyrosine phosphorylation and ubiquitination of the CD 16 zeta subunit . ^^^ Taken together , our data demonstrate that CD 16 engagement induces zeta chain ubiquitination and strongly suggest a role for lck in regulating this modification . . ^^^ |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08637 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|