| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :1.1761046 |
| One of protein kinase C ( PKC ) isozymes , PKC beta binds to receptor for activated C kinase 1 ( RACK 1 ) , and their complex is suggested to be translocated to melanosomes . 1.1761046^^^ |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| By comparison , phorbol ester stimulated translocation of this activity and of PKC delta and epsilon immunoreactivity was absent in cortex from aged animals , as well as the translocation of the calcium dependent PKC beta , also known to interact with RACK 1 . ^^^ |
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| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| UV / DECA treatment of synthetic peptides modeled after the RACK 1 binding site in the C 2 region of PKC beta induced modification of Ser 218 Leu Asn Pro Glu Trp Asn Glu Thr 226 , but not of a control peptide . ^^^ |
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| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| Acute morphine ( 30 mg kg ( 1 ) , i . p . , 2 h ) induced significant increases in the densities of RACK 1 ( 33 % ) , PKC alpha ( 35 % ) and PKC beta ( 23 % ) . ^^^ In contrast , chronic morphine ( 10 100 mg kg ( 1 ) , i . p . , 5 days ) induced a decrease in RACK 1 levels ( 22 % ) , paralleled by decreases in the levels of PKC alpha ( 16 % ) and PKC beta ( 16 % ) . 3 . ^^^ Spontaneous ( 48 h ) and naloxone ( 2 mg kg ( 1 ) , i . p . , 2 h ) precipitated morphine withdrawal after chronic morphine induced marked up regulations in the levels of RACK 1 ( 38 41 % ) , PKC alpha ( 51 52 % ) and PKC beta ( 48 62 % ) . 4 . ^^^ In the same brains and for all combined treatments , there were significant positive correlations between the density of RACK 1 and those of PKC alpha ( r=0 . 85 , n = 35 ) and PKC beta ( r=0 . 75 , n=32 ) . 5 . ^^^ |
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| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| We detected the receptor for activated C kinase 1 ( RACK 1 ) , the specific receptor for activated protein kinase C beta ( PKC beta ) , to be up regulated in bovine cord forming EC in vitro and in angiogenically active stages of bovine corpora lutea in vivo . ^^^ |
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| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| Enhanced PKC beta 2 translocation and PKC beta 2 RACK 1 interactions in PKC epsilon induced heart failure : a role for RACK 1 . ^^^ Although receptors for activated C kinase ( RACKs ) have been shown to direct PKC signal transduction , the mechanism through which RACK 1 , a selective PKC beta 2 RACK , participates in PKC beta 2 mediated cardiac hypertrophy and failure remains undefined . ^^^ More importantly , we demonstrate that high levels of PKC epsilon activation induce a significant colocalization of PKC beta 2 with RACK 1 ( 154 + / 7 % of control ) and a marked redistribution of PKC beta 2 to the particulate fraction ( 17 + / 2 % of total PKC beta 2 in control mice vs . 49 + / 5 % of total PKC beta 2 in hypertrophied mice ) , without compensatory changes of the other eight PKC isoforms present in the mouse heart . ^^^ This enhanced PKC beta 2 activation is coupled with increased RACK 1 expression and PKC beta 2 RACK 1 interactions , demonstrating PKC epsilon induced PKC beta 2 signaling via a RACK 1 dependent mechanism . ^^^ |
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| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| RACK 1 , an intracellular adapter for activated PKC beta , also co immunoprecipitated with alpha ( IIb ) beta ( 3 ) , but in this case , the interaction was constitutive . ^^^ These studies demonstrate that the interaction of alpha ( IIb ) beta ( 3 ) with activated PKC beta is regulated by integrin occupancy and can be mediated by RACK 1 and that the interaction is required for platelet spreading triggered through alpha ( IIb ) beta ( 3 ) . ^^^ |
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| Interacting proteins: P05771 and P63244 |
Pubmed |
SVM Score :0.0 |
| A relevant consequence of RACK 1 reduced expression was the observation that release of tumor necrosis factor alpha following lipopolysaccharide challenge and mitogen induced lymphocye proliferation , which involves PKC beta activation , was significantly reduced in elderly subjects . ^^^ |
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