| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.73496211 |
| We show that CITED 2 interacts with and co activates all isoforms of transcription factor AP 2 ( TFAP 2 ) . 0.73496211^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| Gene knockout studies indicate that CITED 2 is required for neural crest and neural tube development and that it functions as a co activator for transcription factor AP 2 ( TFAP 2 ) . ^^^ They also suggest the existence of cell type and TFAP 2 isoform specific co activation by CITED 2 and CITED 4 , which may result in differential modulation of TFAP 2 function . . ^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| Physical and functional interactions among AP 2 transcription factors , p300 / CREB binding protein , and CITED 2 . ^^^ The transcriptional co activators and histone acetyltransferases p300 / CREB binding protein ( CBP ) interact with CITED 2 , a transcription factor AP 2 ( TFAP 2 ) co activator . p300 / CBP , CITED 2 , and TFAP2A are essential for normal neural tube and cardiac development . ^^^ Here we show that p 300 and CBP co activate TFAP2A in the presence of CITED 2 . ^^^ TFAP2A transcriptional activity was modestly impaired in p 300 ( + / ) and CBP ( + / ) mouse embryonic fibroblasts ; this was rescued by ectopic expression of p300 / CBP . p 300 , TFAP2A , and endogenous CITED 2 could be co immunoprecipitated from transfected U 2 OS cells indicating that they can interact physically in vivo . ^^^ CITED 2 interacted with the dimerization domain of TFAP2C , which is highly conserved in TFAP2A / B . ^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| Cited 2 ( CBP / p300 interacting transactivator with ED rich tail 2 ) is required for embryonic development , coactivation of transcription factor AP 2 , and inhibition of hypoxia inducible factor 1 transactivation . ^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| Malformations of the septum , outflow tract and aortic arch are the most common congenital cardiovascular defects and occur in mice lacking Cited 2 , a transcriptional coactivator of TFAP 2 . ^^^ CITED 2 and TFAP 2 were detected at the Pitx2c promoter in embryonic hearts , and they activate Pitx2c transcription in transient transfection assays . ^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| Previous studies have focused on the role of Cited 2 in cardiac neural crest cell development , as Cited 2 can bind the transcription factor Tfap 2 , and thus affect the expression of Erbb 3 in neural crest cells . ^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| CITED 2 encodes a CREBBP / EP300 interacting transcriptional modulator of HIF1A and TFAP 2 . ^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| Cited 2 interacts with cAMP responsive element binding protein binding protein ( CBP ) / p300 , TFAP 2 , Lhx 2 , and nuclear receptors , such as peroxisome proliferator activated receptor and estrogen receptor to function as a transcriptional modulator . ^^^ |
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| Interacting proteins: Q99967 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
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