| Interacting proteins: Q5SW96 and P05549 |
Pubmed |
SVM Score :0.0 |
| Functional dissection of an AP 2 beta 2 appendage binding sequence within the autosomal recessive hypercholesterolemia protein . ^^^ |
|
| Interacting proteins: Q5SW96 and P05549 |
Pubmed |
SVM Score :0.0 |
| ARH is a modular adaptor protein that interacts with the LDL receptor , clathrin , and AP 2 . ^^^ A highly conserved 20 amino acid sequence in the C terminal region of ARH bound the beta ( 2 ) adaptin subunit of AP 2 . ^^^ |
|
| Interacting proteins: Q5SW96 and P05549 |
Pubmed |
SVM Score :0.0 |
| GST pulldown experiments indicate that the phosphotyrosine binding domain of ARH interacts with the internalization sequence ( NPVY ) in the cytoplasmic tail of LDLR , and that conserved motifs in the C terminal portion of the protein bind to clathrin and to the beta 2 adaptin subunit of AP 2 . ^^^ |
|
| Interacting proteins: Q5SW96 and P05549 |
Pubmed |
SVM Score :0.0 |
| Xenopus autosomal recessive hypercholesterolemia protein couples lipoprotein receptors with the AP 2 complex in oocytes and embryos and is required for vitellogenesis . ^^^ |
|
| Interacting proteins: Q5SW96 and P05549 |
Pubmed |
SVM Score :0.0 |
| Autosomal recessive hypercholesterolemia ( ARH ) is an adaptor protein that binds to the FXNPXY motif of the low density lipoprotein receptor as well as clathrin and AP 2 . ^^^ |
|
| Interacting proteins: Q5SW96 and P05549 |
Pubmed |
SVM Score :0.0 |
| The disease is caused by mutations in ARH , which encodes a putative adaptor protein that interacts with the cytoplasmic tail of the LDLR , phospholipids , and two components of the clathrin endocytic machinery , clathrin and adaptor protein 2 ( AP 2 ) in vitro . ^^^ The phosphotyrosine binding domain of ARH plus either the clathrin box or the AP 2 binding region were required for both clustering and internalization of the LDLR . ^^^ These results demonstrate that ARH must bind the LDLR tail and either clathrin or AP 2 to promote receptor clustering and internalization of LDL . . ^^^ |
|
| Interacting proteins: Q5SW96 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
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