| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| After exposure to Oncostatin M , AIDS KS cells assumed a spindle morphology , had an increased ability to proliferate in soft agar , and secreted increased amounts of interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) is a cytokine that shares a structural and functional relationship with interleukin 6 , leukemia inhibitory factor , and granulocyte colony stimulating factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| An integrated CDF / CNTF profile also reveals similar sequence / structure motifs in a group of hematopoietic cytokines composed of granulocyte colony stimulating factor , interleukin 6 , and a novel factor called oncostatin M ; a more distant relationship is indicated with interleukin 3 and interferons alpha / beta . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M is a member of a cytokine family that includes leukemia inhibitory factor , granulocyte colony stimulating factor , and interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The rank order for LDL uptake stimulation was oncostatin M much greater than interleukin 6 = interleukin 1 = transforming growth factor beta 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 signal transducer gp 130 mediates oncostatin M signaling . ^^^ Oncostatin M ( OM ) is a multifunctional cytokine that is structurally and functionally related to interleukin 6 ( IL 6 ) and leukemia inhibitory factor ( LIF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Mitogen activated protein kinases and ribosomal S 6 protein kinases are involved in signaling pathways shared by interleukin 11 , interleukin 6 , leukemia inhibitory factor , and oncostatin M in mouse 3T3 L 1 cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor / leukemia inhibitory factor / interleukin 6 / oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors . ^^^ Ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) compose a family of distantly related cytokines that initiate signaling by inducing either homodimerization of the `` beta ' ' signal transducing receptor component gp 130 ( in the case of IL 6 ) or heterodimerization between gp 130 and the gp 130 related LIFR beta ( in the case of CNTF , LIF , and OSM ) ; dimerization of beta receptor components in turn activates members of the Jak / Tyk family of receptor associated tyrosine kinases . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor constitute the IL 6 family of cytokines and play important roles in hematopoiesis , immune response , and nervous system . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Activation of Fes tyrosine kinase by gp 130 , an interleukin 6 family cytokine signal transducer , and their association . gp 130 is a signal transducing subunit of receptors for the interleukin 6 ( IL 6 ) related cytokine subfamily including IL 6 , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor , indicating that gp 130 mediated signals are involved in the immune response , hematopoiesis , inflammation , and endocrine and nervous system activity . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The etiology of HIV associated KS is still unknown and coinfection with herpes simplex virus ( HSV ) , cytomegalovirus ( CMV ) , or human papillomavirus ( HPV ) as well as certain growth stimulating cytokines ( transforming growth factors , TGF ; tumor necrosis factor alpha , TNF alpha ; interleukin 6 , IL 6 ; tat ; vascular endothelial growth factors , VEGF ; oncostatin M ) produced by HIV infected cells may be cofactors . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| It is now recognized that the beta subunit of the interleukin 6 ( IL 6 ) receptor , also known as gp 130 , is a common signal transducer shared by other cytokines , including ciliary neurotrophic factor , leukemia inhibitor factor , oncostatin M , and IL 11 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor , oncostatin M , leukemia inhibitory factor , and interleukin 6 are related cytokines that initiate signaling by homodimerizing the signal transducing receptor component gp 130 or by heterodimerizing gp 130 with a gp 130 related receptor component . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) , interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) share functional properties , a predicted common helical framework , and partially identical receptor components . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| AIDS associated Kaposi ' s sarcoma ( KS ) cells express oncostatin M ( OM ) specific receptor but not leukemia inhibitory factor / OM receptor or interleukin 6 receptor . ^^^ Oncostatin M ( OM ) , which shares functional similarity and structural homology to leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) , functions as a potent growth factor for AIDS associated Kaposi ' s sarcoma derived cells ( AIDS KS cells ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| However , it is now clear that there is a complex interaction between the cytokines with interleukin 6 predominant , but also involving interleukin 1 , tumour necrosis factor and a group of recently described cytokines including interleukin 11 , leukaemia inhibitory factor and oncostatin M all of which influence the levels of acute phase proteins . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Although many of these acute phase proteins are predominantly derived from the liver and the response can be elicited from liver cells incubated in tissue culture with cytokines such as interleukin 6 ( IL 6 ) , interleukin 1 ( IL 1 ) , tumor necrosis factor alpha , interferon gamma , leukemia inhibitory factor , interleukin 11 ( IL 11 ) , and oncostatin M , there is now evidence that the response can also be elicited in extrahepatic tissues and cell types . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Indeed , it is involved in signal transduction of interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Down regulation of interleukin 6 receptor alpha chain in interleukin 6 transduced melanoma cells causes selective resistance to interleukin 6 but not to oncostatin M . ^^^ The cytokines interleukin 6 ( IL 6 ) and oncostatin M are able to inhibit the growth of cell lines obtained from early but not advanced melanomas . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) has recently been found to share receptor components with , and to be structurally related to , a family of broadly acting cytokines , including interleukin 6 , leukemia inhibitory factor , and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of macrophage differentiation in response to leukemia inhibitory factor / oncostatin M / interleukin 6 : the effect of enforced expression of the SCL transcription factor . ^^^ We examined growth factor induced macrophage differentiation in M 1 leukemia cells that simultaneously display receptors for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) and Oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M , which all use gp 130 as a signal transducer , significantly inhibited mGHRF secretion by cultured placental cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Their conversion into astrocytes , as determined by immunofluorescence analysis of glial fibrillary acidic protein expression , was induced by oncostatin M as well as leukemia inhibitory factor ( LIF ) and ciliary neurotrophic factor , but not interleukin 6 , and required extracellular matrix . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Using a reverse transcription polymerase chain reaction based assay system for monitoring the expression of multiple phenotypic markers in cultured sympathetic neurons , we present further evidence that , in addition to cholinergic differentiation factor / leukemia inhibitory factor and ciliary neurotrophic factor , oncostatin M , growth promoting activity , interleukin 6 , and interleukin 11 belong in this family . