Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Tumor necrosis factor alpha increased the integrin alpha 2 beta 1 expression and cell attachment to type 1 collagen in human dermal fibroblasts . ^^^ This TNF induced cell attachment could be reduced significantly by anti integrin alpha 2 beta 1 antibody . ^^^ These data suggest that the increased attachment of human dermal fibroblasts to type 1 collagen appears to be mediated predominantly through the augmentation of integrin alpha 2 beta 1 expression by TNF . . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Localization of integrin alpha 2 and integrin beta 1 in human stellate cells was examined by immunoelectron microscopy . ^^^ Immunostaining was performed with a mouse monoclonal anti human integrin alpha 2 or integrin beta 1 antibody and goat anti mouse IgG coupled with 10 nm immunogold . ^^^ Integrin alpha 2 and integrin beta 1 were detected on the surfaces of cell bodies , cellular processes , and microprojections . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Flow cytometric analyses were carried out to detect expression of antigens : Lewis a ( Lea ) , Lewis 10 ( Lex ) , sialyl Lewis a ( sLea ) , sialyl Lewis 10 ( sLex ) , E cadherin , CD44v6 , integrin alpha 2 ( CD49b ) , integrin alpha 3 ( CD49c ) , integrin alpha 4 ( CD49d ) , integrin alpha 5 ( CD49e ) , and integrin beta 1 ( CD 29 ) . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
The human integrin VLA 2 is a collagen receptor on some cells and a collagen / laminin receptor on others . ^^^ The integrin heterodimer VLA 2 , previously known as a collagen receptor , is now shown also to be a laminin receptor . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
In an earlier study we had demonstrated that oncogenic Ki ras4BVal 12 , but not oncogenic Ha rasVal 12 , blocks the apicobasal polarization of colon epithelial cells by preventing normal glycosylation of the integrin beta 1 chain of the collagen receptor . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
OBJECTIVE : We sought to determine whether expression of CD 51 ( vitronectin and fibronectin receptor ) , CD 54 ( intercellular adhesion molecule 1 ) , HLA DR ( activation marker ) , CD 29 ( beta 1 integrin ) , CD49b ( collagen receptor ) , and CD11b ( complement receptor ) exhibit a circadian rhythm in asthma . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
By this technique , blood group A , B determinants were shown to be immobilized by monoclonal antibodies specific for GPIa , Ic ' , 9 , IIb / IIIa and strongly by mab specific GPIIa , but not by mab specific for HLA class 1 molecules . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Separation of important new platelet glycoproteins ( GPIa , GPIc , GPIc * , GPIIa and GMP 140 ) by f . p . l . c . ^^^ The aim of the present study was to separate rapidly , under non denaturing conditions , and characterize minor glycoproteins such as Very Late Antigens ( VLA ) ( GPIa , GPIc , GPIc * and GPIIa ) and GMP 140 ( also known as PADGEM ) . ^^^ Five minor [ GPIa , GPIc , GPIc * , GPIIa and GMP 140 ( PADGEM ) ] , as well as a major ( GPIIIb ) glycoprotein , were eluted at low salt concentrations . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
The patient ' s serum immunoprecipitated two proteins from 125I labeled HPA 5b positive platelets that migrated under both nonreducing and reducing conditions on sodium dodecyl sulfate polyacrylamide gels at molecular weights characteristic of GPIa ( 150 Kd and 165 Kd , respectively ) and GPIIa ( 120 Kd and 145 Kd , respectively ) . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
This report focuses on newly reported integrins ( GPIa , GPIc , GPIIa ) , selectins ( GMP 140 ) and GPIIIb , previously known as ' minor ' surface oriented platelet glycoproteins . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
