Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Differential phosphorylation of CK 8 and CK 18 by 12 O tetradecanoyl phorbol 13 acetate in primary cultures of mouse hepatocytes . ^^^ The two hepatocyte cytokeratins CK 8 and CK 18 ( 55 , 000 and 49 , 000 M ( r ) respectively ) were phosphorylated , CK 8 being more phosphorylated than CK 18 . ^^^ Treatment of the hepatocytes with 150 nM 12 O tetradecanoyl phorbol 13 acetate ( TPA ) an activator of protein kinase C induced a transient increase in the level of phosphorylation of CK 8 but not CK 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Northern and Western blot analyses with cDNAs and antibodies for CK 8 , CK 14 , CK 18 and vimentin confirmed that rat hepatocytes express CK 8 and CK 18 genes only , whereas T51B cells express CK 8 , CK 14 and vimentin genes in the absence of CK 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Intermediate filaments of rat hepatocytes are composed of cytokeratins 8 and 18 ( CK 8 and CK 18 , respectively ) . ^^^ However , the CK 18 mRNA level varied in a manner that was different from that of CK 8 mRNA , showing that the modes of expression of the two genes were independent . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The induction of CK 8 and CK 18 occurs at the mRNA level and , although both CK 8 and CK 18 mRNAs are expressed , CK 18 protein does not accumulate whereas CK 8 is incorporated into intermediate filaments . ^^^ Our results suggest that activation of a H ras gene can alter the normal differentiation program of epidermal cells and that the ability to synthesize CK 8 and CK 18 could be related to tumor progression . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Acid hydrolysis of CK 8 and CK 18 , purified from [ 3H ] glucosamine labeled cells , generated free glucosamine . ^^^ Using chemical analysis , the stoichiometry of glycosylation was found to be 1 . 5 and 2 molecules of N acetylglucosamine / protein molecule of CK 8 and CK 18 , respectively . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Reconstitution experiments demonstrated that purified CK 8 or CK 18 associated with a 40 kD tryptic fragment of purified PKC epsilon , or with a similar species obtained from cells that express the fragment constitutively but do not express CK8 / 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
T51B Ni , a subclone selected by prolonged exposure of the parental clone to nickel subsulfide contains CK 8 and CK 18 ( its usual partner in simple epithelium ) , as well as CK 14 , at a lower level . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
MAb CAM 5 . 2 to CK 8 and 18 reacted with 20 and MAb CY 90 to CK 18 with 25 primary melanomas , whereas MAb KS B17 . 2 and MAb CK 5 to CK 18 labeled 8 and 6 tumors , respectively . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
All the tumour specimens reacted with monoclonal antibodies to CK 7 , CK 8 , CK 18 and CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The expression of cytokeratins ( CKs ) 8 , 18 and 19 was analyzed in male and female rat gonads from the undifferentiated stage ( 12 . 5 days of gestation ) until two weeks after birth by indirect immunofluorescence , using specific monoclonal antibodies anti CK 8 ( LE 41 ) , anti CK 19 ( LP2K ) and anti CK 18 ( LE 65 and RGE 53 ) . ^^^ In the undifferentiated blastema , the somatic cells were stained for CK 8 and CK 19 , whereas no detectable immunoreactivity for CK 18 was obtained . ^^^ At the onset of testicular differentiation , when the first Sertoli cells differentiate in the gonad of 13 . 5 day old male fetuses , positive staining for CK 18 became evident , in addition to CK 8 and CK 19 expression . ^^^ In the following days , CK 8 , CK 18 and CK 19 were detected in Sertoli cells in the differentiating seminiferous cords , but progressively the reactivity for CK 19 decreased and was no longer observed after 18 . 5 19 . 5 days of gestation . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Secretory cells of lacrimal acini reacted with antibodies to S 100 protein and simple epithelium type cytokeratins CK 7 , CK 8 , CK 18 , and CK 19 . ^^^ Unlike myoepithelial cells , basal ductal cells were immunopositive for CK 7 , CK 8 , CK 18 , and CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
With tumor progression changes in epitope configurations of CK 8 and CK 18 were detected , as concluded from immunohistochemical assays with the panel of monoclonal antibodies for each of these two CKs . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
A previously uncharacterized monoclonal antibody , MRCTU / J1 , has been shown to recognize rat CK 18 and together with antibodies against human CK 8 , 18 and 19 , has been used to examine the possible lineage of tumour cells and also to identify the altered foci that might be most relevant to tumorigenesis . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Flow cytometric analysis of DNA content and keratins by using CK 7 , CK 8 , CK 18 , CK 19 , and KL 1 monoclonal antibodies in benign and malignant human breast tumors . ^^^ An enhancement of keratin expression in malignant tumors was observed with CK 19 ( P less than 0 . 001 ) , KL 1 ( P less than 0 . 01 ) , CK 8 ( P less than 0 . 05 ) , and CK 18 ( n . s . ) compared to benign tumors . ^^^ The comparison of keratin expression in aneuploid and diploid malignant tumors revealed reduced CK 8 , CK 18 , and CK 19 in the former . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Cytokeratins CK 8 and CK 18 are the two keratins expressed in the liver . ^^^ Coculturing hepatocytes with rat liver epithelial cells ( RLEC ) , which favours active expression of liver specific genes , resulted in a gradual decline of cytokeratin mRNAs , whereas pure hepatocyte cultures , which exhibit rapid phenotypic changes , expressed increasing levels of CK 8 and CK 18 transcripts . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Results show that : 1 ) An increased expression of CK 8 and CK 18 is seen in the TCC tumor cells at the interface with peritumoral stroma in the tumor invasion front and with intratumoral stroma ( ' interface phenomenon ' ) . ^^^ Other than reflecting a quantitative change , this phenomenon might be explained by unmasking of CK 8 and CK 18 epitopes occurring in these regions . 2 ) Although in general the expression of CK 13 in local TCC is decreased with increase of histopathologic parameters for progression , ie , grade and stage , an extensive proportion of CK 13 positive tumor cells still can be found in some TCCs , even in metastases . 3 ) Morphologically recognizable types of aberrant differentiation in TCC , i . e . , pseudosarcomatous or squamous differentiation and marked loss of differentiation , show altered expression of many of the CKs studied . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Antibodies that recognize cytokeratins CK 8 and CK 18 labeled normal and reactive RPE cells in all specimens . ^^^ Immunoblotting supported the presence of CK 8 and CK 18 in human RPE . ^^^ Antibodies to CK 8 and CK 18 are valuable markers of normal and reactive human RPE cells , but a panel of reagents is necessary to document reactive changes in the cytoskeleton . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We show by SDS PAGE immunoblots and dot blot assays that this antibody is unreactive with both the denatured and the renatured individual polypeptides but binds strongly to heterotypic coiled coil complexes of CK 18 with several members of the complementary basic ( type 2 ) CK subfamily , notably with CK 8 ; i . e . , its most frequent natural partner . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
