| Interacting proteins: P05771 and P49841 |
Pubmed |
SVM Score :0.0 |
| We identified low nanomolar inhibitors of PKC beta with good to excellent selectivity vs other PKC isozymes and GSK 3beta . ^^^ |
|
| Interacting proteins: P05771 and P49841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P49841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05771 and P49841 |
Pubmed |
SVM Score :0.0 |
| Potent inhibitors ( single digit nanomolar IC ( 50 ) ) for PKC beta and GSK 3beta were identified , and compounds showed good selectivity over PKC alpha , gamma , delta , epsilon , and zeta . ^^^ |
|
| Interacting proteins: P05771 and P49841 |
Pubmed |
SVM Score :0.0 |
| Compound 33 and 36 displayed 1 2 orders of magnitude selectivity at GSK 3 beta against CDK 2 , PKC beta 2 , Rsk 3 and little or no inhibitions to the other 62 protein kinases . ^^^ Compound 46 was at least 100 fold more selective towards GSK 3 beta than PKC beta 2 , and it had little or no activity against a panel of 65 protein kinases , almost behaved as a GSK 3 beta ' specific inhibitor ' . ^^^ |
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