From 125I labeled EC , an anti platelet antiserum was found to immunoprecipitate major surface polypeptides comigrating with platelet GPIa , GPIIa and GPIIIa , and a protein with relative molecular mass Mr = 54 , 000 . ^^^ On the other hand , anti EC antisera precipitated mostly GPIa , GPIc , GPIIa and GPIIIa from 125I labeled platelets . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Sera from two patients with systemic lupus erythematosus ( SLE ) contained antibodies that immunoprecipitated surface molecules from platelets and fibroblasts that comigrated on SDS PAGE and two dimensional O ' Farrell gels with platelet GPIa ( VLA alpha 2 chain ) and platelet GPIIa ( VLA beta chain ) . ^^^ Two dimensional O ' Farrell analysis demonstrated no differences in the molecular weight or isoelectric point of GPIa and GPIIa obtained from platelets of alloantibody reactive or unreactive donors . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Utilizing one dimensional SDS PAGE , two dimensional O ' Farrell gel electrophoresis , and nonreduced reduced two dimensional gel electrophoresis , we show that reduced VLA molecules of platelets are composed of three chains of molecular weights 165 , 000 , 145 , 000 , and 140 , 000 that possess the physicochemical properties of platelet glycoproteins GPIa , GPIc alpha , and GPIIa . ^^^ GPIa corresponds to the VLA 165 , 000 alpha 2 chain , GPIIa corresponds to a 145 , 000 Mr VLA beta chain , and GPIc alpha corresponds to a 140 , 000 Mr VLA alpha chain . ^^^ Platelet proteins GPIa and GPIIa exist as a mixed heterodimer in detergent lysates and correspond with the VLA 2 heterodimer found on activated T lymphocytes and other cell types . ^^^ The mAb A 1A5 , which binds to the VLA beta chain , binds to platelet GPIIa and precipitates both the GPIIa GPIa and GPIIa GPIc heterodimers , and binds to 4 , 926 + / 740 sites per platelet . ^^^ A VLA 2 specific mAb , 12F1 , which binds to the VLA alpha 2 chain reacts with GPIa and immunoprecipitates only the GPIIa GPIa heterodimer , and binds to 1 , 842 + / 449 sites per platelet . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
This platelet aggregation activity was dose dependently inhibited by specific GPIbalpha antibodies , but not by those antibodies against platelet GPIa , GPIIa , GPIIb and GPIIIa . . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Flow cytometric analysis showed that TMVA did not bind to platelet GPIX , GPIIb , GPIIIa , GPIa , GPIIa and GPIV . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
No mutation was identified in the genes encoding for GPIa or GPIIa . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Both OCs and FBGCs expressed the alpha chains of the vitronectin receptor ( CD 51 ) and of the VLA 2 ( CDw49b ) and VLA 4 ( CDw49d ) molecules as well as their respective beta chains , gpIIIa ( CD 61 ) and CD 29 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
CD45RO , VLA beta 1 ( CD 29 ) , VLA 5 alpha ( CD49e ) , LFA 1 ( CD11a / 18 ) , and CD 2 were found to be closely coregulated on CD4+ T cells , while regulation of VLA 2 alpha ( Cd49b ) , VLA 4 alpha ( CD49d ) and CD 44 was quite discordant . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
HTSC express CD 54 ( ICAM 1 ) , CD49a ( VLA 1 ) , CD49b ( VLA 2 ) , CD49c ( VLA 3 ) , CD49e ( VLA 5 ) , CD49f ( VLA 6 ) , CD 29 , CD 51 , CD 44 and produce vinculin , beta tubulin , alpha actin , vimentin , fibronectin , laminin and collagen types 1 , 3 and 4 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
The levels of beta 1 ( CD 29 ) , VLA 1 ( CD49a ) , VLA 2 ( CD49b ) , and VLA 3 ( CD49c ) integrins were high , whereas those of VLA 5 ( CD49e ) and VLA 6 ( CD49f ) were faint , and that of VLA 4 ( CD49d ) was undetectable . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Human , rabbit , and avian osteoclasts reacted with monoclonal antibodies against human beta 1 integrins ( CD 29 , CD49b , CD49d ) , beta 3 integrins ( CD 51 , CD 61 ) , as well as human macrophage associated antigen CD 68 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Surface marker analysis revealed that HSM 1 expressed CD 4 , CD 13 , CD11a , CD11b , Leu 8 , CD49b , CD49d , CD49e , CD 29 and HLA DR . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Basement membrane proteins , laminin , and collagen type 4 , as well as vitronectin and fibronectin , were identified in the intima and there was corresponding expression of integrin and non integrin receptors ( e . g . , CD 29 , CD49b , CD49d , CD49e , CD49f , CD 51 , CD 61 , CD 44 ) for these matrix proteins . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