With monoclonal antibodies specific for individual cytokeratins , the expression of CK 18 , CK 8 , CK 7 , and CK 19 could be shown in these cells . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Surprisingly , on pure or mixed K 562 cells , we found positive labeling with KL 1 , CK 8 , and CK 18 antibodies ( results confirmed by immunocytology ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We found that in SV 40 transformed fibroblasts the CK 18 gene is constitutively transcribed into translatable mRNA but that the protein is rapidly degraded in the absence of its complex partner , CK 8 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
This MAb detects the CK 8 , CK 18 and CK 19 consistently present in all layers of normal and neoplastic urothelium , colonic epithelium and mammary epithelium . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Reactivity with mAb CAM 5 . 2 to cytokeratin ( CK ) 8 and mAb CY 90 and KS B17 . 2 to CK 18 disappeared from the iris epithelium by the 28th gestational week . mAb 1A4 to alpha SMA labeled its anterior layer from the 28th week on . mAbs DE U 10 and D 33 to desmin labeled dilator fibers by the 37th week , and focal reactivity for CK 8 and 18 concurrently appeared . ^^^ It was labeled increasingly for desmin from the 18th week on , whereas initial reactivity for vimentin gradually disappeared after the 22nd week . mAbs to vimentin , CK 8 , and CK 18 labeled the ciliary epithelium and the retinal pigment epithelium in all eyes , except for lack of CK 8 and 18 in the nonpigmented ciliary epithelium at the 13th week . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
During thymus ontogeny , both cytokeratins of simple lining epithelia , as CK 8 and CK 18 , as well as the CK1 / CK10 pair ( typical marker of terminal stage of keratinization ) , were expressed since early stages of thymus development . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The serum of 24 patients with biopsy proven non small cell lung cancer ( NSCLC ) and a similar number of controls was examined for evidence of CK 8 and CK 18 . ^^^ Biopsy specimens showed CK 8 expression in all 24 cases by immunochemistry and CK 18 in 22 cases . ^^^ This is the first study to demonstrate that a subgroup of NSCLC patients have intact CK 8 and CK 18 peptides in their serum , and their detection may correlate with advanced disease . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Partial sequence of the two proteins showed a 100 % homology to cytokeratin 18 ( CK 18 ) and 8 ( CK 8 ) , respectively . ^^^ Cell fractionation into cytosolic and particulate fractions revealed that all four proteins , the kinase , uPAR , CK 18 , and CK 8 , were present in the particulate fraction . ^^^ In vivo , CK 8 , and to a lesser degree CK 18 , were found to be phosphorylated on serine residues . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
A panel of mouse monoclonal antibodies detecting differentiation antigens of epithelial cells was used to determine the phenotype of the cultures : all cells expressed cytokeratin polypeptides of simple epithelial ( CK 7 , CK 8 , CK 18 , and CK 19 ) , whereas polypeptides typical of stratified epithelial ( CK 5 , CK 10 , CK 13 , and CK 16 ) were not detected . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
CKAE1 / AE3 and CK 19 were strongly expressed in all morphological patterns of adamantinoma emphasizing their epithelial origin , while the antibodies to CK 8 and CK 18 showed a high percentage of negative responses . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Biochemical experiments indicate that forskolin does n ' t interfere with the cytokeratin profile , since the three cytokeratins normally found in intestine ( CK 8 , CK 18 , CK 19 ) are similarly expressed in both control and forskolin Caco 2 cells . ^^^ Analysis of 32P labeled cytokeratin extracted from the two cell populations demonstrates that forskolin quantitatively increases the phosphorylation of type 1 cytokeratin ( CK 18 and CK 19 ) , whereas the phosphorylation of type 2 cytokeratin ( CK 8 ) is altered both quantitatively and qualitatively with the emergence of a new phosphorylation site . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Furthermore , well differentiated carcinoma cells may also gain an ability to synthesize new types of CKs that are not characteristic of the normal oesophageal epithelium ( CK 8 and CK 18 characteristic of most simple epithelia , and CK 10 characteristic of keratinizing epithelia ) . ^^^ At the interface zone , observed in sections of well differentiated carcinomas , CK 8 and CK 18 mRNA were expressed in intermediate cell layers , and the centrally located cell layers were found positive for CK 10 mRNA . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The hepatocytes were labeled with [ 35S ] methionine or [ 32P ] orthophosphate to study , respectively , the level of amino acid incorporation into IF proteins ( CK 8 and CK 18 ) and their phosphorylation levels . ^^^ The response to the tumor promoter 12 O tetradecanoyl phorbol 13 acetate stimulation of the phosphorylation of CK 8 and CK 18 was also elicited in contrast to control hepatocytes . ^^^ This was associated with an increase in labeled amino acid incorporation into CK 8 and CK 18 as well as in actin . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : A CK immunohistochemical study was carried out on histologic sections from hepatocellular carcinomas ( HCCs ) and preneoplastic lesions from 118 monkeys chronically dosed with diethylnitrosamine ( DEN ) , using mAbs to CK 8 , CK 18 , CK 7 , and CK 19 . ^^^ RESULTS : Normal monkey hepatocytes differed from human hepatocytes by displaying CK 19 in addition to the CK 8 / CK 18 pairs , whereas the CK pattern of the bile duct epithelial cells was identical in monkey and human liver . ^^^ The majority of the HCC cases displayed one of the three CKs normally present in monkey hepatocytes , whereas positive expression of all three CKs ( CK 8 , CK 18 , CK 19 ) and negative CK 7 was preserved in only 19 . 5 % of the HCC cases . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The tumours expressed CK 19 in 86 % , CK 8 in 46 % , CK 18 in 97 % , CK 13 in 83 % , CK 10 in 34 % and CK 7 in 29 % of cases . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Moreover , CK 14 was the only CK gene whose expression was inhibited in MT containing hepatic cells , in the sense that the expression of the CK 7 , CK 8 , CK 18 , and CK 19 genes was not affected . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In media containing bovine pituitary extract , CT , and EGF , cultures had a mean population doubling time of 14 . 7 + / 1 . 8 hours , maintained a nonstratified phenotype , and expressed the cytokeratin ( CK ) profile of basal / intermediate urothelium : CK 7 , CK 8 , CK 17 , CK 18 and CK 19 , with variable expression of CK 13 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunohistochemically , the tumour cells showed coexpression of cytokeratins typical of stratified epithelia ( CK1 / 5 / 10 / 14 ) and cytokeratins of the simple epithelial type , namely CK 7 , CK 8 , CK 18 , and CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