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M , interleukin 2 , interleukin 6 and interleukin 8 in breast cyst fluid . ^^^ In this study , the concentrations of the cytokines , oncostatin M ( OSM ) , interleukin 2 ( IL 2 ) , interleukin 6 ( IL 6 ) and interleukin 8 ( IL 8 ) were measured in breast cyst fluid , OSM , IL 2 and IL 6 having been shown to have growth inhibitory actions on tumour cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) is structurally and functionally related to a subclass of hematopoietic cytokines including leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , granulocyte colony stimulating factor ( G CSF ) , and interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In this report we document the derivation of pluripotential embryonic stem ( ES ) cells in the absence of a feeder layer by supplementation of culture media with either ciliary neurotrophic factor or oncostatin M , or with a combination of interleukin 6 ( IL 6 ) plus soluble interleukin 6 receptor ( sIL 6R ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a cytokine which shares a common gene structure and amino acid sequence similarity with leukemia inhibitory factor ( LIF ) , granulocyte colony stimulating factor ( G CSF ) and interleukin 6 ( IL 6 ) , suggesting evolution from a common ancestral gene . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) is a member of the cytokine family that includes leukaemia inhibitory factor ( LIF ) , granulocyte colony stimulating factor ( G CSF ) , and interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| An accumulation of such alterations may be responsible for the progressive loss of responsiveness to several independent growth inhibitors for melanocytes or early stage melanomas , including interleukin 6 , transforming growth factor beta , and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We have also shown with the use of oncostatin M specific antisense oligodeoxynucleotides that KS cell proliferation is inhibited , which correlated with a more precipitous decline in the production of interleukin 6 by these cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) is structurally related to interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Recently , gp 130 , the signal transducer for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophice factor ( CNTF ) , was identified as the low affinity receptor for oncostatin M ( OM ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) and related cytokines , such as leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) and IL 11 exhibit multiple functions and redundancy in biological activities and play important roles in the immune response , hematopoiesis , the nervous system and acute phase reactions . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Four of the cytokines ( interleukin 6 , interleukin 11 , leukemia inhibitory factor , and oncostatin M ) inhibited hydrocortisone induced adipocyte differentiation in a dose dependent manner based on lipid accumulation and lipoprotein lipase enzyme activity . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 receptor associated signal transducer , gp 130 , is shared by receptor complexes for leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and interleukin 11 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 , leukemia inhibitory factor , and oncostatin M exert a broad range of similar biological activities through association of their receptors with the signal transducing component gp 130 . ^^^ In this report , we show that interleukin 6 , leukemia inhibitory factor , and oncostatin M stimulate the assembly of protein complexes that recognize conserved sequences within the enhancers of two genes ( interferon regulatory factor 1 and Fc gamma receptor type 1 ) that are rapidly activated by these cytokines . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotropic factor , interleukin 11 , leukemia inhibitory factor , and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M , leukemia inhibitory factor , and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp 130 . ^^^ We analyzed the stimulatory effect of oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , IL 11 , and the inhibitory effect of anti IL 6 antibody ( Ab ) , anti IL 6 receptor monoclonal antibody ( mAb ) , and anti gp 130 mAb on the growth of human plasmacytoma cells freshly isolated from a patient with multiple myeloma . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M binds directly to gp 130 and behaves as interleukin 6 antagonist on a cell line expressing gp 130 but lacking functional oncostatin M receptors . ^^^ Oncostatin M ( OM ) and interleukin 6 ( IL 6 ) are functionally related cytokines , which trigger similar biological responses because they share gp 130 as a common signal transducing transmembrane receptor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotropic factor are a family of cytokines and neuronal differentiation factors which bind to composite plasma membrane receptors sharing the signal transducing subunit gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| New approaches to the treatment of Kaposi ' s sarcoma include inhibition of angiogenic and Kaposi ' s sarcoma stimulating growth factors , eg , interleukin 6 , fibroblast growth factor , tumor necrosis factor , oncostatin M , and the HIV tat gene product . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The biological functions of LIF are mediated through a receptor and a signal transducer , gp 130 , which is also used by factors like interleukin 6 ( IL 6 ) , cilliary neurotropic factor ( CNTF ) , and oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , interleukin 11 , and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| A recently defined family of cytokines , consisting of ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) , utilize the Jak Tyk family of cytoplasmic tyrosine kinases . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Selection and characterization of a variant of human melanoma cell line , A 375 resistant to growth inhibitory effects of oncostatin M ( OM ) : coresistant to interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Other peptides that share signal transduction mechanisms with LIF ciliary neurotropic factor , oncostatin M and interleukin 6 also caused expression of GFAP in these cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Differentiation induction in murine M 1 leukemia cells by interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) is postulated to occur via a common receptor chain , gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) , a 28 kilodalton glycoprotein cytokine , is structurally and functionally related to interleukin 6 and leukemia inhibitory factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| It is now clear that there is a complex interaction between the cytokines with interleukin 6 predominant , but also involving interleukin 1 , tumor necrosis factor and a group of recently described cytokines including as well interleukin 11 , leukaemia inhibitory factor and oncostatin M all of which influence the levels of acute phase proteins . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Detection of receptors for interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , and ciliary neurotrophic factor in bone marrow stromal / osteoblastic cells . ^^^ The functional receptor complexes assembled in response to interleukin 6 and 11 ( IL 6 and IL 11 ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , all involve the signal transducer gp 130 : IL 6 and IL 11 induce homodimerization of gp 130 , while the rest heterodimerize gp 130 with other gp 130 related beta subunits . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The major pathogenic factors that may possibly induce AIDS KS are HIV itself or other sexually transmitted agents , HIV tat gene , some oncogenes and cytokines such as interleukin 6 , basic fibroblast growth factor , transforming growth factor beta , oncostatin M , and platelet derived growth factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The steady state mRNA levels of the interleukin 6 receptor ( IL 6R , gp 80 ) and its signal transducing molecule , gp 130 , were examined in the rat hepatoma cell line , H 35 , stimulated by cytokines IL 6 , IL 1 , oncostatin M ( OSM ) and / or Dexamethasone ( Dex ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| This observation is consistent with the evolution of the interleukins 6 , 11 and 12 , granulocyte colony stimulating factor ( G CSF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and the ciliary neurotrophic factor complexes from a common ancestral complex which included a homodimer of gp 130 like signalling receptors and an interleukin 6 receptor like non signalling receptor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Anti gp 130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor or oncostatin M . ^^^ Five cytokines activate the gp 130 IL 6 transducer : ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| CNTF , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) and oncostatin M ( OSM ) share a predicted common helical framework and partially identical receptor components . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 ( IL 6 ) related cytokine subfamily that includes IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interestingly , four major KS cytokines , namely interleukin 1beta , interleukin 6 , tumor necrosis factor alpha , and oncostatin M , all of which are known autocrine growth factors for AIDS KS cells , significantly increased the expression of functional GRs in cultured AIDS KS cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Moreover , other members of the CNTF cytokine family that use gp 130 and / or LIF receptor beta as their signal transducing receptors LIF , oncostatin M , interleukin 6 , and interleukin 11 had similar effects on increasing ChAT activity and reducing 5HT expression in RN46A cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , interleukin 6 ( IL 6 ) , and interleukin 11 ( IL 11 ) are structurally and functionally related cytokines . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) is a cytokine that shares a structural and functional relationship with interleukin 6 , leukemia inhibitory factor , and granulocyte colony stimulating factor , which regulate the proliferation and differentiation of a variety of cell types . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is structurally and functionally similar to leukaemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) and ciliary neurotrophic factor ( CNTF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 ( IL 6 ) cytokine family , which includes IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , IL 11 and cardiotrophin 1 ( CT 1 ) , exhibits pleiotropy and redundancy in biological activities . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In contrast , oncostatin M , an interleukin 6 type cytokine produced by activated T lymphocytes and monocytes , had a differential effect on TIMP mRNA levels . ^^^ Interleukin 6 itself had no effect on synovial lining cells but a complex of interleukin 6 and the soluble interleukin 6 receptor induced activation of signal transducer and activator of transcription ( STAT ) factors in these cells and regulated TIMP 1 and TIMP 3 expression in a similar fashion as oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Therefore , the objective of this study was to determine the effectiveness of several heterologous hematopoietic cytokines at maintaining the isolated porcine inner cell masses ( pICM ) in an undifferentiated state . pICMs ( day 7 ) were isolated by immunosurgery and cultured 4 days in one of six treatments : control medium , human leukemia inhibitory factor ( hLIF ; 1 , 000 mu / ml ) , human interleukin 6 ( hIL 6 ; 100 ng / ml ) , hIL 6 + hIL 6 soluble receptor ( hIL 6 + sR ; 100 ng / ml + 2 . 5 micrograms / ml ) , human oncostatin M ( hOSM ; 100 ng / ml ) , or rat ciliary neurotrophic factor ( rCNTF ; 100 ng / ml ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Kaposi ' s sarcoma is a multifocal lesion that is reported to be greatly influenced by cytokines such as interleukin 6 ( IL 6 ) and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Receptors for the cytokines leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) and interleukin 11 ( IL 11 ) are members of the structurally conserved hemopoietin receptor superfamily . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Three cytokines , interleukin 6 ( IL 6 ) , leukaemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) , that bind to composite receptors including a common signal transducer gp 130 suppressed proliferation of a mouse B cell hybridoma cell line 2E3 O cultured in serum free medium , while they enhanced antibody production of the cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 and related cytokines , interleukin 11 , leukaemia inhibitory factor , oncostatin M , ciliary neurotrophic factor and cardiotrophin 1 , are all pleiotrophic , from the haematopoietic to the nervous system , and exhibit overlapping biological activities . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effects of the interleukin 6 ( IL 6 ) family cytokines , such as IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) , on the production of tissue inhibitor of matrix metalloproteinases 1 ( TIMP 1 ) in human articular cartilage . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 and related cytokines , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 are all pleiotropic and exhibit overlapping biological functions . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a member of the interleukin 6 family of cytokines , was found to be highly expressed in the late fetal and early neonatal rat testis , as well as in the maturing and adult testis . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The binding of ciliary neurotrophic factor is specific , sensitive to phosphatidylinositol specific phospholipase C and partially inhibited by leukemia inhibitory factor , but not inhibited by other members of the human neurokine family , including interleukin 6 , interleukin 22 and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In addition , a 5 h treatment with interleukin 6 or oncostatin M stimulated the activity of this promoter severalfold . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Later in development , LIF , CNTF , oncostatin M and interleukin 6 promote the survival of cultured neurons . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Regulation of oligodendrocyte cell survival and differentiation by ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M , and interleukin 6 . ^^^ In this review we focus on oligodendrocytes and their progenitors and how differentiation and survival are regulated by four neuropoietic cytokines : ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M , and interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Influence of subunit combinations on signaling by receptors for oncostatin M , leukemia inhibitory factor , and interleukin 6 . ^^^ Oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , and interleukin 6 ( IL 6 ) induce expression of a similar set of acute phase plasma protein genes in hepatic cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The synovial expression and serum levels of interleukin 6 , interleukin 11 , leukemia inhibitory factor , and oncostatin M in rheumatoid arthritis . ^^^ OBJECTIVE : To determine the expression of interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) and their major cellular sources in the joints of rheumatoid arthritis ( RA ) patients , as well as the correlation of circulating levels of these IL 6 type cytokines and C reactive protein ( CRP ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of