| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| A protein tyrosine kinase associated with the GPI linked proteins CD 59 , CD 55 , and CD 48 in human T cells , and with Thy 1 in mouse T cells was identified as p56lck , a protein tyrosine kinase related to Src . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| Signal transduction and glycophosphatidylinositol linked proteins ( lyn , lck , CD 4 , CD 45 , G proteins , and CD 55 ) selectively localize in Triton insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes . ^^^ In the present study , we observed lck , lyn , src , hck , CD 4 , CD 45 , G proteins , and CD 55 ( decay accelerating factor ) expression in the buoyant low density Triton insoluble ( LDTI ) fraction of selected leukemic cell lines and granulocytes . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| It was previously reported that the glycosylphosphatidylinositol ( GPI ) anchored CD 55 molecule provides a co stimulatory signal for T lymphocytes and is constitutively associated with the Src related kinase p56lck . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| In hematopoietic cells , these low density Triton insoluble ( LDTI ) microdomains ( also called caveolae related domains ) are dramatically enriched in signaling molecules , such as cell surface receptors ( CD 4 and CD 55 ) , Src family tyrosine kinases ( Lyn , Lck , Hck , and Fyn ) , heterotrimeric G proteins , and gangliosides ( GM 1 and GM 3 ) . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| Cr ( 3 ) treatment also increased the expression and activation of Src family tyrosine kinases viz . p56lck , p59fyn , and p53 / 56lyn , as seen by immunoblotting and immune complex kinase assay . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| Instead , Fyn and Lck were activated in A 549 cells , indicating activation of specific Src family kinases in response to Cr ( 6 ) . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| Treatment of lymphocytes with Na [ Cr ( 5 ) O ( ehba ) ( 2 ) ] and K ( 2 ) Cr ( 2 ) O ( 7 ) leads to the activation of the Src family protein tyrosine kinases namely , p 56 ( lck ) , p 59 ( fyn ) , and p56 / 53 ( lyn ) , which then activates caspase 3 , both of which are under the partial influence of ROS . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| Both p56lck and p59fyn were associated with DAF in DAF transfected EL 4 cells . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| Studies of decay accelerating factor ( DAF ) or CD 59 in either the C 32 cell line or the HeLa cell line transfected with PTK cDNA demonstrated that the GPI anchored proteins associated noncovalently with p56lck and p59fyn but not with p60src . ^^^ A chimeric PTK consisting of the 10 amino terminal residues of p56lck or p59fyn replacing the corresponding amino acids in p60src was sufficient for association with DAF , but the converse constructs containing the first 10 amino acids of p60src plus the remainder of p56lck or p59fyn did not associate with DAF . ^^^ Mutation of cysteine to serine at positions 3 and 6 in p59fyn or positions 3 and 5 in p56lck abolished the association of these kinases with DAF . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| Preincubation of lymphocytes with PP 2 , a selective Src family tyrosine kinase inhibitor , abolishes the activation of caspase 3 indicating that Src family tyrosine kinases viz . p56lck , p59fyn and p53 / 56lyn are mediators of caspase 3 activation during Cr ( 3 ) exposure . ^^^ Collectively , our findings support a plausible mechanism in which Cr ( 3 ) mediates ROS generation that precedes the up regulation of p56lck , p59fyn and p53 / 56lyn which eventually activates caspase 3 to promote apoptotic cell death of lymphocytes . ^^^ |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08174 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|