On heat shock , incorporation of [ 3H ] leucine into cytoskeletal proteins such as cytokeratins CK 8 and CK 18 was reduced and significant amounts of two new proteins having an average molecular mass of 80 kDa and 90 kDa were found to be tightly associated with cytoskeletal proteins . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The expression and cellular distribution of desmin , alpha smooth muscle actin ( A SMA ) and cytokeratin no . 8 ( CK 8 ) and no . 18 ( CK 18 ) in normal adult , neonatal and fetal rat liver were examined immunohistochemically on cryostat sections . ^^^ From day 16 of gestation the pre hepatocytes became desmin negative , remained CK 8 and CK 18 positive . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Furthermore , the results show that a mixed biological phenotype ( ie , CK 8 , CK 18 and CK 7 and / or CK 19 ) can be found both among morphologically pure HCCs and peripheral CCs , suggesting that these two forms could share a common histogenesis . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunohistochemical examination revealed that all epithelial components in the ameloblastic fibroma like area showed expression of CK 8 , CKs 13 , 16 , CK 14 , CK 18 and CK 19 , and coexpression of these cytokeratins and vimentin . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In normal mammary gland , luminal cells showed abundant hybridization with complementary RNA ( cRNA ) probes for CK 7 , CK 8 , CK 18 , and CK 19 . ^^^ In primary carcinomas , both messenger RNAs ( mRNAs ) and proteins of CK 8 and CK 18 were generally expressed to a degree similar to that of normal epithelia , but a lower level of mRNA and protein of CK 18 was observed in metastatic carcinomas . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Expression of Ep CAM in ectocervical lesions did not coincide with a reappearance of the simple epithelium cytokeratins ( CK 8 and CK 18 ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The cells of the cylindroma lacked vimentin but expressed additionally CK 7 , CK 8 and CK 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The levels of all cytokeratin forms resolved ( CK 7 , CK 8 , CK 15 and CK 18 ) were significantly lower in carcinomas than in fibroadenomas . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
By using MAbs , we found no immunoreactivity against CK 18 either in normal or affected epithelia , whereas we found suprabasal reaction ( 5 / 11 ) against CK 8 in the snuff user ' s epithelia . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
A loss of expression of the luminal epithelial specific keratins CK 8 and CK 18 was also observed in advanced stage , poorly differentiated carcinomas . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
These differences were in the same order of magnitude as those observed comparing a breast carcinoma to a lung carcinoma . ( 3 ) The levels of all cytokeratin forms resolved ( CK 7 , CK 8 , CK 15 , and CK 18 ) were significantly lower in carcinomas compared to fibroadenomas . ( 4 ) The levels of high molecular weight tropomyosins ( 1 3 ) were lower in carcinomas compared to fibroadenomas . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
When we compared the time course of viscosity increase of CK 8 in combination with either CK 13 , CK 18 , CK 19 or CK 20 , we found that the cytokeratin pairs 8 : 18 and 8 : 20 attained the highest viscosity values , whereas the cytokeratin pair 8 : 19 displayed a relatively low value . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Numerous immunohistochemical analyses of CK expression have been conducted using such monoclonal antibodies as CAM5 . 2 , which react with CK 8 , CK 18 , and CK 19 , and AE1 / AE3 , which react with CKs 1 8 , 10 , 14 16 and 19 in chordoma . ^^^ All of the chordoma specimens showed a strong positive immunoreactivity for CK 8 and CK 19 , whereas nine ( 56 . 3 % ) chordoma specimens showed a positive immunoreaction for CK 18 . ^^^ All of the notochord specimens were also positive for CK 8 and CK 19 , but none showed a positive immunoreaction for keratin 903 , CK 7 , or CK 18 . ^^^ The expression of CK 8 and CK 19 , observed in all of the chordoma and notochord specimens , was thus considered to be maintained throughout the neoplastic transformation , although some aberrant CK expressions ( CK 7 , CK 18 , and keratin 903 ) also occurred in the chordoma specimens examined in this study . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
METHODS : Eight cases of ASC of the liver were analyzed both clinicopathologically and immunohistochemically using antibodies of cytokeratin ( CK ) 7 , CK 8 , CK 18 , CK 19 , and CK 903 ( CK 5 , CK 10 , CK 11 , and CK 14 ) . ^^^ Almost all ACs were positive for both CK 8 and CK 18 , whereas the SCCs were positive for CK 8 in only 3 cases ( 37 . 5 % ) and for CK 18 in no cases . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The remaining tested antibodies ( CK 7 , CK 8 , CK 13 , CK 18 , CK 20 , alpha smooth muscle actin ) were negative in all cases . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
A protein panel [ p 53 , p 21 , PCNA , bcl 2 , Ki 67 , total cytokeratin ( CK ) , CK 8 , CK 10 , CK 17 , CK 18 , CK 19 , vimentin ] involved in cell cycling and epithelial differentiation was assessed immunocytochemically in all organotypic cultures with fibroblasts , in tumor cells cultivated as a monolayer , and in the original tumor sample . ^^^ The CK staining pattern seen in cultured epithelia toward embryonic CKs , CK 8 and CK 18 , suggested a simple epithelial phenotype . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Spindle shaped cells reacted with MAb CAM 5 . 2 to CK 8 in 13 of 18 eyes , but only one specimen was labeled with MAb CY 90 to CK 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
With the exception of CK 8 and CK 18 expression , the morphological and immunocytochemical characteristics of the immortalized lines closely resembled those of their respective tissues of origin and primary cultures , and all differed significantly from the HeLa cervical adenocarcinoma cell line . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Cytokeratins ( polyclonal , CAM5 . 2 , CK 7 , CK 8 , CK 18 , and CK 19 ) were expressed in the ducts and ductules but not in the acinus , and EMA expression was noted in the acinus but rarely in the ducts . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Five monoclonal antibodies specific for CK 4 , CK 8 , CK 13 , CK 18 and CK 19 were used and applied to 16 neonatal , three infantile and one adult thymus specimen , which had been obtained at autopsy , that were normal macroscopically and microscopically . ^^^ CK 4 , CK 8 , CK 13 , CK 18 and CK 19 were expressed simultaneously in the cortex , medulla and subcapsular area with the exception of CK 4 , which showed expression on the adult thymus . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Larynx : CK 14 , CK 15 ( basal , ciliated , nonciliated cells ) , CK 8 , CK 18 , CK 19 ( not in basal cells ) , CK 4 , and CK 13 ( cuboidal and squamoid cells of ventral half ) . ^^^ Lung : bronchial epithelium CK 14 and CK 15 ( basal cells only ) ; bronchial and alveolar epithelium CK 7 , CK 8 , CK 18 , and CK 19 ; bronchiolar epithelium similar but less CK 8 and no CK 7 ; pleural mesothelium CK 7 , CK 8 , and CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Intermediate filament and cytokeratin typing showed a clear predominance of the simple epithelial cytokeratins CK 8 , CK 18 and CK 19 , although the expression was reduced in comparison to the hormone receptor positive reference cell lines MCF 7 and ZR 75 1 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Results showed that the level of CK 8 , CK 18 and CK 19 expression was not altered whatever the culture substrate used . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunoblotting revealed the reaction of this CK extract to 2 pan CK antibodies , i . e . , K8 . 13 , which recognizes type 2 basic CK , and C 11 , which recognizes CK 4 , CK 5 , CK 6 , CK 8 , CK 10 , CK 13 , CK 18 . ^^^ Among monospecific antibodies , anti CK 7 ( LDS 68 ) , CK 8 ( M 20 ) , CK 13 ( KS 1A3 ) , CK 18 ( CY 90 ) , and CK 19 ( BA 17 ) antibodies showed positive reactions . ^^^ These results of one and two dimensional electrophoretic analysis suggest the presence of CK 5 , CK 7 , CK 8 , CK 13 , CK 14 , CK 15 , CK 17 , CK 18 , and CK 19 in the normal submandibular gland . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