chemokines by leukemia inhibitory factor , interleukin 6 and oncostatin M . ^^^ Leukemia inhibitory factor ( LIF ) . oncostatin M ( OsM ) and interleukin 6 ( IL 6 ) are members of a cytokine family , which are produced by activated macrophages and glomerular mesangial cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M , but not interleukin 6 or leukemia inhibitory factor , stimulates expression of alpha 1 proteinase inhibitor in A 549 human alveolar epithelial cells . ^^^ Since hepatocyte A 1 Pi production is stimulated by interleukin 6 ( IL 6 ) and other gp 130 cytokines , such as leukemia inhibitory factor ( LIF ) and oncostatin M ( OM ) , we investigated the role of these cytokines in regulating A 1 Pi in lung epithelial cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) are members of the interleukin 6 ( IL 6 ) subfamily of cytokines that use a common signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Alkaline phosphatase , a marker of differentiation in the human alveolar adenocarcinoma cell line A 549 , is inducible by conditioned medium from lung fibroblasts and by cytokines including oncostatin M and interleukin 6 , but only in the presence of a glucocorticoid , dexamethasone . ^^^ HS 1 isolated from the medium ( HS1m ) of subconfluent A 549 cells was shown to replace dexamethasone in induction experiments with fibroblast conditioned medium , oncostatin M and interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The phosphatase activity metabolized adenosine monophosphate to free phosphate and was the liver / bone / kidney alkaline phosphatase isoenzyme : activity was temperature and levamisole sensitive , 1 phenylalanine resistant , and linked to the cell surface via phospholipid , and migrated at a size identical to this isozyme . interleukin 6 was identified as the phosphatase inducing factor in wound fluid and the related cytokines , leukaemia inhibiting factor , and oncostatin M , caused a similar degree of alkaline phosphatase induction . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The stimulation by Flk 2 ligand ( FL ) of blast colony formation by murine bone marrow cells was selectively potentiated by the addition of regulators sharing in common the gp 130 signaling receptor leukemia inhibitory factor ( LIF ) , oncostatin M , interleukin 11 , or interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We investigated the serum concentration of interleukin 6 ( IL 6 ) and the IL 6 family of cytokines ( leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) and ciliary neurotrophic factor ( CNTF ) using an enzyme linked immunosorbent assay ( ELISA ) in 64 patients with systemic lupus erythematosus ( SLE ) and 15 healthy controls . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| By contrast , interleukin 6 , interleukin 11 , and leukemia inhibitory factor had no effect on aromatase activity of THP 1 cells , whereas tumor necrosis factor alpha , oncostatin M , and platelet derived growth factor were slightly inhibitory of aromatase activity . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| To measure levels of oncostatin M ( OSM ) in the synovial fluid of rheumatoid arthritis ( RA ) patients and to examine the activities of human OSM in the regulation of human synovial fibroblast ( HSF ) production of chemokines and matrix metalloproteinases ( MMP 1 and MMP 3 ) in vitro . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M , leukaemia inhibitory factor and interleukin 6 trigger different effects on alpha 1 proteinase inhibitor synthesis in human lung derived epithelial cells . ^^^ Interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) and leukaemia inhibitory factor ( LIF ) share a common signal transducing subunit in each of their receptors and thus mediate an overlapping spectrum of biological activities . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M and the interleukin 6 and soluble interleukin 6 receptor complex regulate alpha 1 antichymotrypsin expression in human cortical astrocytes . alpha 1 Antichymotrypsin ( ACT ) is an acute phase protein expressed in the brain which specifically colocalizes with amyloid beta during Alzheimer ' s disease . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor , interleukin 6 , and oncostatin M : inhibition of meningioma cell growth in vitro by recombinant oncostatin M . ^^^ To further our knowledge of this process , the authors investigated the presence and function of the cytokines leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and oncostatin M ( OSM ) on meningioma cell proliferation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Serum levels of interleukin 6 ( IL 6 ) , oncostatin M , soluble IL 6 receptor , and soluble gp 130 in patients with systemic sclerosis . ^^^ OBJECTIVE : To determine whether serum interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , soluble IL 6 receptor ( sIL 6R ) , and soluble gp 130 ( sgp 130 ) levels in patients with systemic sclerosis ( SSc ) are elevated and whether they are correlated with the clinical or serological features of the disease . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We studied the effect of the multifunctional neuropoietic cytokines , including oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) , on anaplastic glioma cell lines . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Many of these biological functions parallel those of interleukin 6 , Oncostatin M , ciliary neurotrophic factor , interleukin 11 and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The hematopoietin family includes interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 , ) leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , granulocyte colony stimulating factor ( G CSF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The inhibitory potency of oncostatin M on CYP expression was compared with that of other cytokines belonging to the interleukin 6 receptor family ( interleukin 6 , interleukin 11 and leukemia inhibitory factor ) , and interferon gamma , which is recognized to inhibit human CYP expression , and granulocyte colony stimulating factor , a cytokine that shares structural homology with the interleukin 6 family but has a different transduction signal . ^^^ At that time , oncostatin M showed the highest inhibitory effects on CYP1A2 activity ( 38 % of control ) , followed by interferon ( 49 % of control ) and interleukin 6 ( 60 % of control ) , whereas minor effects were produced by the other cytokines ( 74 80 % ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of a family of cytokines that includes ciliary neurotrophic factor , interleukin 6 , interleukin 11 , cardiotrophin 1 , and leukemia inhibitory factor ( LIF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Using such paired lines , and other experimental systems , we have obtained evidence that shows early stage melanoma cell lines may be deficient in inducing angiogenesis , are highly sensitive to the growth inhibitory effects of a plethora of cytokines , including transforming growth factor beta , interleukin 6 , and oncostatin M , and are more sensitive to undergoing spontaneous apoptosis in several conditions including when growth in anchor age independent , 3 dimensional tissue culture . