| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| In addition , eIF 2alpha was cleaved by recombinant active caspase 3 in vitro . ^^^ |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| In vitro analysis using purified eIF 2 and purified caspases showed cleavage of eIF2alpha by caspase 3 , 6 , 8 , and 10 but not 9 . ^^^ Caspase 3 most efficiently cleaved eIF2alpha and this could be inhibited by addition of Ac DEVD CHO in vitro . ^^^ When eIF 2 . 2B complex was used as substrate , only caspase 3 was capable of eIF2alpha cleavage , which was not affected by phosphorylation of the alpha subunit . ^^^ |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| We report here that inhibition of caspase 3 activity reduces phosphorylation of PKR and to a certain extent , cleavage of PKR and eIF2alpha in neurons exposed to Abeta peptide . ^^^ |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| During apoptosis , translation undergoes significant down regulation that correlates with caspase 3 mediated cleavage of several translation factors , including eIF4G , 4EBP1 and eIF2alpha . ^^^ |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| Consistent with these results , we found evidence for the activation of unfolded protein response ( UPR ) marked by elevated levels of phosphorylated translation initiation factor , eIF2alpha , increased expression of chaperone proteins such as glucose regulated protein 78 and activation of caspase 12 , a cysteine proteinase in the ER , mediating caspase 3 activation and apoptosis . ^^^ |
|
| Interacting proteins: P05198 and P42574 |
Pubmed |
SVM Score :0.0 |
| TNFalpha treatment induced eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase PKR . ^^^ In addition , expression of a phospho mimetic Ser ( 51 ) to Asp mutant eIF2alpha activated caspase 3 , indicating that eIF2alpha phosphorylation is sufficient to induce apoptosis . ^^^ |
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