CD 29 and CD49d were detected on cells from day 0 to 4 weeks of culture ; CD49b , CD49c , CD49f , CD 18 , and CD 54 expression was negligible . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Analysis of the beta 1 integrin subfamily ( CD 29 , CD49b , CD49d , CD49e , and CD49f ) showed no significant change , except that CD49e was significantly decreased on the HTLV infected cell lines . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Surface expression of the beta 2 integrin chains ( CD11a , CD11b , CD11c and CD 18 ) , and the beta 1 integrin chains ( CD49b , CD49d , CD49f and CD 29 ) , as well as that of members of the immunoglobulin superfamily ( CD 2 , CD 54 , CD 56 and CD 58 ) , were analyzed by one or two color flow cytometry . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Phenotypic analysis of SLP cells on Day 8 demonstrated no change in the surface expression of CD 29 ( beta 1 ) , CD49b , d , e , and f ( alpha chains ) compared with cells from normal controls ; however , there was an increase of CD 29 expression on SLP cells on Day 8 ( 77 . 2 + / 5 . 1 % ) compared with Day 0 ( 53 . 2 + / 3 . 1 % ; P < 0 . 01 ) . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
We have found that pretreatment of a human oral mucosal epithelial cell line KB with natural human interferon alpha ( IFN alpha ) augments the expression of intercellular adhesion molecule 1 ( ICAM 1 ) , and the complex of CD 29 and CD49b , which is known as very late antigen ( VLA ) 2 , in a dose dependent manner , whereas the expression of other adhesion molecules such as CD 44 leukocyte function associated antigen 3 ( LFA 3 ) , VLA 4 and endothelial leukocyte adhesion molecule 1 ( ELAM 1 ) did not show any significant changes under the same conditions . ^^^ However , the adhesion of the above mentioned T cells to KB cells was not inhibited by specific antibodies against ICAM 1 , CD 29 , and CD49b . ^^^ The results thus show that adhesion molecules other than ICAM 1 , CD 29 , AND CD49b are responsible for the induced adhesion between T cells and IFN alpha pretreated KB cells . . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Expression of the CD 29 , CD49b and CD 31 adhesion molecules on the platelet surface was unaffected by storage in Diatube H . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Eighteen of the mAbs to different human CD antigens ( CD11a , CD 14 , CD 18 , CD 21 , CD 27 , CD 29 , CD49a , CD49b , CD49d , CD49e , CD 51 , CD 61 , CD62L , CD62P , CD 63 , CDw 78 , CD 98 , CD 100 ) stained bovine antigens with an almost identical cellular distribution to that reported in humans . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Spermatozoa were incubated with antibodies against alpha 1 ( CD49a ) , alpha 2 ( CD49b ) , alpha 3 ( CD49c ) , alpha 4 ( CD49d ) , alpha 5 ( CD49e ) , alpha 6 ( CD49f ) chains of beta 1 integrins , beta 1 ( CD 29 ) , beta 2 ( CD 18 ) , alpha 5 ( CD 51 ) , beta 3 ( CD 61 ) and beta 4 integrin chains , the LFA 3 ( Lymphocyte function antigen , CD 58 ) from the immunoglobulin superfamily and the extra cellular matrix proteins laminin , fibronectin and collagen 4 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
We confirmed previous observations that human bronchial epithelial cells constitutively express CD 29 , CD 44 , CD49a , CD49b , CD49c , CD49d , CD49e , CD49f , CD 51 , CD 54 ( ICAM 1 ) , CD 61 , and HLA class 1 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
In contrast to a minority of DCs in whole blood , the majority of isolated DCs expressed the beta 2 integrins and there were a greater number of cells bearing CD 44 , CD 54 and some of the beta 1 integrins ( notably CD49b , CD49d , CD49e and CD 29 ) . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
No significant difference was observed in the expression of cell surface VLA molecules ( CD 29 , CD49b , CD49d , CD49e , CD49f ) between blood and marrow blast cells . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
In combination with IL 2 and IL 4 , eotaxin enhances the expression of adhesion molecules such as ICAM 1 and several integrins ( CD 29 , CD49a , and CD49b ) on T lymphocytes and thus promotes adhesion and aggregation of T lymphocytes . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Anti CD 9 , CD 26 , CD 29 , CD 31 , CD 36 , CD 44 , CD49a , CD49b , CD49c , CD49d , CD49e , CD49f , CD 54 , CD 55 , CD 56 , CD62E & P , CD 71 , CD 98 , CD 102 , CD 106 , CD 146 , CD 151 monoclonals and NFL NPH , S 100 antiserums were used . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