All SHs at day 10 immunocytochemically showed positivity for albumin , transferrin , CK 8 , and CK 18 , which are markers for hepatocytes . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In this study , we prepared GST fusion proteins which contained either 174 amino acids from the C terminus of CK 8 ( CK8f ) or 134 amino acids from the C terminus of CK 18 ( CK18f ) . ^^^ CK 18 may participate in the oligomer , together with CK 8 , based on its ability to bind t PA . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The intensification of immunolabelling with some CK 8 and CK 18 antibodies may underly an active role in tumour invasion and foci of CK 17 positive cells may represent proliferating populations . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In simulated cultures of proliferative intraocular disorders , cells decreased or retained their CK 7 , CK 8 , and CK 18 , retained Vim , and increased CK 19 and GFAP , while their mesenchymal morphology became clearer over time . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
An indirect immunocytochemical technique was used to detect circulating epithelial cells after centrifugation on Ficoll gradient and fixation of mononuclear cells on slides , using a monoclonal antibody directed against three cytokeratins : CK 8 , CK 18 and CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The phenotype of the tumors expressing bcl 2 was confirmed by immunocytochemical assessment of the cytokeratin ( CK ) profile ( CK 8 , CK 18 , CK 7 , and CK 19 ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In this study , antibodies that selectively recognize phosphorylated epitopes of CK 8 or CK 18 were used to analyze CK8 / 18 phosphorylation states in normal human and murine livers , human AH biopsies , and livers of 3 , 5 diethoxycarbonyl 1 , 4 dihydrocollidine ( DDC ) intoxicated mice , the last serving as model for MB induction . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Here we report that mice lacking the CK 8 gene and hence CK intermediate filaments in hepatocytes , but still expressing the type 1 partner , ie , the CK 18 gene , do not form MBs but suffer from extensive porphyria and progressive toxic liver damage , leading to the death of a considerable number of animals ( 7 of 12 during 12 weeks of intoxication ) . ^^^ Our observations show that 1 ) in the absence of CK 8 as well as in the situation of a relative excess of CK 18 over CK 8 no MBs are formed ; 2 ) the loss of CK 8 is not compensated by other type 2 CKs ; and 3 ) porphyria and toxic liver damage are drastically enhanced in the absence of CK 8 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Three out of six of these foci contained `` progenitor cells ' ' , which are small cells immunoreactive for CK 18 , CK 7 , CK 19 , OV 6 , chrom A and stained more intensely for CK 8 than surrounding hepatocytes . ^^^ Sixteen out of 29 small cell dysplastic foci consisted of `` progenitor cells ' ' and intermediate hepatocyte like cells which were immunoreactive for CK 7 , CK 18 , OV 6 , chrom A and showed a stronger cytoplasmic positivity for CK 8 than surrounding hepatocytes . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Neuroendocrine markers , CK 8 and CK 18 can aid in confirming their presence . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The present study also reports a comparative analysis by immunolabeling , SDS PAGE , and immunoblotting with anticytokeratins CK 8 , CK 18 , and CK 19 antibodies of both the ovarian follicle and the intestine of Podarcis sicula . ^^^ This study shows the presence in the ovarian follicle of this reptile only of keratin forms of homologues to the CK 8 and CK 18 of mammals and the lack of CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Pan CK , CK 8 , CK 18 , and CK 19 were more frequently demonstrated in PNT than SPT . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In addition , more extensive phenotyping of ' progenitor cells ' was performed on sections from frozen material from five patients , using antibodies against CK 7 , CK 8 , CK 18 , CK 19 , chromogranin A , and the rat oval cell marker OV 6 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Neoplastic cells forming ductlike structures in the MHC of monkey No . 2 stained with LMWCK , CK 7 , CK 8 , CK 18 , BSCK , and GST but not with HMWCK or CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
RESULTS : All immortohepatocytes in culture stained positive by immunohistochemistry for the hepatocyte markers albumin , AFP , CK 8 and CK 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In two thirds of the advanced disease biopsies , the entire pathological lining epithelium was strongly reactive for both CK 8 and CK 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Columnar ( respiratory ) epithelium in inverted papillomas abundantly expressed CK 7 , CK 8 , CK 18 , and CK 19 . ^^^ Transitional ( cuboidal ) and squamous epithelium in inverted papillomas comparably expressed CK 7 , CK 8 , CK 18 , and CK 19 . ^^^ Transitional ( cuboidal ) and squamous epithelium in nonpaillomatous mucosa were negative for CK 7 , CK 8 , CK 18 , and CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Renal and extrarenal MRTs showed positive immunoreactivity for both CK 8 and CK 18 . ^^^ Classical type ESs were diffusely positive , not only for CK 8 and CK 18 , but also for other cytokeratin subunits including CK 4 , 6 , 10 , 13 , 16 , 17 , and `` high molecular weight ' ' CKs ( CK 1 , 5 , 10 , and 14 ) . ^^^ In conclusion , the inclusion bodies of RCs show immunoreactivity confined to CK 8 , CK 18 , and vimentin . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We hypothesized that serum antibodies to CK 8 , CK 18 and CK 19 may be formed in patients with AIH . ^^^ We established an enzyme linked immunosorbent assay ( ELISA ) to quantify anti CK 8 , anti CK 18 and anti CK 19 antibodies in sera of patients with AIH . ^^^ In addition , we quantified circulating CK 8 : anti CK 8 antibody as well as CK 18 : anti CK 18 antibody immune complexes in patients ' sera , by an enzyme linked immunosorbent assay ( ELISA ) . ^^^ Furthermore , to evaluate the expression of CK 8 , CK 18 and CK 19 in liver tissue , immunohistochemical stainings were performed . ^^^ Significantly high levels of anti CK 8 , anti CK 18 and anti CK 19 antibodies were demonstrated in patients with AIH compared with normal volunteers and patients with chronic active hepatitis C ( CH C ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The suitability of `` real time ' ' quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) for the detection of isolated carcinoma cells in bone marrow was investigated by evaluating the expression of cytokeratin ( CK ) 7 , CK 8 , CK 18 , CK 19 , and CK 20 in 17 gastrointestinal cancer cell lines , 64 control bone marrow specimens from noncancer patients , and 30 bone marrow specimens from patients with gastric or colorectal cancer . ^^^ RT PCR products for CK 8 and CK 18 were detected in all cancer cell lines , but only 16 , 5 , and 11 cell lines provided evidence for CK 19 , CK 7 , and CK 20 transcription . ^^^ Variable numbers of bone marrow specimens from noncancer patients demonstrated background transcription of CK 8 ( 78 . 1 % ) , CK 18 ( 95 . 3 % ) , CK 19 ( 35 . 9 % ) , CK 20 ( 29 . 6 % ) , and CK 7 ( 16 . 7 % ) . ^^^ Maximal background transcription for CK 8 , CK 18 , and CK 19 ranged from 52 . 2 to 56 . 1 copies / 10 ( 3 ) copies glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) , the corresponding values of 0 . 06 and 0 . 