| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.55938752 |
| The neuroendocrine protein 7B2 represents a specific binding protein for PC 2 , and the protein proSAAS , which interacts with PC 1 , exhibits certain structural and functional homologies with 7B2 . 0.55938752^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| Site directed mutagenesis of the prohormone convertase PC 2 was used to define the effect of certain residues on the zymogen activation of proPC 2 and on its binding to the neuroendocrine protein 7B2 . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 prevents premature activation of PC 2 , an enzyme involved in the processing of prohormones in the secretory pathway . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 contains two domains , a 21 kDa protein required for prohormone convertase 2 ( PC 2 ) maturation and a carboxyl terminal ( CT ) peptide that inhibits PC 2 at nanomolar concentrations . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 is known to be involved in the biosynthesis and activity of prohormone convertase 2 ( PC 2 ) . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormone convertase PC 2 . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 is a binding protein for the prohormone convertase 2 ( PC 2 ) and is required for the intracellular conversion of proPC 2 to active PC 2 . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| Neuroendocrine protein 7B2 is essential for proteolytic conversion and activation of proprotein convertase 2 in vivo . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 has been implicated in activation of prohormone convertase 2 ( PC 2 ) , an important neuroendocrine precursor processing endoprotease . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| PC 2 is the only member of this family whose activation requires intracellular interaction with a helper protein , the neuroendocrine protein 7B2 . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 and its 31 residue carboxyl terminal ( CT ) peptide potently and specifically inhibit prohormone convertase 2 ( PC 2 ) . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| In addition to these differences , PC 2 , unlike PC 1 and other members of the family , specifically binds the neuroendocrine protein 7B2 . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The eukaryotic subtilisin prohormone convertase 2 ( PC 2 ) is known to require in vivo exposure to the neuroendocrine protein 7B2 in order to produce an enzymatically active species capable of proteolytic action on prohormone substrates . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| The serine protease prohormone convertase 2 ( PC 2 ) , principally involved in the processing of polypeptide hormone precursors in neuroendocrine tissues , requires interaction with the neuroendocrine protein 7B2 to generate an enzymatically active form . 7B2 null mice express no PC 2 activity and release large quantities of uncleaved ACTH , resulting in a lethal endocrine condition that resembles pituitary Cushing ' s ( Westphal , C . ^^^ |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05408 and P16519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.55938752 |
| The neuroendocrine protein 7B2 represents a specific binding protein for PC 2 , and the protein proSAAS , which interacts with PC 1 , exhibits certain structural and functional homologies with 7B2 . 0.55938752^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| Site directed mutagenesis of the prohormone convertase PC 2 was used to define the effect of certain residues on the zymogen activation of proPC 2 and on its binding to the neuroendocrine protein 7B2 . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 prevents premature activation of PC 2 , an enzyme involved in the processing of prohormones in the secretory pathway . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 contains two domains , a 21 kDa protein required for prohormone convertase 2 ( PC 2 ) maturation and a carboxyl terminal ( CT ) peptide that inhibits PC 2 at nanomolar concentrations . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| PC 2 is the only member of this family whose activation requires intracellular interaction with a helper protein , the neuroendocrine protein 7B2 . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 and its 31 residue carboxyl terminal ( CT ) peptide potently and specifically inhibit prohormone convertase 2 ( PC 2 ) . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| In addition to these differences , PC 2 , unlike PC 1 and other members of the family , specifically binds the neuroendocrine protein 7B2 . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The eukaryotic subtilisin prohormone convertase 2 ( PC 2 ) is known to require in vivo exposure to the neuroendocrine protein 7B2 in order to produce an enzymatically active species capable of proteolytic action on prohormone substrates . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The serine protease prohormone convertase 2 ( PC 2 ) , principally involved in the processing of polypeptide hormone precursors in neuroendocrine tissues , requires interaction with the neuroendocrine protein 7B2 to generate an enzymatically active form . 7B2 null mice express no PC 2 activity and release large quantities of uncleaved ACTH , resulting in a lethal endocrine condition that resembles pituitary Cushing ' s ( Westphal , C . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| Neuroendocrine protein 7B2 is essential for proteolytic conversion and activation of proprotein convertase 2 in vivo . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 is known to be involved in the biosynthesis and activity of prohormone convertase 2 ( PC 2 ) . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormone convertase PC 2 . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 is a binding protein for the prohormone convertase 2 ( PC 2 ) and is required for the intracellular conversion of proPC 2 to active PC 2 . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| The neuroendocrine protein 7B2 has been implicated in activation of prohormone convertase 2 ( PC 2 ) , an important neuroendocrine precursor processing endoprotease . ^^^ |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16519 and P05408 |
Pubmed |
SVM Score :0.0 |
| NA |
|