| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| In contrast to the T cell protein tyrosine kinase , Lck , ZAP 70 did not phosphorylate the cytoplasmic portion of the TCRzeta chain or short peptides corresponding to the CD3epsilon or the TCRzeta immunoreceptor tyrosine based activation motifs . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| To determine whether CD 3 ( ) CD8alpha alpha+ IEL represent precursors of T cells developing extrathymically , we examined IEL from knockout mice lacking the recombination activating gene 1 ( rag 1 ) , CD3epsilon , or both Lck and Fyn , in which thymic T cell development is arrested . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| When levels were semiquantitated using densitometry , significant decreases of TCRzeta ( P = 0 . 029 ) and p 56 ( lck ) ( P = 0 . 029 ) but not CD3epsilon ( P = 0 . 131 ) , compared with control levels , were found . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| About 50 % of the T cells from young mice that formed conjugates with peptide pulsed APC were found to form complexes , at the site of binding to the APC , containing CD3epsilon , linker for activation of T cells ( LAT ) , and Zap 70 in a central area and c Cbl , p 95 ( vav ) , Grb 2 , PLC gamma , Fyn , and Lck distributed more uniformly across the interface area . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| As compared to peripheral blood ( PB ) T lymphocytes , SF T cells from some ( but not all ) of the patients analyzed expressed lower levels of TCRalphabeta , CD3epsilon , TCRzeta , p 56 ( lck ) and LAT , while p 59 ( fyn ) , phospholipase C gamma 1 and ZAP 70 expression was unaltered . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| In tolerant cells , these phenomena were much more marked , the CD3epsilon and zeta chains no longer associated , and the Src kinases p56Lck and p59Fyn were inactive . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that , although the TfR is typically absent from lipid rafts at steady state , stimulation with a mitogenic mixture of anti CD 3 Abs of human Jurkat T cells leads to a rapid compartmentalization of the TfR into lipid rafts accompanying that of CD3epsilon and activated Lck . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| Cross linking of 4 1BB , a member of the TNFR family , increased tyrosine phosphorylation of TCR signaling molecules such as CD3epsilon , CD3zeta , Lck , the linker for activation of T cells , and SH 2 domain containing leukocyte phosphoprotein of 76 kDa ( SLP 76 ) . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| We conclude that TCR / CD3 induced CD3zeta phosphorylation and ZAP 70 recruitment do not absolutely require Lck or other PP 2 inhibitable SFK activity , but that SFK activity is absolutely required for CD3epsilon and ZAP 70 phosphorylation . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| Crry costimulation induced clustering of lipid rafts , increasing their content in Crry , CD3epsilon , and p 59 60 forms of p56lck , and caused actin polymerization close to the site of activation in Th 2 cells . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| These included three novel PTPN 22 substrates ( Vav , CD3epsilon , and valosin containing protein ) and two known substrates of PEP , the mouse homolog of PTPN 22 ( Lck and Zap 70 ) . ^^^ |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07766 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|