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) is a member of the cytokine family which regulates the proliferation and differentiation of a variety of cell types and includes interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and granulocyte colony stimulating factor ( G CSF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The transmembrane protein gp 130 is a shared component of the receptor complexes for the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 , leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Because stem cell factor , interleukin 6 ( IL 6 ) , and oncostatin M , but not IL 3 , IL 11 , leukemia inhibitory factor , granulocyte colony stimulating factor , granulocyte macrophage colony stimulating factor , thrombopoietin , and Flk 2 ligand were detected in reverse transcription polymerase chain reaction analysis of AGM S 3 cells , the cells seem to express species cross reactive molecule ( s ) other than the cytokines examined and which act on primitive hematopoietic progenitor / stem cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| To investigate when the neurotrophic cytokines ciliary neurotrophic factor ( CNTF ) , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , interleukin 6 ( IL 6 ) and cardiotrophin 1 ( CT 1 ) act on developing sensory neurones and whether they co operate with neurotrophins in regulating neuronal survival , we studied the in vitro trophic effects of these factors on two well characterized populations of cranial sensory neurones at closely staged intervals throughout embryonic development . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| However , TGF beta does not act synergistically with the neuropoietic cytokines oncostatin M , leukemia inhibiting factor , or interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The receptor gp 130 is utilized by cytokines including interleukin 6 , leukemia inhibitory factor , oncostatin M , cilary neurotrophic factor and cardiotrophin . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 ( IL 6 ) family of cytokines that share the gp 130 receptor subunit . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Blocking signaling through the Gp 130 receptor chain by interleukin 6 and oncostatin M inhibits PC 3 cell growth and sensitizes the tumor cells to etoposide and cisplatin mediated cytotoxicity . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is an interleukin 6 ( IL 6 ) family cytokine known in particular to induce the synthesis of acute phase proteins by hepatocytes . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| It is clear that interleukin 3 , interleukin 6 , interleukin 11 , stem cell factor , leukaemia inhibitory factor and oncostatin M all influence the proliferation and maturation of megakaryocytes . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We found that oncostatin M ( OSM ) , an interleukin 6 family cytokine , in combination with glucocorticoid , induced maturation of hepatocytes as evidenced by morphological changes that closely resemble more differentiated hepatocytes , expression of hepatic differentiation markers and intracellular glycogen accumulation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) is a member of the interleukin 6 ( IL 6 ) cytokine subfamily . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Using specific ELISAs , PEL cell lines were found to produce large amounts of interleukin 6 ( IL 6 ; 10 5000 pg / ml ) , IL 6 soluble receptor ( IL 6sR ; 30 600 pg / ml ) , IL 10 ( 600 80 , 000 pg / ml ) and oncostatin M ( OSM ; 50 80 pg / ml ) which in most cases were significantly higher than the levels produced by the Burkitt , B NHL or myeloma cell lines ; on the contrary , PEL cell lines did not elaborate significant levels of macrophage inhibitory protein ( MIP 1alpha ) and leukemia inhibitory factor ( LIF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We investigated the serum concentration of interleukin 6 ( IL 6 ) and four IL 6 family cytokines oncostatin M ( OSM ) , leukaemia inhibitory factor ( LIF ) , interleukin 11 ( IL 11 ) and ciliary neurotrophic factor ( CNTF ) as well as IL 6 soluble receptor ( sIL 6R ) using an enzyme linked immunosorbent assay ( ELISA ) in 67 patients with multiple myeloma ( MM ) and 24 healthy controls , for a possible association between the serum levels of these peptides with disease activity and known prognostic factors . sIL 6R was detectable in all 67 and IL 6 in 65 ( 97 % ) patients . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Developmental requirement of gp 130 signaling in neuronal survival and astrocyte differentiation . gp 130 is a signal transducing receptor component used in common by the interleukin 6 ( IL 6 ) family of hematopoietic and neurotrophic cytokines , including IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , oncostatin M , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 and oncostatin M induced growth inhibition of human A 375 melanoma cells is STAT dependent and involves upregulation of the cyclin dependent kinase inhibitor p27 / Kip1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In this study , we have shown that oncostatin M and interleukin 6 induce a dose and time dependent increase in fibrinogen levels in the conditioned medium of human hepatoma cells ( HepG 2 ) . ^^^ When HepG 2 cells were treated simultaneously with oncostatin M or interleukin 6 and ciprofibrate ( 100 nmol / l ) , the production of fibrinogen in the conditioned media was strongly affected and a significant decrease in the mRNA levels of the fibrinogen beta chain was observed . ^^^ Oncostatin M and interleukin 6 induced fibrinogen release was inhibited in a dose dependent manner by ciprofibrate and , to lesser extent , by bezafibrate , fenofibric acid and clofibric acid . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Enhanced production of interleukin 6 ( IL 6 ) , oncostatin M and soluble IL 6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis . ^^^ OBJECTIVES : To determine whether the spontaneous production of interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , soluble IL 6 receptor ( sIL 6R ) and soluble gp 130 ( sgp 130 ) from peripheral blood mononuclear cells ( PBMC ) is increased in patients with systemic sclerosis ( SSc ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 ( IL 6 ) family of cytokines and was originally identified by its ability to inhibit proliferation of melanoma cells but augment the growth of normal fibroblasts . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a glycoprotein interleukin 6 cytokine known to inhibit bone resorption in fetal long bone cultures . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| GCSF is a member of the long chain subtype of the class 1 cytokine superfamily , which includes growth hormone , erythropoietin , interleukin 6 and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M induces interleukin 6 and cyclooxygenase 2 expression in human vascular smooth muscle cells : synergy with interleukin 1beta . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Regulated expression of alternate transcripts from the mouse oncostatin M gene : implications for interleukin 6 family cytokines . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Gp 130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Different epitopes are required for gp 130 activation by interleukin 6 , oncostatin M and leukemia inhibitory factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To compare synovial fluid ( SF ) levels of oncostatin M ( OSM ) , tumor necrosis factor alpha ( TNFalpha ) , and interleukin 6 ( IL 6 ) in patients with rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) and to determine which correlate best with SF levels of antigenic keratan sulfate ( Ag KS ) , a marker of aggrecan catabolism , and pyridinium crosslinks , markers of the degradation of mature collagen molecules . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 , leukemia inhibitory factor , and ciliary neurotrophic factor also induced Stat complexes more selectively and to a lesser magnitude than oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Aromatase expression in adipose tissue is regulated via the distal promoter I . 4 , under the control of glucocorticoids and class 1 cytokines such as oncostatin M , interleukin 6 , and interleukin 11 , as well as tumor necrosis factor alpha . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Stimulation of osteoclast differentiation in vitro by mouse oncostatin M , leukaemia inhibitory factor , cardiotrophin 1 and interleukin 6 : synergy with dexamethasone . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The related cytokines , interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , and leukemia inhibitory factor ( LIF ) direct the formation of specific heteromeric receptor complexes to achieve signaling . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The production of cysteine protease by two human osteosarcoma cell lines ( MG 63 and SaOS 2 ) was analyzed , as well as their modulation by interleukin 1beta ( hIL 1 beta ) , interleukin 6 ( hIL 6 ) , insulin growth factor 1 ( hIGF 1 ) , oncostatin M ( hOSM ) , leukemia inhibitory factor ( hLIF ) and growth hormone ( hGH ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a multifunctional member of the interleukin 6 cytokine family . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Rat ciliary neurotrophic factor ( rCNTF ) , human oncostatin M ( hOSM ) , and interleukin 6 and soluble interleukin 6 receptor ( IL 6 / sIL 6R ) were found to support clonal growth of RES cells , but the cytokines did not reach the efficiency of the colony forming ability of leukemia inhibitory factor ( LIF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M regulation of interleukin 6 expression in astrocytes : biphasic regulation involving the mitogen activated protein kinases ERK1 / 2 and p 38 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 superfamily and a multifunctional cytokine that effects the growth and differentiation of many different cell types . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) and other members of the interleukin 6 cytokines , like ciliary neurotrophic factor and leukemia inhibitory factor , can induce differentiation of glial cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M and interleukin 6 inhibit cell cycle progression by prevention of p27kip1 degradation in HepG 2 cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a multifunctional cytokine , a member of the interleukin 6 / leukemia inhibitory factor ( IL 6 / LIF ) family , that can regulate a number of connective tissue cell types in vitro including cartilage and synovial tissue derived fibroblasts , however its role in joint inflammation in vivo is not clear . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Relationship between circulating interleukin 10 ( IL 10 ) with interleukin 6 ( IL 6 ) type cytokines ( IL 6 , interleukin 11 ( IL 11 ) , oncostatin M ( OSM ) ) and soluble interleukin 6 ( IL 6 ) receptor ( sIL 6R ) in patients with multiple myeloma . ^^^ We investigated the serum concentration of the interleukin 10 ( IL 10 ) , along with cytokines of interleukin 6 ( IL 6 ) family ( IL 6 , IL 11 and oncostatin M OSM ) , as well as soluble receptor for IL 6 ( sIL 6R ) , in 121 patients with multiple myeloma ( MM ) and 28 healthy subjects . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| This family includes interleukin 6 , interleukin 11 , oncostatin M , leukaemia inhibitory factor , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| This study investigated the ability of normal human osteoblasts ( hOb ) and osteogenic sarcoma cells ( MG 63 and SaOS 2 ) to produce gelatinases and undergo modulation by interleukin 1beta ( IL 1beta ) , interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , leukaemia inhibitory factor ( LIF ) , growth hormone ( GH ) and insulin like growth factor 1 ( IGF 1 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Signalling of interleukin 6 type cytokines via gp 130 , leukemia inhibitory factor ( LIF ) receptor and oncostatin M receptor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Its growth is accelerated by corticosteroids , Oncostatin M , the HIV tat protein , Interleukin 6 , fibroblast growth factor , interleukin 1 , and tumor necrosis factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Induction of interleukin 6 and oncostatin M by radiation in Kaposi ' s sarcoma cell lines . ^^^ Supernatants from irradiated cells were collected at different time points for measurement of the interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , and basic fibroblast growth factor ( bFGF ) by ELISA . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of cytokines such as leukaemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , oncostatin M and interleukin 11 on the secretion of these hormones by the cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In our RT PCR screen for cytokine expression in human brain tumors we discovered increased levels of oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) and leukemia inhibitory factor ( LIF ) , all belonging to the interleukin 6 ( IL 6 ) cytokine family , in most of the tumors . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The cytokines that signal through the common receptor subunit gp 130 , including ciliary neurotrophic factor ( CNTF ) , interleukin 6 , leukemia inhibitory factor ( LIF ) and oncostatin M , have pleiotropic functions in CNS development . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Changes in the secretory activity of two transplantable melanoma lines ( differing in many biological features ) as regards nitric oxide ( NO ) release and interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) and oncostatin M ( OSM ) secretion were the subject of the present study . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Oncostatin M ( OSM ) is a member of the interleukin 6 cytokine family , with well documented effects on cell growth and differentiation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Autocrine production and synergistic growth promoting activity of interleukin 6 and oncostatin M in a new human myeloma cell line TU 1 . ^^^ This conditioned medium contained interleukin 6 ( IL 6 ) and oncostatin M ( OSM ) , and possibly other unknown growth factors as well . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The IL 6 family cytokines , interleukin 6 , interleukin 11 , oncostatin M , and leukemia inhibitory factor , enhance mast cell growth through fibroblast dependent pathway in mice . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , an interleukin 6 type cytokine , acts via the gp 130 signaling receptor to inhibit proliferation and induce differentiation of breast cancer cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OM ) is a pleiotropic cytokine of the interleukin 6 family , whose in vivo properties and physiological function remain in dispute and poorly defined . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The cytokines oncostatin M ( OSM ) and interleukin 6 have been shown to be mainly responsible for this effect , which is mediated via the interaction of cytokine inducible transcription factors with regulatory elements within the gene . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| An enhancer positioned approx . 1 . 2 kb from the end of the last exon in the 3 ' flanking sequence modulates cytokine induced expression by interleukin 6 and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , which is predominantly expressed in bone marrow , is a member of the interleukin 6 family of cytokines , and appears to play important roles in hematopoiesis and the development of the liver . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The expression of oncostatin M and leukemia inhibitory factor ( LIF ) , JAK STAT activators and members of the interleukin 6 family of cytokines , were examined in a series of primary ovarian carcinomas using immunohistochemistry . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The effects of the related cytokines interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) and oncostatin M on bone resorption and cytosolic Ca ( 2+ ) signaling were compared in isolated rat osteoclasts . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a member of the interleukin 6 ( IL 6 ) cytokine family , acts on a variety of cells and elicits diversified biological responses , suggesting potential roles in the regulation of cell survival , differentiation and proliferation . 