| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.73886515 |
| CD 5 represents a likely TCR / CD3 associated substrate for protein tyrosine kinases ( p56lck or p59fyn ) and an alternative signaling pathway within a multimeric TCR complex . . 0.73886515^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :1.2447049 |
| In this study , we demonstrate that CD 5 is coupled to the protein tyrosine kinase p56lck and can act as a substrate for p56lck . 1.2447049^^^ The T cell antigen CD 5 acts as a receptor and substrate for the protein tyrosine kinase p56lck . 0.96135992^^^ CD 5 interaction with p56lck represents a novel variant of a receptor kinase complex in which receptor can also serve as substrate . 0.84460199^^^ In vivo labelling with 32P ( 1 ) also showed a four to fivefold increase in Y 394 occupancy in p56lck when associated with CD 5 . 0.81158691^^^ Coexpression of CD 5 with p56lck in the baculovirus expression system resulted in the phosphorylation of CD 5 on tyrosine residues . 0.66346288^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| IVMP significantly reduced mRNA levels for T cell specific transcription factor 7 ( p=0 . 02 ) , T cell specific protein tyrosine kinase ( p=0 . 02 ) , T cell surface glycoprotein CD 5 ( p=0 . 05 ) and interferon stimulated gene factor 3 gamma subunit ( p=0 . 04 ) . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| In human T cells CD 45 is reported to associate with both cell surface and intracellular molecules including CD 2 , CD4 / CD8 , CD 5 , p56lck and p59fyn . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| In T lymphocytes , CD 2 forms part of a loosely associated membrane complex which includes the T cell receptor ( TcR ) for antigen , the CD 3 subunits , CD 4 or CD 8 , CD 5 and the protein tyrosine kinases p56lck and p59fyn . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| Receptor mediated activation of LCK does not in itself lead to activation of this Tec kinase since induction of LCK by ligation of CD 4 or CD 5 did not result in activation of EMT . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| These include increased expression of CD 5 and Bcl 2 , termination of RAG 1 and pre T ( alpha ) gene expression , and a switch in lck promoter usage . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| All glycosylphospha tidylinositol ( GPI ) anchored proteins ( CD 14 , CD16B , CD 48 , CD 59 , CD 87 and GPI anchored versions of CD 2 and CD 25 ) and protein tyrosine kinase ( PTK ) Lck but not transmembrane proteins ( CD 2 , CD 4 , CD 5 , CD 6 , CD 8 ) and PTK ZAP 70 were in part localized in buoyant , lipid rich , detergent resistant membrane GPI microdomains of the COS cells . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| The results show that Lck expression is a feature of CD 5 ( + ) , B 1 cells , suggesting a potential role for Lck in the self renewal capacity of this B cell subpopulation and supporting the notion that B 1 cells are the subset undergoing oncogenic transformation in B CLL . ^^^ Furthermore , we show that the CD 5 ( ) , B 2 subpopulation , while normally lacking Lck expression , acquires the capacity to express Lck ectopically upon transformation by EBV . . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| The results demonstrate that low level expression of CD 5 on CD 4 ( ) CD 8 ( ) ( double negative , DN ) thymocytes is independent of TCR gene rearrangement ; however , induction of CD 5 surface expression on DN thymocytes requires engagement of the pre TCR and is dependent upon the activity of p 56 ( lck ) . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| The CD 5 regulated substrates included CD3zeta , ZAP 70 , Syk , and phospholipase Cgammal but not the Src family tyrosine kinase p 56 ( lck ) . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| Using a T cell line deficient in the tyrosine kinase p 56 ( lck ) and the same cell line reconstituted with this kinase , we show that p 56 ( lck ) expression is required for efficient CD 5 tyrosine phosphorylation . ^^^ Using tyrosine phosphorylated peptides corresponding to CD 5 cytoplasmic sequences we also show that the Src homology 2 ( SH 2 ) domain of p 56 ( lck ) binds prominently to pY429SQP , with 30 fold less affinity to pY463DLQ and not to pY441PAL . ^^^ Taken together these results suggest that both Y 429 and Y 463 can recruit p 56 ( lck ) , and that these residues are the only prominent sites for CD 5 tyrosine phosphorylation . . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| The analysis of Lck and CD 3 deficient Jurkat cells shows that tyrosine phosphorylation of CD 5 requires Lck activity . ^^^ We propose that T cell activation mediates CD 5 tyrosine phosphorylation at residues Y 429 and Y 463 mainly through the activation of Lck . . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| Here we show that pMHC contact modulates the expression of CD 5 by naive CD 4 T cells in a process that requires the continued expression of p 56 ( lck ) . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| The disappearance of T cells in the absence of Fyn and Lck was associated with a complete loss of TCRzeta chain phosphorylation and down regulation of CD 5 , both of which are also MHC contact dependent , indicating that the Src family kinases are critical for transducing a TCR MHC survival signal . . ^^^ |
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| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| CD 6 also associated with Lck , Fyn , and ZAP 70 , although at lower levels but additionally coprecipitated the Tec family kinase Itk , which is absent from CD 2 , CD 5 , and TCR complexes . ^^^ Lck together with Itk was the best combination of kinases , effectively phosphorylating synthetic peptides corresponding to a cytoplasmic sequence of CD 5 . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that B 1 cells , which are characterized by CD 5 surface expression , specifically exhibit significant levels of the tyrosine kinase Lck in man . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| They hypothesize that the key event in T cell activation is the formation of multimolecular complexes consisting of the TCR and several other polypeptides , including CD 4 or CD 8 , CD 2 , CD 5 and the associated tyrosine kinases p 59 ( fyn ) and p 56 ( lck ) . . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| Splenic B 1 cells express CD 5 but not Lck and are not hyporesponsive ; however , within the peritoneum , these B 1 cells are induced to express Lck and acquire a hyporesponsive phenotype . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| This hyperactivity correlates with decreased expression of CD 5 ; however , developmental tuning can occur independently of CD 5 , correlating instead with differences in the distribution of Lck . ^^^ |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06127 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|