| The role of interleukin 6 , interleukin 16 , tumor necrosis factor alpha and endotoxin in hepatic resection . ^^^ MATERIALS AND METHODS : Cytokines such as interleukin 16 , interleukin 6 and tumor necrosis factor alpha were serially measured both before and after hepatic resection . ^^^ RESULTS : The levels of interleukin 16 and interleukin 6 increased immediately after operation , while that of tumor necrosis factor alpha was only slightly elevated . ^^^ The increase in interleukin 6 was more prominent than that in interleukin 16 . ^^^ CONCLUSIONS : Therefore , interleukin 6 is considered to be a more sensitive marker of surgical stress than interleukin 1 beta and CRP , while both interleukin 6 and interleukin 16 are suggested to induce hepatic regeneration and the production of acute phase protein in the liver . ^^^ |