| Cell adhesion to immobilized galectin 8 is mediated by sugar protein interactions with integrins , and galectin 8 triggers integrin mediated signaling cascades including Tyr phosphorylation of focal adhesion kinase and paxillin . ^^^ Cell adhesion is potentiated in the presence of Mn ( 2+ ) , whereas it is interrupted in the presence of soluble galectin 8 , integrin beta ( 1 ) inhibitory antibodies , EDTA , or thiodigalactoside but not by RGD peptides . ^^^ Furthermore , cells readily adhere onto immobilized monoclonal galectin 8 antibodies , which are equipotent to integrin antibodies in promoting cell adhesion . ^^^ |