The expression of adhesion structures on mesothelial cells such as CD 44 , the beta integrin chain CD 29 , the beta 3 integrin chain CD 61 and alpha chains CD 49 alpha ( alpha 1 ) , CD49b ( alpha 2 ) , CD49c ( alpha 3 ) , CD49e ( alpha 5 ) , and CD 51 ( alpha 5 ) is described . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Flow cytometry of the cell surface antigen expression indicated that CD49b , CD 29 , carcinoembryonic antigen ( CEA ) , sialyl Lewis a ( sLea ) , and CD49c were positive in more than 70 % of the cells . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Other molecules expressed by the cultured stromal cells include CD 29 , CD49a , CD49b , CD49d , CD49f , CD51 / 61 , CD 54 , CD 55 , CD 56 , CD 58 , CD 59 , CD 61 , CD 71 , CD79b , CD 81 , CD 82 , CD 90 , CD 95 , CD107a , CD 130 , and CD 147 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
At 14 weeks of culture , more mature CHMCs expressed CD11b , CD11c , CD 29 , CD49b , CD49c , CD49d , CD49e , CD 51 , CD 61 , and CD 54 and weakly expressed CD 18 and CD11a . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
The effect of mAbs to CD 49 ( alpha integrin ) subunits of CD 29 was also examined . mAbs to CD49e and CD49f inhibited both responses , while anti CD49b and CD49d significantly inhibited responses to KC only . ^^^ These data suggest that CD 29 plays a critical role in neutrophil migration in pulmonary inflammation and that CD49b and CD49d mediate CD 18 independent neutrophil accumulation . . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
RESULTS : Cell surface expression of the following integrin alpha and beta subunits was quantified : beta 1 ( CD 29 ) , alpha 2 ( CD49b ) , alpha 5 ( CD49e ) and alpha 6 ( CD49f ) . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
TEC were treated with TCDD at concentrations of 0 . 001 , 0 . 01 , 0 . 1 , 1 . 0 or 10 . 0 nM or with 100 nM PCB 126 ( 3 , 3 ' , 4 , 4 ' , 5 pentachlorobiphenyl ) for 3 days , and were then analysed by flow cytometry for expression of surface antigens using monoclonal antibodies against Hassall ' s bodies ( TE 8 , TE 16 ) or against surface structures such as CD 29 , CD49b , CD49e , CD49f , CD 51 , CD 54 , CD 58 , CD 61 and CD 106 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
The immunoprofile of MOLP 8 corresponds to that seen typically in primary MM cells : positive for cytoplasmic immunoglobulin ( Ig ) delta / lambda chains , CD 10 , CD 29 , CD 38 , CD 40 , CD 44 , CD49b , CD49d , CD 54 , CD 56 , CD 58 , CD 71 , CD 138 and PCA 1 ; the cells were negative for surface Igs and various other B cell , T cell and myelomonocyte associated immunomarkers . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Prostate basal epithelial cells do not express the CD antigens characteristic of prostate secretory cells ; and the basal cell CD markers , CD 29 , CD 44 , CD49b , CD49f , CD 104 , and nerve growth factor receptor ( NGFR ) are not expressed by cancer cells . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
METHODS : Tumor cell adhesion to endothelial cell monolayers was evaluated in the presence of 0 . 1 and 1 microM MMF and compared to unstimulated controls . beta 1 integrin analysis included alpha1beta1 ( CD49a ) , alpha2beta1 ( CD49b ) , alpha3beta1 ( CD49c ) , alpha4beta1 ( CD49d ) , alpha5beta1 ( CD49e ) , and alpha6beta1 ( CD49f ) receptors , and was carried out by reverse transcriptase polymerase chain reaction , confocal microscopy and flow cytometry . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Analysis by flow cytometry demonstrated that pancreatic MSCs express cell surface antigens used to define MSCs isolated from bone marrow such as CD 13 , CD 29 , CD 44 , CD49b , CD 54 , CD 90 and CD 105 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
The analysis for expression of adhesion receptors alphaL ( CD11a ) , alpha 2 ( CD49b ) , alpha 3 ( CD49c ) , alpha 4 ( CD49d ) , alpha 5 ( CD49e ) , alpha 6 ( CD49f ) , beta 1 ( CD 29 ) , L selectin ( CD62L ) , ICAM 1 ( CD 54 ) , PECAM 1 ( CD 31 ) , HCAM ( CD 44 ) , and P selectin ( CD62P ) was performed by two color flow cytometry . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
Ionizing radiation caused an up regulation of the cell surface expression of intercellular adhesion molecule 1 ( ICAM 1 ) and integrins beta 1 ( CD 29 ) , alpha 2 ( CD49b ) , alpha 5 ( CD49e ) and alpha 6 ( CD49f ) in keratinocytes , which was inhibited by 1alpha , 25 ( OH ) 2D3 . ^^^
Interacting proteins: P17301 and P05556 Pubmed SVM Score :0.0
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