2 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a pluripotent cytokine of the interleukin 6 ( IL 6 ) family , is produced in a number of inflammatory conditions . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Serum interleukin 6 ( IL 6 ) , IL 1beta and Oncostatin M remained stable throughout the study , while tumour necrosis factor alpha increased . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : Changes in the sensitivity of two lines of transplantable melanoma cells to the antiproliferative activity of interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , tumor necrosis factor alpha ( TNF alpha ) during melanoma progression were the subject of this study . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a cytokine of the interleukin 6 ( IL 6 ) family secreted by activated monocytes , and is expressed in atherosclerotic plaque . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In addition , oncostatin M ( OSM ) , an interleukin 6 family cytokine , down regulated the expression of cyclin D 1 and D 2 in a primary culture of fetal hepatocytes in which OSM induces hepatic differentiation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The related members of the interleukin 6 ( IL 6 ) family of cytokines , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) and IL 6 are inflammatory mediators that control differentiated cell functions as well as proliferation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Members of the interleukin 6 family of cytokines include leukaemia inhibitory factor ( LIF ) , interleukin 6 , interleukin 11 , cardiotrophin , ciliary neurotropic growth factor , oncostatin M and the recently discovered cardiotropin like cytokine ( NNT 1 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Murine oncostatin M ( OSM ) , a member of the interleukin 6 ( IL 6 ) related cytokine subfamily , stimulates definitive hematopoiesis and liver development . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low affinity LIF specific receptor and the gp 130 receptor chain also used as the receptor for interleukin 6 , oncostatin M , cardiotrophin 1 , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| These include preproglucagon , APOJ , cadherin 2 , phosphoglucoisomerase , oncostatin M , PAX 6 , HGF , and cytokeratin 18 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M , an interleukin 6 family cytokine , upregulates matrix metalloproteinase 9 through the mitogen activated protein kinase kinase extracellular signal regulated kinase pathway in cultured smooth muscle cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We show here that hepatocyte growth factor ( HGF ) induced early transition of albumin ( ALB ) negative stem cells to ALB positive hepatic precursors resembling hepatoblasts and then oncostatin M ( OSM ) promoted their differentiation to tryptophan 2 , 3 dioxygenase ( TO ) positive mature hepatocytes . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a cytokine of the interleukin 6 family , is expressed in rheumatoid arthritis , multiple sclerosis , multiple myeloma , and other inflammatory and neoplastic conditions . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M belongs to the interleukin 6 family of cytokines and acts as a multifunctional cytokine during murine embryogenesis and in inflammatory reactions . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Bone marrow cell derived hepatocyte like colonies appeared after several days of coculture in medium containing HSLF , oncostatin M ( OSM ) and hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 cytokine family , which is involved in definitive hematopoiesis , the development of liver , and local inflammation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a multifunctional cytokine that belongs to the interleukin 6 ( IL 6 ) family . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Studies with cultured cells and mouse models of disease have ascribed proinflammatory and anti inflammatory functions to oncostatin M ( OSM ) and the related cytokine , interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We therefore investigated the effects of oncostatin M ( OSM ) and hepatocyte growth factor ( HGF ) in long term three dimensional ( 3D ) culture using macroporous poly L lactic acid ( PLLA ) scaffolds on the restoration of such liver specific functions of the fraction . 3D culture using PLLA scaffolds with OSM remarkably enhanced the albumin production and cytochrome P 450 1A1 / 2 capacity with the culture time . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The related members of the interleukin 6 ( IL 6 ) family of cytokines , IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M , act as major inflammatory mediators and induce the hepatic acute phase reaction . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Treatment of hOB cells with particular peptide growth factors ( basic fibroblast growth factor , epidermal growth factor ) , steroid hormones ( dexamethasone , 1 , 25 dihydroxyvitamin D ( 3 ) ) , and cytokines [ interleukin 6 ( IL 6 ) , IL 13 , oncostatin M ] with known involvement in bone cell physiology had no significant effect on PAPP A expression . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The combination of STAT cross linking and inactivation of receptor functions rendered PDT treated cells refractory for at least 24 hours to interleukin 6 and oncostatin M , cytokines known to be elevated at site of tissue damage and inflammation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that growth arrest ( GA ) treatments serum and growth factor withdrawal and growth inhibitory IL 6 family cytokines ( Interleukin 6 and Oncostatin M ( OSM ) ) increase STAT 3 phosphorylation ( pSTAT 3 ) , increase CCAAT enhancer binding protein delta ( C / EBPdelta ) gene expression and induce GA of primary , finite lifespan human mammary epithelial cells ( HMECs ) , and immortalized breast cell lines ( MCF 10A and MCF 12A ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a member of the interleukin 6 ( IL 6 ) cytokine family , has yet to be well studied , especially in the context of the central nervous system ( CNS ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of chondrocyte metabolism by oncostatin M and interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| INTRODUCTION : Oncostatin M ( OSM ) is a multifunctional cytokine of the interleukin 6 family implicated in embryonic development , differentiation , inflammation , and regeneration of various tissues , mainly the liver , bone , and the central nervous and hematopoietic systems . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| HNNEC and HNSCC displayed a prominent signaling in response to oncostatin M , interleukin 6 , IFN gamma , and epidermal growth factor . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| They were allowed to outgrow on the plated culture with the stepwise addition of growth factors acidic fibroblast growth factor ( aFGF ) , hepatocyte growth factor ( HGF ) and oncostatin M ( OSM ) into the culture medium . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Leptin can be considered as a pro inflammatory cytokine that belongs to the family of long chain helical cytokines and has structural similarity with interleukin 6 , prolactin , growth hormone , IL 12 , IL 15 , granulocyte colony stimulating factor and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Using real time PCR , RT PCR , cDNA microarray , immunostaining and efflux assays we demonstrated that stimulation of NHEK and primary human dermal fibroblasts with interleukin 6 ( IL 6 ) , in combination with its soluble alpha receptor , or oncostatin M ( OSM ) for 24 72 h resulted in an upregulation of MRP expression and activity . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a member of the interleukin 6 family of cytokines , is thought to be expressed mostly by activated T lymphocytes and monocytes in adult animals . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 and oncostatin M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p 38 mitogen activated protein kinase and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Acetylcholinesterase inhibitors effects on oncostatin M , interleukin 1 beta and interleukin 6 release from lymphocytes of Alzheimer ' s disease patients . ^^^ The result showed an increase in oncostatin M , interleukin 1 beta ( IL 1 beta ) and interleukin 6 ( IL 6 ) secretion in AD patients compared to healthy controls , and a decrease of cytokine levels in each AD patients treated for 1 month with an acetylcholinesterase inhibitor ( AchEI ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 family of cytokines . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Inflammatory cytokines interleukin 6 and oncostatin m induce plasminogen activator inhibitor 1 in human adipose tissue . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Here , we aimed to investigate whether oncostatin M ( OSM ) was present in gingival crevicular fluid ( GCF ) and to clarify the correlation of GCF OSM and interleukin 6 ( IL 6 ) levels with the severity of periodontitis . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a member of interleukin 6 family cytokines , contributes to the development of nociceptive sensory neurons . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) subfamily of cytokines , including oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , and IL 6 , has been implicated in a variety of physiological responses , such as cell growth , differentiation , and inflammation . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The secretory activity was described by determining total protein , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , oncostatin M ( OSM ) , interleukin 10 ( IL 10 ) and nitric oxide ( NO ) content in the supernatants after 1 , 6 , 24 and 48 hours in cell culture . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , and the related cytokines IL 11 , leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) , are potent stimulators of osteoclastic bone resorption . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 ( IL 6 ) family of cytokines is a family of structurally and functionally related proteins , including IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 ( CT 1 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Through controlled stimulation with single or combined forms of hepatotrophic growth factors ; hepatocyte growth factor ( HGF ) , dexamethasone ( DEX ) and oncostatin M ( OSM ) , we investigated the progressive maturation of CE ES cells , in relation to the control , CD ES cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M is a pleiotropic cytokine belonging to the interleukin 6 family that is expressed by several cell types including activated human T lymphocytes , macrophages , and neutrophils . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a cytokine of the interleukin 6 ( IL 6 ) family , can either promote or inhibit cell growth in various normal and tumor cells . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| This effect is mimicked by interleukin 6 , 1beta and oncostatin M pre treated non sclerotic osteoblasts . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) induce DNA synthesis in Swiss 3T3 cells through common signaling mechanism ( s ) , whereas other related cytokines such as interleukin 6 and ciliary neurotrophic factor do not cause this response . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : Oncostatin M is a multifunctional cytokine belonging to the interleukin 6 family of cytokines . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| HGF synthesis in human lung fibroblasts is regulated by oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , granulocyte colony stimulating factor ( G CSF ) , interleukin 6 ( IL 6 ) , and interleukin 11 ( IL 11 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In these cultures , OSM induced proliferation , collagen synthesis , and interleukin 6 secretion , whereas it inhibited alkaline phosphatase activity . ^^^ These data represent the first report of OSM ' s effects on bone cell function and indicate that , like some other members of the LIF / interleukin 6 subfamily , OSM has potent bone regulatory activity . . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Oncastatin M ( OSM ) is one member of the leukemia inhibitory factor / interleukin 6 family of cytokines that has been shown to be a growth regulatory molecule . ^^^ In osteoblastic cultures , OSM causes marked phenotypic changes and the enhanced secretion of interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The effects of these cytokines on HSF activity are related to variations of IL 6 and OSM secretion . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 and ciliary neurotrophic factor , two cytokines related structurally to OSM and LIF , were not active as EC growth inhibitors . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The magnitude of the heat shock element ( HSE ) HSF binding induced by incubating the cells in a 0 . 7 osM medium was comparable in intensity and time course with that induced by a 44 degrees C heat shock . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| OSM is structurally and functionally related to leukaemia inhibitory factor ( LIF ) , another cytokine in the interleukin 6 ( IL 6 ) family . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| The effect of OSM was compared with those of leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| We have investigated the serum concentrations of interleukin 6 ( IL 6 ) and two IL 6 family cytokines oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) in 63 patients with B cell chronic lymphocytic leukemia ( B CLL ) and 17 healthy controls using the enzyme linked immunosorbent assay ( ELISA ) method . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Each neuropoietic cytokine of IL 11 , OSM and CT 1 has its own specific temporal mRNA expression pattern , which is also different from those of ciliary neuro trophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| While OSM expression in the liver starts in mid gestation and decreases in postnatal stages , hepatocyte growth factor ( HGF ) is mainly expressed in the liver in the first few days after birth . ^^^ In this study , we compared the effect of OSM and HGF on the differentiation of fetal hepatic cells in vitro . ^^^ Like OSM , HGF in the presence of dexamethasone induced expression of glucose 6 phosphatase , tyrosine amino transferase and carbamoyl phosphate synthase , and accumulation of glycogen in fetal hepatic cells , although to a lesser extent than OSM . ^^^ Interestingly , while both OSM and HGF up regulated production of albumin , secretion of albumin occurred only in response to OSM . ^^^ In addition , although hepatic maturation induced by OSM depends on STAT 3 , HGF failed to activate STAT 3 and HGF induced differentiation was independent of STAT 3 . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this interaction is found for OSM but not for other interleukin 6 type cytokines . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined whether human adipose tissue derived stromal cells ( hADSC ) can differentiate into hepatic lineage in vitro . hADSC , that were induced to differentiate into hepatocyte like cells by the treatment of HGF and OSM , had morphology similar to hepatocytes . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| After 4 weeks of differentiation with growth factors bFGF , HGF , and OsM , we obtained hepatocyte like cells that expressed a subset of hepatic genes , secreted albumin and urea , stored glycogen , and showed inducible CYP3A4 mRNA levels . ^^^ |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|