76 copies for CK 7 and CK 20 being distinctly lower . ^^^ Maximal background expression values of the different CKs as obtained in the control series were exceeded once ( CK 20 ) , twice ( CK 18 and CK 19 ) , and 18 times ( CK 7 ) in bone marrow specimens from cancer patients , with none of these specimens exceeding the maximal background expression value of CK 8 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The present study demonstrates that the majority of cells in embryonic urogenital sinus epithelium and developing prostatic epithelium ( rat , mouse , and human ) co expressed luminal cytokeratins 8 and 18 ( CK 8 , CK 18 ) , the basal cell cytokeratins ( CK 14 , CK 5 ) , p 63 , and the so called transitional or intermediate cell markers , cytokeratin 19 ( CK 19 ) and glutathione S transferase pi ( GSTpi ) . ^^^ The majority of luminal cells in adult rodent and human prostates only expressed luminal markers ( CK 8 , CK 18 ) , while the basal epithelial cell compartment contained several distinct subpopulations . ^^^ However , a small fraction of adult prostatic basal epithelial cells co expressed the full spectrum of basal and luminal epithelial cell markers ( CK 5 , CK 14 , CK 8 , CK 18 , CK 19 , p 63 , GSTpi ) . ^^^ These progenitor / stem cells differentiate into mature luminal cells by maintaining CK 8 and CK 18 , and losing all other makers . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The cells were double stained with a ubiquitin antibody and one of the following antibodies : CK 8 , CK 18 , tubulin , mutant ubiquitin ( UBB+1 ) , transglutaminase , phosphothreonine , and the 20S and 26S proteasome subunits P 25 and Tbp 7 , respectively . ^^^ These results support the concept that MBs are aggresomes of CK 8 and CK 18 and are a result of inhibition of the ubiquitin proteasome pathway of protein degradation possibly caused by UBB+1 . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
CK 8 and CK 18 expression was studied by competitive reverse transcriptase polymerase chain reaction , in situ hybridization , Western blot analysis , and immunofluorescence microscopy . ^^^ Common bile duct ligation and cholic acid feeding significantly stimulated CK 8 and CK 18 mRNA and protein levels compared to controls , whereas UDCA had no effect . ^^^ Our results show that potentially toxic bile acids induce hepatocytic CK 8 and CK 18 expression and phosphorylation whereas nontoxic UDCA has no effect on CKs . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
RESULTS : The expression of CK 8 , CK 13 and CK 18 were observed in 39 , 9 and all 43 of the columnar epithelial linings , respectively . ^^^ Metaplastic squamous epithelia expressed more CK 13 , and less CK 18 and CK 8 . ^^^ Of the 33 metaplastic linings , 24 expressed CK 8 , 23 CK 13 and 26 linings expressed CK 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The results suggest that CK 8 , CK 18 and CK 19 expression and distribution pattern could be of predictive value as a marker of disease progression as defined by the appearance of lymph node metastases in oesophageal squamous cell cancer . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
RESULTS : Of the maxillary cysts , 20 , 29 and 19 squamous epithelial linings were positive for CK 8 , CK 13 and CK 18 , respectively ; of the mandibular cysts , 10 , 20 and 11 linings were positive for these CKs , respectively . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
RESULTS : Thirteen cases ( eight DCIS and five IDC ) showed expression of CK 8 , CK 14 , CK 18 , vimentin , and EGFR , consistent with a stem cell phenotype , whereas 44 cases ( 27 DCIS and 17 IDC ) showed expression of CK 8 and CK 1 , weak or negative expression of CK 18 , but were negative for vimentin and EGFR , consistent with a luminal cell phenotype . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
To further elucidate the histogenesis of carcinomas arising in a PTC , mAbs to hair follicle stem cells and to hair follicle differentiation specific cytokeratins ( mAbs to cytokeratin [ CK ] 7 , CK 8 , CK 18 , and CK 19 as well as mAbs to CD8 / CK15 and CD 34 ) were studied on paraffin embedded sections of two cases of carcinoma arising in a PTC , one anaplastic carcinoma , and one poorly differentiated squamous cell carcinoma ( SCC ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We evaluated the expression patterns of a broad range of low to intermediate molecular weight cytokeratins ( CK 7 , CK 8 , CK 10 , CK 17 , CK 18 , CK 19 , and CK 20 ) and high molecular weight cytokeratins ( K 903 : a combination of CK 1 , CK 5 , CK 10 , and CK 14 ; and CK5 / 6 ) in these cases . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunohistochemical ( IHC ) stains were performed for CK 8 , CK 18 , CK 19 , vimentin , villin , Tamm Horsfall protein ( THP ) , renal cell carcinoma marker ( RCC ) , epithelial membrane antigen ( EMA ) , ulex europaeus agglutinin ( UEA 1 ) , soy bean agglutinin ( SBA ) , peanut agglutinin ( PNA ) , and MIB 1 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Like DDC refeeding , both CBDL and CA feeding of drug primed mice significantly increased CK 8 and CK 18 mRNA and protein levels ( with excess of CK 8 ) and resulted in ubiquitination and abnormal phosphorylation of CKs . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
METHODS : CK 8 and CK 18 mRNA and protein levels were investigated by reverse transcriptase polymerase chain reaction and Western blotting . ^^^ RESULTS : Despite unchanged mRNA levels , CK 8 and CK 18 protein levels were significantly elevated in PBC suggesting stabilization of CKs , possibly due to decreased degradation . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Anti CK antibodies , including OV TL12 / 30 ( CK 7 ) , c 51 ( CK 8 ) , DC 10 ( CK 18 ) and IT Ks20 . 8 ( CK 20 ) did not react with the amyloid deposits . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
RESULTS : Immunoreactivities for CK 8 , CK 18 , CK 7 and the receptor for LN were observed in all the six HCC cell lines examined . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The expressions of MUC 1 , MUC 2 , MUC5AC , MUC 6 , CK 7 , CK 8 , CK 13 , CK 14 , CK 18 , CK 19 and CK 20 were evaluated immunohistochemically in 426 adenocarcinomas and 60 hepatocellular carcinomas using the tissue array method . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunostaining for CK 7 , CK 8 , CK 18 , CK 19 , CK 20 , alpha fetoprotein , p CEA , and HepPar 1 revealed that hepatoid areas of both primary and metastatic HAC have a specific immunoprofile , distinctive of this entity . ^^^ On the one hand , positivity of virtually all HACs for alpha fetoprotein , CK 8 , CK 18 , and the membranous , canalicular staining for polyclonal carcinoembryonic antigen underline its hepatoid nature . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Partial amino acid sequencing analysis demonstrated that these Ub immunoreactive spots corresponded to CK 8 and CK 18 ; however , since they did not have an amino terminal domain , and were located at lower molecular weight positions than intact CK 8 and CK 18 on the 2 D gel , they were regarded as degradation products . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunocytochemistry ( ICC ) was used to detect the expression of hepatic proteins such as AFP , ALB , cytokeratin 8 ( CK 8 ) and cytokeratin 18 ( CK 18 ) in the cells on the days 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , and 15 . ^^^ ICC showed that AFP , ALB , CK 8 , and CK 18 began to be expressed on day 8 , day 10 , day 10 , and day 11 respectively . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The expression of hepatic proteins , such as alpha fetoprotein ( AFP ) , albumin ( ALB ) , cytokeratin 8 ( CK 8 ) , cytokeratin 18 ( CK 18 ) , in cytoplasm was analyzed by immunocytochemistry ( ICC ) . ^^^ Our ICC assay showed that differentiating cells did not express hepatic proteins , such as AFP , ALB , CK 8 , and CK 18 until day 7 , day 9 , day 11 , and day 11 , respectively ( up to 2 days later when growth factors are not present ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Cytokeratins CK 8 and CK 18 were overexpressed in both HuCCA 1 and HCC , while CK 7 and CK 19 were only expressed in HuCCA 1 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The overall positive rates were 84 . 