| Two dimensional electrophoresis in conjunction with matrix assisted laser desorption / ionization time of flight ( MALDI TOF ) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC induced apoptosis is accompanied by increased levels of caspase 1 , checkpoint suppressor 1 , caspase 4 , NF kappaB inhibitor , AP 2 , c Jun N terminal kinase , melanoma inhibitor , granzyme K , G1 / S specific cyclin D 3 , cystein rich protein , Ras related protein Rab 37 or Ras related protein Rab 13 , and reduced levels of EMS ( oncogene ) , ATP synthase , tyrosine phosphatase , Cdc25c , 14 3 3 protein or specific structure of nuclear receptor . ^^^ |