| Interacting proteins: O14713 and P05556 |
Pubmed |
SVM Score :0.73138374 |
| Likewise in human cells , ICAP 1 associated specifically with the beta 1 but not beta 2 , beta 3 , or beta 5 tails . 0.73138374^^^ |
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| Interacting proteins: O14713 and P05556 |
Pubmed |
SVM Score :0.0 |
| Molecular basis for interaction between Icap 1 alpha PTB domain and beta 1 integrin . ^^^ Icap 1 alpha is a 200 amino acid protein that binds to the COOH terminal 13 amino acids ( ( 786 ) AVTTVVNPKYEGK ( 798 ) ) of the integrin beta ( 1 ) subunit . ^^^ The sequences of Icap 1 alpha , residues 58 200 , and the beta ( 1 ) integrin , residues 786 797 , were aligned to the available PTB peptide structures to generate a high quality structural model . ^^^ Site directed mutagenesis showed that Leu ( 135 ) , Ile ( 138 ) , and Ile ( 139 ) of Icap 1 alpha , residues predicted by the model to be in close proximity to ( 792 ) NPKY ( 795 ) , and Leu ( 82 ) and Tyr ( 144 ) , residues expected to form a hydrophobic pocket near Val ( 787 ) , are required for the Icap 1 alpha beta ( 1 ) integrin interaction . ^^^ These findings indicate that Icap 1 alpha is a PTB domain protein , which recognizes the NPXY motif of beta ( 1 ) integrin . ^^^ |
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| Interacting proteins: O14713 and P05556 |
Pubmed |
SVM Score :0.0 |
| Intracellularly , ILK , ICAP 1 and CD 47 might assist the transduction of the integrin dependent signals . . ^^^ |
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