7 % for CK 4 , 3 . 2 % for CK 5 , 28 . 7 % for CK 6 , 71 . 1 % for CK 7 , 96 . 6 % for CK 8 , 0 % for CK 10 , 81 . 6 % for CK 13 , 0 . 3 % for CK 14 , 4 . 1 % for CK 16 , 0 % for CK 17 , 99 . 4 % for CK 18 , 89 . 7 % for CK 19 , and 30 . 0 % for CK 20 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Positive staining rates of MBs in 37 cases were as follows : CK 8 , 100 % ( 37 / 37 ) ; CK 18 , 100 % ( 37 / 37 ) ; CK 19 , 57 % ( 21 / 37 ) . ^^^ Thus , all present MBs were composed of similar material with common antigenic determinants , regardless of underlying disease ; in particular , they consistently contained CK 8 and CK 18 , and frequently contained CK 7 , CK 19 , and CK 20 . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Here , we describe for the first time in human umbilical cord blood cells ( UCB ) the pattern of expression of a panel of markers ( nestin , CK 8 , CK 18 ) and transcription factors ( Isl 1 , Pdx 1 , Pax 4 , Ngn 3 ) considered important for beta cells differentiation . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Thirty nine cases of AOT from three Oral Diagnosis services ( Brazil , Mexico and Guatemala ) were studied , considering their clinical , radiographic , and histological features and immunohistochemical expression of cytokeratins ( AE1 / AE3 , 34betaE12 , CK 1 , CK 5 , CK 6 , CK 7 , CK 8 , CK 10 , CK 13 , CK 14 , CK 16 , CK 18 , and CK 19 ) , vimentin and Ki 67 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Xenotransplants were characterized with histochemistry ( HE , PAS ) , immunohistochemistry ( cytokeratin ( CK ) 7 , CK 8 , CK 18 , CK 19 , CK 20 , vimentin , chromogranin A ( Chr A ) , alpha 1 antichymotrypsin ( alpha 1 chym ) , beta catenin , laminin 5 , pancreatic and duodenal homeobox gene 1 ( pdx 1 ) , sonic hedgehog protein ( shh ) , Patched ( ptc ) ) , Western blotting and real time PCR ( CK 7 , CK 8 , CK 20 , Chr A , pdx 1 , shh , ptc ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
METHODS : We used the urothelium of anuric patients on long term hemodialysis , sampled at the time of renal transplantation , to investigate the expression of urothelial differentiation associated antigens , including uroplakins ( UPIa , UPIb , UPII , and UPIIIa ) , cytokeratin isotypes ( CK 7 , CK 8 , CK 13 , CK 14 , CK 17 , CK 18 , and CK 20 ) , nuclear hormone receptors [ peroxisome proliferators activated receptor gamma ( PPAR gamma ) and retinoid 10 receptor alpha ( RXR alpha ) ] , and a cell cycle marker ( Ki 67 ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Cells characterized by a group of markers ( Nestin , CK 8 , CK 18 ) and transcription factors ( Isl 1 , Pdx 1 , Pax 4 , Ngn 3 ) important for beta cell differentiation have been detected in umbilical cord blood . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
CBP was suppressed in basal cytokeratin positive HMECs ( CK5 / 6+ , CK14+ , CK 8 , CK 18 , CK 19 ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Uranium treatment triggered differential expression of 18 spots , of which 14 corresponded to fragments of cytokeratin 8 ( CK 8 ) and cytokeratin ( CK 18 ) and 1 to peroxiredoxin 1 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
These CK5+ / CK6+ cells had decreased expression of luminal epithelial CK 8 , CK 18 , and CK 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
RESULTS : In contrast to MCF 7 and MTSV 1 7 reference cell lines , all micrometastatic cancer cell lines displayed loss of epithelial cytokeratins ( CK 8 , CK 18 , and CK 19 ) and ectopic expression of vimentin commonly present in mesenchymal cells . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We determined , using ERalpha activating function 2 mutants , that helix 12 ( H 12 ) of ERalpha , but not its F domain , is essential for fulvestrant induced ERalpha CK 8 and CK 18 interactions . ^^^ CK18 positive human breast cancer cells , and CK 8 and CK 18 depletion by small interference RNAs partially blocked fulvestrant induced receptor degradation . ^^^ Furthermore , fulvestrant induced ERalpha degradation was not observed in CK 8 or CK 18 negative cancer cells , suggesting that these two intermediate filament proteins are necessary for fulvestrant induced receptor turnover . ^^^ Using an ERalpha green fluorescent protein construct in fluorescence microscopy revealed that fulvestrant induced cytoplasmic localization of newly synthesized receptor is mediated by its interaction with CK 8 and CK 18 . ^^^ We suggest that fulvestrant induces ERalpha to interact with CK 8 and CK 18 , drawing the receptor into close proximity to nuclear matrix associated proteasomes that facilitate ERalpha turnover . . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Recently , breast epithelium in the terminal ductal lobular unit has been sub classified based on the expression of several cytokeratin markers as stem cells ( CK5 / 6 + ) , luminal cells ( CK 8 , CK 18 + ) , and basal cells ( CK 14 , CK 17 + ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Most ductal carcinoma in situ cases are diffusely positive for luminal cell markers ( CK 8 , CK 18 , CK 19 ) , but negative for basal cell markers ( CK5 / 6 and CK 14 ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The marker genes and corresponding proteins of hepatocytes and BE cells such as AFP , ALB , CK 8 , CK 18 , CK 7 , CK 19 and GGT , etc . were detected by reverse transcriptase polymerase chain reaction ( RT PCR ) , immunocytochemistry ( ICC ) and enzymatic histochemistry . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunohistochemical staining detected PrECs positive in varying degrees for p 63 , CK 8 , and CK 18 , with only the rare cell being positive for chromogranin A . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Using a panel of antibodies to ER alpha , PR , HER 2 / neu , and EGFR , along with cytokeratin ( CK ) markers ( CK5 / 6 , CK 8 , CK 14 , CK 17 , and CK 18 ) , we found that all 3 cell origin subtypes can express ER alpha and PR , and their expression is higher in non high grade DCIS than in high grade DCIS ; the expression of HER 2 / neu is associated with luminal subtype only in non high grade DCIS , but can be seen in all 3 subtypes in high grade DCIS ; the expression of EGFR is low and is present only in luminal cell subtypes in both high and non high grade DCIS . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Clear cell RCCs typically showed a restricted expression pattern of CK 8 , CK 18 and Vim . ^^^ Papillary RCCs typically expressed CK 7 , CK 8 , CK 18 , CK 19 , and Vim and could be distinguished from MA ( CK 7 ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Human liver parenchymal cells have a very simple cytokeratin composition and express only one cytokeratin pair : cytokeratin 8 ( a type 2 cytokeratin , molecular weight 52 kD ) and cytokeratin 18 ( a type 1 cytokeratin , molecular weight 45 kD ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Three distinct types of alveolar cells were detected according to their pattern of immunoreactivity : type 2 cells strongly expressing cytokeratins 8 and 18 and weakly expressing cytokeratins 7 and 19 in the cell periphery ; type 1 cells predominantly positive for cytokeratins 7 and 19 and weakly for cytokeratin 8 ; and a newly defined third cell type 3 ( alveolar brush cell ) with cytokeratin 18 abundantly expressed but organized in an unusual intracellular ( `` globular ' ' ) structure . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The mRNAs of the other six genes ( those encoding for cytokeratin 8 , cytokeratin 18 ( Endo B ) , TIMP 2 and three unknown sequences ) were not found in YS , but were present in LYs . ^^^ Interestingly , CTLA 1 is a non epithelial ( hematopoietic ) cell specific gene in terms of transcription , while cytokeratin 8 and cytokeratin 18 are both epithelium specific genes . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
