| By yeast two hybrid screenings and coimmunoprecipitation , we show here that p76RBE is a specific binding protein of RhoB and binds selectively to the GTP bound form of this small GTPase . p76RBE also binds in vitro to components of the cytoskeleton , including cytokeratin 18 . p76RBE is essentially cytoplasmic in transfected COS 7 mammalian cells and seems to be recruited to an endosomal compartment when coexpressed with the activated form of RhoB . p76RBE was shown to be mainly expressed in tissues with high secretion activity . 0.75696737^^^ |