By contrast , cytokeratin 18 , a differentiation marker of simple epithelia , and to a lesser extent cytokeratin 8 , was consistently found in stromal tissue of the `` transition zone ' ' , but only scarcely in the stroma of the `` peripheral zone ' ' from normal prostate , and was completely unexpressed in benign hyperplasia . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Subsequent blotting with a panel of specific cytokeratin antibodies strongly supported the idea that the two proteins were cytokeratin 8 and cytokeratin 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Differential screening isolated four differentially expressed genes : cytokeratin 8 , cytokeratin 18 , Hsp 27 and GPCR Br . ^^^ Sequence analysis revealed that 11 clones were from previously described genes : HEK 8 , neuropeptide Y receptor Y 1 , p 21 WAF 1 , p 55 PIK , cytokeratin 18 ( cloned twice ) , fructose 1 , 6 biphosphatase , cytokeratin 8 , TGFbeta 1 binding protein , elongation factor 1alpha2 and pS 2 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Six antibodies bound selectively to cytokeratin 8 , 14 to cytokeratin 18 , and 10 to cytokeratin 19 , as demonstrated by using native , recombinant , and synthesized antigens . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In addition , we observed that a number of unrelated genes including alpha tubulin , beta actin , gamma actin , cytokeratin 8 , cytokeratin 18 , and c myc are overexpressed in cultured hepatocytes , and they are also overexpressed during liver carcinogenesis and in transplantable tumors . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Of those , alpha 3 / alpha 7 tubulin and vimentin were down regulated , while cytokeratin 8 , cytokeratin 18 , G1 / S special cyclin D 2 , follistatin related protein , NEL protein , platelet activating factor acetylhydrolase IB alpha subunit , and thioredoxin peroxidase 2 were upregulated during differentiation of ES cells to neural cells . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Vimentin , cytokeratin 8 and cytokeratin 18 are not specific markers for M cells in human palatine tonsils . ^^^ Standard immunohistochemical methods were used to detect the presence of vimentin , cytokeratin 8 , cytokeratin 18 , macrophages and Langerhans cells in the human tonsillar epithelium in formalin fixed and frozen tissue specimens . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The intermediate filament network in simple glandular epithelial cells predominantly consists of heterotypic complexes of cytokeratin 8 ( K 8 ) and cytokeratin 18 ( K 18 ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The expressions of cytokeratin 8 , cytokeratin 18 and vimentin were detected by immunocytochemistry . mRNA expressions of matrix metalloproteinases ( MMPs ) and tissue inhibitors of metalloproteinases ( TIMPs ) were detected by semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ The original strong positive expression of cytokeratin 8 and cytokeratin 18 was changed in all morphologically changed HPMCs to negative , but the expression of vimentin maintained positive . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
However , differences were found for the two cell lines with respect to the type of cytokeratin : in ECV 304 cells mainly cytokeratin 18 ( 45 kDa ) is found , whereas in T 24 cells cytokeratin 8 ( 52 kDa ) is predominant . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Proteins that were highly enriched in the IMCD fraction included cytokeratin 8 , cytokeratin 18 , transglutaminase 2 , aminopeptidase B , T plastin , heat shock protein ( HSP ) 27 , HSP 70 , and lactate dehydrogenase A . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Interestingly , nine protein spots were identified as intermediate microfilament proteins , including cytokeratins ( five spots for cytokeratin 8 , two for cytokeratin 19 , and one for cytokeratin 18 ) and vimentin . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
An immunohistochemical panel consisting of desmin , smooth muscle actin , S 100 , vimentin , CD 34 , carcinoembryonic antigen , pancytokeratin , cytokeratin 7 , cytokeratin 8 , cytokeratin 17 , cytokeratin 18 , cytokeratin 19 , and cytokeratin 20 was applied to paraffin sections . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Arsenic / TPA treatment resulted in increased expression of alpha fetoprotein , k ras , c myc , estrogen receptor alpha , cyclin D 1 , cdk2na , plasminogen activator inhibitor 1 , cytokeratin 8 , cytokeratin 18 , glutathione S transferases and insulin like growth factor binding proteins in liver and liver tumors from both male and female mice . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In this study , we identified the components of the 7G10 MAb bound complex as cytoskeletal filaments : vimentin , cytokeratin 8 , cytokeratin 18 , actin , and hair type 2 basic keratin . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
F 9 embryonal carcinoma cells ( F9EC ) can be induced to differentiate in vitro into epithelial cells expressing keratin 8 ( K 8 ) and keratin 18 ( K 18 ) . cDNAs corresponding to K 8 and K 18 mRNAs were cloned and used to study the change in the abundance of these mRNAs during differentiation of F 9 cells into parietal endoderm like cells by treatment with retinoic acid ( RA ) or with RA and dibutyryl cAMP ( Bt2cAMP ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Species with molecular masses of 54 ( keratin 7 ) , 52 ( keratin 8 ) , 42 ( keratin 18 ) , and 40 ( keratin 19 ) kiloDaltons were the most abundant in proliferating cultured cells , but cells isolated directly from the eye were found to lack keratin 7 and 19 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Immunoblotting experiments suggest that this protein is equivalent to the mammalian type 1 keratin 18 protein , which typically pairs with keratin 8 to form filaments . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
This chromosome contains several genes for type 2 keratins and also the gene for keratin 18 , the type 1 keratin that is coexpressed with keratin 8 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
When rat liver keratin filaments reconstituted by type 1 keratin 18 ( molecular mass 47 kDa ; acidic type ) and type 2 keratin 8 ( molecular mass 55 kDa ; basic type ) in a 1 : 1 ratio were used as substrates , all the protein kinases phosphorylated both of the constituent proteins to a significant rate and extent , and disassembly of the keratin filament structure occurred . ^^^ Kinetic analysis suggested that all these protein kinases preferentially phosphorylate keratin 8 , compared to keratin 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin 8 ( Endo A ) is expressed in simple epithelia , together with keratin 18 ( Endo B ) . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Human keratin 18 ( K 18 ) and keratin 8 ( K 8 ) and their mouse homologs , Endo B and Endo A , respectively , are expressed in adult mice primarily in a variety of simple epithelial cell types in which they are normally found in equal amounts within the intermediate filament cytoskeleton . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Frozen sections were stained with monoclonal antibodies M 20 ( keratin 8 ) , M 9 ( keratin 18 ) , and LP2K ( keratin 19 ) with the use of the indirect immunoperoxidase technique . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin 8 ( K 8 ) and keratin 18 ( K 18 ) are intermediate filament proteins normally expressed in simple epithelial tissues and persistently expressed in a wide variety of carcinomas . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin 8 appeared in vallate taste cells at P 0 ( postnatal day 0 ) , followed by keratins 7 and 19 at P 1 , and keratin 18 at P 2 P3 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin 8 ( mK 8 ) and its partner keratin 18 ( mK 18 ) are the first intermediate filament proteins expressed during mouse embryogenesis . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Analysis of frozen tissue sections by in situ hybridization revealed that , in the adult intestine , keratin 18 and 19 mRNAs are restricted to the region of the crypts , keratin 8 mRNA is found along the entire crypt villus axis , and keratin 20 mRNA is expressed only by the differentiated villus cells . ^^^ Upon completion of villus formation at 20dg ( 2 days before birth ) keratin 18 and 19 mRNAs become strictly confined to cells at the base of the nascent villi and we observed the appearance of keratin 20 mRNA which , like keratin 8 mRNA , is expressed by the entire epithelium . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin filaments in simple epithelial cells are heteropolymers of keratin 8 ( K 8 ) and keratin 18 ( K 18 ) , which can be stained by the monoclonal antibody ( MAb ) LE 61 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We reported earlier that phosphorylation in vitro of keratin filaments reconstituted from rat type 1 keratin 18 and type 2 keratin 8 by cAPM dependent protein kinase induces disassembly of the keratin filament structure . ^^^ Keratin 8 rather than keratin 18 was the major target of the kinase . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Feeding ethanol to rats results in dephosphorylation of one site on keratin 8 and one site on keratin 18 at all time points beginning with 6 weeks of ethanol treatment . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin 8 , keratin 18 and desmoplakin I / II are the major cytoskeleton associated targets for microcystin LR induced phosphorylation . ^^^ Phosphopeptide mapping shows that four specific tryptic phosphopeptides are highly phosphorylated predominantly in the soluble pool of keratin 18 , whereas keratin 8 shows no indications of such assembly state specific sites . ^^^ Phosphopeptide maps of keratins phosphorylated in vivo and in vitro indicate that Ca2+ / calmodulin dependent kinase may be involved in regulating the serine specific phosphorylation of both keratin 8 and keratin 18 , while cAMP dependent protein kinase does not seem to play a major role in this context . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin 8 ( K 8 ) and keratin 18 ( K 18 ) are the most common and characteristic members of the large intermediate filament gene family expressed in ' simple ' or single layer epithelial tissues of the body . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin filaments in simple epithelial cells are heteropolymers of keratin 8 ( K 8 ) and keratin 18 ( K 18 ) polypeptides . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratin 8 ( K 8 ) and keratin 18 ( K 18 ) form intermediate filaments characteristic of liver and other single cell layered , internal epithelia and their derivative cancers . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The expression of hsp 90 client protein genes was not affected , but hsc hsp 70 , hsp90beta , keratin 8 , keratin 18 and caveolin 1 were deregulated following treatment . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
In the resting breast , keratin 18 and keratin 8 were detected in luminal epithelial cells in a filamentous form , whereas in lactating tissue it was present in a punctate form in luminal cells and also seen as granules in the lumen of alveoli . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We have previously described a mutation in the keratin 18 gene in a patient with cryptogenic cirrhosis , but the importance of mutations in the keratin 8 and keratin 18 genes in such patients is unclear . ^^^ METHODS : We tested for mutations in the keratin 8 and keratin 18 genes in purified genomic DNA isolated from 150 explanted livers and 89 peripheral blood specimens from three groups of patients : 55 patients with cryptogenic liver disease ; 98 patients with noncryptogenic liver disease , with causes that included alcohol use , autoimmunity , drug use , and viral infections ; and 86 randomly selected inpatients and outpatients who provided blood to the hematology laboratory . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Moreover , the 1 : 1 ratio of keratin type 1 ( keratin 18 ) and type 2 ( keratin 8 ) necessary for the assembly of intermediate filaments is disturbed and the equilibrium shifted toward keratin 8 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The following candidate genes have been examined in detail to determine whether polymorphisms in them may be responsible for this variation : transferrin , transferrin receptor 1 , transferrin receptor 2 , ferritin L , ferritin H , IRP 1 , IRP 2 , HFE , beta ( 2 ) microglobulin , mobilferrin / calreticulin , ceruloplasmin , ferroportin , NRAMP 1 , NRAMP 2 ( DMT 1 ) , haptoglobin , heme oxygenase 1 , heme oxygenase 2 , hepcidin , USF 2 , ZIRTL , duodenal cytochrome b ferric reductase ( DCYTB ) , TNFalpha , keratin 8 , and keratin 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Co polymers of the type 2 keratin 8 and type 1 keratin 18 form the major intermediate filament network in simple epithelia . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The proteins identified were heat shock protein 90 alpha , and beta , heterogeneous nuclear ribonucleoprotein F , RNA polymerase 2 mediating protein , cytoskeletal keratin 8 , cytoskeletal keratin 18 , ubiquitin conjugating enzyme E 2 18 kDa and nucleoside diphosphate kinase B . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Mutation of the cytoskeletal intermediate filament proteins keratin 8 and keratin 18 ( K8 / K18 ) is associated with cirrhosis in humans , whereas transgenic mice that overexpress K 18 Arg89 > Cys ( R89C ) have significant predisposition to liver injury . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
To investigate whether clusterin has a function in the stress response to misfolded keratins , we performed transfection studies utilizing expression constructs encoding ubiquitin , p 62 , Hsp 27 , clusterin , keratin 8 , and keratin 18 . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
RESULTS : We identified 10 novel keratin 8 and 18 heterozygous variants in 44 of 467 explants and 11 of 349 controls : keratin 18 deletion ( delta 64 71 ) , a keratin 8 frameshift that truncates the last 14 amino acids ; 8 missense keratin 8 and 18 alterations ; and several new polymorphisms . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
We also determined that a type 1 keratin gene , KRT 18 , is located next to its partner , KRT 8 , in this cluster . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
The results suggested that , along with PSA , PSM ( FOLH 1 ) , kallikrein 2 , and a 2 macroglobulin , cell signaling genes EGFR , HER 2 , HER 3 , TOP 2 , KRT 8 , KRT 18 , VEGF , CD 44 , VIM , CAV 1 , and CAV 2 may serve as diagnostic and prognostic markers in PC . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
Keratins 8 and 18 ( KRT 8 and KRT 18 genes ; K 8 and K 18 proteins ) variants are risk factors for developing end stage liver disease and may be associated with inflammatory bowel disease and chronic pancreatitis . ^^^
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05787 and P05783	Pubmed	SVM Score :0.0
NA